CN217162365U - Mouse trachea noninvasive drug delivery device - Google Patents
Mouse trachea noninvasive drug delivery device Download PDFInfo
- Publication number
- CN217162365U CN217162365U CN202220331931.XU CN202220331931U CN217162365U CN 217162365 U CN217162365 U CN 217162365U CN 202220331931 U CN202220331931 U CN 202220331931U CN 217162365 U CN217162365 U CN 217162365U
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- Prior art keywords
- needle
- noninvasive
- trachea
- mouse
- arc
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 210000003437 trachea Anatomy 0.000 title claims abstract description 25
- 238000012377 drug delivery Methods 0.000 title claims abstract description 7
- 241000699666 Mus <mouse, genus> Species 0.000 claims description 24
- 241000699670 Mus sp. Species 0.000 claims description 4
- 230000007704 transition Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 8
- 238000002474 experimental method Methods 0.000 abstract description 5
- 206010061218 Inflammation Diseases 0.000 abstract description 3
- 230000004054 inflammatory process Effects 0.000 abstract description 3
- 241001465754 Metazoa Species 0.000 abstract description 2
- 238000000465 moulding Methods 0.000 abstract description 2
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 3
- 206010002091 Anaesthesia Diseases 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 238000005452 bending Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000005034 decoration Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 210000003194 forelimb Anatomy 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 210000003928 nasal cavity Anatomy 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
Images
Landscapes
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The utility model belongs to the field of medical auxiliary instruments, in particular to a noninvasive mouse trachea drug delivery device, which comprises a needle head and an injector connected with the needle head; the needle head comprises an eversion round bulge at the top, an arc-shaped bent needle tube in the middle and a connecting piece at the bottom; the radian of the arc-shaped bent needle tube is 30 degrees. The utility model discloses can avoid having the wound to administer the influence of the inflammatory reaction that arouses to animal experiment result, control medicine dosage that can be accurate and easy and simple to handle, improve mouse trachea and dosed moulding efficiency.
Description
Technical Field
The utility model belongs to medical treatment auxiliary instrument field, concretely relates to mouse trachea does not have device of dosing of creating.
Background
Mouse trachea administration is a common animal model for researchers to research pathogenesis of lung diseases and mainly comprises two modes of invasive trachea administration and noninvasive trachea administration. The invasive tracheal administration mode mainly comprises the following steps: anaesthetizing the mouse, cutting the skin of the trachea part with a scalpel, pulling the muscle layer wrapped outside the trachea with a pair of surgical forceps, and puncturing the lumen of the trachea with an insulin syringe for medicine injection. The drug dosage can be accurately controlled by invasive trachea administration, but the invasive injury to the trachea can also cause inflammatory reaction of the organism to a certain degree, and the experimental result is influenced. Noninvasive trachea administration starts from the way that liquid is instilled through a nasal cavity and enters a lung through the trachea through respiration, the mode requires deep anesthesia of a mouse, and the liquid in the nasal cavity is sprayed out due to the fact that the anesthesia of the mouse cannot be in place in the operation process, so that the medicine dosage is inaccurate. Recently, there is also a liquid lung spray device, which atomizes the liquid and delivers the atomized medicine to the mouse lung through a thin tube. The mode is mainly characterized in that the medicine is atomized, the number of parts of the device is large, the medicine conveying pipe is long and thin, the trachea injury caused by the over-deep placement is easily caused, and the operation inconvenience is brought to a simple noninvasive trachea administration model.
SUMMERY OF THE UTILITY MODEL
The utility model discloses an overcome prior art's defect, provide a device of dosing is not had to mouse trachea.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
a mouse trachea noninvasive drug delivery device comprises a needle and an injector connected with the needle; the needle head comprises an eversion round bulge at the top, an arc-shaped bent needle tube in the middle and a connecting piece at the bottom; the radian of the arc-shaped bent needle tube is 30 degrees.
The connecting piece with the crooked needle tubing of arc and the protruding integrated into one piece of rounding of turning up, the connecting piece include with the crooked needle tubing of arc be connected the circular arc excessive and with the cylinder type recess of syringe connection.
The syringe is provided with a volume mark.
The injector comprises a needle cylinder and a piston arranged in the needle cylinder; the top of the needle cylinder is provided with a cylindrical bulge matched with the cylindrical groove.
