CN211734328U - Full-automatic nucleic acid purification system based on magnetic bead method - Google Patents
Full-automatic nucleic acid purification system based on magnetic bead method Download PDFInfo
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- CN211734328U CN211734328U CN201921848969.9U CN201921848969U CN211734328U CN 211734328 U CN211734328 U CN 211734328U CN 201921848969 U CN201921848969 U CN 201921848969U CN 211734328 U CN211734328 U CN 211734328U
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Abstract
The utility model discloses a full-automatic nucleic acid purification system based on magnetic bead method relates to biological medicine technical field, specifically is a full-automatic nucleic acid purification system based on magnetic bead method, including the base platform, reagent board and "character cut in bas-relief" fixed block, the upper surface of base platform has been seted up and has been pressed the groove, presses the inside sliding connection in groove to have movable dog, "character cut in bas-relief" fixed block fixed connection is at the upper surface of base platform, the equal fixedly connected with slider in the left and right sides of "character cut in bas-relief" fixed block, and reagent board sliding connection is in the inside of "character cut in bas-relief" fixed block. This full-automatic nucleic acid purification system based on magnetic bead method sets up through the cooperation of slider and spout, and the spout of the in-process reagent board left and right sides that uses can be followed the slider and slided in the inside of "character cut in bas-relief" fixed block to having played and having made the reagent board gliding effect around can only, reached and carried out upper and lower spacing purpose to the reagent board, collided with the reagent board when having avoided the bar magnet to cross the plug from top to bottom.
Description
Technical Field
The utility model relates to a biological medicine technical field specifically is a full-automatic nucleic acid purification system based on magnetic bead method.
Background
The nucleic acid extraction technology of the magnetic bead method adopts a nanotechnology to improve and modify the surface of superparamagnetic nanoparticles to prepare superparamagnetic silicon carbide nanobeads, and the paramagnetic beads can be specifically identified and efficiently combined with nucleic acid molecules on a microscopic interface. The superparamagnetic property of the magnetic beads is utilized, under the action of an external magnetic field, DNA or RNA can be separated from samples such as blood, animal tissues, food, pathogenic microorganisms and the like, and the process is simple, rapid and easy to automate.
The full-automatic nucleic acid purification system based on the magnetic bead method disclosed in the chinese utility model patent application publication No. CN208883839U, though, the full-automatic nucleic acid purification system based on the magnetic bead method can be matched with the conventional 96-well plate on the market to automatically complete the nucleic acid extraction and purification process; the full touch screen control of the inclined plane is more humanized, and the operation of a user is facilitated; the safety and the accuracy of the experiment are ensured by the anti-pollution measures of the filter system and the ultraviolet lamp; the lifting structure of the heating module improves the nucleic acid extraction efficiency and is convenient for a user to take out the reagent plate; however, the reagent plate in the full-automatic nucleic acid purification system based on the magnetic bead method has 12 columns, each column has 8 holes, and each 6 columns can be used for placing a set of complete nucleic acid extraction reagent, including lysate, magnetic beads, tertiary cleaning solution, eluent and the like, so 16 samples can be extracted at one time from the reagent plate 10, and the horizontal movement motor group and the vertical movement motor group move according to a pre-programmed route program each time, the magnetic separation module is accurately placed in the hole corresponding to the reagent plate, if the reagent plate is not limited, or whether the reagent plate is correctly placed is not known when the reagent plate is placed, the danger that the magnetic rod collides with the hole on the reagent plate can be generated, the vertical movement distance range of the heating module is fixed, and if the whole reagent plate is placed in a suspension manner with the base platform, the heating module cannot be contacted with the reagent plate when working.
SUMMERY OF THE UTILITY MODEL
Technical problem to be solved
To prior art not enough, the utility model provides a full-automatic nucleic acid purification system based on the magnetic bead method has solved the problem that proposes in the above-mentioned background art.
(II) technical scheme
In order to achieve the above purpose, the utility model discloses a following technical scheme realizes: the utility model provides a full-automatic nucleic acid purification system based on magnetic bead method, includes the base platform, reagent board and "character cut in bas-relief" fixed block, the upper surface of base platform has been seted up and has been pressed the indent, the inside sliding connection who presses the indent has movable dog, the upper surface at the base platform of "character cut in bas-relief" fixed block fixed connection, the equal fixedly connected with slider in the left and right sides of "character cut in bas-relief" fixed block, reagent board sliding connection is in the inside of "character cut in bas-relief" fixed block.
Optionally, the upper surface swing joint of base platform has the reagent board, the spout has been seted up to the left and right sides of reagent board.
Optionally, the surface of reagent board down fixedly connected with pull handle and cushion respectively from the top, the cushion and the one side swing joint of activity dog.
Optionally, a spring is installed inside the pressing groove, and one end of the spring is fixedly connected with the movable stop block.
Optionally, the number of the sliding blocks is two, the upper surfaces of the two sliding blocks are rotatably connected with pulleys, and the number of the pulleys is several.
Optionally, the number of the sliding grooves is two, and pulleys are connected to the two sliding grooves in a sliding mode.
