CN211834409U

CN211834409U - Wearable blood glucose meter

Info

Publication number: CN211834409U
Application number: CN202020189468.0U
Authority: CN
Inventors: 郑兆柱; 关诗陶; 吴昕蒙; 席瑞凡; 李翔宇; 李刚; 王晓沁
Original assignee: Suzhou University
Current assignee: Liu Yingqian
Priority date: 2020-02-20
Filing date: 2020-02-20
Publication date: 2020-11-03
Anticipated expiration: 2030-02-20

Abstract

The utility model relates to a wearable glucometer, which comprises a main body unit wearable on a human body, a detection unit arranged on the main body unit, a digital/analog circuit conversion module, a display and a pressure stabilization unit; the detection unit comprises a micro-needle seat and a plurality of nano-micro-needles arranged on the micro-needle seat, the nano-micro-needles are used for contacting and minimally-invasively penetrating into the skin of a human body so as to measure the blood glucose concentration biological signals of the human body, each nano-micro-needle comprises a micro-needle body and a silk fibroin layer wrapped outside the micro-needle body, and the micro-needle body is also provided with glucose oxidase which is exposed outside the silk fibroin layer; the digital/analog circuit conversion module is respectively and electrically connected with the detection unit and the display, and the biological signals of the blood glucose concentration acquired by the detection unit are displayed on the display after being converted by the digital/analog circuit conversion module; the pressure stabilizing unit comprises an elastic buffer element, and the detection unit is connected with the main body unit through the elastic buffer element.

Description

Wearable blood glucose meter

Technical Field

The utility model relates to the field of medical equipment, especially, relate to a wearable blood glucose meter.

Background

The traditional blood sugar detection methods mainly comprise the following three methods: extracting venous blood for detection, blood sugar detection of a rapid blood sugar tester and blood sugar detection of a blood sugar test paper colorimetric method. However, these blood sampling measurements not only bring endless physical and mental double troubles to patients, but also are easy to infect and cause more serious consequences. Therefore, there is a necessary trend to develop a minimally or even non-invasive blood glucose concentration measuring system to alleviate the pain of diabetic patients.

Wearable devices, also known as wearable computing devices, generally refer to electronic communication devices embedded in clothing or in the form of accessories or personal wear. Such devices can be comfortably worn by a user and serve to extend perception, monitor status, and improve work efficiency. Among the existing clinical medical laboratory detection technologies, the biosensing technology is gradually a new research hotspot in the medical field due to the advantages of simple and convenient operation, high sensitivity, rapid analysis, small size, easy carrying, low cost and the like. The biosensor technology mainly applies a microelectrode sensor, and the nano material plays an important role in the preparation of the biosensor due to the characteristics of good adsorption capacity, large specific surface area, many surface active sites, high catalytic efficiency and the like, so the nano microneedle is an optimal device for realizing the biosensor technology.

Many types of wearable blood glucose meters, such as the wearable blood glucose monitoring devices disclosed in CN107280686A, CN205795708U, CN107088070A, CN107088070A, CN 107174257A, are currently available, and the emphasis is on optimizing the device composition and signal transmission of the blood glucose monitoring device, which is also one of the hot spots of research. However, the acquisition of the biological signal is the most important thing of the wearable device, and the process of acquiring the biological signal by the blood glucose monitoring mode when the wearable blood glucose meter is used is complex.

SUMMERY OF THE UTILITY MODEL

For solving the technical problem, the utility model aims at providing a wearable blood glucose meter, this blood glucose meter equipment is simple and convenient portable, and the cost of manufacture is not high, measures accurately, utilizes nanometer micropin real-time supervision human internal blood sugar concentration, and the electron that produces through the glucose oxidase on the micropin and glucose reaction turns into visual blood sugar concentration data and monitors to realize the monitoring of high accuracy to the blood sugar, and reach the painless degree of wicresoft when carrying out blood sugar detection to the human body.

