CN211826077U - Portable time-resolved fluorescence immunoassay analyzer - Google Patents
Portable time-resolved fluorescence immunoassay analyzer Download PDFInfo
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- CN211826077U CN211826077U CN202020280378.2U CN202020280378U CN211826077U CN 211826077 U CN211826077 U CN 211826077U CN 202020280378 U CN202020280378 U CN 202020280378U CN 211826077 U CN211826077 U CN 211826077U
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Abstract
The utility model discloses a portable time-resolved fluorescence immunoassay appearance, including the shell with set up the core in the shell, the core includes power module, the master control board, goes up the light path module, light path module down, goes up the light path module, down the light path module be connected with master control board, power module respectively, portable time-resolved fluorescence immunoassay appearance still includes the motion module, the motion module is including the circular shape carousel that is used for bearing reagent sample, the center of carousel is provided with the rotation axis, the output shaft of rotation axis and motor. The utility model provides an analysis appearance has improved detection efficiency. The utility model discloses a data real-time detection can be accomplished to portable time-resolved fluorescence immunoassay appearance, uploads the monitoring in real time.
Description
Technical Field
The utility model relates to a fluorescence immunoassay technical field, more specifically relates to a portable time-resolved fluorescence immunoassay appearance.
Background
Time-Resolved Fluorescence (TRF) immunoassay is a microanalysis method developed in the last decade. The principle of the time-resolved fluoroimmunoassay method is that trivalent rare earth ions (such as Eu europium, Sm samarium, Te terbium and dy dysprosium) are used as tracers to mark proteins, polypeptides, hormones, antibodies, nucleic acid probes or bioactive cells, and after a reaction system (such as antigen-antibody immunoreaction, biotin avidin reaction, nucleic acid probe hybridization reaction, killing reaction of target cells and effector cells and the like) occurs, a portable time-resolved fluoroimmunoassay analyzer is used for measuring the fluorescence intensity in a final product, so that the concentration of a substance to be measured in the reaction system is judged.
Compared with other labeling methods such as chemiluminescence, radioimmunity, enzyme-linked immunosorbent assay and the like, the TRF has obvious advantages in sensitivity, stability and multiple labeling detection, and has wide application prospect. At present, the kit is mainly used for inspection projects which need high sensitivity and accurate quantification, and comprises clinical infectious disease inspection (hepatitis B series, HCV, HIV and the like), endocrine inspection (thyroid series TSH and the like, diabetes series Insulin and the like, growth hormone hGH and the like, gynecological FSH and the like), tumor marker inspection (AFP, CEA and the like), genetic inspection, hematology inspection, cytology inspection and various scientific research projects. The clinical detection projects applying the TRF reach 52 types, and the TRF is applied to 24 types of scientific research reagents in the scientific research field. With the development of inspection medicine, the measurement of trace and ultramicro quantity will be more and more, and the pollution problem of radioactivity will be more and more emphasized, so that the time-resolved fluorescence (TRF) immunoassay method has wider and wider application space.
The prior art discloses a portable time-resolved fluoroimmunoassay analyzer, and this analyzer includes the bottom plate, installs main control system and transmission system on the bottom plate, and transmission system includes spout and draw-in groove, and light path detecting system is installed to the upper end of spout, installs positioning system on the spout, and main control system is connected with transmission system, light path detecting system and positioning system. Through the movement time of the draw-in groove in the main control system control transmission system, when the draw-in groove moves to the end of spout, the draw-in groove is fixed at the end of spout so, and the operating personnel of being convenient for places the reagent sample, and after fixing reagent sample, the draw-in groove will detect the card and transport appointed position, carry out testing work.
The analyzer can only detect one reagent sample at a time, has low detection efficiency and cannot meet the requirements of people.
SUMMERY OF THE UTILITY MODEL
The to-be-solved technical problem of the utility model is to provide a simple structure, portable time-resolved fluorescence immunoassay appearance that detection efficiency is higher.
The utility model discloses a portable time-resolved fluoroimmunoassay analyzer, including the shell and the core that sets up in the shell, the core includes power module, main control panel, goes up light path module, light path module down, go up light path module, light path module down and be connected with main control panel, power module respectively, portable time-resolved fluoroimmunoassay analyzer still includes the motion module, the motion module includes the circular carousel that is used for supporting reagent sample, the center of carousel is provided with the rotation axis, the rotation axis is connected with the output shaft of motor, the motor is used for driving the carousel rotates, so that a plurality of reagent samples on the carousel pass through the space between last light path module and the light path module down in proper order, goes up light path module and sends the exciting light and hits on reagent sample and makes reagent sample arouse and send fluorescence, and light path module down detects fluorescence, the portable time-resolved fluorescence immunoassay analyzer further comprises a client and a cloud platform, wherein the main control board is in wireless connection with the client, the client is connected with the cloud platform through the internet, the cloud platform is used for storing experimental data, a receiving module, a data processing module, a storage module and a communication module are arranged in the client, and the receiving module, the storage module and the communication module are all connected with the data processing module; the receiving module is used for receiving the data transmitted by the main control panel and transmitting the data to the data processing module; the data processing module analyzes data and transmits results to the storage module and the communication module; the communication module is connected with the cloud platform through the Internet.