(III) advantageous effects
The utility model provides a full-automatic nucleic acid purification system based on magnetic bead method possesses following beneficial effect:
1. this full-automatic nucleic acid purification system based on magnetic bead method, cooperation setting through slider and spout, the spout of the in-process reagent board left and right sides of using can be followed the slider and slided in the inside of "character cut in bas-relief" fixed block, thereby played and made the reagent board can only gliding effect around, reached and carried out spacing purpose from top to bottom to the reagent board, prevented because reagent board and base platform surface debris arouse the reagent board to place not level, collided with the reagent board when having avoided the magnetic rod to cross and insert from top to bottom.
2. This full-automatic nucleic acid purification system based on magnetic bead method, setting through the pulley, the frictional resistance of spout and slider has been reduced, make this reagent board pull that also can be smooth and easy when fully loaded, cooperation setting through spring and activity dog, the normal propelling of reagent board is not influenced to the in-process activity dog that uses, when reagent board impels preset position, this activity dog is bounced by the spring, thereby the effect that prevents reagent board backexit has been played, spacing purpose around the reagent board has been reached, prevented because vibrations or other external factors make reagent board backward slip, thereby the collision of magnetic rod with reagent board has been avoided.
Drawings
FIG. 1 is a schematic view of the mounting structure of the reagent plate of the present invention;
FIG. 2 is a schematic structural view of the reagent plate of the present invention;
FIG. 3 is a schematic structural view of the base table of the present invention;
fig. 4 is an enlarged schematic view of a portion a of fig. 3 according to the present invention;
fig. 5 is a schematic cross-sectional view of the structure at B in fig. 3 according to the present invention.
In the figure: 1. a base table; 2. a reagent plate; 3. a concave-shaped fixed block; 4. pressing the groove; 5. a movable stop block; 6. a slider; 7. a chute; 8. a pull handle; 9. a soft cushion; 10. a spring; 11. a pulley.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments.
Referring to fig. 1 to 5, the present invention provides a technical solution: a full-automatic nucleic acid purification system based on a magnetic bead method comprises a base table 1, a reagent plate 2 and a concave-shaped fixing block 3, wherein the upper surface of the base table 1 is movably connected with the reagent plate 2, sliding grooves 7 are formed in the left side and the right side of the reagent plate 2, the number of the sliding grooves 7 is two, pulleys 11 are connected in the two sliding grooves 7 in a sliding manner, the friction resistance between the sliding grooves 7 and sliding blocks 6 is reduced through the arrangement of the pulleys 11, so that the reagent plate 2 can be smoothly pulled and pulled when fully loaded, the sliding grooves 7 in the left side and the right side of the reagent plate 2 can slide in the concave-shaped fixing block 3 along the sliding blocks 6 in the using process through the matching arrangement of the sliding blocks 6 and the sliding grooves 7, the effect that the reagent plate 2 can only slide back and forth is achieved, the purpose of limiting the reagent plate 2 up and down is achieved, the reagent plate is prevented from being placed unevenly due to sundries on the surfaces, the collision between the magnetic rod and the reagent plate 2 during the up-down insertion is avoided, the upper surface of the base platform 1 is provided with a pressing groove 4, the inside of the pressing groove 4 is slidably connected with a movable stop block 5, the surface of the reagent plate 2 is fixedly connected with a pull handle 8 and a cushion 9 from top to bottom respectively, the cushion 9 is movably connected with one surface of the movable stop block 5, the inside of the pressing groove 4 is provided with a spring 10, one end of the spring 10 is fixedly connected with the movable stop block 5, the movable stop block 5 does not influence the normal propulsion of the reagent plate 2 during the use process through the matching arrangement of the spring 10 and the movable stop block 5, when the reagent plate 2 is propelled to a preset position, the movable stop block 5 is bounced by the spring 10, thereby the function of preventing the reagent plate 2 from retreating backwards is achieved, the purpose of front-back limit of the reagent plate 2 is achieved, the reagent plate is prevented from sliding backwards due to the vibration, thereby the collision between the, "character cut in bas-relief" fixed block 3 fixed connection is at the upper surface of base platform 1, "character cut in bas-relief" fixed block 3's the equal fixedly connected with slider 6 in the left and right sides, and the quantity of slider 6 is two, and the upper surface of two sliders 6 rotates and is connected with pulley 11, and pulley 11's quantity is a plurality of, and 2 sliding connection of reagent board are in the inside of "character cut in bas-relief" fixed block 3.
The electrical components presented in the document are all electrically connected with an external master controller and 220V mains, and the master controller can be a conventional known device controlled by a computer or the like.
