CN211560518U - Rat trachea device of dosing - Google Patents
Rat trachea device of dosing Download PDFInfo
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- CN211560518U CN211560518U CN201922072630.0U CN201922072630U CN211560518U CN 211560518 U CN211560518 U CN 211560518U CN 201922072630 U CN201922072630 U CN 201922072630U CN 211560518 U CN211560518 U CN 211560518U
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Abstract
The utility model discloses a rat trachea device of dosing, including the injection tube, the needle tubing, needle ball and push rod, first division wall divide into liquid injection chamber and gas injection chamber with the injection tube, needle tubing one end links to each other with the connector, the second division wall falls into liquid pipeline and gas pipeline with the needle tubing, the needle ball is connected to the one end that the connector was kept away from to the needle tubing, the needle ball includes the gasbag, catheter and protective layer, the gasbag links to each other with gas pipeline, the catheter sets up around the gasbag and links to each other with liquid pipeline, evenly set up a plurality of miniature syringe needles on the catheter, the protective layer sets up in the catheter outside, set up a plurality of needle holes of wearing on the protective layer, miniature syringe needle and the same and the position of needle. The utility model provides a rat trachea dosing device, which realizes noninvasive dosing of rat trachea, is simple and convenient to operate and improves the experimental efficiency; the trachea is not damaged, the wound of the rat trachea is avoided, and the experimental efficiency and the success rate are improved; realize the uniform administration around the trachea.
Description
Technical Field
The utility model relates to a medical science animal experiment technical field especially relates to a rat trachea device of dosing.
Background
With the continuous development of modern medicine, the application of experimental animals in medical research has been continuously paid attention to and popularized. Rats are the most widely used animals in the experiment, and because the lung has a larger absorption area, the alveolar epidermis is thin, the lung blood volume is rich, the medicine is easy to absorb, and the first pass effect is avoided. In addition to the lungs themselves, intratracheal administration is increasingly the mode of choice for the modeling of many systems. The tracheal administration technology directly affects the success rate of animal models and is very important in the whole experimental process.
At present, the common methods for tracheal administration include tracheotomy and nasal drip. Reviewing the previous experimental study, the method has some disadvantages in use due to the basic conditions that the rat body type is still small, the glottis is narrow and the trachea is thin.
Tracheotomy method: the method needs to cut the skin of the neck of a rat, expose the trachea and puncture the trachea, the damage to the local and surrounding tissues of the trachea caused by the postoperative infection and the operation is difficult to master, and the survival rate and the local infection are easy to influence certain infection indexes. And is not suitable for experimental design requiring repeated intratracheal administration, and infection influence is difficult to accurately evaluate.
Nasal drip: the medicine is easy to overflow from the oral cavity, so that the administration efficiency is reduced, and the animal is easy to suffocate, so that the experimental result is influenced.
SUMMERY OF THE UTILITY MODEL
The utility model provides a pair of rat trachea device of dosing has solved one or more among the prior art problem.
The utility model provides a rat trachea drug delivery device, which comprises an injection tube, a needle ball and a push rod,
one end of the injection tube is provided with an opening, the other end of the injection tube opposite to the opening is provided with a connector, a first partition wall is arranged in the injection tube and extends to the connector from the opening, the first partition wall divides the injection tube into a liquid injection cavity and a gas injection cavity,
one end of the needle tube is connected with the connector, a second partition wall which has the same length as the needle tube is arranged in the needle tube, the second partition wall divides the needle tube into a liquid pipeline and a gas pipeline, the liquid pipeline and the gas pipeline are respectively communicated with the liquid injection cavity and the gas injection cavity, one end of the needle tube, which is far away from the connector, is connected with a needle ball,
the needle ball comprises an air bag, a liquid guide pipe and a protective layer, the air bag is connected with a gas pipeline, the liquid guide pipe is arranged around the air bag and is connected with a liquid pipeline, a plurality of micro injection needles are uniformly arranged on the liquid guide pipe, the protective layer is arranged on the outer side of the liquid guide pipe, a plurality of needle penetrating holes are arranged on the protective layer, the number of the micro injection needles and the needle penetrating holes are the same, the positions of the micro injection needles and,
the two push rods are respectively inserted into the liquid injection cavity and the gas injection cavity.