The utility model relates to a wearable glucometer, which comprises a main body unit, a detection unit, a digital/analog circuit conversion module, a display and a pressure stabilization unit, wherein the detection unit, the digital/analog circuit conversion module, the display and the pressure stabilization unit are arranged on the main body unit; wherein the content of the first and second substances,

the main body unit can be worn on a human body;

the detection unit comprises a micro-needle seat and a plurality of nano micro-needles arranged on the micro-needle seat, the nano micro-needles are used for contacting and minimally-invasively penetrating into the skin of a human body so as to measure the blood glucose concentration biological signals of the human body, each nano micro-needle comprises a micro-needle body and a silk fibroin layer wrapped outside the micro-needle body, and the micro-needle body is also provided with glucose oxidase which is wrapped inside the silk fibroin layer;

the digital/analog circuit conversion module is respectively and electrically connected with the detection unit and the display, and the biological signals of the blood glucose concentration acquired by the detection unit are displayed on the display after being converted by the digital/analog circuit conversion module;

the pressure stabilizing unit comprises an elastic buffer element, and the detection unit is connected with the main body unit through the elastic buffer element.

Furthermore, the main body unit comprises a shell, the detection unit, the digital/analog circuit conversion module and the pressure stabilization unit are positioned in the shell, the shell is provided with a lower surface, the lower surface is arranged close to the skin of a human body, a through hole is formed in the lower surface, and the nano micro-needle penetrates out of the through hole and is in contact with the skin of the human body.

Further, the diameter of the through hole is smaller than that of the micro needle seat so as to limit the micro needle seat in the shell. The detection unit makes the nanometer micropin on the micropin seat outwards pop out through elastic buffer element, and when the micropin seat contacted with the lower surface, the nanometer micropin reached maximum and popped out, avoids the micropin excessively to invade human skin and causes the injury.

Furthermore, the through hole is circular, and the micro needle seat is circular.

Further, the housing has an upper surface disposed opposite the lower surface, and the display is located on the upper surface.

Furthermore, the number of the nano-micro-needles is 3, the nano-micro-needles are provided with electrodes, the electrodes are respectively used as a working electrode, an auxiliary electrode and a reference electrode when contacting and minimally invasive penetrating into the skin of the human body, and the working electrode, the auxiliary electrode and the reference electrode are respectively and electrically connected with the digital/analog circuit conversion module.

Furthermore, the digital/analog circuit conversion module is internally provided with a circuit structure which displays the biological signals of the blood glucose concentration detected by the detection unit as current signals, and the current introduced by the Working Electrode (WE), the Reference Electrode (RE) and the auxiliary electrode (CE) is received, then processed in the module and displayed on the display. The silk fibroin layer on the surface of the nano microneedle endows the nano microneedle with good biocompatibility.

Furthermore, the working electrode and the reference electrode are platinum metal electrodes, and the auxiliary electrode is a silver electrode.

Furthermore, the pressure stabilization unit comprises a supporting plate which is positioned in the shell, one end of the elastic buffer element is connected with the supporting plate, and the other end of the elastic buffer element is connected with one side of the microneedle seat, which is far away from the nanometer microneedle.

Further, glucose oxidase is located on the needle tip of the microneedle body.

Further, the elastic buffer element is a spring.

Furthermore, the main body unit is of a wristwatch structure and is provided with a watchband, and the main body unit is worn on a human body through the watchband. The wrist strap type wearable device has the advantages of small display screen, capability of realizing measurement at any time, high close relation with the limb movement of a user and the like.

Further, the display is an LED display screen.

Further, the length of the nano microneedle is 500 nm-1000 nm, the thickness of the silk fibroin layer 201 is 100 nm-20 mu m, and the number of the glucose oxidases is 0.05-5U/piece.