The utility model discloses a portable time-resolved fluoroimmunoassay analyzer, wherein, the light path module includes the luminous component, spotlight submodule piece and the reflector that set gradually, wherein luminous component is connected with the main control panel; the exciting light emitted by the light emitting component is reflected on the reagent sample through the light condensing submodule and the reflecting mirror.
The utility model discloses a portable time-resolved fluorescence immunoassay appearance, wherein, spotlight submodule piece is including the first lens of last light path, last light path light filter, last light path second lens that set gradually, and the exciting light that luminous component sent loops through and incides to the reflector behind the first lens of last light path, last light path light filter, the last light path second lens.
The utility model discloses a portable time-resolved fluorescence immunoassay appearance, wherein, the light path module is including the filtering submodule piece and the detection submodule piece that set gradually down, and wherein the detection submodule piece is connected with the master control board, and the light that passes the reagent sample incides to on the detection submodule piece after filtering photon module.
The utility model discloses a portable time-resolved fluorescence immunoassay appearance, wherein, the light filtering submodule is including the first lens of lower light path, lower light path light filter, the lower light path second lens that set gradually, and the fluorescence that the reagent sample arouses is incident to the detection submodule piece through the first lens of lower light path, lower light path light filter, down behind the light path second lens.
The utility model discloses a portable time-resolved fluoroimmunoassay appearance, wherein, the top of shell is provided with the handle.
The utility model discloses a portable time-resolved fluoroimmunoassay appearance when detecting, can place a plurality of reagent samples simultaneously on the carousel, through the removal of the main control panel control carousel, makes the reagent sample on the carousel obtain detecting in proper order. Therefore, the portable time-resolved fluoroimmunoassay analyzer of the utility model does not need to frequently change the reagent sample in the detection process, thereby improving the detection efficiency.
The utility model discloses a portable time-resolved fluoroimmunoassay analyzer is based on the on-the-spot short-term test of earlier stage and long-range on-line monitoring early warning prevention and control system platform, can accomplish data real-time detection, uploads the monitoring in real time.
Drawings
Fig. 1 is a main sectional view of a main body of a schematic structural view of the portable time-resolved fluoroimmunoassay analyzer of the present invention;
FIG. 2 is a sectional view of the main body of the portable time-resolved fluoroimmunoassay analyzer according to the present invention;
FIG. 3 is a schematic diagram showing the connection of the portable time-resolved fluoroimmunoassay analyzer of the present invention;
fig. 4 is a schematic structural diagram of the upper optical path module and the lower optical path module.
Detailed Description
As shown in fig. 1, 2, 3, and 4, the portable time-resolved fluoroimmunoassay analyzer of the present invention includes a host, the host includes a housing 1 and a movement disposed in the housing 1, the movement includes a power module 4, a main control board 7, an upper optical path module 5, and a lower optical path module 6, the upper optical path module and the lower optical path module are respectively connected to the main control board and the power module, the portable time-resolved fluoroimmunoassay analyzer further includes a motion module, the motion module includes a circular turntable 2 for supporting a reagent sample, a rotation shaft 3 is disposed at the center of the turntable, the rotation shaft is connected to an output shaft of a motor 40, the motor is used to drive the turntable to rotate, so that a plurality of reagent samples on the turntable sequentially pass through a space between the upper optical path module and the lower optical path module, the upper optical path module emits an excitation light to strike on the reagent sample to excite the reagent sample to emit fluorescence, the lower light path module detects the fluorescence.
The utility model discloses a portable time-resolved fluoroimmunoassay analyzer, wherein, the upper optical path module 5 comprises a light-emitting component 51, a light-gathering submodule and a reflector 55 which are arranged in sequence, wherein, the light-emitting component 51 is connected with a main control panel 7; the excitation light emitted from the light emitting unit 51 is reflected on the reagent sample by the condenser sub-module and the mirror 55.
The utility model discloses a portable time-resolved fluorescence immunoassay appearance, wherein, the spotlight submodule is including the first lens 52 of last light path, last light path light filter 53, last light path second lens 54 that set gradually, and the exciting light that sends of luminous component 51 loops through and incides to reflector 55 behind the first lens 52 of last light path, last light path light filter 53, last light path second lens 54.