The beneficial effects are as follows:
(1) the medicine is accurately pushed and injected into the trachea, noninvasive administration of the rat trachea is realized, incision steps are reduced, the operation is simple and convenient, and the experimental efficiency is improved;
(2) the trachea is not damaged, the trachea of the rat is prevented from being wound, postoperative infection is avoided, adverse effects on experimental results are reduced, the survival rate of the rat is improved, and the experimental efficiency and success rate are improved;
(3) micro injection needles are uniformly arranged on the catheter in the needle ball, so that the uniform administration at the periphery in the trachea is realized;
(4) the protective layer is arranged on the outer side of the liquid guide pipe, so that the micro-injection needle is prevented from puncturing the trachea and playing a role in protection, and the needle penetrating hole is formed in the protective layer, so that the micro-injection needle can conveniently probe out of the protective layer under the action of the air bag to administer the medicine.
In some embodiments, the liquid injection chamber and the gas injection chamber are the same size and shape.
In some embodiments, the liquid conduit and the gas conduit are the same size and shape.
In some embodiments, the end of the syringe far away from the connector is provided with a locking groove protruding outwards along the inner surface of the syringe, the push rod comprises a push rod head, and a push rod clamping groove matched with the locking groove is formed in the position of the push rod close to the push rod head.
In some embodiments, the syringe barrel exterior surface is provided with scale markings.
In some embodiments, the end of the needle cannula distal to the connector is at an angle of 165 ° to the end of the needle cannula proximal to the connector.
In some embodiments, the catheter is connected to the liquid conduit via the inlet port and the balloon is connected to the gas conduit via the inlet port.
In some embodiments, the microneedle device includes a tip portion that is directed through the catheter toward the cover layer, and a drug inlet port disposed in the catheter and in communication with the catheter.
In some embodiments, the protective layer is stainless steel.
In addition, in the technical solutions of the present invention, the technical solutions can be implemented by adopting conventional means in the art, which are not specifically described.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the embodiments or the technical solutions in the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
Fig. 1 is a schematic structural view of a rat trachea drug delivery device provided by an embodiment of the present invention.
Fig. 2 is a schematic structural view of a needle tube of the rat tracheal drug delivery device shown in fig. 1.
Fig. 3 is a schematic view of the inner structure of a needle ball of the rat tracheal drug delivery device shown in fig. 1.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below with reference to the accompanying drawings and embodiments. It is to be understood that the specific embodiments described herein are merely illustrative of but not limiting of the invention. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", "both ends", "both sides", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the elements referred to must have a specific orientation or be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.
In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Example (b):
as shown in figures 1-3, a rat trachea administration device comprises a substantially cylindrical injection tube 1, a needle tube 2, a needle ball 3 and a push rod 4.
One end of the injection tube 1 is provided with an opening 11, the other end of the injection tube 1 opposite to the opening 11 is provided with a connector 12, a first partition wall 13 is arranged inside the injection tube 1, the first partition wall 13 extends from the opening 11 to the connector 12, and the first partition wall 13 divides the injection tube 1 into a liquid injection cavity 14 and a gas injection cavity 15. The liquid injection chamber 14 and the gas injection chamber 15 are independent from each other without interfering with each other. Wherein the liquid injection chamber 14 and the gas injection chamber 15 may be the same in size and shape.
In an alternative embodiment, the end of syringe barrel 1 remote from connector 12 is provided with a locking groove 16 protruding outward along the inner surface of syringe barrel 1, push rod 4 comprises a push rod head 41, and push rod 4 is provided with a push rod slot 42 adjacent to push rod head 41 and matching with locking groove 16. Thus, the cooperation of the locking slot 16 and the push rod slot 42 allows for a metered dose of air to be inflated into the balloon and a metered dose to be administered.
In an alternative embodiment, the outer surface of the syringe barrel 1 is provided with scale markings. Therefore, when in use, the inflating volume of the air bag is convenient to control, so that the extending length of the micro-injector is controlled; the injection liquid dosage can be conveniently controlled.