The detection unit of the utility model utilizes the silk fibroin layer to embed the glucose oxidase. Glucose oxidase catalyzes glucose in body fluid to be oxidized to generate gluconic acid and hydrogen peroxide, the hydrogen peroxide is oxidized on the surface of the platinum electrode to generate oxygen, electrons are released, and the electrons are transferred along with the platinum electrode to form current. The current intensity is therefore proportional to the glucose concentration, which translates to the glucose level in the body fluid. Utilize the utility model discloses a during wearable glucometer monitoring blood sugar, only need dress the main part unit on the human body, one side and the human contact that will have nanometer micropin, nanometer micropin can the wicresoft pierce human skin in, produce electron and form the electric current after glucose oxidase on the nanometer micropin reacts with the interior glucose of body fluid, this current signal transmission to digital/analog circuit conversion module, it handles the back with current signal and converts digital signal into, this digital signal shows on the display, make the monitoring person can directly acquire blood sugar concentration data by the display. In addition, the contact of wearable blood glucose meter and human body fluid is the key of realizing the long-time real-time supervision of glucose level, the utility model discloses adopt the pressure stabilization unit innovatively, can solve the problem that wearable blood glucose meter can't stabilize the contact with the human body for a long time. The utility model discloses the nanometer micropin of fibroin cladding that utilizes to contain glucose oxidase makes the glucose under the human skin produce the electron through chemical reaction, with the leading-in digital analog circuit conversion module of electric current, operation demonstrates real-time blood glucose concentration on the electronic display ware in the process module.

Borrow by above-mentioned scheme, the utility model discloses at least, have following advantage:

1. the utility model discloses a nanometer micropin structure of wearable blood glucose meter, not only simple structure, strong adaptability, cost are lower, make micropin sensor and body fluid contact through the wicresoft mode moreover to the realization is continuous carries out real-time supervision to concentration under the degree of wicresoft, has broken through the shortcoming that traditional blood glucose monitoring mode process is complicated simultaneously, and the person of facilitating the use in time knows the health condition, avoids leading to the harm to health because of the discovery problem is too late.

2. The utility model discloses break through the inaccurate problem of traditional monitoring blood sugar mode, utilize detecting element and digital/analog circuit conversion module to carry out the conversion between chemical signal and the signal of telecommunication, combine the display to show the reading simultaneously, further improve the utility function of wearable watch, equipment humanized characteristics are more obvious.

3. The utility model can realize the real-time monitoring and reflecting of the blood sugar concentration; meanwhile, the design concept of the traditional blood glucose meter is broken through, the size of the wearable blood glucose meter for real-time monitoring is reduced, the precision of the wearable blood glucose meter for real-time monitoring is improved, and the cost for detecting blood glucose is reduced; the complexity of detecting the blood sugar is reduced.

4. The utility model discloses a pressure stabilization unit can guarantee that nanometer micropin invades human skin with the minimal invasion degree for a long time, can not let the micropin too outstanding simultaneously, causes the injury to the human body, can protect it not impaired when nanometer micropin meets great pressure again.

5. The utility model discloses utilize silk fibroin as glucose oxidase's embedding matrix, can keep the activity of enzyme for a long time, guarantee micropin sensor validity, measuring result's validity.

The above description is only an overview of the technical solution of the present invention, and in order to make the technical means of the present invention clearer and can be implemented according to the content of the specification, the following description is made with reference to the preferred embodiments of the present invention and the detailed drawings.

Drawings

FIG. 1 is a schematic diagram of the lower surface structure of a wearable glucose meter;

FIG. 2 is a schematic diagram of the upper surface structure of a wearable glucose meter;

FIG. 3 is a schematic diagram of the wearable glucose meter in a disassembled state (not shown in the watch band);

fig. 4 is a schematic structural diagram of the detection unit.

Description of reference numerals:

1-a body unit; 3-a display; 4-digital/analog circuit conversion module; 5-a wire; 11-lower surface; 12-a through hole; 13-a watchband; 14-upper surface; 20-nano microneedles; 21-a micro-needle seat; 60-a resilient cushioning element; 61-a support plate; 200-microneedle body; 201-silk fibroin layer; 202-electrode slice.

