CN211697837U - Analysis device - Google Patents

Abstract

The utility model relates to an analytical equipment, include: a sample supply device for supplying a sample to an empty reactor; the transfer device is used for bearing the reactor; a reagent supply device for supplying a reagent to the reactor in the transfer device; the reaction device is used for reacting the reactor containing the reagent and the sample; and a transfer means for transferring the reactor between the transfer means and the reaction means; wherein, the transfer device is independently arranged outside the reaction device, and the transfer device and the reaction device are not overlapped in space.

Description

Analysis device

Technical Field

The utility model relates to an analysis and test technical field especially relates to an analytical equipment.

Background

Chemiluminescence immunoassay systems utilize chemiluminescence and immunoreaction principles to correlate optical signals with the concentration of substances to be detected and analyze the content of the substances to be detected in samples, and are increasingly widely applied due to the characteristics of high sensitivity, specificity, wide linear range and the like. With the increase of the amount of the sample to be detected, the requirements of the clinical laboratory on the volume and the test flux of the chemiluminescence immunoassay system are higher and higher. The chemiluminescence immunoassay system needs to realize the functions of conveying samples, storing reagents, sucking and discharging analysis liquids such as sample reagents, transferring reactors, cleaning and separating and the like, and has extremely high requirements on automatic control.

The existing analysis device has the disadvantages of complex structure, large volume and high production cost.

SUMMERY OF THE UTILITY MODEL

In view of the above, it is necessary to provide an analysis apparatus for solving the above-mentioned problems.

An analysis device comprising:

a sample supply device for supplying a sample to the reactor;

the transfer device is used for carrying and transferring the reactor needing to discharge the reagent;

a reagent supply device for supplying a reagent to the reactor in the transfer device;

the reaction device is used for reacting the reactor containing the reagent and the sample; and

a transfer device for transferring the reactor between the transfer device and the reaction device; the transfer device is independently arranged on the outer side of the reaction device, and the rotation center of the transfer device is arranged on the outer side of the reaction device.

In one embodiment, the reaction device comprises a rotatable reaction disc, the transfer device comprises a rotatable middle rotating disc, and the reaction disc and the middle rotating disc rotate independently.

In one embodiment, the diameter of the rotating disc is smaller than that of the reaction disc.

In one embodiment, the sample supply device, the reagent supply device, and the reaction device are arranged in a clockwise direction on the outer periphery of the relay device in a plan view.

In one embodiment, the reaction tray is provided with a washing separation site, an incubation site and a measurement site, and the reactor can be carried at the washing separation site, the incubation site and the measurement site.

In one embodiment, a plurality of circles of reaction sites arranged in an annular shape are arranged on the reaction disk, the innermost circle is a cleaning separation site, the outermost circle is a measurement site, an incubation site is arranged between the cleaning separation site and the measurement site, and the incubation site is provided with at least one circle.

In one embodiment, the washing separation site, the incubation site and the measurement site are arranged along a radial direction of the reaction disk.

In one embodiment, the transfer trajectory of the transfer device covers at least the wash separation site, the incubation site and the measurement site.

In one embodiment, the transfer track of the transfer device extends along a radius of the reaction disk, and at least covers all reaction sites on the reaction disk along the radius. The reagent supply device is provided with at least two groups, and the two groups of reagent supply devices alternately discharge reagents to the reactor on the transfer device.

In one embodiment, the reagent supply device comprises a reagent tray for carrying a reagent and a reagent discharge unit for aspirating the reagent in the reagent tray and discharging the reagent to a reactor.

In one embodiment, the diameter of the center rotary disk is smaller than the diameter of the reagent disk.

In one embodiment, the device further comprises a supply tray, wherein a temporary storage groove for loading the reactor is arranged on the supply tray, the supply tray can rotate independently to drive the temporary storage groove to be transferred at different stations, and the sample supply device is used for discharging samples to the reactor on the supply tray.

In one embodiment, the transfer track of the transfer device covers at least the feed tray, the transfer device and the reaction device.

In one embodiment, the transfer device comprises a rotatable middle turntable, and the circle center of the middle turntable and the circle center of the supply disc are respectively positioned at two sides of the transfer track of the transfer device.

In one embodiment, the reactor further comprises a dilution transportation device for temporarily storing the reactor, wherein the dilution transportation device is arranged between the reaction device and the transfer device; after the supply tray receives the sample provided by the sample supply device, the reactor receives the diluent provided by the reagent supply device through the transfer device, and the reactor is transferred to the dilution transportation device after dilution.

Has the advantages that: reaction unit and transfer device independent setting do not have overlapping in space, have not only avoided transfer device and the nested setting of reaction unit to lead to the structure complicated, with high costs, occupation area big scheduling problem, have also solved the restriction of reaction unit centering device structure and size, the position of more nimble, high-efficient, reasonable overall arrangement transfer device.

Drawings

FIG. 1 is a schematic structural view of an analysis apparatus according to an embodiment of the present application;

FIG. 2 is a diagram of the steps of an immunoassay in one embodiment of the present application;

FIG. 3 is a schematic structural diagram of a relay device included in the analysis device according to an embodiment of the present application;

FIG. 4 is a schematic diagram of a reaction site on a reaction apparatus according to an embodiment of the present application;

FIG. 5 is a schematic diagram of a transfer device according to an embodiment of the present application;

FIG. 6 is a diagram of a transfer trajectory of a transfer device in an embodiment of the present application;

FIG. 7 is a cycle length diagram of an analysis device in one embodiment of the present application;

FIG. 8 is a schematic diagram of a dilution unit according to an embodiment of the present application;

FIG. 9 is a graph illustrating the performance of a grabbing unit in one embodiment of the present application during a certain period;

FIG. 10 is a graph illustrating the performance of a gripper unit of a transfer device during a cycle, according to one embodiment of the present application;

FIG. 11 is a graphical representation of the performance of the embodiment of FIG. 10 in multiple test items.

Reference numerals: 11. a first station; 12. a second station; 13. a third station; 14. a fourth station; 15. a fifth station; 16. a sixth station; 100. a reagent supply device; 110. a reagent storage unit; 111. a first reagent tray; 112. a second reagent disk; 120. a reagent discharge unit; 121. a first row of reagent elements; 122. a second row of reagent elements; 200. a sample supply device; 300. a reactor supply; 310. a bin structure; 320. a supply chute; 400. a reaction device; 410. a reaction disc; 420. reaction sites; 421. cleaning the separation site; 422. an incubation position; 423. a measurement bit; 430. a measurement assembly; 500. a transfer device; 510. transferring a driving piece; 520. a middle rotating disc; 530. a temporary storage bit; 600. a transfer device; 611. a first grasping unit; 612. a second grasping unit; 621. a first grasping drive; 622. a second grasping drive; 630. a guide rail; 631. cleaning, separating and aligning; 632. incubating and aligning; 633. measuring and aligning; 634. discarding the alignment; 635. relay alignment; 636. transfer alignment; 700. a supply unit; 710. a supply tray; 720. a temporary storage tank; 800. a blending unit; 810. a vibrating member; 820. vibrating the hole; 830. a blending drive; 900. and (4) a dilution transportation device.

Detailed Description

In order to facilitate understanding of the present invention, the present invention will be described more fully hereinafter with reference to the accompanying drawings. The preferred embodiments of the present invention are shown in the drawings. The invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. In contrast, when an element is referred to as being "directly on" another element, there are no intervening elements present. The terms "vertical," "horizontal," "left," "right," and the like as used herein are for illustrative purposes only.

Fig. 1 is a schematic configuration diagram of an analysis apparatus according to an embodiment of the present invention, and the analysis apparatus includes a reagent supplying apparatus 100, a sample supplying apparatus 200, a reactor supplying apparatus 300, and a reaction apparatus 400. In operation, the sample provided by the sample supply device 200 is added to the reactor provided by the reactor supply device 300, and the reagent provided by the reagent supply device 100 is also added to the reactor provided by the reactor supply device 300, wherein the reactor contains a mixture of the sample and the reagent, and then the mixture of the sample and the reagent is transferred to the reaction device 400 for reaction. Since the functions and structures are similar, both to suck and add liquid into the reactor, the sample supply device 200 and the reagent supply device 100 may be combined into a supply device or collectively referred to as a supply device, i.e., a supply device including the sample supply device 200 and the reagent supply device 100. As shown in fig. 1, the sample supply device 200, the reagent supply device 100, and the reaction device 400 are disposed around the relay device 500, that is, the relay device 500 is disposed at an intermediate position to function as a relay reactor, and the relay device 500 is disposed at the intermediate position, and the relay device 500 is relatively close to other structures, so that the overall transfer time of the reactor can be shortened, and the work efficiency can be improved. Further, the sample supply device 200, the reagent supply device 100, and the reaction device 400 are arranged in the counterclockwise direction around the relay device 500 in the top view, so that the respective mechanisms can be operated in order, the spatial interference can be reduced, and the operation efficiency can be improved.

Specifically, the reactor supply device 300 may provide a clean and empty reactor, and the sample supply device 200 may add a sample to the empty reactor. The analysis apparatus in one embodiment further includes a supply unit 700, the supply unit 700 is used for receiving the reactor provided by the reactor supply apparatus 300, and the sample supply apparatus 200 is used for supplying the sample to the empty reactor on the supply unit 700. The analysis apparatus in one embodiment further includes a transfer apparatus 500 and a transfer apparatus 600, and an operation path of the transfer apparatus 600 covers at least the supply unit 700, the transfer apparatus 500, and the reaction apparatus 400. The transferring device 600 transfers the reactor to which the sample is added from the supplying unit 700 to the relay device 500, and receives the reagent supplied from the reagent supplying device 100 at the relay device 500, that is, the reagent supplying device 100 may add the reagent again to the reactor to which the sample is added of the relay device 500, in which case the reactor contains the mixture of the sample and the reagent. The transfer device 600 is also used to transfer a reactor containing a mixture of a sample and a reagent to the reaction device 400 for a reaction, which may include one or more of incubation, washing, and measurement.