Compared with the prior art, the utility model discloses following beneficial effect has:
the utility model discloses a device syringe needle radian of not having wound of mouse trachea is 30 degrees, is the natural radian of doing according to the bending structure of mouse neck, and when the mouse was lain on the back on the dissection table, the experiment operator left hand pressed down the mouse forelimb, and right hand operating device got into the trachea from the mouse oral cavity and carried out not having wound and dose.
The arrangement of the eversion round bulge can avoid the influence of inflammatory reaction caused by invasive administration on animal experiment results, the injector can accurately control the drug dosage and is simple and convenient to operate, and the tracheal administration molding efficiency of the mice is improved.
Drawings
FIG. 1 is a schematic diagram of the overall structure of a noninvasive tracheal administration device for mice;
FIG. 2 is a schematic view of the overall construction of the needle and the connector;
in FIG. 1: 1 syringe, 2 needle;
in fig. 2: 21 outward turning and rounding the bulge, 22 arc bending needle tubes and 23 connecting pieces.
Detailed Description
The present invention will be described in detail with reference to the accompanying drawings and specific embodiments.
Examples
Fig. 1-2 show a mouse trachea noninvasive drug delivery device, which comprises a needle 2 and a syringe 1 connected with the needle; the needle head comprises an eversion round bulge 21 at the top, an arc-shaped bent needle tube 22 in the middle and a connecting piece 23 at the bottom; the radian of the arc-shaped bent needle tube is 30 degrees. When in use, the mouse is naturally bent according to the neck structure of the mouse; the needle head and the injector adopt a split design, and the needle head can be freely and alternately connected with the injector.
The connecting piece with the crooked needle tubing of arc and the protruding integrated into one piece of rounding of turning up, whole syringe needle adopts stainless steel metal material, the connecting piece include with the crooked needle tubing of arc connect the circular arc excessive and with the cylinder type recess of syringe connection. The eversion round bulge can avoid the puncture of the mucous membrane layer of the tracheal wall caused by the contact of the top end;
the injector comprises a needle cylinder and a piston arranged in the needle cylinder; the top of the needle cylinder is provided with a cylindrical bulge matched with the cylindrical groove.
The syringe is provided with a volume mark.
The utility model discloses an operating principle does: when the experiment operation is carried out, a mouse is placed on the dissecting table after being anesthetized, special fixation is not needed, the device is made according to the natural radian made by the bent structure of the neck of the mouse, when the mouse lies on the dissecting table in a supine position, an experiment operator presses the forelimb of the mouse with the left hand, and the device with the right hand enters the trachea from the oral cavity of the mouse to carry out noninvasive administration.
The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, a plurality of improvements and decorations can be made without departing from the design concept of the present invention, and these improvements and decorations should also be regarded as the protection scope of the present invention.
Claims (4)
1. A mouse trachea noninvasive drug delivery device is characterized by comprising a needle and an injector connected with the needle; the needle head comprises an eversion round bulge at the top, an arc-shaped bent needle tube in the middle and a connecting piece at the bottom; the radian of the arc-shaped bent needle tube is 30 degrees.
2. The noninvasive trachea administration device for mice of claim 1, wherein the connecting piece is integrally formed with the curved needle tube and the outward-turning round and round protrusion, and the connecting piece comprises a circular arc transition connected with the curved needle tube and a cylindrical groove connected with the syringe.
3. The device for tracheal noninvasive administration of mice of claim 1, wherein the syringe is provided with volume markers.
4. The noninvasive mouse tracheal drug delivery device of claim 2, wherein the injector comprises a barrel and a piston disposed in the barrel; the top of the needle cylinder is provided with a cylindrical bulge matched with the cylindrical groove.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220331931.XU CN217162365U (en) | 2022-02-18 | 2022-02-18 | Mouse trachea noninvasive drug delivery device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220331931.XU CN217162365U (en) | 2022-02-18 | 2022-02-18 | Mouse trachea noninvasive drug delivery device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN217162365U true CN217162365U (en) | 2022-08-12 |
Family
ID=82739245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202220331931.XU Expired - Fee Related CN217162365U (en) | 2022-02-18 | 2022-02-18 | Mouse trachea noninvasive drug delivery device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN217162365U (en) |
-
2022
- 2022-02-18 CN CN202220331931.XU patent/CN217162365U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20220812 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |