CN211884744U

CN211884744U - Continuous albumin dialysis adsorption purification system

Info

Publication number: CN211884744U
Application number: CN201921384261.2U
Authority: CN
Inventors: 王卫利
Original assignee: Tianjin First Central Hospital
Current assignee: Tianjin First Central Hospital
Priority date: 2019-04-02
Filing date: 2019-08-25
Publication date: 2020-11-10
Anticipated expiration: 2029-08-25

Abstract

The utility model discloses a last albumin dialysis adsorbs clean system, the system includes blood return circuit and albumin regeneration circulation circuit, the blood return circuit includes that high flux cerini dialyser cerini connects the human circulation, albumin regeneration circulation circuit connects gradually high flux cerini dialyser cerini, broad spectrum adsorption column, bilirubin adsorption column through the dialysis pipeline, is filled with the albumin dialysate in the return circuit. The system of the utility model has small volume of the hemodialysis loop, and can avoid the problem of unstable circulation caused by overlarge capacity of the extracorporeal blood loop; the albumin has regeneration circulation, can efficiently remove protein-bound toxin of liver failure children, and can remove water-soluble small and medium molecular toxin by a hemodialysis and/or filtration system sequentially. The utility model discloses the system consumptive material is from the wide range of selection, but albumin dislysate cyclic regeneration utilizes, effectively reduces children's artifical liver treatment expense, and operation flow is simple, can effectively alleviate medical personnel's operating pressure.

Description

Continuous albumin dialysis adsorption purification system

Technical Field

The utility model relates to a non-biotype children artificial liver system.

Background

An Artificial Liver Support System (ALSS), which is an extracorporeal Support System for temporarily replacing a part of the functions of the Liver, removes various harmful substances, supplements essential substances, improves the internal environment, creates conditions for Liver function recovery, or serves as a bridge before Liver transplantation. The artificial liver is classified into non-biological type artificial liver, biological type artificial liver and mixed type artificial liver. The non-biological artificial liver technology belongs to the field of blood purification technology essentially, and a series of artificial liver technologies including plasma replacement, plasma (blood) perfusion/bilirubin adsorption, hemofiltration, hemodialysis and the like have been developed based on the basic principles of blood purification of dispersion, convection and adsorption.

Novel artificial liver hybridization techniques have been continuously explored and developed, and some relatively mature commercial treatment models are applied to adult artificial liver support treatment, such as Molecular Adsorption and Recirculation (MARS), Plasma component Separation and Adsorption (FPSA), also known as Prometheus System. The mechanisms of operation of both MARS and Prometheus systems are based on the principle of adsorption, with simultaneous hybridization of dialysis or/and filtration technologies. However, the Prometheus system is not suitable for children due to the large volume of extracorporeal circulation (700-; meanwhile, the two artificial liver systems are complex to operate, and the equipment and the consumables are expensive.

SUMMERY OF THE UTILITY MODEL

In order to solve the problem existing in the prior art, the utility model provides a continuous albumin dialysis adsorption purification system to solve the problem that the current artificial liver hybridization technique is not suitable for the small-weight children because the extracorporeal circulation capacity is big.

The technical scheme of the utility model is that:

a Continuous Albumin Dialysis Adsorption Purification System (CADAPS) comprises a blood loop and an Albumin regeneration circulation loop, wherein the blood loop comprises a high-flux dialyzer connected with human body circulation, the Albumin regeneration circulation loop is sequentially connected with the high-flux dialyzer, a broad-spectrum adsorption column and a bilirubin adsorption column through a Dialysis pipeline, and Albumin dialysate is filled in the loop.

The albumin regeneration circulation loop connecting pipeline is a standard interface, and seamless sequential conventional hemodialysis can be realized.

The continuous albumin dialysis adsorption purification system is applied to the artificial liver of children.

The utility model has the advantages that:

1. the utility model discloses CADAPS's blood return circuit has only designed hemodialysis, and the return circuit volume is little, can avoid because of the too big circulation instability that leads to of extracorporeal blood return circuit capacity, and is particularly crucial to little heavy children.