For example, the above-mentioned analyzing device may be an immunoassay device which quantitatively or qualitatively measures a target substance to be measured, such as an antigen and an antibody contained in a blood sample. The overall operation of the immunoassay device will be described by taking a one-step method as an example. FIG. 2 is a diagram showing the steps of the immunoassay in one embodiment, as shown in FIG. 2, the immunoassay as a whole performs the following steps:

s1, providing a reactor;

s2, adding a sample and a reagent into the reactor;

s3, uniformly mixing the sample and the reagent in the reactor;

s4, incubating the uniformly mixed sample and reagent;

s5, washing and separating the incubated sample and the reagent;

s6, adding a signal reagent into the reactor, and performing signal incubation;

and S7, measuring the luminescence quantity.

Specifically, in S1, a reactor is first supplied through the reactor supply device 300.

In S2, the reagent and the sample are added to the reactor by the reagent supplying apparatus 100 and the sample supplying apparatus 200, respectively, and the order of adding the reagent and the sample is not limited, and the reagent and the sample may be added in sequence, or the sample and the reagent may be added in sequence. For example, the sample may be first supplied through the sample supply apparatus 200, the sample may be added to the reactor, then the reagent may be supplied through the reagent supply apparatus 100, and then the reagent may be added to the reactor by the apparatus shown in fig. 1. The sample may be a blood sample. Reagents typically include multiple components, including, for example, magnetic particles, enzyme labels, diluents, and dissociation agents, etc., depending on the particular assay. Depending on the reaction mode, a plurality of reagent components required for one analysis item may be added to the reactor at one time, or may be added to the reactor in a plurality of steps, respectively.

In S3, the reactor is shaken to mix the reagents and the sample in the reactor. Of course, in some tests, the blending step is not required, and the step S3 may be skipped at this point.

In S4, the mixture of the sample and the reagent in the reactor is incubated, and the incubation time is usually 5 to 60 minutes. Wherein the incubation refers to a process of an antigen-antibody binding reaction in a constant temperature environment, or a process of a biotin avidin binding reaction in a constant temperature environment.

In S5, washing and separation refers to a process of capturing magnetic particles after the binding reaction by magnetic force while removing unbound labeled antibody and other unreacted or bound components.

In S6, after washing and separation, the signal reagent is continuously added to the reactor, and signal incubation is performed for 1 to 6 minutes. The signal incubation refers to a process of adding a signal reagent into the reactor after washing and separating, and reacting for a period of time under a constant temperature environment to enhance the signal. Because of the different types of the signal reagents, some luminescent systems do not require signal incubation, and the measurement of step S7 can be directly performed after the signal reagents are added. The signaling agent may be one or more. Some signaling agents may also include a first component agent and a second component agent.

In S7, the signal reagent reacts with the original mixture in the reactor to produce the luminescence of the reactant. The signal reagent is usually one of the universal reagents, and the universal reagent means that one signal reagent can be commonly used in different analysis items. Through the above steps, the content of the analyte contained in the sample is quantitatively or qualitatively determined.

Taking the embodiment shown in fig. 1 as an example, step S1 is performed by the reactor supply apparatus 300. Step S2 is completed by the reagent supplying apparatus 100, the specimen-supplying apparatus 200, the supplying unit 700, and the relay apparatus 500. Step S3 is performed by the kneading unit 800. Steps S4-S6 are performed by the reaction apparatus 400. Cleaning and separating assembly

The reactor supply apparatus 300 serves to store and supply reactors. The reactor feed device 300 may include a tray structure or a silo structure 310. Wherein, the tray structure is arranged on the tray with orderly reactors; the silo structure 310 is a random placement of the reactor within the silo. Since the tray structure occupies a large space volume due to the orderly arrangement of the reactors in the tray structure, the silo structure 310 is preferably adopted in order to reduce the occupied volume of the reactor feeding device 300 and make the overall structure compact. In one embodiment, as shown in fig. 1, the reactor feeding apparatus 300 includes a magazine structure 310, a sequencing structure and a feeding chute 320, the reactors are randomly placed in the magazine structure 310, and the randomly placed reactors in the magazine are sequenced by the sequencing structure to be discharged to the feeding unit 700 through the feeding chute 320 one by one. The supply unit 700 is used for buffering the reactor.

As shown in FIG. 1, in one embodiment, the feed unit 700 includes a feed tray 710 and a feed drive that drives the feed tray 710 to rotate about a central axis of the feed tray 710. The periphery of the feed tray 710 is provided with a plurality of temporary storage grooves 720 which are circumferentially distributed at intervals and are used for temporarily storing the reactor. The supply drive drives the supply tray 710 to rotate so that one empty staging slot 720 is aligned with the supply chute 320 of the reactor supply assembly 300, and after a reactor is transferred from the supply chute 320 to the staging slot 720, the supply drive drives the supply tray 710 to rotate so that the next empty staging slot 720 is aligned with the supply chute 320 of the reactor supply assembly 300. At least three temporary storage tanks 720 are provided, at a certain moment, at least one temporary storage tank 720 is used for receiving the reactor provided by the reactor supply device 300, the reactor in at least one temporary storage tank 720 receives the sample provided by the sample supply device 200, and the reactor in at least one temporary storage tank 720 is transferred to the transfer device 500 by the transfer device 600.

In one embodiment, as shown in fig. 1, the analysis apparatus includes a supply unit 700, and a reactor supply device 300, a sample supply device 200, and a transfer device 500 provided around a supply tray 710 in the supply unit 700, and a transfer device 600 capable of transferring a reactor between the supply unit 700 and the transfer device 500. Wherein, after the supply unit 700 receives the reactor provided by the reactor supply device 300, the supply tray 710 rotates at an angle and receives the sample provided by the sample supply device 200, so that the sample is added into the reactor; then, the supply tray 710 continues to rotate, and after the supply tray 710 rotates by a certain angle, the transfer device 600 transfers the reactor containing the sample to the relay device 500.

The relay device 500 is used for carrying and transporting a reactor to be discharged with a reagent. Further, the transfer device 500 is also used for carrying and transferring the reactor to be mixed after the discharged reagent is discharged. Fig. 3 shows at least a schematic structural view of a relay device 500 included in the analysis device. As shown in fig. 3, the transfer device 500 includes a transfer driver 510 and a transfer disk 520 connected to the transfer driver 510, wherein the transfer disk 520 is used for carrying the reactor, and the transfer driver 510 drives the transfer disk 520 to rotate around the central axis of the transfer disk 520, so as to move the reactor on the transfer disk 520 to different positions. The periphery of the middle turntable 520 is provided with a plurality of temporary storage positions 530 which are circumferentially distributed at intervals and used for temporarily storing the reactor, wherein the temporary storage positions 530 can be understood as groove structures arranged on the middle turntable 520 or can be understood as clamps which are fixedly arranged on the middle turntable 520 and used for clamping the reactor. In one embodiment, the plurality of temporary bits 530 are arranged in a ring on the middle turntable 520.

In one embodiment, at least four temporary storage locations 530 are provided, at a certain time, at least one temporary storage location 530 is used for receiving the reactor transferred from the supply unit 700 by the transfer device 600, the reactor in at least one temporary storage location 530 is used for receiving the reagent supplied by the reagent supply device 100, the reactor in at least one temporary storage location 530 is used for mixing the reagent and the sample, and the reactor in at least one temporary storage location 530 is transferred to the reaction device 400 by the transfer device 600. In one embodiment, as shown in fig. 1, the analysis apparatus includes a relay device 500, and a supply unit 700, a reagent supply device 100, and a kneading unit 800 disposed at a circumferential direction of a relay disk 520 of the relay device 500; the analysis apparatus further includes a reaction unit 400 disposed at the outer periphery of the relay unit 500, and a transfer unit 600 capable of transferring the reactor between the relay unit 500 and the reaction unit 400. After the transfer device 500 receives the reactor containing the sample transferred by the transfer device 600 from the supply unit 700, the transfer disk 520 rotates at an angle and continues to receive the reagent provided by the reagent supply device 100, so that the reagent is added to the reactor containing the sample; then, the middle rotating disc 520 continues to rotate, and the reagent and the sample in the reactor are uniformly mixed through the uniformly mixing unit 800; then the middle rotating disc 520 continues to rotate, and the transfer device 600 transfers the reactor after mixing to the reaction device 400. In order to improve the working efficiency of the middle rotating disk 520, so that a plurality of reactors can be temporarily stored on the middle rotating disk 520, the number of the temporary storage positions 530 on the middle rotating disk 520 can be more than four, and simultaneously, in order to prevent the larger size of the middle rotating disk 520 from causing the larger size of the whole equipment, at most eight temporary storage positions 530 on the middle rotating disk 520 are arranged.

In one embodiment, the number of the temporary storage bits 530 on the middle turntable 520 is 3 to 8. If the number of temporary storage bits 530 on the middle rotating disk 520 is less than 3 in one embodiment, it is difficult to process multiple tasks in parallel, such as processing in and out of the receiving reactor, receiving the reagent provided by the reagent supply apparatus 100, and mixing the reagent and the sample in the reactor. If in one embodiment, the number of buffer sites 530 in the intermediate turntable 520 is too large, such as more than 8, the intermediate turntable 520 occupies a large space, and the residence time of the reactor in the intermediate turntable 520 is long, thereby reducing the testing efficiency.