The utility model discloses a portable time-resolved fluorescence immunoassay appearance, wherein, light path module 6 is including the filtering submodule piece and the detection submodule piece that set gradually down, and wherein the detection submodule piece is connected with the master control board 7, and the light that passes reagent sample 9 incides to the detection submodule piece after filtering the photon module on.
The utility model discloses a portable time-resolved fluorescence immunoassay appearance, wherein, the light filtering submodule is including the first lens of lower light path 61 that sets gradually, light path light filter 62, light path second lens 63 down, and the fluorescence that reagent sample 9 arouses is incident to the detection submodule behind light path first lens, lower light path light filter, the lower light path second lens down.
The utility model discloses a portable time-resolved fluorescence immunoassay appearance, wherein, the light path module is still including photomultiplier down, photomultiplier sets up between light filtering submodule piece and detection submodule piece, and photomultiplier is connected with the master control board.
The utility model discloses a portable time-resolved fluoroimmunoassay appearance, wherein, be provided with power indicator and operation pilot lamp on portable time-resolved fluoroimmunoassay appearance's the shell.
The utility model discloses a portable time-resolved fluoroimmunoassay analyzer, wherein, the top of shell is provided with handle 100.
The utility model discloses a portable time-resolved fluoroimmunoassay analyzer, wherein, still include customer end and cloud platform, the main control board wireless connection customer end, customer end pass through internet connection cloud platform, the cloud platform is used for storing experimental data, the customer end embeds has receiving module, data processing module, storage module, display module and communication module, receiving module, storage module, display module and communication module all are connected with data processing module; the receiving module is used for receiving the data transmitted by the main control panel and transmitting the data to the data processing module; the data processing module analyzes data and transmits results to the storage module and the communication module; the communication module is connected with the cloud platform through the Internet.
The utility model discloses a portable time-resolved fluorescence immunoassay appearance operation, go up the light path module and send the exciting light and beat and make reagent sample arouse on the reagent sample on the carousel and send fluorescence, lower light path module detects fluorescence.
A plurality of sample holders 21 for holding reagent samples 9 are arranged on the turntable 2, and each sample holder 21 can be provided with a reagent sample 9.
Portable time-resolved fluoroimmunoassay appearance is in the work, main control panel control motor 40, motor 40 control rotation axis 3 is rotatory, rotation axis 3 rotates and drives carousel 2 rotatory, consequently can place a plurality of reagent samples on the carousel, the analysis appearance is when having detected a reagent sample, main control panel makes the carousel rotate, make next reagent sample be located the light path of the exciting light that the light path module sent, it sends the exciting light to restart the light path module, can arouse next reagent sample. Therefore, the analyzer does not need to change the reagent samples frequently in the detection process.
When the analyzer operates, the upper optical path module 5 emits excitation light to irradiate on the reagent sample 9 on the turntable 2, so that the reagent sample 9 is excited to emit fluorescence, and the lower optical path module 6 detects the fluorescence;
in the above scheme, the upper optical path module 5 includes a light emitting component 51, a light gathering sub-module and a reflective mirror 55, which are sequentially arranged, wherein the light emitting component 51 is connected with the main control board 7, and excitation light emitted by the light emitting component 51 is emitted onto the reagent sample 9 after passing through the light gathering sub-module and the reflective mirror 55.
The light-gathering submodule comprises an upper light path first lens 52, an upper light path optical filter 53 and an upper light path second lens 54 which are sequentially arranged, and exciting light emitted by the light-emitting component 51 sequentially passes through the upper light path first lens 52, the upper light path optical filter 53 and the upper light path second lens 54 and then is incident to a reflector 55.
The lower light path module 6 comprises a light filtering submodule and a detection submodule which are arranged in sequence, the detection submodule is connected with the main control panel 7, and light passing through the reagent sample 9 is incident on the detection submodule after passing through the light filtering photon module.
In this embodiment, the light filtering submodule includes a lower light path first lens 61, a lower light path optical filter 62, and a lower light path second lens 63, which are sequentially arranged, and fluorescence excited by the reagent sample 9 passes through the lower light path first lens 61, the lower light path optical filter 62, and the lower light path second lens 63 and then enters the detection submodule.
In the above scheme, the main control board 7 controls the light emitting component 51 to emit excitation light, the excitation light is emitted onto the reagent sample 9 through the light condensing submodule and the reflective mirror 55, so that the reagent sample 9 is excited to emit fluorescence, the excited fluorescence is emitted onto the detection submodule after passing through the light filtering submodule, and the detection submodule detects the fluorescence to obtain a detection result.