The needle tube 2 is in a long and thin tube shape, one end of the needle tube 2 is connected with the connector 12, a second partition wall 21 which is as long as the needle tube 2 is arranged in the needle tube 2, the second partition wall 21 divides the needle tube 2 into a liquid pipeline 22 and a gas pipeline 23, the liquid pipeline 22 and the gas pipeline 23 are respectively communicated with the liquid injection cavity 14 and the gas injection cavity 15, and one end of the needle tube 2, which is far away from the connector 12, is connected with the needle ball 3. The liquid conduit 22 and the gas conduit 23 are independent of each other and do not interfere with each other. Wherein the liquid conduit 22 and the gas conduit 23 may be the same size and shape.
In an alternative embodiment, the end of the barrel 2 distal to the hub 12 is angled 165 from the end of the barrel 2 proximal to the hub 12. Thereby, the needle tube 2 is easily inserted into the rat trachea.
The needle ball 3 comprises an air bag 31, a liquid guide tube 32 and a protective layer 33, the air bag 31 is connected with the gas pipeline 23, the liquid guide tube 32 is arranged around the air bag 31 and connected with the liquid pipeline 22, a plurality of micro injection needles 321 are uniformly arranged on the liquid guide tube 32, the protective layer 33 is arranged on the outer side of the liquid guide tube 32, a plurality of needle penetrating holes are arranged on the protective layer 33, and the micro injection needles 321 and the needle penetrating holes have the same number and correspond to each other in position.
Specifically, the air bag 31 can be made of rubber, latex or other suitable materials, and can be expanded after being inflated and can be reduced after being deflated; the airbag 31 is connected to the gas pipe 23 through the gas inlet 311. The catheter 32 may be made of plastic or other suitable material, and is soft and can be bent around the surface of the balloon 31, and the catheter 32 is connected to the liquid conduit 22 through the inlet 322. The protective layer 33 may be made of smooth stainless steel and is wrapped around the outside of the catheter 32.
Specifically, the micro-injection needle 321 includes a needle head portion that is directed toward the protective layer 33 through the catheter 32, and a drug inlet that is provided in the catheter 32 and communicates with the catheter 32.
In alternative embodiments, if micro-needles 321 are sufficiently numerous, the effect of aerosolizing the drug injection may be achieved, resulting in more uniform delivery.
The push rods 4 are two and inserted into the liquid injection chamber 14 and the gas injection chamber 15 from the openings 11, respectively, for injecting the medicine and the air.
When the device is used specifically, the needle tube 2 and the needle ball 3 are sent to the trachea of a rat to push the push rod 4 corresponding to the gas injection cavity 15, air enters the air bag 31 through the gas pipeline 23, the air bag 31 inflates, the liquid guide tube 32 expands along with the inflation of the air bag to drive the micro injection needle 321 to penetrate through the corresponding needle penetrating hole to extend out of the protective layer 33, then the push rod 4 corresponding to the liquid injection cavity 14 is pushed, liquid medicine enters the liquid guide tube 32 through the liquid pipeline 22 and finally enters the micro injection needle 11, and injection and administration are completed. When the number of the micro-injection needles 321 is enough, the effect of medicine injection atomization can be realized, and atomization administration can be realized.
After the administration is finished, the push rod 4 corresponding to the gas injection cavity 15 is drawn outwards, the air bag 31 is deflated, the volume is reduced, the micro-injection needle 321 is retracted into the protective layer 33 from the corresponding needle penetrating hole, and the device can be drawn out without damaging the trachea of the rat.
The utility model provides a rat trachea device of dosing has following beneficial effect:
(1) the medicine is accurately pushed and injected into the trachea, noninvasive administration of the rat trachea is realized, incision steps are reduced, the operation is simple and convenient, and the experimental efficiency is improved;
(2) the trachea is not damaged, the trachea of the rat is prevented from being wound, postoperative infection is avoided, adverse effects on experimental results are reduced, the survival rate of the rat is improved, and the experimental efficiency and success rate are improved;
(3) micro injection needles are uniformly arranged on the catheter in the needle ball, so that the uniform administration at the periphery in the trachea is realized;
(4) the protective layer is arranged on the outer side of the liquid guide pipe, so that the micro-injection needle is prevented from puncturing the trachea and playing a role in protection, and the needle penetrating hole is formed in the protective layer, so that the micro-injection needle can conveniently probe out of the protective layer under the action of the air bag to administer the medicine.