In one embodiment, as shown in fig. 3, the blending unit 800 is disposed below the middle turntable 520, the middle turntable 520 rotates to enable the reactors in the temporary storage 530 on the middle turntable 520 to sequentially correspond to the blending unit 800, and the blending unit 800 can vibrate the reactors to blend the reagents and the samples in the reactors. For example, the kneading assembly may include a vibrating member 810, a kneading driving member 830 for driving the vibrating member 810 to vibrate, and a lifting driving member, and the vibrating member 810 may be provided with a vibrating hole 820. The lifting driving member drives the vibrating member 810 and the vibrating member 810 to lift, so that the reactor can be inserted into the vibrating hole 820, and the mixing driving member 830 drives the vibrating member 810 to eccentrically vibrate, so that the reagent and the sample in the reactor are uniformly mixed due to vibration.

In one embodiment, as shown in FIG. 3, when the middle rotating disk 520 rotates, the temporary bits 530 on the middle rotating disk 520 move synchronously with the middle rotating disk 520, and each temporary bit 530 can move to the position a, the position b, the position c and the position d in turn. Position a may be a transfer position in which the reactor enters and exits the transfer plate 520. The position d can be a mixing position, and the reactor mixes the sample and the reagent in the reactor at the mixing position. Position b may be a reagent row position at which the reactor receives reagent. Position c may also be a reagent draining position. In the clockwise direction, the position a, the position b, the position c, and the position d are arranged in this order when the middle rotary table 520 is viewed from above. Wherein the reactor enters and exits the centering disk 520 at the position a, and referring to fig. 1, the reagent supply device 100 discharges the reagent from the reactor on the centering disk 520 at the position c, and the mixing unit 800 mixes the reagent and the sample in the reactor at the position d. The plurality of reactors on the middle turntable 520 move to the position a in sequence and can be taken away by the transfer device 600 from the middle turntable 520, that is, the transfer device 600 only takes and places the reactors at the position a, the length of the transfer track of the transfer device 600 can be shortened, and the taking and placing of the reactors can be realized only by one transfer device 600, so that the number of the transfer devices 600 can be reduced.

As shown in fig. 1, the transfer trajectory of the transfer device 600 passes through the position a. And the center of the middle rotary table 520 and the position c are on the same side of the transfer track of the transfer device 600. This arrangement can reduce the volume of space occupied by the middle rotary disk 520 and avoid spatial interference of the transfer device 600 and the reagent supply device 100.

As shown in fig. 1, when the analysis apparatus includes two reagent supply apparatuses 100, the middle rotary disk 520 may receive the reagents supplied from the two reagent supply apparatuses 100 at the position b and the position c, respectively; in some embodiments, the middle rotary disk 520 may also receive the reagents provided by two reagent supply devices 100 one after the other at the position c. Preferably, the middle rotary plate 520 may also sequentially receive the reagents provided by the two reagent supply devices 100 at the position c, so that the size of the middle rotary plate 520 and the space occupied by the reagent supply devices 100 may be further reduced, the flexibility and efficiency of the reagent supply devices 100 may be improved, and the processing task capacity per unit area of the relay device 500 and the reagent supply devices 100 may be increased.

As shown in fig. 1, the reaction apparatus 400 and the relay board 520 of the relay apparatus 500 are independently provided, and specifically, the relay apparatus 500 is provided outside the reaction apparatus 400, and the rotation center of the relay apparatus 500 is provided outside the reaction apparatus 400. That is, the relay device 500 and the reaction device 400 do not overlap each other in a space in a plan view. Further, the diameter of the middle rotary disk 520 is smaller than the diameter of the reagent disk. The problems of complex structure, high cost, large occupied area and the like caused by the nested arrangement of the middle rotary table 520 and the reaction device 400 are solved, the limitation of the reaction disc 410 of the reaction device 400 on the structure, the size, the spatial position and the temporary storage position distribution of the middle rotary table 520 is also solved, and the position of the middle rotary table 520 and the temporary storage position on the middle rotary table can be more flexibly, efficiently and reasonably arranged. The nested arrangement of the middle rotating disc 520 and the reaction device 400 means that the middle rotating disc 520 and the reaction device 400 are coaxially arranged, and the reaction device 400 is nested in the middle rotating disc 520. In one embodiment, as shown in fig. 1, the reagent supplying device 100 includes a reagent storage unit 110 and a reagent discharge unit 120; the reagent storage unit 110 is used to store reagents, and the reagent discharging unit 120 is used to suck and discharge the reagents stored in the reagent storage unit 110 to the reactor on the relay device 500.

In some embodiments, the reagent storage unit 110 may be a cartridge-type structure, i.e., a stationary reagent cartridge, or a disk-type structure as shown in fig. 1, i.e., a rotatable reagent disk for storing reagents. Since the middle rotating disk 520 is used for temporarily storing the reactors, the residence time of each reactor in the middle rotating disk is short, but the reagent disk stores some reagents for a long time, in order to meet the requirement of reagent storage and ensure that the size of the whole machine is small, the diameter of the middle rotating disk 520 is set to be smaller than that of the reagent disk.

The reagent storage unit 110 shown in fig. 1 is described below in a tray structure. The reagent storage unit 110 is provided with a plurality of reagent sites for placing reagent containers, and the disk type reagent storage unit 110 can be driven by the driving unit to rotate around the central axis of the reagent storage unit 110 under the control of the control center, so that the reagent sites on the reagent storage unit 110 can be sequentially rotated to positions where they can be accessed by the row reagent unit 120.

In one embodiment, if the reagent includes a magnetic particle reagent component, since the magnetic particle reagent component naturally settles down, the reagent storage unit 110 may include a mixing structure, which can rotate or oscillate the magnetic particle reagent component container of the reagent site, thereby mixing the magnetic particle reagent components in the reagent container.

In one embodiment, the reagent storage unit 110 may include a refrigerator capable of providing a stable low temperature environment for the reagent in the reagent container when long-term preservation of the reagent is required, thereby extending the preservation time of the reagent.

In one embodiment, the reagent storage unit 110 may include a barcode scanner for identifying barcode information on the reagent container to identify and distinguish reagents of different analytical items. In order to make the whole machine compact and reduce the cost, the bar code scanner can adopt a fixed design, for example, fixed relative to the whole machine.

In a conventional analyzer, one reagent storage unit 110 is generally provided, and in order to increase the number of reagent containers, i.e., the number of reagent sites, accommodated in the reagent storage unit 110, it is necessary to increase the size of the reagent storage unit 110. However, the reagent storage unit 110 with a large size not only occupies a large space area, which is inconvenient for the layout of the whole machine and the production and manufacturing, but also has a high requirement for motion control, i.e. any one reagent position is required to be positioned in a short time to a position where the reagent can be acquired by the row reagent unit 120, so that the high-speed operation of the whole machine cannot be realized.

To this end, in one embodiment of the present application, the assay device comprises at least two independently driven reagent supply devices 100, as shown in FIG. 1. The reagent storage units 110 in the two reagent supplying devices 100 are a first reagent disk 111 and a second reagent disk 112, respectively, and the first reagent disk 111 and the second reagent disk 112 are each driven to rotate by an independent driving unit. Through the independent arrangement and the drive of two reagent feeding devices 100, not only is the size of each reagent tray small, and the reagent tray is beneficial to the overall arrangement and the motion control of the reagent tray, but also the reagent storage quantity of the overall machine is effectively expanded. In addition, the reliability of the whole machine operation is improved, and when one reagent supply device 100 fails, the other reagent supply device 100 can be continuously used.

In one application scenario, 3 TSH (thyroid stimulating hormone) reagent containers each containing 100 TSH (thyroid stimulating hormone) to be tested need to be loaded, and all of the 3 TSH reagent containers can be loaded on the first reagent tray 111; it is also possible to load 3 TSH reagent containers all on the second reagent disk 112; alternatively, 1 TSH reagent container may be loaded on the first reagent disk 111, and another 2 TSH reagent containers may be loaded on the second reagent disk 112; alternatively, 1 TSH reagent container may be loaded on the second reagent disk 112, and another 2 TSH reagent containers may be loaded on the first reagent disk 111. That is, the first reagent disk 111 and the second reagent disk 112 may store reagent components required for one test item, respectively. Therefore, the two reagent disks can alternately output the reagents, so that the time for taking the reagents is shortened, and the working efficiency is improved.

In one embodiment, in order to fully take into account the usage requirements, cost and layout, 15-50 reagent sites are provided on each reagent disk, e.g. 25 reagent sites are provided on each of the first and second reagent disks 111, 112.

In one embodiment, as shown in FIG. 1, the row reagent unit 120 is used for reagent uptake and discharge, for example, the row reagent unit 120 extracts a reagent from a reagent container in the reagent storage unit 110 and then discharges the reagent to a reactor in the relay device 500. As shown in fig. 1, when the test throughput is high, in order to improve the reagent sucking and discharging efficiency, the reagent discharging units 120 correspond to the reagent storage units 110 one by one, and the two reagent discharging units 120 are also independently controlled to alternately discharge the reagents into the reactors in the relay apparatus 500 independently; a row reagent unit 120 may also be provided when the test throughput is not high. Typically, the reagent discharge unit 120 includes a metal needle, a pipetting drive mechanism, a syringe or infusion pump, valves, fluid lines, and the like. To accomplish the reagent sucking and discharging actions thereof, the row reagent unit 120 may perform horizontal movement and vertical movement. The horizontal movement usually has several movement forms of rotation, X direction, Y direction, etc. or the combination of several movement forms. As a preferred embodiment, the row reagent unit 120 may perform a horizontal linear movement and a vertical movement, and the horizontal linear movement is traced on a line connecting the center of the reagent storage unit 110 and the position c of the middle turntable 520. Specifically, two line reagent units 120 and two reagent storage units 110 are provided, and the line reagent units 120 correspond to the reagent storage units 110 one to one. The horizontal linear motion trajectories of the two rows of reagent units 120 intersect at a position c of the middle rotary plate 520 along the radial direction of the respective corresponding reagent storage units 110. The two rows of reagent units 120 independently alternate the discharge of reagent into the reactor in position c of the relay device 500. Therefore, the movement stroke of the reagent discharging unit 120 is reduced to the greatest extent, the efficiency of processing tasks is improved, the layout of the whole machine is more reasonable and compact, and the space interference of various movement components is reduced.

