CN211460231U

CN211460231U - Single-electrode implanted blood glucose sensor

Info

Publication number: CN211460231U
Application number: CN201922015128.6U
Authority: CN
Inventors: 梁波; 叶学松; 任航旭
Original assignee: Zhejiang University ZJU
Current assignee: Zhejiang University ZJU
Priority date: 2019-11-20
Filing date: 2019-11-20
Publication date: 2020-09-11
Anticipated expiration: 2029-11-20

Abstract

The utility model discloses a single electrode implanted blood sugar sensor, it contains a basement, and the plane is fixed with the negative electrode of aciculiform positive electrode and platykurtic under the basement. The lower end of the flat negative electrode is decorated with conductive gel close to the skin, and the needle-shaped positive electrode and the upper end of the flat negative electrode are both connected with conductive strips. A printed circuit board is fixed on the upper end of the conducting strip, and the electric signals of the positive and negative electrodes are connected with the contact of the printed circuit board through the conducting strip. The utility model discloses a needle positive electrode pierces and stops in the superficial top layer of human skin, and the negative electrode then is fixed in the body surface to this comes blood sugar reaction current and converts blood sugar concentration parameter output in continuously surveying the body fluid, realizes the continuous measurement to blood sugar, and has the characteristics that the wound is little, easy operation, technology is simplified.

Description

Single-electrode implanted blood glucose sensor

Technical Field

The utility model relates to a medical treatment monitoring instrument technical field's device, more specifically say, relate to a single electrode implanted blood glucose sensor.

Background

Monitoring of blood glucose is very important for diabetics, and blood glucose values help to assess conditions of glucose metabolism disorders in diabetics. The diabetes management can be effectively carried out by real-time continuous dynamic monitoring of the blood sugar, and the blood sugar is maintained at a normal value by timely injecting insulin or supplementing glucose.

At present, there is a method for monitoring in vitro after blood collection, but the change of glucose concentration in the body of a diabetic patient is influenced by various factors, and the instantaneous concentration of the glucose concentration is unpredictable under the influence of various factors such as environmental temperature, mood change, physical activity and the like. When the method is used for controlling the blood sugar level, blood must be taken for many times every day, which causes heavy burden on the mind and body of a patient.

The existing portable dynamic blood glucose sensor comprises 2 to 3 electrodes, the front ends of all the electrodes need to be invaded into the skin of a human body in the using process and stay on the superficial layer of the skin of the human body, so that at least 2 to 3 wounds are generated, the complexity of operation is increased, and a plurality of wounds can generate certain psychological pressure on a patient.

At present, two electrodes can be integrated at an intrusion end in order to reduce wounds, but the method needs more complex process means.

SUMMERY OF THE UTILITY MODEL

The utility model provides a single electrode implanted blood glucose sensor to the above-mentioned not enough that prior art exists. The working electrode of the sensor is punctured into and stays on the superficial layer of human skin, while the reference electrode is attached and fixed on the surface of the human skin, so that the blood sugar is continuously monitored, and only one wound is generated.

The utility model provides a technical scheme that its technical problem adopted as follows:

a single electrode implanted blood sugar sensor is provided with a base and a printed circuit board, wherein a needle-shaped positive electrode and a flat negative electrode are fixed on the bottom surface of the base, and the distance between the tip of the needle-shaped positive electrode and the bottom surface of the base is larger than the distance between the bottom surface of the flat negative electrode and the bottom surface of the base; the fixed ends of the needle-shaped positive electrode and the flat negative electrode are respectively connected with corresponding signal contacts on a printed circuit board through different conducting strips to form a double-electrode system for detecting blood sugar.

Preferably, the needle-shaped positive electrode is of a multilayer composite structure, the needle core positioned in the center is made of a metal material, and the outside of the needle core is sequentially wrapped with a catalytic metal layer, a biosensing layer and a biocompatible polymer permeation membrane layer.

Further, the catalytic metal layer is a platinum layer.

Further, the biosensing layer is a glucose oxidase layer.

Furthermore, the biocompatible polymer permeable membrane layer is a polyurethane layer.

Preferably, the inner structure of the flat negative electrode is made of metal, and the surface of the inner structure is compounded with a silver/silver chloride layer.

Preferably, a counter electrode is further fixed on the bottom surface of the base, and the counter electrode is also connected with a corresponding signal contact on the printed circuit board through a conducting strip to form a three-electrode system.

Preferably, the bottom surface of the flat negative electrode, which is used for being attached to the skin of a human body, is covered with a conductive layer. If the sensor is provided with a counter electrode, the bottom surface of the counter electrode, which is used for being attached to the skin of a human body, needs to be covered with a conductive layer. Further, the conductive layer is a conductive gel.

