CN211537676U - Synthetic reation kettle of liquid preparation based on irinotecan - Google Patents
Synthetic reation kettle of liquid preparation based on irinotecan Download PDFInfo
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- CN211537676U CN211537676U CN201922373462.9U CN201922373462U CN211537676U CN 211537676 U CN211537676 U CN 211537676U CN 201922373462 U CN201922373462 U CN 201922373462U CN 211537676 U CN211537676 U CN 211537676U
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Abstract
The utility model discloses a liquid preparation synthesis reaction kettle based on irinotecan, which comprises a reaction kettle body, a cross flow stirring device and a vacuumizing device; the output end of the cross-flow stirring device is fixed at the upper end of the outer wall of the reaction kettle body, and the output end of the cross-flow stirring device extends into the reaction kettle body and is rotationally connected with the interior of the reaction kettle body; a connector is fixedly arranged on the left side of the top of the reaction kettle body; the starting end of the connector is communicated with the interior of the reaction kettle body, and the terminating end of the connector is communicated with the input end of the vacuumizing device; the utility model improves the structure of the prior art, and utilizes the cross flow rotation mode of the opposite stirring device, thereby evenly mixing the liquid preparation; the utility model discloses still utilize evacuating device to reduce the boiling point of the inside liquid preparation of reation kettle body and improve the efficiency of stirring.
Description
Technical Field
The utility model relates to a medicine field specifically is a synthetic reation kettle of liquid preparation based on irinotecan.
Background
Irinotecan (ExatecanMesilate) is used as a pharmaceutical camptothecin derivative, which is used as an active ingredient during the preparation of liquid formulations. The preparation process of the liquid preparation is long in use of a reaction kettle, the reaction kettle is broadly understood to be a container for physical or chemical reaction, the heating, evaporation, cooling and low-speed mixing functions required by the process are realized through the structural design and parameter configuration of the container, and the reaction kettle is widely applied to industries such as petroleum, chemical engineering, rubber, pesticides, dyes, medicines, foods and the like.
Chinese patent CN209549455U discloses a reaction kettle, which comprises a kettle body, a stirring device, a feeding device, a discharging pipe and a temperature control device, wherein the stirring device comprises a driving mechanism, a stirring rod and a stirring paddle; the driving mechanism is arranged at the top of the kettle body; the stirring rod is vertically and rotatably arranged in the kettle body; the top of puddler with actuating mechanism's output transmission is connected, the stirring rake sets up the bottom of puddler. The technique has the following defects: the stirring shaft of the stirring device in the device rotates in a single direction, so that the stirring is uneven and the stirring efficiency is low.
SUMMERY OF THE UTILITY MODEL
The utility model aims to solve the technical problem that a crossflow rotation mode of subtend stirring is provided, can improve the synthetic reation kettle of liquid preparation based on irinotecan of stirring efficiency.
The utility model discloses a following technical means realizes solving above-mentioned technical problem:
a liquid preparation synthesis reaction kettle based on irinotecan comprises a reaction kettle body, a cross flow stirring device and a vacuumizing device; the cross-flow stirring device is fixed on the reaction kettle body, and the output end of the cross-flow stirring device extends into the reaction kettle body and is rotationally connected with the reaction kettle body; the top of the reaction kettle body is fixedly provided with a connector; the starting end of the connector is communicated with the interior of the reaction kettle body, and the terminating end of the connector is communicated with the input end of the vacuumizing device; the utility model improves the structure of the prior art, and utilizes the cross flow rotation mode of the opposite stirring device, thereby evenly mixing the liquid preparation; the utility model discloses still utilize evacuating device to reduce the boiling point of the inside liquid preparation of reation kettle body and improve the efficiency of stirring.