As shown in fig. 1, the reaction apparatus 400 is used for incubation, washing separation and measurement of reactants in a reactor. The reaction apparatus 400 includes a reaction disk 410 and a reaction driving member for driving the reaction disk 410 to rotate about its central axis. The reaction tray 410 is provided with a plurality of reaction sites 420, and the reaction sites 420 may be holes, grooves, brackets, or bases for fixing the reactor. As shown in fig. 4, fig. 4 is a schematic structural diagram of reaction sites 420 on the reaction device 400 in an embodiment, and the reaction sites 420 at least include a washing separation site 421, an incubation site 422, and a measurement site 423. The reaction sites 420 are annularly arranged on the reaction disk 410, and the inner circle is a cleaning separation site 421; the outer circle is a measurement bit 423; an incubation position 422 is arranged between the inner ring and the outer ring, and a plurality of rings are arranged on the incubation position 422. The reactor provided at the incubation position 422 performs an incubation process, the reactor provided at the washing and separating position 421 performs a washing and separating process, and the reactor provided at the measurement position 423 performs a measurement process or prepares for measurement.

In one embodiment, as shown in fig. 4, the reaction sites 420 on the reaction disk 410 are arranged in a group along the radial direction of the reaction disk 410, each group includes a washing separation site 421, an incubation site 422 and a measurement site 423, and several groups are arranged along the circumferential direction of the reaction disk 410.

In one embodiment, referring to fig. 1, the transfer track of the transfer device 600 extends along a radius of the reaction tray 410, and covers at least all reaction sites on the reaction tray 410 along the radius. When the reaction disc 410 rotates circumferentially, all the reaction sites 420 on the reaction disc 410 can be covered by the transfer tracks of the transfer device 600, so that the problem of taking and placing the reactors on different circles of reaction sites 420 is solved, the layout of the whole machine is compact, and the occupied space is small.

In one embodiment, as shown in fig. 1, the transfer device 500 includes a rotatable middle turntable 520, and the center of the middle turntable 520 and the center of the supply tray 710 are respectively located at two sides of the transfer track of the transfer device 600. With the arrangement, the middle rotating disc 520 and the supply disc 710 respectively occupy the space on both sides of the transfer device 600, thereby not only shortening the movement stroke of the transfer device 600, but also ensuring the compact layout of the whole device and small occupied space.

In one embodiment, as shown in fig. 1, the reaction apparatus 400 includes a temperature control assembly, which includes a thermal insulation pan, a thermal insulation device, a heater, a temperature sensor, a temperature control circuit, and other components, to provide a constant temperature incubation environment for the reaction apparatus 400 and reduce heat dissipation.

In one embodiment, the reaction apparatus 400 further comprises a cleaning and separating assembly. As shown in FIG. 4, when the reactor at the cleaning and separating position 421 is transferred to the position where the cleaning and separating module is located, the cleaning and separating module starts to clean and separate the reactor to remove the unbound components in the reactant. The cleaning and separating assembly comprises a magnetic assembly and a flushing assembly. Wherein, the magnetic assembly provides magnetic force to collect the magnetic particles in the reactor to the inner wall of the reactor. Due to factors such as response time, moving distance and resistance in the magnetic force, a certain time, usually several seconds to several tens of seconds, is required for collecting the magnetic particles on the inner wall of the reactor, so that the reactor needs to pass through the magnetic force for a period of time before waste liquid (including unbound components) is sucked each time. In this embodiment, the magnetic assembly may be directly mounted or fixed near the cleaning and separating location 421, so that the magnetic assembly is closer to the reaction location 420, thereby reducing the collecting time of magnetic particles and improving the cleaning and separating efficiency. The washing assembly is arranged above the cleaning separation position 421, the washing assembly comprises a liquid suction needle and a liquid suction pipe connected with the liquid suction needle, the liquid suction needle is driven by a liquid suction driving part to enter and exit the reactor positioned at the cleaning separation position 421, and unbound components in the reactor are sucked. In one embodiment, the washing assembly further comprises a liquid injection needle and a liquid injection pipe connected with the liquid injection needle, and the liquid injection needle is used for injecting the washing buffer liquid into the reactor.

Generally, each washing and separating step comprises a process of one-time liquid absorption and one-time injection of a washing buffer; typically three to four wash separation steps are performed. In one embodiment, in order to improve the effect of cleaning and separating the reactor and reduce the reaction residues in the reactor, in conjunction with fig. 4, a mixer may be disposed at the cleaning and separating position 421, and the mixer is used to uniformly distribute the magnetic particles in the reactor again after injecting the cleaning buffer. The washing assembly is arranged above the cleaning separation position 421, and can directly clean and separate the reactor of the cleaning separation position 421, so that an independent cleaning separation rotating device is not required to be arranged, and the reactor is prevented from being transferred between the independent cleaning separation assembly and the reaction device 400. The device has the advantages of simple integral structure and high operation efficiency.

In one embodiment, the reaction apparatus 400 further comprises a measuring component 430, wherein the measuring component 430 is disposed on the thermal insulating pot and measures the signal in the reactor at the measuring position 423. The signal is an electric signal, a fluorescent signal or a weak chemiluminescent signal generated after a signal reagent is added into the reactor. In one embodiment, the measurement assembly 430 includes a weak light detector photomultiplier tube (PMT) or other sensitive photo-sensing device that converts the measured optical signals to electrical signals that are transmitted to a control center. In addition, in order to improve the measurement efficiency and ensure the measurement consistency, the measurement assembly 430 may further include optical structures such as optical signal collection and calibration. The measuring assembly 430 is connected or mounted to the reaction apparatus 400 in a general manner, such as directly mounted and fixed to the reaction apparatus 400 or mounted to the reaction apparatus 400 through an optical fiber connection, so that the signal in the reactor on the outermost reaction site 420 can be directly measured, an independent measuring unit is avoided, the transfer of the reactor between the reaction apparatus 400 and the measuring assembly 430 is omitted, the overall mechanism is more compact, the cost is lower, the control process is simpler and more efficient, and the processing efficiency and reliability are higher.

In one embodiment, as shown in fig. 1, an analysis apparatus includes a transfer device 600, and the transfer device 600 moves a reactor from a first position to a second position along a first direction, wherein the first position is at least one of a supply unit 700, a transfer device 500, and a reaction device 400, the second position is at least one of the supply unit 700, the transfer device 500, and the reaction device 400, in other embodiments, the first position may be a structure other than the supply unit 700, the transfer device 500, and the reaction device 400, and the second position may be a structure other than the supply unit 700, the transfer device 500, and the reaction device 400.

Fig. 5 is a schematic structural diagram of a transfer device 600 in an embodiment, where the transfer device 600 includes a guide rail 630 and a grasping unit moving along the guide rail 630, and a spatial path along which the grasping unit moves along the guide rail 630 is a transfer track of the transfer device 600. The number of the grabbing units can be selected according to actual conditions, and in order to improve the comprehensive working capacity of the transfer device 600, preferably, at least two grabbing units are provided, namely a first grabbing unit 611 and a second grabbing unit 612. As shown in fig. 5, the guide rail 630 of the transfer device 600 is provided with one, and the guide rail 630 of the transfer device 600 is provided with a first grip unit 611 and a first grip driving member 621 that drives the first grip unit 611 to slide along the guide rail 630, and with a second grip unit 612 and a second grip driving member 622 that drives the second grip unit 612 to slide along the guide rail 630. The first driving member and the second driving member are independently provided, and thus, the first and second grasping units 611 and 612 move independently of each other. Wherein the guide rail 630 may extend in a first direction, the first direction extending substantially in a horizontal direction. The first and second grasping units 611 and 612 are sequentially disposed along the extending direction of the guide rail 630. Therefore, two grabbing units can move only by arranging one guide rail 630, the transfer track of the transfer device 600 is on the same straight line, the number of the guide rails is reduced, the space layout of the whole machine is facilitated, the space interference of a plurality of transfer devices is prevented, and the problem of large occupied space in order to avoid interference is solved, so that the size of the equipment is reduced under the condition of improving the flux of the equipment, and the equipment is more miniaturized. Furthermore, the moving track of the transfer device is on a straight line, and the transfer operation of the grabbing unit is completed on the straight line track, so that the total stroke of the transfer operation is shortened, and the transfer operation efficiency of the transfer device is improved. In a traditional implementation mode, a corresponding transfer device is usually arranged for each transfer operation, or one transfer device is shared by 1-2 transfer operations, because the transfer operations are usually more and are not on the same track, the arrangement modes increase the number and the spatial distribution of the transfer devices, for example, in order to realize high-throughput testing, more than 3 transfer devices in a distributed layout are needed, so that the whole machine is complex in structure, large in size and inconvenient to control. In the embodiment of the application, all transfer operations can be completed only by arranging one transfer device, so that the cost of the device is greatly saved, the device is compact in structure and convenient to control, and the interference condition of different transfer devices in time and space can not occur.

In one embodiment, as shown in fig. 5, the first grasping unit 611 and the second grasping unit 612 of the grasping unit are identical in structure and each include a frame body slidably connected to the guide rail 630, for example, the frame body can slide along a horizontal direction relative to the guide rail 630, an elevating block slidably connected to the frame body along a vertical direction, and a jaw provided on the elevating block, and the jaw can be lifted and lowered with the elevating block to clamp the reactor.