2. The CADAPS of the utility model adopts an albumin dialysate adsorption mode to replace direct blood or plasma adsorption, thereby avoiding secondary adsorption column coagulation of children patients caused by the limited blood flow speed of treatment; the speed adjustable range of the CADAPS albumin dialysate is large, the adsorption column is not easy to block, and the treatment is guaranteed to be completed. The CADAPS efficiently integrates the dispersion and adsorption principles of blood purification, designs albumin regeneration circulation for albumin-bound toxin, can solve the problem that the toxins such as bilirubin and bile acid of children with liver failure are difficult to remove clinically at present, can perform seamless and sequential hemodialysis and/or hemofiltration, can effectively regulate the serious complications such as acute renal failure, cerebral edema, gastrointestinal insufficiency and the like frequently secondary to children with liver failure and the balance of water electrolysis hyaluronic acid alkali, and is expected to remarkably improve the treatment level of the liver failure of children.

3. The utility model discloses CADAPS albumin regeneration circulation circuit has adopted albumin adsorption regeneration's technique, also is a continuation blood purification technique, and sustainable long-time treatment is until the adsorption column saturation, and the treatment process is little to the circulation influence, and the treatment is abundant. Meanwhile, because the CADAPS can perform seamless and sequential hemodialysis and/or hemofiltration, the problem of unstable circulation caused by repeated blood introduction and blood return is avoided.

4. The utility model discloses CADAPS is good to the compatibility of equipment and consumptive material, and this system can be used to the hemofilter of present the overwhelming majority of brands, and the consumptive material is wide from the selected surface, can seamless sequential persistence kidney substitution treatment, and the sequential treatment need not change the cerini dialyser cerini, will greatly reduce children's artificial liver treatment expense. The system has simple operation process and can effectively reduce the working pressure of medical personnel.

Description of the drawings:

FIG. 1 is a schematic diagram of the system of the present invention;

wherein: 1-high-flux dialyzer; 2-broad spectrum adsorption column; 3-bilirubin adsorption column; 4-pump.

The specific implementation mode is as follows:

the technical solution of the present invention will be described in detail with reference to the accompanying drawings and the detailed description.

The dialyzer and the adsorption column used in the utility model are conventional commercial materials.

The utility model discloses a novel artificial liver support System to children lasts Albumin Dialysis and adsorbs clean System (continuousubu Albumin Dialysis and adsorption Purification System, CADAPS), including blood return circuit and Albumin regeneration circulation circuit, Albumin regeneration circulation circuit is based on Albumin Dialysis principle, two adsorption columns of series connection (a broad spectrum adsorption column 2, a bilirubin adsorption column 3) on Albumin dialysate passageway, forms closed-loop Albumin regeneration circulation circuit, can high-efficiently clear away liver failure children's protein and combine the toxin. The connecting pipeline is a standard interface, so that a seamless sequential hemodialysis and/or filtration system can be realized, and water-soluble small and medium molecular toxins can be removed; furthermore, the sequential treatment does not require filter replacement, only dialysate replacement. Only the high-flux dialyzer 1 is arranged on the blood loop, the volume of the blood chamber is small, and the device is suitable for children with small weight.

Taking a baby with weight of 4kg as an example, the extracorporeal circulation blood volume in the system blood loop of the utility model is 60-70ml which is far lower than 700ml of the extracorporeal circulation blood volume of the Prometheus system, which is particularly critical for the baby with small weight; the required albumin dialysate of albumin regeneration circulation circuit is about 700ml, generally sustainable treatment more than 8h, and ordinary non-circulation regeneration system then needs albumin dialysate 2400ml/h, to the albumin dialysate of high price, the utility model discloses greatly reduced treatment cost.

The invention has been described above by way of example, and it should be noted that any simple variants, modifications or other equivalent substitutions by a person skilled in the art without spending creative effort may fall within the scope of protection of the present invention without departing from the core of the present invention.

Claims

1. The continuous albumin dialysis adsorption purification system is characterized by comprising a blood loop and an albumin regeneration circulation loop, wherein the blood loop comprises a high-pass dialyzer connected with human body circulation, the albumin regeneration circulation loop is sequentially connected with the high-pass dialyzer, a broad-spectrum adsorption column and a bilirubin adsorption column through a dialysis pipeline, and albumin dialysate is filled in the loop.

2. The continuous albumin dialysis adsorption purification system of claim 1, wherein the albumin regeneration circulation loop connection line is a standard interface for seamless sequential routine hemodialysis.