Detailed Description

The following describes the present invention in further detail with reference to examples. The following examples are intended to illustrate the invention, but are not intended to limit the scope of the invention.

Examples

Referring to the drawings, the present invention provides a wearable blood glucose meter, which comprises a main unit 1, a detection unit, a digital/analog circuit conversion module 4, a display 3 and a pressure stabilization unit, wherein the detection unit, the digital/analog circuit conversion module 4, the display 3 and the pressure stabilization unit are disposed on the main unit 1.

The main body unit 1 is of a wristwatch structure, the main body unit 1 is provided with a watchband 13, and the main body unit 1 is worn on a human body through the watchband 13. The main body unit 1 comprises a shell, the detection unit, the digital/analog circuit conversion module 4 and the pressure stabilization unit are positioned in the shell, the shell is provided with an upper surface 14 and a lower surface 11 which are oppositely arranged, the lower surface 11 is arranged close to the skin of a human body, and the lower surface 11 is provided with a circular through hole 12. The display 3 is an LED display screen which is fixed to the upper surface 14 of the main unit 1.

The detection unit comprises a

micro-needle seat

21 and 3 nano-micro-needles 20 arranged on the micro-needle seat 21, the nano-micro-needles 20 are used for contacting and minimally-invasively penetrating into the skin of a human body to measure the biological signals of the blood glucose concentration of the human body, and the nano-micro-needles 20 penetrate out of the through holes 12 on the lower surface 11 of the main body unit 1 and contact with the skin of the human body. The micro needle holder 21 is a circular plate. The diameter of the through hole 12 on the lower surface 11 of the main body unit 1 is smaller than the diameter of the micro-needle seat 21 so as to limit the micro-needle seat 21 inside the housing and prevent the micro-needle from excessively protruding. When the micro-needle seat 21 contacts with the lower surface 11, the nano micro-needle 20 extends out to the maximum extent, and the micro-needle is prevented from excessively invading the skin of the human body to cause injury.

The nano-micro-needle 20 comprises a conical micro-needle body 200 and a silk fibroin layer 201 wrapped outside the micro-needle body 200, an electrode plate 202 is connected inside each micro-needle body 200 in an insertion manner, and the electrode plate 202 is electrically connected with the digital/analog circuit conversion module 4 through a lead 5. The width of the microneedle body 200 is sequentially reduced from the direction close to the microneedle base 21 to the direction away from the microneedle base. The needle tip of the microneedle body 200 is further provided with glucose oxidase, and the glucose oxidase is embedded in the silk fibroin layer 201. Preferably, the length of the nano-micro needle 20 is 500nm to 1000nm, the thickness of the silk fibroin layer 201 is 100nm to 20 μm, and the number of glucose oxidases is 0.05 to 5U/piece. The needle tip of the microneedle body 200 plays a role in providing glucose oxidase and transferring electrons, and the silk fibroin layer 201 plays a role in protecting the microneedle body 200, embedding the glucose oxidase and providing good biocompatibility. By inserting electrode pads 202 made of different materials into the 3 nano-microneedles 20, the nano-microneedles 20 are respectively used as a working electrode, an auxiliary electrode and a reference electrode. The electrode plates 202 of the working electrode and the reference electrode are made of platinum metal, the electrode plates 202 of the auxiliary electrode are made of silver, and the electrode plates 202 have the function of transmitting current.

The digital/analog circuit conversion module 4 is electrically connected with the electrode plate 202 of the detection unit, and is also electrically connected with the display 3 through the lead 5 in the shell of the main body unit 1, and the biological signals of blood glucose concentration collected by the detection unit are displayed on the display 3 after being converted by the digital/analog circuit conversion module 4, so that the monitoring of blood glucose is more intuitive. The digital/analog circuit conversion module 4 is internally provided with a circuit structure for displaying the detected blood sugar concentration as a current signal, and the circuit structure receives the currents led in by the working electrode, the reference electrode and the auxiliary electrode, processes the currents in the module and converts the currents into digital signals.