Fig. 6 is a diagram of a transfer trajectory of the transfer device 600 in one embodiment. An analysis apparatus includes a transfer apparatus 600, and the transfer apparatus 600 includes a first grasping unit 611 and a second grasping unit 612. The straight lines of the moving tracks of the first grabbing unit (611) and the second grabbing unit (612) are overlapped. The grabbing unit of the transfer device 600 moves along the guide rail 630 to pick and place the reactor at the cleaning separation alignment 631, the incubation alignment 632, the measurement alignment 633, the abandoning alignment 634, the relay alignment 635 and the transit alignment 636. In connection with the embodiment shown in fig. 1, the reaction site 420 of the reaction apparatus 400 at least comprises a washing separation site 421, an incubation site 422 and a measurement site 423. When the cleaning separation position 421 corresponds to the cleaning separation position 631 of the transfer device 600, the pick-up unit can pick up and place the reactor of the cleaning separation position 421. When the incubation position 422 corresponds to the incubation alignment 632 of the transfer device 600, the grabbing unit can pick and place the reactor of the incubation position 422. When the measurement position 423 corresponds to the measurement alignment position 633 of the transfer device 600, the grasping unit can take and place the reactor of the measurement position 423. In conjunction with the embodiment shown in fig. 3, the temporary storage location 530 on the transfer device 500 can at least move to a position a, which can be a neutral position, and the picking unit can pick and place the neutral position reactor when the neutral position corresponds to the neutral position 636. As shown in fig. 1, a relay position may be disposed between the transfer device 500 and the reaction device 400, the relay position may correspond to the relay alignment position 635, the first grabbing unit 611 may grab the reactor at the cleaning separation alignment position 631, place the reactor at the relay alignment position 635 on the relay position, then the second grabbing unit 612 grabs the reactor at the relay position 635 at the relay alignment position, and then move the reactor to the transfer alignment position 636. In connection with the embodiment shown in fig. 3, the temporary storage location 530 on the relay device 500 can move to a location b, a location c, and a location d, where the location d can be a blending location, the location b can be a reagent discharging location, and the location c can also be a reagent discharging location. In conjunction with the embodiment shown in fig. 1, a disposal position may be disposed between the reaction device 400 and the transfer device 500, and when the disposal position corresponds to the disposal alignment position 634, the grabbing unit may pick up and dispose the reactor in the disposal position, or the grabbing unit may dispose the reactor to the disposal position.

In one embodiment, referring to fig. 6, the straight lines of the moving tracks of the first grasping unit (611) and the second grasping unit (612) are overlapped, and at least one segment of the transfer track of the first grasping unit 611 overlaps with the transfer track of the second grasping unit 612. For example, in fig. 6, the moving tracks of the first grasping unit 611 and the second grasping unit 612 are overlapped at the incubation alignment 632, the measurement alignment 633, the discarding alignment 634 and the relay alignment 635, for example, the first grasping unit 611 may grasp the reactor from the cleaning separation alignment 631, then place the reactor at the relay alignment 635, and the second grasping unit 612 may move the reactor placed at the relay alignment 635 to the transfer alignment 636. Referring to fig. 6, the sequences of the cleaning separation alignment 631, the incubation alignment 632, the measurement alignment 633, the discarding alignment 634, the relay alignment 635, and the transit alignment 636 are not necessarily arranged in the order shown in fig. 6, and may be rearranged as needed.

As shown in fig. 1, when the analysis device is operated, each sub-device operates in order according to the duty cycle. The working cycle, or simply cycle, is the shortest time interval during which the execution object can recur cyclically during the working process, and it usually has a fixed length of time, for example, the suction and discharge steps, the homogenisation step, the washing separation step, the measurement step take time to execute, serially or in parallel, in a controlled order. The concrete meaning of the parallelism is that a plurality of task operations can be carried out simultaneously; or when the previous task operation has already started and has not ended, the subsequent task operation may be started. Because the same component can usually only execute one task at a time, the same component usually acts or tasks in series in one period; different components may typically perform tasks at the same time, and thus different components may typically perform actions or tasks in parallel during the same cycle.

In order to improve the working efficiency, for the device with speed bottleneck, it can be realized by increasing the number of the devices, for example, in fig. 1, two reagent trays, a first reagent tray 111 and a second reagent tray 112 are provided. As another example, it may be achieved by extending the duty cycle of the device, when there is only one reagent disk, the duty cycle length required for one reagent disk may be twice the duty cycle length of the two reagent disks working in cooperation.

In one embodiment, as shown in FIG. 1, the analyzer comprises two sets of reagent supplying apparatuses 100, a relay apparatus 500 and a transfer apparatus 600. One set of the reagent supply devices 100 comprises a first reagent disk 111 and a first row of reagent elements 121, and the other set of the reagent supply devices 100 comprises a second reagent disk 112 and a second row of reagent elements 122, wherein each of the first row of reagent elements 121 and the second row of reagent elements 122 is a reagent row unit 120.

As shown in fig. 7, fig. 7 is a cycle length diagram of the analysis apparatus in an embodiment, in which the relay device 500 and the transfer device 600 operate in a first cycle T1, the first row of reagent elements 121 and the second row of reagent elements 122 operate in a second cycle T2, and the time length of the second cycle T2 is 2 times that of the first cycle T1. The first row of reagent elements 121 and the second row of reagent elements 122 operating in the second period T2 are alternately discharged to the reactor of the same temporary storage location 530 of the relay device 500 by a time length of one first period T1. As shown in fig. 7, when the continuous operation is started, the transfer device 600 transfers one reactor to the transfer device 500 every first period T1. The transfer device 500 rotates and advances the reactor one position per first cycle T1. The first row reagent element 121 sucks reagent from the first reagent disk 111 every second period T2 and discharges the reagent to the reactor on the relay device 500, for example, for convenience of understanding, the sucked reagent corresponds to a section a of the second period T2 and the discharged reagent corresponds to a section B of the second period T2. The second row of reagent elements 122 draws reagent from the second reagent tray 112 and discharges reagent to the reactor on the relay device 500 every second cycle T2. Similarly, the aspirated reagent corresponds to period A of the second period T2, and the discharged reagent corresponds to period B of the second period T2. The same sequence of movements of the first row of reagent elements 121 and the second row of reagent elements 122 is staggered by a first period T1, i.e. when the first row of reagent elements 121 sucks reagent, the second row of reagent elements 122 discharges reagent; when the first row of reagent elements 121 discharges reagent, the second row of reagent elements 122 aspirates reagent. Specifically, the first row of reagent elements 121 and the second row of reagent elements 122 may discharge reagent to the reactor at the same location of the relay device 500. That is, the relay device 500 transfers one of the reactors to a specific position to receive the reagent discharged from the first row of reagent elements 121 in the nth first cycle, and the relay device 500 transfers the other reactor to the specific position to receive the reagent discharged from the second row of reagent elements 122 in the N +1 th first cycle. As shown in fig. 1, the specific position may be position c. In fig. 1, the moving tracks of the first row of reagent elements 121 and the second row of reagent elements 122 can both cover the position c, that is, they are overlapped or intersected at the position c, so that the arrangement is such that the area covered by the first row of reagent elements 121 and the second row of reagent elements 122 is small, and the overall structure is more compact. In the above embodiment, the duty cycle of the reagent storage units 110 is the same as the duty cycle of the first row of reagent elements 121 and the second row of reagent elements 122, and is 2 times the duty cycle of the relay device 500 and the transfer device 600, and the operation sequences of the two sets of reagent storage units 110 are staggered and parallel to each other with a first cycle T1 therebetween. In this way, the analyzer includes only two sets of reagent storage units 110, one set of transfer device 500 and one set of transfer device 600, which not only reduces the occupied space of the analyzer, but also effectively improves the working efficiency of the analyzer.

An embodiment of the present application further provides a dilution apparatus, as shown in fig. 8, fig. 8 is a schematic structural diagram of the dilution apparatus in an embodiment, and the dilution apparatus includes a reagent supply apparatus 100, a sample supply apparatus 200, a reactor supply apparatus 300, a transfer apparatus 500, a transfer apparatus 600, a supply unit 700, and a dilution conveyance apparatus 900. Among them, the reagent supplying device 100, the sample supplying device 200, the reactor supplying device 300, the relay device 500, the transferring device 600, and the supplying unit 700 are the same as those of the above-described embodiment. A dilution transportation means 900 is provided between the reaction means 400 and the transfer means 500. The transport distance of the reactor containing the diluted sample can be reduced. The dilution transportation device 900 is provided with at least one loading position for loading a reactor containing a diluted sample, and can linearly reciprocate between the movement traces of the transfer device 600 and the sample supply device 200. Preferably, the dilution transportation device 900 is provided with at least two carrying positions for carrying the reactor containing the diluted sample, which can be used alternately, thereby improving the efficiency of automatic dilution of the sample.

As shown in fig. 8, the supply unit 700 of the dilution apparatus is provided with a first station 11 and a second station 12, the first station 11 is used for receiving the sample in the first reactor and the diluted sample in the second reactor, and the second station 12 is used for transferring the first reactor and the second reactor out of the supply unit 700 by the transfer apparatus 600. The transfer device 500 is provided with a fourth station 14, a fifth station 15, and a sixth station 16. The fourth station 14 is used for the transfer device 600 to move the first reactor and the second reactor into and out of the transfer device 500, the fifth station 15 is used for the first reactor to receive diluent and the second reactor to receive reagent, and the sixth station 16 is respectively used for mixing the reactants in the first reactor and the second reactor.

