CN211884136U

CN211884136U - Rat periodontitis model building operation fixing device

Info

Publication number: CN211884136U
Application number: CN202020044890.7U
Authority: CN
Inventors: 安莹; 马志伟; 刘玲侠; 曲红蕾; 张琳琳; 陈芳
Original assignee: Fourth Military Medical University FMMU
Current assignee: Fourth Military Medical University FMMU
Priority date: 2020-01-10
Filing date: 2020-01-10
Publication date: 2020-11-10
Anticipated expiration: 2030-01-10

Abstract

The invention discloses a fixing device for rat periodontitis modeling operation, which comprises a plate with an inclined surface, wherein a plurality of through holes are formed in the surface of the plate, a plurality of fixing nails for fixing maxilla are arranged on the side edge of the high end of the plate, and a plurality of fixing nails for fixing four limbs are arranged on the side edge of the high end of the plate. The fixing device for rat periodontitis modeling operation can well fix the limbs, the upper jaw and the lower jaw of a rat, the operation visual field is wide, the oral cavity structure of the rat is clearly exposed, the operation space for performing ligature or scratch operation is large, the operation success rate is greatly improved, and the device can be used for researching the space-time expression change of periodontal tissues in the development process of mild periodontitis to severe periodontitis and providing conditions and basis for further researching periodontitis.

Description

Rat periodontitis model building operation fixing device

Technical Field

The utility model relates to a medical instrument, concretely relates to rat periodontitis model operation fixing device.

Background

Periodontitis is a major disease that compromises oral health and is also a major cause of oral tooth loss. According to statistics, periodontitis accounts for about 30% -44% of tooth extraction reasons, and therefore, the research on the causes and treatment methods of periodontitis is the key point of research of scholars at home and abroad. Many causes of periodontitis are caused, researches on cytokine network regulation are concerned, and in order to research the role of cytokine network regulation in the occurrence and development of periodontitis, a stable and reliable experimental periodontitis animal model needs to be established. The utility model discloses a ligature method of different materials establishes periodontitis animal model to seek an effective and simple and easy periodontitis model building mode, provide the condition for further research periodontitis's morbidity process and treatment. An experimental periodontitis animal model is established, and a basis is provided for researching occurrence, development and treatment of periodontitis in different periods and different degrees. The method comprises the steps of ligating the first upper molar of a rat by using 200-250g rat and silk or orthodontic ligature wire, and obtaining materials at 2 weeks, 4 weeks and 6 weeks respectively to observe pathological changes of the rat. Results compared with the control group, the rats in the orthodontic ligature wire group have periodontitis manifestations of gingival bleeding, periodontal pocket formation and alveolar bone resorption in different degrees in clinical and pathological histology aspects; most of the silk threads fall off in the observation period of the silk thread ligation group, and the periodontitis expression is not induced. In order to facilitate observing the periodontitis performance, the application designs a rat periodontitis model-making operation fixing device, the operation visual field is wide, the rat oral cavity structure is clear to be exposed, the operation space for tying or scratching is large, and the operation success rate is greatly improved.

SUMMERY OF THE UTILITY MODEL

For solving the technical problem of unstable fixation of the rat in the prior art, the utility model discloses a

A fixing device for rat periodontitis model-making operation is characterized by comprising a cylinder body, a lower fixing plate, a lower flat plate and a control rod, wherein the lower fixing plate is contacted with the abdominal side of a rat; the cylinder body and the lower fixing plate are fixedly connected by transparent materials in a hot melting mode; the lower fixing plate is fixedly connected with the lower flat plate through a connecting block; the plane of the upper side of the lower fixing plate is a plane parallel to the axis of the cylinder; the cylindrical surface on the inner surface side of the cylinder is in a horn shape, and the opening towards the front is gradually reduced; a vent hole and an operation hole are formed at the front end of the cylinder body, when a fixed rat is accommodated, the fixed rat breathes through the vent hole, and the upper molars of the rat are opened and closed through the operation hole; the side surface of the lower flat plate is provided with first fixing buckles for four limbs of a rat, the number of the first fixing buckles is 4, and the first fixing buckles are symmetrically arranged on the side surface of the lower flat plate in pairs; and the front end of the lower fixing plate is provided with a second fixing buckle for fixing the lower molar of the rat.