The pressure stabilizing unit comprises an elastic buffer element 60 and a support plate 61, the support plate 61 is positioned in the casing, one end of the elastic buffer element 60 is fixedly connected with the support plate 61, and the other end is connected with one side of the microneedle seat 21 far away from the nano microneedle 20. The detection unit makes the nano-micro-needle 20 on the micro-needle seat 21 protrude outwards through the elastic buffer element 60. Preferably, the resilient cushioning element 60 is a spring.

Utilize the utility model discloses a during wearable glucometer monitoring blood sugar, only need wear main part unit 1 on the human body, one side and the human contact that will have nanometer micropin 20, nanometer micropin 20 can the wicresoft pierce in human skin, produce electron and form the electric current after glucose oxidase on the nanometer micropin 20 reacts with the interior glucose of body fluid, this current signal transmission is to digit analog circuit conversion module 4, it handles the back with current signal and converts digital signal into, this digital signal shows on display 3, make the monitoring person can directly acquire blood sugar concentration data by display 3.

The utility model discloses utilize the nanometer micropin 20 of silk fibroin cladding that contains glucose oxidase to make the glucose under the human skin produce the electron through chemical reaction, with the leading-in digital analog circuit conversion module 4 of electric current, the operation through digital analog circuit conversion module 4 demonstrates real-time blood glucose concentration on display 3.

The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, it should be noted that, for those skilled in the art, a plurality of modifications and variations can be made without departing from the technical principle of the present invention, and these modifications and variations should also be regarded as the protection scope of the present invention.

Claims

1. A wearable blood glucose meter, characterized in that: the pressure stabilizing device comprises a main body unit, a detection unit, a digital/analog circuit conversion module, a display and a pressure stabilizing unit, wherein the detection unit, the digital/analog circuit conversion module, the display and the pressure stabilizing unit are arranged on the main body unit;

the main body unit can be worn on a human body;

the pressure stabilizing unit comprises an elastic buffer element, and the detecting unit is connected with the main body unit through the elastic buffer element.

2. The wearable glucose meter of claim 1, wherein: the main part unit includes a casing, detecting element, digital/analog circuit conversion module and pressure stabilization unit are located in the casing, the casing has the lower surface, the lower surface is close to human skin setting, be equipped with the through-hole on the lower surface, nanometer micropin by wear out in the through-hole and contact with human skin.

3. The wearable glucose meter of claim 2, wherein: the diameter of the through hole is smaller than that of the micro needle seat so as to limit the micro needle seat in the shell.

4. The wearable glucose meter of claim 2, wherein: the shell is provided with an upper surface opposite to the lower surface, and the display is positioned on the upper surface.

5. The wearable glucose meter of claim 1 or 2, wherein: the number of the nano micro needles is 3, the nano micro needles are provided with electrodes and respectively serve as a working electrode, an auxiliary electrode and a reference electrode when contacting and minimally invasive penetrating into human skin, and the working electrode, the auxiliary electrode and the reference electrode are respectively and electrically connected with the digital/analog circuit conversion module.

6. The wearable glucose meter of claim 5, wherein: the working electrode and the reference electrode are platinum metal electrodes, and the auxiliary electrode is a silver electrode.

7. The wearable glucose meter of claim 2, wherein: the pressure stabilization unit comprises a supporting plate, the supporting plate is located in the shell, one end of the elastic buffer element is connected with the supporting plate, and the other end of the elastic buffer element is connected with one side, far away from the nano microneedle, of the microneedle seat.

8. The wearable glucose meter of claim 1, wherein: the glucose oxidase is positioned on the needle tip of the microneedle body.

9. The wearable glucose meter of claim 1, wherein: the elastic buffer element is a spring.

10. The wearable glucose meter of claim 1, wherein: the main body unit is of a wristwatch structure and is provided with a watchband, and the main body unit is worn on a human body through the watchband.