As shown in fig. 8, the supply unit 700 includes a supply tray 710, a temporary storage slot 720 for accommodating the reactor is disposed on the supply tray 710, and the supply tray 710 can rotate to drive the temporary storage slot 720 to move circularly at the first station 11 and the second station 12; the transfer device 500 comprises a transfer disc 520, a temporary storage location 530 for accommodating the reactor is arranged on the transfer disc 520, and the transfer disc 520 can rotate to drive the temporary storage location 530 to circularly move at the fourth station 14, the fifth station 15 and the sixth station 16. Specifically, the transfer device 600 is used to transfer the reactor between the supply unit 700 and the transfer device 500, and the transfer device 600 is also capable of transferring the reactor between the transfer device 500 and the dilution transportation device 900. The reagent supply apparatus 100 is used to add a diluent to the reactor. The sample supply apparatus 200 is used not only for discharging a sample but also for transferring a diluted sample between different reactors, and for example, the sample supply apparatus 200 includes a movable suction needle through which both the sample and the diluted sample can be sucked and discharged. The diluent of a certain item can be a component of the reagent of the item, and can also be a general diluent. The diluent is stored in the reagent supplying apparatus 100.

A dilution method can be performed by a dilution device, and also by the analysis device in the above embodiment. The dilution method comprises the following steps:

s101, adding a sample to the first reactor of the first station 11 of the supply unit 700.

The first reactor may be first provided to the supply unit 700 through the reactor supply device 300 and then moved to the first station 11 of the supply unit 700. The sample may be added to the first reactor of the first station 11 by the sample supply device 200.

S102, the first reactor is transferred to the fifth station 15 of the transfer device 500, and the first station 11 of the supply unit 700 receives the second reactor.

The supply unit 700 rotates to rotate the first reactor out of the first station 11, and the supply unit 700 rotates to drive the second reactor into the first station 11. The reactor on the supply unit 700 may be transferred to the transfer device 500 by the transfer device 600, and the transfer device 500 rotates to transfer the first reactor to the fifth station 15.

And S103, adding a diluent to the first reactor of the fifth station 15 to obtain a diluted sample.

A diluted sample may be obtained by adding a diluent to the first reactor of the fifth station 15 through the reagent supplying apparatus 100.

And S104, uniformly mixing the diluted sample in the first reactor.

A homogenisation unit 800 may be provided to homogenise the diluted sample in the first reactor at the fifth station 15. The transfer device 500 may be rotated to move the first reactor to another station for mixing.

S105, transferring the first reactor from the transfer device 500 to a dilution transportation device 900.

The first reactor may be transferred from the transfer device 500 to the dilution conveyance device 900 by the transfer device 600.

And S106, transferring a part of the diluted sample in the first reactor to the second reactor.

A part of the diluted sample in the first reactor of the dilution transportation device 900 is sucked by the sample supply device 200 and discharged to the second reactor of the relay device 500.

S107, transferring the second reactor to a fifth station 15 of the transfer device 500, and continuously adding reagents to the second reactor.

The second reactor may be transferred to the fifth station 15 of the transfer device 500 by the transfer device 600, and the addition of the reagent to the second reactor may be continued.

And S108, uniformly mixing the mixture in the second reactor.

The mixture in the second reactor at the fifth station 15 may be homogenised. The transfer device 500 may be rotated to move the second reactor to another station for mixing.

In the above embodiment, the diluted reactor is temporarily stored in the dilution transportation device 900, and then the mixture in the reactor located on the dilution transportation device 900 is transferred to the reactor on the supply unit 700 by the sample supply device 200. Therefore, the diluted reactor does not need to be temporarily stored back to the supply unit 700, the workload of the supply unit 700 can be effectively reduced, and the operation efficiency and the operation stability of the whole device can be improved. Further, the dilution transportation device 900 is independently disposed between the reaction device 400 and the transfer device 500, only carries the transportation of the reactor containing the diluted sample, and moves linearly between the transfer device 600 and the sample supply device 200, without being limited by other dilution processes and operations such as sample addition, reagent addition, and mixing, thereby improving the efficiency of the dilution device to achieve automatic dilution of the sample to the maximum extent.

In some embodiments, the supply tray 710 rotates to circulate the buffer slot 720 between the first station 11 and the second station 12. The intermediate rotating disk 520 drives the temporary storage bit 530 to rotate circularly at the fourth station 14 and the fifth station 15. The supply plate 710 and the middle rotating plate 520 are matched to rotate, and the transfer reactor is orderly arranged, so that the working efficiency is improved.

In one embodiment, the reactor may receive a diluent or reagent at a fifth station 15 and perform a blending operation at the fifth station 15. In one embodiment, the reactor receives diluent or reagents at the fifth station 15 and a blending operation is performed at the sixth station 16.

In one embodiment, the method further comprises the step of discarding the first reactor after transferring a portion of the diluted sample in the first reactor to the second reactor.

In one embodiment, a sample analysis method is provided, comprising the steps of:

and S210, adding the sample and the first reagent into the reactor and uniformly mixing.

S220, the reactor containing the sample and the first reagent is incubated for the first time at the incubation position 422 of the reaction tray 410.

And S230, transferring the reactor after the first incubation to a cleaning and separating position 421 of the reaction disc 410 for first cleaning and separating.

S240, transferring the reactor to a middle rotating disc 520, adding a second reagent and uniformly mixing.

S250, transferring the reactor added with the second reagent to the incubation position 422 of the reaction tray 410 for the second incubation.

And S260, transferring the reactor after the second incubation to a cleaning and separating position 421 of the reaction disc 410 for second cleaning and separating.

S270, adding a signal reagent into the reactor.

S280, the reactor added with the signal reagent is transferred to a measuring position 423 of the reaction disc 410 for measurement.

In one embodiment, the method further comprises the step of transferring the measured reactor to a disposal location for disposal of the reactor.

Specifically, in step S210, the method further includes the following steps:

s211, providing a reactor, and adding a sample into the reactor.

S212, transferring the reactor filled with the sample to a middle rotating disc 520 and adding a first reagent;

and S213, oscillating the reactor to uniformly mix the sample and the first reagent in the reactor.

Specifically, in step S220, the method further includes the following steps:

s221, transferring the mixed reactor containing the sample and the first reagent from the middle rotating disk 520 to the incubation position 422 of the reaction disk 410;

s222, the reactor containing the sample and the first reagent rotates with the reaction disk 410 and performs a first incubation, and the incubation time can be set according to specific test items, and is generally 3 minutes to 60 minutes.

In step S230, the reactor rotates with the reaction disk 410, and the first cleaning and separating of the reactor is performed by the cleaning and separating assembly.

In one embodiment, a sample analyzer is provided to perform the above-described sample analyzing method, and as shown in fig. 1, the sample analyzer includes at least a supplying unit, a mixing unit 800, a reaction unit 400, a transfer unit 600, a washing and separating unit, and a signal reagent adding unit. The supplying apparatus includes a sample supplying apparatus 200 and a reagent supplying apparatus 100, wherein the sample supplying apparatus 200 in the supplying apparatus is used for adding a sample to a reactor, and the reagent supplying apparatus 100 is used for adding a reagent to the reactor. The following example describes the steps of a sample analysis method performed by a sample analysis apparatus.

In step S210, the reactor is supplied to the supply tray 710 by the reactor supply device 300, the supply tray 710 can rotate around the center of the supply tray 710, the sample supply device 200 supplies the sample into the reactor when the reactor rotates to a position corresponding to the sample supply device 200, and the transfer device 600 transfers the reactor from the supply tray 710 to the middle rotary plate 520 when the supply tray 710 rotates the reactor to the operating range of the transfer device 600. The intermediate rotary table 520 is provided with a temporary storage location 530 for carrying a reactor, and the intermediate rotary table 520 can also rotate around the central axis of the intermediate rotary table 520. The intermediate turntable 520 rotates the reactor to a position corresponding to the reagent supply device 100, and supplies the first reagent into the reactor through the reagent supply device 100, and the intermediate turntable 520 rotates the reactor to a position of the kneading unit 800, and the kneading unit 800 kneads the sample and the first reagent in the reactor. The middle turntable 520 then rotates the reactor to the working range of the transfer device 600, and the reactor is transferred to the reaction device 400 through the transfer device 600.

In step S220, the reaction apparatus 400 includes a reaction tray 410, a reaction site 420 for carrying a reactor is disposed on the reaction tray 410, the reaction site 420 is annularly disposed on the reaction tray 410, and according to the function of the reaction site 420, the reaction site 420 can be divided into an incubation site 422 for incubation, a washing separation site 421 for washing separation, and a measurement site 423 for measurement. The transfer device 600 is capable of transferring the reactor between the incubation position 422, the washing separation position 421 and the measurement position 423. For the first incubation, the reactor is incubated for the first incubation at incubation site 422.

In step S230, the reaction apparatus 400 includes a washing and separating component, after the first incubation is completed, the reactor is transferred from the incubation position 422 to the washing and separating position 421 by the transferring apparatus 600, and the reactor in the washing and separating position 421 is subjected to the first washing and separating by the washing and separating component.

In step S240, the transfer device 600 transfers the reactor to the middle rotary table 520, the middle rotary table 520 rotates the reactor to a position corresponding to the reagent supplying device 100, and the second reagent is added to the reactor by the reagent supplying device 100. The middle rotating disc 520 continuously rotates the reactor to a position corresponding to the blending unit 800, and the mixture in the reactor is blended by the blending unit 800. The intermediate turntable 520 continues to rotate the reactor into the operating range of the transfer device 600.

In step S250, the transferring device 600 transfers the reactor to which the second reagent is added to the incubation position 422 of the reactor for the second incubation.

In step S260, the transferring device 600 transfers the reactor after the second incubation is completed to the washing and separating position 421 of the reaction tray 410 to perform the second washing and separating by the washing and separating module.

In step S270, the reaction apparatus 400 includes a signal agent adding component, and a signal agent is added to the reactor through the signal agent adding component.

In step S280, the reactor is transferred to the measurement site 423 by the transfer device 600 for measurement.