Preferably, the transparent material is transparent propylene.

Drawings

FIG. 1 is a block diagram of an embodiment of the present invention;

1. barrel, 2, bottom plate, 3, bottom plate, 4, two fixed buckles, 5, rat, 6, connecting block, 7, control rod, 8, insertion groove

Detailed Description

As shown in the attached figure 1, the fixing device for rat periodontitis modeling operation comprises a cylinder body 1, a lower fixing plate 2 contacted with the abdominal side of a rat, a lower flat plate 3 arranged below the lower fixing plate 2 and a control rod 7, wherein an insertion groove 8 for inserting the control rod 7 is formed in the cylinder body 1, and the control rod 7 is arranged in the insertion groove 8 and is used for fixing rats with different body sizes; the cylinder 1 and the lower fixing plate 2 are fixedly connected by a transparent material in a hot melting mode; the lower fixing plate 2 is fixedly connected with the lower flat plate 3 through a connecting block 6; the plane of the upper side of the lower fixing plate 2 is a plane parallel to the axis of the cylinder 1; the cylindrical surface on the inner surface side of the cylinder body 1 is in a horn shape, and the opening towards the front is gradually reduced; a vent hole 9 and an operation hole 10 formed at the front end of the cylinder 1, wherein when a fixed rat is accommodated, the fixed rat breathes through the vent hole 9, and the upper molars of the rat are opened and closed through the operation hole 10; the side surface of the lower flat plate 3 is provided with a first fixing buckle 4 used for the limbs of a rat, the number of the first fixing buckles is 4, and the first fixing buckles are symmetrically arranged on the side surface of the lower flat plate 3 in pairs; and the front end of the lower fixing plate 2 is provided with a second fixing buckle for fixing the lower molar of the rat.

Preferably, the transparent material is transparent propylene.

After the rats are anesthetized by 5% chloral hydrate, the four limbs are respectively tied with strings and fixed on four fixing nails at two sides of the wood board, the head side of the rat is positioned at the front end side of the cylinder body 12, two lower molar teeth of the rat are fixed on a second fixing buckle in the front side edge of the lower fixing plate 222 by the strings, and the four limbs of the rat are respectively and correspondingly fixed on the four fixing buckles at two sides of the wood board by the strings.

During operation, the upper molars of the rat are lifted by a string, the left and right cheeks are propped open by using forceps through the operation hole 10, the internal structure of the oral cavity of the rat is clearly exposed, the upper molars and the lower molars are respectively arranged in two rows, each row is three, and then the establishment of the experimental periodontitis animal model can be smoothly carried out.

Although the description given above and in the description contains many specifics, these should not be construed as limiting the scope of the invention but as merely providing examples and illustrations of some of the embodiments of the invention. The scope of the invention should, therefore, be determined by the appended claims and their legal equivalents, rather than by the examples given in the specification.

Claims

1. A fixing device for rat periodontitis model-making operation is characterized by comprising a cylinder body, a lower fixing plate, a lower flat plate and a control rod, wherein the lower fixing plate is contacted with the abdominal side of a rat; the cylinder body and the lower fixing plate are fixedly connected by transparent materials in a hot melting mode; the lower fixing plate is fixedly connected with the lower flat plate through a connecting block; the plane of the upper side of the lower fixing plate is a plane parallel to the axis of the cylinder; the cylindrical surface on the inner surface side of the cylinder is in a horn shape, and the opening towards the front is gradually reduced; a vent hole and an operation hole are formed at the front end of the cylinder body, when a fixed rat is accommodated, the fixed rat breathes through the vent hole, and the upper molars of the rat are opened and closed through the operation hole; the side surface of the lower flat plate is provided with first fixing buckles for four limbs of a rat, the number of the first fixing buckles is 4, and the first fixing buckles are symmetrically arranged on the side surface of the lower flat plate in pairs; and the front end of the lower fixing plate is provided with a second fixing buckle for fixing the lower molar of the rat.

2. The rat periodontitis model operation fixture device according to claim 1, wherein: the transparent material is transparent propylene.