The foregoing are only embodiments of the present invention, which are not intended to limit the scope of the present invention, and it should be understood that modifications and substitutions can be made by those skilled in the art without departing from the inventive concept, and all such modifications and substitutions are intended to be included within the scope of the appended claims. In this case all the details may be replaced with equivalent elements, and the materials, shapes and dimensions may be any.
Claims (9)
1. A rat trachea drug delivery device which is characterized in that,
comprises an injection tube (1), a needle tube (2), a needle ball (3) and a push rod (4),
an opening (11) is formed in one end of the injection tube (1), a connector (12) is arranged at the other end, opposite to the opening (11), of the injection tube (1), a first partition wall (13) is arranged inside the injection tube (1), the first partition wall (13) extends from the opening (11) to the connector (12), the first partition wall (13) divides the injection tube (1) into a liquid injection cavity (14) and a gas injection cavity (15),
needle tubing (2) one end with connector (12) link to each other, be provided with in needle tubing (2) with needle tubing (2) isometric second division wall (21), second division wall (21) will needle tubing (2) fall into liquid pipeline (22) and gas pipeline (23), liquid pipeline (22) with gas pipeline (23) respectively with liquid injection chamber (14) with gas injection chamber (15) intercommunication, needle tubing (2) are kept away from the one end of connector (12) is connected needle ball (3),
the needle ball (3) comprises an air bag (31), a liquid guide pipe (32) and a protective layer (33), the air bag (31) is connected with the gas pipeline (23), the liquid guide pipe (32) surrounds the air bag (31) and is connected with the liquid pipeline (22), a plurality of miniature injection needles (321) are uniformly arranged on the liquid guide pipe (32), the protective layer (33) is arranged on the outer side of the liquid guide pipe (32), a plurality of needle penetrating holes are arranged on the protective layer (33), the quantity of the miniature injection needles (321) is the same as that of the needle penetrating holes, and the positions of the miniature injection needles (321) and the needle penetrating holes correspond to each other,
the two push rods (4) are respectively inserted into the liquid injection cavity (14) and the gas injection cavity (15).
2. A rat tracheal drug delivery device according to claim 1, wherein the liquid injection lumen (14) and the gas injection lumen (15) are the same size and shape.
3. A rat tracheal drug delivery device according to claim 2, characterized in that the liquid conduit (22) and the gas conduit (23) are of the same size and shape.
4. A tracheal drug delivery device for rats according to claim 1, wherein one end of the syringe (1) far from the connector (12) is provided with a locking groove (16) protruding outwards along the inner surface of the syringe (1), the push rod (4) comprises a push rod head (41), and a push rod slot (42) matched with the locking groove (16) is formed on the push rod (4) near the push rod head (41).
5. A rat tracheal drug delivery device according to claim 4, wherein the outer surface of the syringe (1) is provided with graduated markings.
6. A rat tracheal drug delivery device as claimed in claim 1, wherein the end of the needle tube (2) distal to the connector (12) is at an angle of 165 ° to the end of the needle tube (2) proximal to the connector (12).
7. A rat tracheal drug delivery device as claimed in claim 1, wherein the catheter (32) is connected to the liquid conduit (22) through a liquid inlet (322), and the balloon (31) is connected to the gas conduit (23) through a gas inlet (311).
8. A rat tracheal drug delivery device according to claim 1, characterized in that said micro-injection needle (321) comprises a needle head directed through said catheter (32) towards said protective layer (33) and a drug inlet provided in said catheter (32) and communicating with said catheter (32).
9. A rat tracheal drug delivery device according to claim 1, characterized in that the protective layer (33) is of stainless steel material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922072630.0U CN211560518U (en) | 2019-11-27 | 2019-11-27 | Rat trachea device of dosing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922072630.0U CN211560518U (en) | 2019-11-27 | 2019-11-27 | Rat trachea device of dosing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN211560518U true CN211560518U (en) | 2020-09-25 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201922072630.0U Active CN211560518U (en) | 2019-11-27 | 2019-11-27 | Rat trachea device of dosing |
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| Country | Link |
|---|---|
| CN (1) | CN211560518U (en) |
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2019
- 2019-11-27 CN CN201922072630.0U patent/CN211560518U/en active Active
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