Preferably, an electrically insulating top cover is mounted on the base, and the printed circuit board is disposed and enclosed in the cavity defined by the two.

Preferably, the printed circuit board comprises a constant potential circuit, a Bluetooth antenna, a metal contact, a microprocessor and a lithium battery.

Compared with the prior art, the utility model discloses following beneficial effect has: only one needle-shaped positive electrode is implanted under the skin, so that the blood glucose reaction current in the body fluid is continuously detected and converted into blood glucose concentration parameters for continuous output. Only one wound is needed in the whole process, so that the pain feeling during implantation can be greatly reduced, and the user experience is increased.

Drawings

Fig. 1 is a schematic view of the overall structure of the present invention;

fig. 2 is an exploded view of the present invention;

fig. 3 is a schematic diagram of a needle-shaped positive electrode of the present invention.

The reference numbers in the figures are: the biosensor comprises a base 1, a needle-shaped positive electrode 2, a flat negative electrode 3, a conducting strip 4, a printed circuit board 5, a top cover 6, a needle core 2.1, a catalytic metal layer 2.2, a biosensing layer 2.3 and a biocompatible polymer permeation film layer 2.4.

Detailed Description

The following description will be made in detail with reference to the accompanying drawings, which are implemented on the premise of the technical solution of the present invention, and the detailed embodiments and the specific operation process are given, but the scope of the present invention is not limited to the following examples.

In a preferred embodiment of the present invention, as shown in fig. 1 and 2, a single electrode implantable blood glucose sensor is provided having a base 1 and a printed circuit board 5. The base 1 is a mounting framework of the whole sensor, and a needle-shaped positive electrode 2 and a flat negative electrode 3 are fixed on the bottom surface of the base 1. The needle-shaped positive electrode 2 is vertically installed with the bottom surface of the base 1, the tip end of the needle-shaped positive electrode is arranged downwards, and the flat negative electrode 3 is flatly attached to the bottom of the base 1. When in use, the tip of the needle-shaped positive electrode 2 is implanted into the surface layer of the skin, and the flat negative electrode 3 is tightly adhered to the surface of the skin, so the distance between the tip of the needle-shaped positive electrode 2 and the bottom surface of the base 1 needs to be larger than the distance between the bottom surface of the flat negative electrode 3 and the bottom surface of the base 1, and the tip of the needle-shaped positive electrode 2 is more protruded relative to the bottom surface of the flat negative electrode 3. The fixed end of the needle-shaped positive electrode 2 is connected with a metal contact point for signal input on the printed circuit board 5 through a conducting strip 4, and the fixed end of the flat negative electrode 3 is connected with another metal contact point for signal input on the printed circuit board 5 through another conducting strip 4, thereby forming a double-electrode system for blood sugar detection. The two electrodes generate an electric signal capable of reflecting the blood glucose concentration through an electrochemical reaction, and transmit the electric signal into the printed circuit board 5. An electrically insulating top cover 6 of plastic material is fitted to the base 1, and a printed circuit board 5 is housed and enclosed in the cavity formed by the two.

In the present invention, the needle-shaped positive electrode 2 and the flat negative electrode 3 function to obtain the blood glucose concentration electric signal in the body fluid, and the printed circuit board 5 functions to receive the blood glucose concentration electric signal collected by the electrodes and perform corresponding processing on the signal. The specific form and circuit structure of the printed circuit board 1-2 can be designed with the required functions, and the current market products can also be adopted, which is not the key of the utility model. Generally, a constant potential circuit, a bluetooth antenna, a metal contact, a microprocessor, a peripheral circuit and a lithium battery are required to be arranged on the printed circuit board 5. The electric signals collected by the electrodes need to be transmitted to a microprocessor of the printed circuit board 5 through metal contacts, and then are wirelessly transmitted to a corresponding upper computer through a Bluetooth antenna.

In a two-electrode system, the needle-shaped positive electrode 2 serves as a working electrode, and the form thereof can be realized by any blood glucose electrode in the prior art. In the present embodiment, however, a needle-shaped positive electrode 2 of a multilayer composite structure as shown in fig. 3 is provided. The needle core 2.1 in the center is made of metal, and the material is stainless steel. The needle core 2.1 is sequentially wrapped with a catalytic metal layer 2.2, a biological sensing layer 2.3 and a biocompatible polymer permeation film layer 2.4. In this embodiment, the catalytic metal layer 2.2 is a platinum layer, the biosensing layer 2.3 is a glucose oxidase layer, and the biocompatible polymer permeable membrane layer 2.4 is a polyurethane Pu layer. The three-layer structure is plated or coated on the periphery of the needle core 2.1 in a nesting mode layer by layer, blood sugar in body fluid can permeate through the Pu layer, the voice oxidation-reduction reaction is carried out in the glucose oxidase layer on the surface of the platinum layer, then the oxidation-reduction potential is generated, and electric signals are transmitted outwards through the needle core 2.1.

