CN211634908U

CN211634908U - Implantable neural stimulator packaging structure

Info

Publication number: CN211634908U
Application number: CN201921547892.1U
Authority: CN
Inventors: 史思思; 李晓波; 李�浩; 金有为
Original assignee: Hangzhou Chengnuo Medical Technology Co ltd
Current assignee: Hangzhou Chengnuo Medical Technology Co ltd
Priority date: 2019-09-18
Filing date: 2019-09-18
Publication date: 2020-10-09
Anticipated expiration: 2029-09-18

Abstract

The utility model discloses an implantable neural stimulator packaging structure, which comprises a ceramic body, a front shell, a charging coil, a circuit board, a stimulator head piece, a rear shell, a bracket and a rechargeable battery, wherein the front shell is respectively connected with the ceramic body and the rear shell, and the charging coil, the circuit board, the stimulator head piece, the bracket and the rechargeable battery are arranged in a space covered by the rear shell; the front shell and the rear shell are both made of biocompatible metal materials, including titanium or titanium alloy and the like; the ceramic body is hermetically connected with the front shell through a welding layer, and is made of biocompatible ceramic materials, such as alumina ceramics, silicon nitride ceramics or zirconia ceramics. The utility model discloses effectively reduce the eddy current effect of implanted stimulation equipment in wireless charging process, the greatly reduced temperature rise generates heat, improves wireless charging efficiency, safe and reliable by a wide margin.

Description

Implantable neural stimulator packaging structure

Technical Field

The utility model belongs to the field of medical equipment, in particular to implantable neural stimulator packaging structure.

Background

An implantable neurostimulator is a device implanted in a human body for treating related nervous system diseases by utilizing an electrical stimulation technology. The nerve stimulation is obviously superior to the medicine in the treatment of a plurality of diseases, has obvious curative effect and small side effect, and is widely accepted and applied in Europe and America. The nerve stimulation which has been put into practical use at present and is approved by FDA in europe and america includes deep brain electrical stimulation, central nerve stimulation, sacral nerve stimulation, vagus nerve stimulator, tibial nerve stimulation, and the like. Known implantable neurostimulator systems typically include a pulse generator, extension leads and electrodes implanted in the body, as well as an extracorporeal control device or an extracorporeal wireless charging device, among others. The signal sent by the pulse generator is transmitted to the electrode through the feed-through connector and the extension lead to stimulate the target tissue, thereby achieving the purpose of electrical stimulation treatment. The internal pulse generators currently used clinically are often classified according to internal batteries: a non-rechargeable pulse generator and a rechargeable pulse generator; the non-rechargeable pulse generator has the disadvantages that the pulse generator power supply battery implanted into a human body can only be used once, the electric energy cannot be supplemented for the pulse generator power supply battery outside the human body, the service life of the pulse generator is 5-8 years, once the electric energy of the battery is exhausted, a patient must go through an operation again to replace a new pulse generator, the pain and the operation risk of the patient are increased, and the economic burden is increased.

The volume of the rechargeable pulse generator is generally smaller than that of the non-rechargeable pulse generator, and the matched external wireless charging part can transmit electric energy to an internal wireless charging coil through an electric field or magnetic field resonance technology to charge the pulse generator implanted under the skin, so that the defect of the non-rechargeable pulse generator is overcome. However, the conventional rechargeable pulse generator has the disadvantages that the pulse generator housing is made of all-metal material, and in the process of in vitro wireless charging, eddy current is generated on the metal surface of the implant, so that local temperature rise is generated, the temperature of the whole stimulation device is raised, the wireless charging efficiency is low, excessive temperature rise can generate adverse effect on human tissues, and the service life of electronic elements in the implant is reduced.

SUMMERY OF THE UTILITY MODEL

The utility model solves the technical problem of overcoming the defects of the prior chargeable nerve stimulator and providing a high-efficiency charging and good-use-feeling nerve stimulator.

In order to solve the above problem, the technical scheme of the utility model is as follows: an implantable nerve stimulator packaging structure comprises a ceramic body, a front shell, a charging coil, a circuit board, a stimulator head piece, a rear shell, a bracket and a charging battery, wherein,

the front shell is connected with the ceramic body and the rear shell respectively, and the charging coil, the circuit board, the stimulator head piece, the bracket and the charging battery are arranged in a space covered with the rear shell; the front shell and the rear shell are both made of biocompatible metal materials, including but not limited to titanium or titanium alloy;

the ceramic body is hermetically connected with the front shell through a welding layer, and is made of a biocompatible ceramic material, including but not limited to alumina ceramic, silicon nitride ceramic or zirconia ceramic;

the circuit board is connected with the charging coil, the stimulator head piece and the charging battery respectively, the circuit board controls the charging coil to work, wireless electric energy received by the charging coil is converted and transmitted to the charging battery, the charging battery supplies power for the whole system, and the circuit board controls stimulus output and transmits the stimulus to the head piece;

the charging coil, the circuit board and the charging battery are arranged on the support, and the stimulator head piece is arranged above the front shell and the rear shell or on one surface of the front shell and the rear shell.