In order to improve the detection precision of the analyzer, in this embodiment, the lower optical path module 6 further includes a photomultiplier tube, the photomultiplier tube is disposed between the light filtering sub-module and the detection sub-module, and the photomultiplier tube is connected to the main control board 7. In this embodiment, a power indicator and an operation indicator are disposed on the housing of the portable time-resolved fluoroimmunoassay analyzer.
The utility model provides an analyzer when detecting, can place a plurality of reagent samples on the carousel simultaneously, through the removal of main control panel control carousel, makes the reagent sample on the carousel obtain detecting in proper order. Therefore, the analyzer does not need to frequently replace reagent samples in the detection process, thereby improving the detection efficiency.
The utility model discloses a portable time-resolved fluoroimmunoassay analyzer is based on the on-the-spot short-term test of earlier stage and long-range on-line monitoring early warning prevention and control system platform, can accomplish data real-time detection, uploads the monitoring in real time.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, a plurality of modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (6)
1. A portable time-resolved fluoroimmunoassay analyzer is characterized by comprising a shell and a machine core arranged in the shell, wherein the machine core comprises a power supply module, a main control panel, an upper light path module and a lower light path module, the upper light path module and the lower light path module are respectively connected with the main control panel and the power supply module, the portable time-resolved fluoroimmunoassay analyzer also comprises a motion module, the motion module comprises a circular turntable used for supporting reagent samples, a rotating shaft is arranged at the center of the turntable and connected with an output shaft of a motor, the motor is used for driving the turntable to rotate so that a plurality of reagent samples on the turntable sequentially pass through a space between the upper light path module and the lower light path module, the upper light path module emits exciting light to be irradiated on the reagent samples to excite the reagent samples to emit fluorescence, and the lower light path module detects the fluorescence, the portable time-resolved fluorescence immunoassay analyzer further comprises a client and a cloud platform, wherein the main control board is in wireless connection with the client, the client is connected with the cloud platform through the internet, the cloud platform is used for storing experimental data, a receiving module, a data processing module, a storage module and a communication module are arranged in the client, and the receiving module, the storage module and the communication module are all connected with the data processing module; the receiving module is used for receiving the data transmitted by the main control panel and transmitting the data to the data processing module; the data processing module analyzes data and transmits results to the storage module and the communication module; the communication module is connected with the cloud platform through the Internet.
2. The portable time-resolved fluoroimmunoassay analyzer of claim 1, wherein the upper optical path module comprises a light emitting part, a light condensing sub-module and a reflective mirror, which are sequentially disposed, wherein the light emitting part is connected with a main control board; the exciting light emitted by the light emitting component is reflected on the reagent sample through the light condensing submodule and the reflecting mirror.
3. The portable time-resolved fluoroimmunoassay analyzer of claim 2, wherein the light-collecting sub-module comprises an upper light path first lens, an upper light path filter and an upper light path second lens, which are sequentially arranged, and the excitation light emitted from the light-emitting component sequentially passes through the upper light path first lens, the upper light path filter and the upper light path second lens and then is incident to the reflector.
4. The portable time-resolved fluoroimmunoassay analyzer of claim 3, wherein the lower optical path module comprises a filtering submodule and a detecting submodule which are arranged in sequence, wherein the detecting submodule is connected with the main control board, and light passing through the reagent sample is incident on the detecting submodule after passing through the filtering photonic module.
5. The portable time-resolved fluoroimmunoassay analyzer of claim 4, wherein the filter submodule comprises a lower optical path first lens, a lower optical path filter and a lower optical path second lens, which are sequentially disposed, and fluorescence excited by the reagent sample passes through the lower optical path first lens, the lower optical path filter and the lower optical path second lens and then enters the detection submodule.
6. The portable time-resolved fluoroimmunoassay analyzer of claim 5, wherein a handle is provided at a top of the housing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020280378.2U CN211826077U (en) | 2020-03-09 | 2020-03-09 | Portable time-resolved fluorescence immunoassay analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020280378.2U CN211826077U (en) | 2020-03-09 | 2020-03-09 | Portable time-resolved fluorescence immunoassay analyzer |
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| Publication Number | Publication Date |
|---|---|
| CN211826077U true CN211826077U (en) | 2020-10-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202020280378.2U Expired - Fee Related CN211826077U (en) | 2020-03-09 | 2020-03-09 | Portable time-resolved fluorescence immunoassay analyzer |
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| Country | Link |
|---|---|
| CN (1) | CN211826077U (en) |
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2020
- 2020-03-09 CN CN202020280378.2U patent/CN211826077U/en not_active Expired - Fee Related
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