Likewise, the flat negative electrode 3 serves as a reference electrode, and may be implemented in any prior art silver/silver chloride electrode. However, in the present embodiment, the inner structure is a flat metal block, and the surface of the metal block is compounded with a silver/silver chloride layer, so as to reduce the cost. In addition, the bottom surface of the flat negative electrode 3 for fitting the human skin is covered with a conductive layer, wherein the conductive layer is preferably a sticky conductive gel. The conductive gel has better viscosity, can contact with the skin to transmit signals in the use process, and simultaneously fixes the single-electrode implantable blood glucose sensor.

When the single-electrode implantable blood glucose sensor is used, the tip of the needle-shaped positive electrode 2 of the single-electrode implantable blood glucose sensor penetrates into the superficial layer of human skin, stays in a tissue fluid layer and is in electrochemical reaction with body fluid, and the flat negative electrode 3 is fixed on the surface of the human skin through conductive gel, so that only one wound is generated. The sensor continuously monitors blood sugar, and data is output to the printed circuit board through the conducting strip in a form of reaction current through the contact, so that the dynamic blood sugar of a human body is monitored.

Of course, if necessary, a counter electrode can be fixed on the bottom surface of the base 1, and the counter electrode is also connected with a corresponding signal contact on the printed circuit board 5 through the conducting strip 4, so that a three-electrode system is formed to improve the stability of blood sugar monitoring.

Additionally, each electrode of the utility model can be installed or attached in 1 bottom surface of base with the detachable form, can dismantle the replacement to it when accomplishing a monitoring process to multiplexing base 1 and printed circuit board 5, reduce use cost. Therefore, the utility model has the characteristics of little wound, simple operation and simplified process.

The above-mentioned embodiments are merely a preferred embodiment of the present invention, but it is not intended to limit the present invention. Various changes and modifications can be made by one of ordinary skill in the pertinent art without departing from the spirit and scope of the present invention. Therefore, all the technical schemes obtained by adopting the mode of equivalent replacement or equivalent transformation fall within the protection scope of the utility model.

Claims

1. A single-electrode implanted blood glucose sensor is characterized by comprising a base (1) and a printed circuit board (5), wherein a needle-shaped positive electrode (2) and a flat negative electrode (3) are fixed on the bottom surface of the base (1), and the distance between the tip of the needle-shaped positive electrode (2) and the bottom surface of the base (1) is larger than the distance between the bottom surface of the flat negative electrode (3) and the bottom surface of the base (1); the fixed ends of the needle-shaped positive electrode (2) and the flat negative electrode (3) are respectively connected with corresponding signal contacts on a printed circuit board (5) through different conducting strips (4) to form a double-electrode system for detecting blood sugar.

2. The single-electrode implantable blood glucose sensor according to claim 1, wherein the needle-shaped positive electrode (2) is a multi-layer composite structure, the needle core (2.1) located at the center is made of metal, and the catalytic metal layer (2.2), the biosensing layer (2.3) and the biocompatible polymer permeation membrane layer (2.4) are sequentially wrapped outside the needle core (2.1).

3. The single-electrode implantable blood glucose sensor of claim 2, wherein the catalytic metal layer (2.2) is a platinum layer.

4. The single-electrode implantable blood glucose sensor of claim 2, wherein the biosensing layer (2.3) is a glucose oxidase layer.

5. The single-electrode implantable blood glucose sensor of claim 2, wherein the biocompatible polymer permeable membrane layer (2.4) is a polyurethane layer.

6. The single-electrode implantable blood glucose sensor as claimed in claim 1, wherein the flat negative electrode (3) has an internal structure made of metal and a silver/silver chloride layer compounded on the surface thereof.

7. The single-electrode implantable blood glucose sensor of claim 1, wherein the flat negative electrode (3) is covered with a conductive layer on the bottom surface for fitting the skin of a human body.

8. The single electrode implantable blood glucose sensor of claim 7, wherein the conductive layer is an electrically conductive gel.

9. The single-electrode implantable blood glucose sensor of claim 1, wherein a counter electrode is further fixed on the bottom surface of the base (1), and the counter electrode is also connected with a corresponding signal contact on the printed circuit board (5) through the conducting strip (4) to form a three-electrode system.

10. The single-electrode implantable blood glucose sensor of claim 1, wherein the base (1) is provided with an electrically insulating cover (6), and the printed circuit board (5) is disposed and enclosed within the lumen defined therebetween.

11. The single-electrode implantable blood glucose sensor of claim 1, wherein the printed circuit board (5) comprises a potentiostatic circuit, a bluetooth antenna, metal contacts, a microprocessor, and a lithium battery.