In some embodiments, the measured reactor is transferred to a disposal location by transfer device 600 to dispose of the reactor.

In the sample analysis method in the above embodiment, the reactor needs to be transferred multiple times, and the sample analysis method may be implemented in a sample analysis apparatus, and when the sample analysis apparatus performs sample analysis, multiple sets of tests are usually performed, and the transfer of the reactor is required for all the multiple sets of tests. In order to improve the working efficiency and make the sample analysis device fully utilize the working time, a reactor transfer method is provided:

the transfer device at least completes 5 times of transfer operation, and each time of transfer operation transfers one reactor between two different operation stations, the transfer operation has at least two mutually exclusive transfer operations, the mutually exclusive transfer operations do not exist simultaneously in the same work cycle, and the beats in different work cycles are overlapped.

The beat is the time period occupied by each transfer operation execution within a duty cycle. The length of each beat may be the same or different, and the multiple beats in a cycle may be consecutive or spaced, and the sequence between the multiple beats is fixed. If the transfer operation corresponding to a certain beat does not exist in a certain working period, the beat is idle. The beat overlap means that time periods in a cycle occupied by the execution of the transfer operation in different work cycles are at least partially overlapped, can be the overlapping of partial execution time periods, and can also be the overlapping of complete execution time periods

The operation station at least comprises a supply contraposition for moving out of an empty reactor or a reactor after adding a sample, a transfer contraposition for moving in a reactor needing adding a reagent or moving out of a reactor after adding a reagent, an incubation contraposition for moving in a reactor needing incubation or moving out of a reactor needing incubation for a period of time or after incubation, and a cleaning contraposition for moving in a reactor needing cleaning and separating or cleaning a reactor after separating.

In some embodiments, when multiple sets of tests are performed in parallel, the following transfer operations may be required:

a first transfer operation: moving empty or drained reactors from the supply tray 710 to the intermediate carousel 520;

and a second transfer operation: moving the reactor to be incubated from the middle rotating disc 520 to the incubation position 422 of the reaction disc 410;

a third transfer operation: moving the reactor to be washed and separated from the incubation position 422 of the reaction tray 410 to the washing and separating position 421 of the reaction tray 410;

a fourth transfer operation: moving the reactor to which the second reagent is added from the incubation position 422 of the reaction tray 410 to the middle rotating tray 520;

a fifth transfer operation: moving the reactor to which the second reagent is added from the washing separation position 421 of the reaction tray 410 to the middle rotary tray 520;

a sixth transfer operation: moving the reactor to be measured from the washing separation location 421 of the reaction tray 410 to the measurement location 423 of the reaction tray 410;

a seventh transfer operation: moving the reactor containing the diluted sample from the middle turntable 520 to the dilution conveyance device 900;

an eighth transfer operation: the reactor with the measurement completed is moved from the measurement position 423 of the reaction tray 410 to the discard position.

In the above-described embodiment, there is provided a transfer device 600 including the first grip unit 611 and the second grip unit 612. The fifth transfer operation transfers the reactor to which the second reagent is added from the washing and separating position 421 of the reaction tray 410 to the middle rotary tray 520, if the reactor is completed only by the first grabbing unit 611, not only the movement stroke is large, but also the second grabbing unit 612 needs to avoid when the first grabbing unit 611 performs the operation, and the two grabbing units cannot work in parallel, which affects the working efficiency of the transfer device 600, so the fifth transfer operation is divided into two sub-operations that can be relayed: the fifth a transfer operation requires transferring the reactor to the relay alignment position 635 and placing the reactor in the relay position by the first grasping unit 611, and the fifth B transfer operation grasps the reactor from the relay position to the relay alignment position 636 by the second grasping unit 612. As shown in fig. 6, the second gripper unit 612 is responsible for a first transfer operation, a second transfer operation, a fourth transfer operation, a fifth B transfer operation, a seventh transfer operation, and an eighth transfer operation, and the first gripper unit 611 is responsible for a third transfer operation, a fifth a transfer operation, and a sixth transfer operation.

In one embodiment, in a two-step test, the following transfer operations are required in order:

a first transfer operation, a second transfer operation, a third transfer operation, a fifth transfer operation, a second transfer operation, a third transfer operation, a sixth transfer operation, and an eighth transfer operation. Therefore, the first transfer operation, the second transfer operation, the third transfer operation, the fifth transfer operation, the second transfer operation, the third transfer operation, the sixth transfer operation, and the eighth transfer operation are sequentially completed by the following grasping units: a second grasping unit 612, a first grasping unit 611 and a second grasping unit 612, a first grasping unit 611, a second grasping unit 612.

For the reactor transfer operation of the same functional station, the grabbing unit firstly moves out the reactor in the station and then moves into another reactor. Therefore, the use efficiency of the functional stations can be improved. Fig. 9 shows a diagram of the execution actions of the grabbing unit in one embodiment in a certain cycle, and in other embodiments, the execution actions may be different from the state shown in fig. 9. As shown in fig. 9, the first transfer operation: moving empty or drained reactors from the supply tray 710 to the intermediate carousel 520; a fourth transfer operation: moving the reactor to which the second reagent is added from the incubation position 422 of the reaction tray 410 to the middle rotating tray 520; fifth B transfer operation: the second grasping unit 612 grasps the reactor from the relay station to the middle turntable 520. The first transfer operation, the fourth transfer operation, and the fifth B transfer operation are mutually exclusive, since all three are moved from other positions to the middle turret 520, and the middle turret 520 can only receive one reactor moved in at a time.

As another example, as shown in fig. 9, the second transfer operation: moving the reactor to be incubated from the middle rotating disc 520 to the incubation position 422 of the reaction disc 410; a seventh transfer operation: the reactor containing the diluted sample is moved from the staging disk 520 to the dilution conveyance 900. The second transfer operation and the seventh transfer operation are mutually exclusive, since both are to remove the reactor from the intermediate carousel 520 to other locations, whereas the intermediate carousel 520 can only remove the reactor to one other location at a time.

As another example, as shown in fig. 9, the sixth transfer operation: transferring the reactor to be measured from the washing separation location 421 of the reaction tray 410 to the measurement location 423 of the reaction tray 410; fifth a transfer operation: the reactor to which the second reagent is to be added is transferred from the washing separation site 421 of the reaction tray 410 to the interface site. The sixth transfer operation and the fifth a transfer operation are also mutually exclusive, since both transfer the reactor from the washing separation position 421 of the reaction tray 410 to other positions (including different positions of the reaction tray 410 itself), and the washing separation position 421 of the reaction tray 410 can only move the reactor to one other position at a time.

The mutually exclusive transfer operation has one and the same station.

The specific work content of the transfer operation in fig. 9 is only an example, and in other embodiments, the specific work corresponding to the transfer operation may not be the content listed in the above embodiments.

For another example, fig. 10 is a diagram illustrating the performance of the gripping unit in one embodiment during a cycle when the transfer device 600 has only one gripping unit. FIG. 11 is a graphical representation of the performance of the embodiment of FIG. 10 when multiple tests are performed in parallel. The first transfer operation, the fourth transfer operation, and the fifth transfer operation in fig. 10 are mutually exclusive, but of course the same type of transfer operation is also mutually exclusive, e.g., the first transfer operation and the first transfer operation are mutually exclusive. The mutually exclusive transfer operations cannot be performed simultaneously in the same cycle. The first transfer operation, the second transfer operation, the third transfer operation, the fourth transfer operation, and the fifth transfer operation in fig. 10 are only defined by one name, and specific operation contents are not limited by the above embodiment.

The specific steps of the reactor transfer method will now be described with reference to the examples shown in fig. 10 and 11:

as shown in fig. 10, each cycle T includes three consecutively performed beats, beat 1, beat 2, and beat 3, respectively. The first transfer operation, the fourth transfer operation, and the fifth transfer operation can be completed only in beat 1 in one cycle, respectively. The third transfer operation can be completed only in beat 2 in each cycle. The second transfer operation can be completed only in beat 3 in each cycle.

In one embodiment, as shown in FIG. 11, the multi-test parallel reactor transfer method is described by taking the first to eighth test items of the M-th to N-th cycles as examples. It should be noted that the first to eighth test items are merely identifiers of test items, and do not necessarily represent the starting sequence of the actual test, and these items may be the same test item, or different test items or partially the same test item. The reactor transfer method includes a first test item, a second test item, a third test item, a fourth test item, a fifth test item, a sixth test item, a seventh test item, and an eighth test item in parallel. Each test item includes three beats in each cycle that are performed in succession. Each test item includes several transfer operations that are performed in succession, wherein:

the first test item includes at least a first transfer operation, a second transfer operation, and a third transfer operation that are performed continuously, the first transfer operation being completed only in beat 1 in a certain cycle, the second transfer operation being completed only in beat 3 in each cycle, and the third transfer operation being completed only in beat 2 in each cycle;

the second test item at least includes a fifth transfer operation and a second transfer operation which are continuously performed, the fifth transfer operation can be completed only in beat 1 in a certain cycle, and the second transfer operation can be completed only in beat 3 in each cycle;

the third test item includes at least a fourth transfer operation and a second transfer operation which are performed successively, the fourth transfer operation being completed only in beat 1 in each cycle;

the fourth test item includes at least a third transfer operation, which can be completed only in beat 2 in each cycle;

the fifth test item includes at least the second transfer operation, which can be completed only in beat 3 in each cycle;

the sixth test item includes at least a third transfer operation, which can be completed only in beat 2 in each cycle;

the seventh test item includes at least the third transfer operation, which can be completed only in beat 2 in each cycle;

the eighth test item includes at least the first transfer operation, which can be completed only in beat 1 in a certain cycle.

As shown in fig. 10, the first transfer operation, the fourth transfer operation, and the fifth transfer operation are mutually exclusive.