Preferably, a step structure is arranged at the joint of the front shell and the ceramic body, and the welding layer is arranged on the wall of the step structure.

Preferably, the ceramic body and the front housing are hermetically connected by other welding methods such as brazing or diffusion welding.

Preferably, the front case-specific part is a hollow structure, and the ceramic body is disposed within the hollow structure of the front case.

Preferably, the charging coil is disposed between the circuit board and the front case corresponding to a position of the ceramic body.

Preferably, the ceramic body is disposed at one side of the front case.

Preferably, the charging coil is disposed at one side of the circuit board corresponding to a position of the ceramic body.

The beneficial effects of the utility model are that, the procapsid links to each other through brazing or diffusion welding or other welding methods realization and the sealed of ceramic body, forms the new casing that specific area is the metal for other parts of pottery after combining, and new casing passes through laser seal welding and links to each other with the back casing and forms complete seal chamber. In the prior art, all shells of an implanted chargeable nerve stimulator are all metal shells, when an implant in a body is charged by using an external wireless charging device, the implant with a complete metal plane is placed in an alternating magnetic field, the surface of the metal shell generates an eddy current phenomenon, the surface of the metal shell and internal components generate temperature rise due to the influence of the eddy current effect, excessive temperature rise generates adverse influence on tissues around the human body, the service life of electronic elements in a metal cavity can be shortened, and the service cycle of the implant is shortened; meanwhile, due to the eddy current effect of the metal shell, the wireless charging efficiency is further reduced, the charging time is too long, and the like. The utility model provides an encapsulation structure effectively reduces the eddy current effect of implanted stimulation equipment in wireless charging process, and greatly reduced temperature rise generates heat, improves wireless charging efficiency by a wide margin.

Drawings

Fig. 1 is an exploded view of an implantable neurostimulator package according to an embodiment of the present invention;

fig. 2 is a structural diagram of a ceramic body and a front housing of an implantable neurostimulator packaging structure according to an embodiment of the present invention;

fig. 3 is an enlarged structure view of the ceramic body and the front housing of the implantable neurostimulator packaging structure of an embodiment of the present invention;

fig. 4 is an exploded view of an implantable neurostimulator package in accordance with yet another embodiment of the present invention;

fig. 5 is an enlarged structure view of the ceramic body and the front housing of the implantable neurostimulator packaging structure of the present invention.

Detailed Description

The preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

Referring to fig. 1-5, an implantable neurostimulator packaging structure comprises a ceramic body 1, a front shell 2, a charging coil 3, a circuit board 4, a stimulator head piece 5, a rear shell 6, a bracket 7 and a charging battery 8, wherein the front shell 2 is connected with the ceramic body 1 and the rear shell 6 respectively, and the charging coil 3, the circuit board 4, the stimulator head piece 5, the bracket 7 and the charging battery 8 are arranged in a space covered with the rear shell 6; the front shell 2 and the rear shell 6 are made of biocompatible metal materials, including titanium or titanium alloy;

the ceramic body 1 is hermetically connected with the front shell 2 through a welding layer, and the ceramic body 1 is made of biocompatible ceramic materials, including alumina ceramics, silicon nitride ceramics or zirconia ceramics;

the circuit board 4 is respectively connected with the charging coil 3, the stimulator head piece 5 and the charging battery 8, the circuit board 4 controls the charging coil 3 to work, wireless electric energy received by the charging coil 3 is converted and transmitted to the charging battery 8, the charging battery 8 supplies power to the circuit board 4, and the circuit board 4 controls stimulation output and transmits stimulation to the head piece 5;

the charging coil 3, the circuit board 4 and the rechargeable battery 8 are placed on the support 7, and the stimulator head piece 5 is arranged above the front housing 2 and the rear housing 6.

The front shell 2 and the ceramic body 1 are connected to form a step structure, and the welding layer is arranged on the wall of the step structure.

The ceramic body 1 and the front case 2 are hermetically joined by brazing or diffusion welding.

Referring to fig. 1 to 3, in a specific embodiment, the middle portion of the front case 2 is a hollow structure, the ceramic body 1 is disposed in the hollow structure of the front case 2, and fig. 3 is an enlarged view of a welding portion between the ceramic body 1 and the front case 2, which are hermetically connected by a welding layer 9; the charging coil 3 is disposed between the circuit board 4 and the front case 2 corresponding to the position of the ceramic body 1.