When the reagent plate pushing device is used, firstly, a reagent plate 2 loaded with a reagent is placed at one end of a base table 1, the reagent plate 2 is pushed from outside to inside, the movable stop dog 5 is provided with an inclined surface, the movable stop dog 5 is contracted into the pressing groove 4 under the pressure of the reagent plate 2, then the sliding groove 7 of the reagent plate 2 is matched with the sliding block 6 of the concave-shaped fixed block 3, the reagent plate 2 can be easily pushed to the bottom of the concave-shaped fixed block 3 under the transmission of the pulley 11, at the moment, the movable stop dog 5 automatically bounces up under the action of the elastic force of the spring due to the fact that the pressing of the reagent plate 2 is separated, the reagent plate 2 is firmly clamped, and the reagent plate 2 is prevented from moving back and forth in the using process; after the reagent plate is used, the reagent plate 2 can be completely withdrawn only by manually pressing the movable stop block 5 and pulling backwards by using the pull handle 8.
In summary, the following steps: the full-automatic nucleic acid purification system based on the magnetic bead method has the advantages that through the matching arrangement of the sliding block 6 and the sliding grooves 7, the sliding grooves 7 on the left side and the right side of the reagent plate 2 can slide in the concave-shaped fixing block 3 along the sliding block 6 in the using process, so that the reagent plate 2 can only slide back and forth, the purpose of limiting the reagent plate 2 up and down is achieved, the reagent plate is prevented from being placed unevenly due to sundries on the surfaces of the reagent plate 2 and the base table 1, the magnetic rod is prevented from colliding with the reagent plate 2 when being inserted up and down, through the arrangement of the pulleys 11, the friction resistance of the sliding grooves 7 and the sliding blocks 6 is reduced, the reagent plate 2 can be smoothly pulled and pulled when being fully loaded, through the matching arrangement of the springs 10 and the movable stoppers 5, the movable stoppers 5 do not influence the normal pushing of the reagent plate 2 in the using process, when the reagent plate 2 is pushed to a preset position, this movable stop 5 is bounced by spring 10 to play the effect that prevents reagent board 2 and withdraw from backward, reached the purpose to reagent board 2 front and back spacing, prevented to make reagent board backward slip owing to vibrations, thereby avoided the collision of bar magnet and reagent board 2.
The above, only be the concrete implementation of the preferred embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and any person skilled in the art is in the technical scope of the present invention, according to the technical solution of the present invention and the utility model, the concept of which is equivalent to replace or change, should be covered within the protection scope of the present invention.
Claims (6)
1. The utility model provides a full-automatic nucleic acid purification system based on magnetic bead method, includes base platform (1), reagent board (2) and "character cut in bas-relief" fixed block (3), its characterized in that: the upper surface of base platform (1) has been seted up and has been pressed indent (4), the inside sliding connection who presses indent (4) has movable dog (5), the upper surface at base platform (1) of "character cut in bas-relief" fixed block (3), the equal fixedly connected with slider (6) of the left and right sides of "character cut in bas-relief" fixed block (3), reagent board (2) sliding connection is in the inside of "character cut in bas-relief" fixed block (3).
2. The system of claim 1, wherein the system comprises: the upper surface swing joint of base platform (1) has reagent board (2), spout (7) have been seted up to the left and right sides of reagent board (2).
3. The system of claim 1, wherein the system comprises: the surface of the reagent plate (2) is fixedly connected with a drawing handle (8) and a soft cushion (9) from top to bottom respectively, and the soft cushion (9) is movably connected with one surface of the movable stop block (5).
4. The system of claim 1, wherein the system comprises: the spring (10) is installed in the pressing groove (4), and one end of the spring (10) is fixedly connected with the movable stop block (5).
5. The system of claim 1, wherein the system comprises: the quantity of slider (6) is two, two the upper surface of slider (6) rotates and is connected with pulley (11), the quantity of pulley (11) is a plurality of.
6. The system of claim 2, wherein the system comprises: the number of the sliding grooves (7) is two, and the sliding grooves (7) are connected with pulleys (11) in a sliding mode.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921848969.9U CN211734328U (en) | 2019-10-30 | 2019-10-30 | Full-automatic nucleic acid purification system based on magnetic bead method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921848969.9U CN211734328U (en) | 2019-10-30 | 2019-10-30 | Full-automatic nucleic acid purification system based on magnetic bead method |
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| CN211734328U true CN211734328U (en) | 2020-10-23 |
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| CN201921848969.9U Active CN211734328U (en) | 2019-10-30 | 2019-10-30 | Full-automatic nucleic acid purification system based on magnetic bead method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114199772A (en) * | 2021-12-17 | 2022-03-18 | 台州市耶大基因与细胞治疗研究院 | Blood cell analyzer |
-
2019
- 2019-10-30 CN CN201921848969.9U patent/CN211734328U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114199772A (en) * | 2021-12-17 | 2022-03-18 | 台州市耶大基因与细胞治疗研究院 | Blood cell analyzer |
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Address after: Room 501, Building A, Jianye Building, No. 96 Xiangxing Road, Xiang'an Industrial Zone, Xiamen Torch High tech Zone, Fujian Province, 361000 Patentee after: Kaishuo Biotechnology (Xiamen) Co.,Ltd. Address before: Room 501, block a, Jianye Building, No.96, Xiangxing Road, industrial zone, torch high tech Zone (Xiang'an), Xiamen City, Fujian Province Patentee before: KAISHUO BIO-TECH (XIAMEN) Co.,Ltd. |