Taking the first test item and the second test item as an example for description, when the first test item and the second test item are judged to be executed simultaneously, in each period of the first test item, whether the second test item has a mutually exclusive transfer operation with the first test item exists or not is judged, if the mutually exclusive transfer operation does not exist in the corresponding period, the first test item and the second test item are executed simultaneously, if the mutually exclusive transfer operation exists in the corresponding period, when the first test item is executed, the second test item is sequentially judged to be executed in each later period, and until the second test item starts to be executed when the second test item does not have the mutually exclusive transfer operation with the first test item in each period of the first test item. Specifically, when the first test item and the second test item are executed simultaneously, in the M-th cycle of the first test item, the second test item has a fifth transfer operation, the first test item has a first transfer operation, and since the fifth transfer operation and the first transfer operation are mutually exclusive, it is determined that the second test item is started to be executed in a later cycle, as shown in fig. 11, when the second test item is started to be executed in a later cycle, in the M-th cycle, the M + 1-th cycle, and the M + 2-th cycle … … -th cycle of the first test item, the second test item does not have a mutually exclusive transfer operation in a corresponding cycle with the first test item, and therefore, the second test item can be executed in a later cycle relative to the first test item.

Subsequent test items of the same are also performed in this manner. That is, the reactor transfer method finally realizes that mutually exclusive transfer operations in the test items do not exist simultaneously in the same work cycle, wherein beats in different work cycles are overlapped. The mutually exclusive transfer operations in the test items do not exist in the same work cycle at the same time, and the following two situations exist:

the first case is: judging whether the Xth test item and the Yth test item are executed simultaneously, in each cycle of the Xth test item, whether the Yth test item has mutually exclusive transfer operation with the Xth test item, if the mutually exclusive transfer operation does not exist in the corresponding cycle, executing the Xth test item and the Yth test item in parallel;

the second case is: if the mutually exclusive transfer operation exists in the corresponding period, sequentially judging that the execution of the Y-th test item is started every one cycle after the delay when the X-th test item is executed, and starting to execute the Y-th test item when the mutually exclusive transfer operation does not exist in the Y-th test item in each cycle of the X-th test item. According to the embodiment, mutually exclusive transfer operations can share the same beat in different periods and do not exist in the same period at the same time, on one hand, beats do not need to be set for the mutually exclusive transfer operations in the same period, the period time is shortened, and the test flux is improved, on the other hand, the mutually exclusive transfer operations can be realized by setting in different periods, so that once each test item starts to be executed, the interruption caused by the mutually exclusive transfer operations cannot occur in the middle, and the consistent execution can be realized.

According to the above embodiment, in other embodiments, a first test item, a second test item, a third test item, and the like that are sequentially performed may also be set, where the reactor transfer method at this time includes at least the first test item and the second test item that are sequentially performed, the first test item includes at least three transfer operations, the second test item includes at least three transfer operations, and the first test item and the second test item include at least mutually exclusive transfer operations, and the reactor transfer method includes the following steps:

in each execution cycle of a first test item, sequencing beats of transfer operation of the first test item according to an execution sequence, wherein the beats are time periods required by each transfer operation;

and in each execution cycle of the first test item, sequentially judging whether mutually exclusive transfer operation exists in the first test item and the second test item in each beat of the first test item when the execution of the second test item is started after each execution cycle is delayed, and if the mutually exclusive transfer operation does not exist in the first test item and the second test item in the same beat, starting to execute the second test item.

In one embodiment, the beats of the mutually exclusive transfer operations are partially overlapping, a beat being a segment of the time required for each transfer operation. For example, in one embodiment, as shown in fig. 10, the beat of the first transfer operation is performed starting at the first second and finishing at the fifth second; the tempo of the fourth transfer operation starts to be executed in the second and finishes in the seventh second. Then the set of mutually exclusive transfer operations overlap between the second and the fifth second.

In one embodiment, the mutually exclusive transfer operations have completely overlapping beats, which is the time period required for each transfer operation. For example, in one embodiment, as shown in fig. 10, the beat of the first transfer operation is performed at the beginning of the first second and the end of the fifth second; the beat of the fourth transfer operation is executed at the beginning of the first second and the execution of the fifth second is completed. The beats of the mutually exclusive set of transfer operations are completely overlapping.

In one embodiment, mutually exclusive transfer operations exist at least in the same operational position. For example, for reactor transfer operations of the same functional station, one of the transfer operations is to move one reactor into the station by the gripper unit, and the mutually exclusive transfer operation is to move another reactor into the station by the gripper unit. The two transfer operations are mutually exclusive, since the station can only receive the transfer of one reactor at a time.

In some embodiments, the above-described transfer operation may be performed by a transfer apparatus, and the transfer apparatus 600 may include a first grip unit 611 and a second grip unit 612; in some embodiments, the transfer device 600 may also include a grasping unit. When the transfer apparatus 600 includes the first grip unit 611 and the second grip unit 612, transfer trajectories of the first grip unit 611 and the second grip unit 612 at least partially overlap. Wherein the overlapping transfer trajectories cover at least two stations. For example, as shown in fig. 6, incubation alignment 632, measurement alignment 633, disposal alignment 634, and relay alignment 635 are overlapped, and the transfer trajectory of the corresponding overlapped portion covers incubation position 422, measurement position 423, disposal position, and relay position.

In one embodiment, the covered stations at least include a relay station, the reactor is grabbed to the relay station by the first grabbing unit 611, and then the reactor is transferred from the relay station to other positions by the second grabbing unit 612, so that the transfer of the reactor is realized on both sides of the relay station.

In one embodiment, the covered stations further include an incubation site 422 and a measurement site 423. In one embodiment, the covered station further includes an incubation site 422 or a measurement site 423.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only represent some embodiments of the present invention, and the description thereof is specific and detailed, but not to be construed as limiting the scope of the present invention. It should be noted that, for those skilled in the art, without departing from the spirit of the present invention, several variations and modifications can be made, which are within the scope of the present invention. Therefore, the protection scope of the present invention should be subject to the appended claims.

Claims (16)

1. An analysis apparatus, comprising:

a sample supply device (200) for supplying a sample to the reactor;

the transfer device (500) is used for carrying and transferring the reactor needing to discharge the reagent;

a reagent supply device (100) for supplying a reagent to the reactor in the relay device (500);

a reaction device (400) for reacting a reactor containing a reagent and a sample; and

a transfer device (600) for transferring the reactor between the transfer device (500) and the reaction device (400); wherein the transfer device (500) is independently arranged outside the reaction device (400), and the rotation center of the transfer device (500) is arranged outside the reaction device (400).

2. The device according to claim 1, wherein the reaction device (400) comprises a rotatable reaction disk (410), the relay device (500) comprises a rotatable central disk (520), and the reaction disk (410) and the central disk (520) rotate independently.

3. The device according to claim 2, wherein the diameter of the intermediate rotating disk (520) is smaller than the diameter of the reaction disk (410).

4. The analyzing apparatus according to claim 2, wherein the sample supply means (200), the reagent supply means (100) and the reaction means (400) are arranged in a clockwise direction at the outer periphery of the relay means (500) in a plan view direction.

5. The analysis device according to claim 2, wherein a washing separation site (421), an incubation site (422) and a measurement site (423) are provided on the reaction disk (410), and the reaction vessel is carried at the washing separation site (421), the incubation site (422) and the measurement site (423).

6. The device according to claim 5, wherein the reaction disc (410) is provided with a plurality of circles of reaction sites (420) arranged in a ring shape, the innermost circle is a cleaning separation site (421), the outermost circle is a measurement site (423), an incubation site (422) is arranged between the cleaning separation site (421) and the measurement site (423), and the incubation site (422) is provided with at least one circle.

7. The device according to claim 5, wherein the washing separation site (421), the incubation site (422), and the measurement site (423) are arranged in a radial direction of the reaction disk (410).

8. The analysis device according to claim 5, wherein the transfer trajectory of the transfer device (600) covers at least the washing separation site (421), the incubation site (422) and the measurement site (423).

9. The analysis apparatus according to claim 8, wherein the transfer trajectory of the transfer means (600) extends along a radius of the reaction disk (410) covering at least all reaction sites on the reaction disk (410) along the radius.

10. The device according to claim 1, wherein the reagent supplying means (100) is provided in at least two sets, and the two sets of reagent supplying means (100) alternately discharge the reagent to the reactor on the relay device (500).

11. The analysis device according to claim 2, wherein the reagent supply device (100) comprises a reagent tray for carrying a reagent and a reagent discharge unit (120) for sucking up the reagent in the reagent tray and discharging the reagent to a reactor.

12. The device according to claim 11, wherein the diameter of the middle rotary disk (520) is smaller than the diameter of the reagent disk.

13. The analysis device according to claim 1, further comprising a supply tray (710), wherein the supply tray (710) is provided with a temporary storage slot (720) for loading a reactor, the supply tray (710) can rotate independently to drive the temporary storage slot (720) to transfer at different stations, and the sample supply device (200) is used for discharging a sample to the reactor on the supply tray (710).

14. The analysis device according to claim 13, wherein the transfer trajectory of the transfer device (600) covers at least the supply tray (710), the relay device (500) and the reaction device (400).

15. The analysis apparatus according to claim 14, wherein the transfer device (500) comprises a rotatable center turntable (520), and the center of the center turntable (520) and the center of the supply tray (710) are respectively located on both sides of the transfer trajectory of the transfer device (600).

16. The analysis device according to claim 13, further comprising a dilution conveyance device (900) for temporarily storing the reactor, the dilution conveyance device (900) being disposed between the reaction device (400) and the transfer device (500); after the supply tray (710) of the reactor receives the sample provided by the sample supply device (200), the reactor receives the diluent provided by the reagent supply device (100) at the transfer device (500), and the reactor is transferred to the dilution transportation device (900) after dilution.

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