Referring to fig. 4 to 5, in still another embodiment, a ceramic body 1 is disposed at one side of a front case 2, and fig. 5 is an enlarged view of a welding portion of the ceramic body 1 and the front case 2, which are hermetically connected via a welding layer 9; the charging coil 3 is disposed at one side of the circuit board 4 corresponding to the position of the ceramic body 1.

The packaging structure of the two specific embodiments can avoid the problems of heating caused by the eddy current effect and reduction of wireless charging efficiency.

The rechargeable battery 8 and the circuit board 4 adopt a flexible connection mode, two metal wires are respectively led out from the positive pole and the negative pole of the rechargeable battery 8 and are connected by tin soldering, an insulating sleeve is sleeved on the metal wires, and the other end of each metal wire is subjected to laser welding with a corresponding bonding pad or flexible connection substance on the circuit board 4.

In the specific embodiment, the brazing filler metal for brazing is selected from Au, and because the titanium material of the front shell 2 is an active element, the active element is not required to be added in the brazing filler metal. Assembling the ceramic body 1 with a cleaned surface with the front shell 2 in a lap joint mode, wherein the lap joint part is of the step structure; the brazing filler metal Au is placed near or between gaps between the ceramic body 1 and the front shell 2, when the ceramic body 1, the front shell 2 and the brazing filler metal Au are heated to a temperature slightly higher than the melting point of the brazing filler metal Au, the brazing filler metal Au is molten (the ceramic body 1 and the front shell 2 are not molten), the brazing filler metal Au is sucked into and filled in the gaps between the ceramic body 1 and the front shell 2 through the capillary action, the molten brazing filler metal Au and the ceramic body 1 interact with the front shell 2 to generate chemical reaction or dissolution, so that the ceramic surface is wetted, and the ceramic body 1 is connected with the front shell 2 through generated reactants, and reliable sealing connection is realized.

When diffusion welding is adopted, under the action of certain temperature and pressure, the surfaces of the front shell 2 and the ceramic body 1 are close to each other and are in contact with each other, the physical contact of the connected surfaces is expanded through local microscopic plastic deformation or through transient liquid phase generated by the connected surfaces, and then the sealed connection is formed through the mutual diffusion and the mutual permeation among atoms for a long time. The diffusion welding forms a welding joint under the condition that the front shell is not melted, so that the combination precision of the front shell 2 to be welded and the ceramic body 1 is higher, the surface contact distance reaches less than 1um, the attractive force between atoms acts and forms a metal bond, and the joint with certain strength is obtained. The temperature of diffusion welding is (0.6-0.8) Tm, wherein Tm is the lowest melting point of the front shell and the ceramic body to be welded, the known melting point of the titanium material is 1668 ℃, and the melting point of the ceramic is 3000 ℃, so the temperature of diffusion welding is selected to be in the range of 1000-1334 ℃; the pressure was set at 30 MPa.

Finally, it is noted that the above-mentioned preferred embodiments illustrate rather than limit the invention, and that, although the invention has been described in detail with reference to the above-mentioned preferred embodiments, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the scope of the invention as defined by the appended claims.

Claims

1. An implantable neural stimulator packaging structure, which is characterized by comprising a ceramic body, a front shell, a charging coil, a circuit board, a stimulator head piece, a rear shell, a bracket and a charging battery, wherein,

the front shell is connected with the ceramic body and the rear shell respectively, and the charging coil, the circuit board, the stimulator head piece, the bracket and the charging battery are arranged in a space covered with the rear shell; the front shell and the rear shell are both titanium or titanium alloy;

the ceramic body is hermetically connected with the front shell through a welding layer, and the ceramic body is alumina ceramic, silicon nitride ceramic or zirconia ceramic;

the circuit board is connected with the charging coil, the stimulator head piece and the charging battery respectively, the circuit board controls the charging coil to work, wireless electric energy received by the charging coil is converted into direct current and transmitted to the charging battery, the charging battery supplies power for the whole system, and the circuit board controls stimulus output and transmits the stimulus to the head piece;

2. The structure of claim 1, wherein a stepped structure is provided where the front housing joins the ceramic body, the weld layer being provided on a wall of the stepped structure.

3. The structure of claim 1, wherein the ceramic body and the front housing are sealingly joined by brazing or diffusion welding.

4. The structure of claim 1, wherein the front housing-specific portion is a hollow structure, and the ceramic body is disposed within the hollow structure of the front housing.

5. The structure of claim 4, wherein the charging coil is disposed between a circuit board and a front housing corresponding to a position of the ceramic body.

6. The structure of claim 1, wherein the ceramic body is disposed on one side of the front housing.

7. The structure of claim 6, wherein the charging coil is disposed at one side of the circuit board corresponding to a position of the ceramic body.