Preferably, the cross-flow stirring device comprises a motor mounting rack, a rotating motor, a rotating shaft, a first helical gear, a first stirring assembly and a second stirring assembly; the motor mounting frame is fixed at the upper end of the outer wall of the reaction kettle body, and the rotating motor is fixed on the motor mounting frame; the input end of the rotating shaft is fixed with the end part of the output shaft of the rotating motor, and the output end of the rotating shaft extends into the reaction kettle body and is rotationally connected with the interior of the reaction kettle body; the first helical gear is coaxially fixed with the output end of the rotating shaft; the input end of the first stirring component is in meshing transmission with the first bevel gear, the input end of the second stirring component is in meshing transmission with the first bevel gear, and the output end of the second stirring component is in rotating connection with the output end of the first stirring component.
Preferably, the first stirring assembly comprises a bearing, a stirring shaft second bevel gear and a first stirring impeller; the outer ring of the bearing is fixed on the top wall of the reaction kettle body, and the top end of the stirring shaft is coaxially fixed with the inner ring of the bearing; the second bevel gear is coaxially fixed with the upper end of the stirring shaft, and the second bevel gear is in meshing transmission with the first bevel gear; the first stirring impeller is fixed at the bottom of the stirring shaft; the output end of the second stirring component is rotationally connected with the stirring shaft; by starting the rotating motor, the output shaft of the rotating motor rotates to drive the rotating shaft to rotate, so that the first helical gear is driven to rotate, and further the second helical gear which is meshed with the first helical gear is driven, and the second helical gear drives the stirring shaft to rotate, so that the first stirring impeller is driven to rotate.
Preferably, the second stirring assembly comprises a shaft sleeve, a third bevel gear and a second stirring impeller; the shaft sleeve is limited in the middle of the stirring shaft and is rotationally connected with the stirring shaft; the third helical gear is coaxially fixed with the upper end of the shaft sleeve and is in meshing transmission with the first helical gear; the second stirring impeller is fixed at the lower end of the shaft sleeve; the first helical gear rotates to drive a third helical gear which is in meshing transmission with the first helical gear to rotate, and the third helical gear rotates to drive the shaft sleeve to rotate so as to drive the second stirring impeller to rotate.
Preferably, the outer wall of the stirring shaft is provided with an annular groove; the inner wall of the shaft sleeve is fixedly provided with an annular bulge, the annular bulge corresponds to the annular groove, and the annular bulge is sleeved in the annular groove and is in running fit with the annular groove.
Preferably, the vacuum pumping device comprises a vacuum pump and a connecting pipeline; the connecting pipeline output end is communicated with the air inlet of the vacuum pump, and the input end of the connecting pipeline is communicated with the termination end of the connector.
Preferably, the feed inlet has been seted up on reation kettle body top right side, reation kettle body bottom has seted up the drain hole.
The utility model has the advantages that:
1. the utility model discloses a structure to prior art improves, utilizes subtend agitating unit's cross-flow rotation mode to make liquid preparation homogeneous mixing.
2. The utility model discloses still utilize evacuating device to reduce the boiling point of the inside liquid preparation of reation kettle body and improve the efficiency of stirring.
Drawings
Fig. 1 is a schematic structural diagram of a liquid preparation synthesis reaction kettle based on irinotecan according to the embodiment of the invention;
fig. 2 is a schematic view of a connection structure of the cross-flow stirring apparatus according to the embodiment of the present invention;
fig. 3 is a schematic view of a connection structure of the first stirring assembly and the second stirring assembly according to the embodiment of the present invention;
fig. 4 is a schematic view of a connection structure of the stirring shaft and the shaft sleeve according to the embodiment of the present invention.
The reference numbers illustrate:
the reaction kettle comprises a reaction kettle body 1, a connector 11, a feeding hole 12, a discharging hole 13, a cross-flow stirring device 2, a motor mounting frame 21, a rotating motor 22, a rotating shaft 23, a first bevel gear 24, a first stirring assembly 25, a bearing 251, a stirring shaft 252, an annular groove 2521, a second bevel gear 253, a first stirring impeller 254, a second stirring assembly 26, a shaft sleeve 261, an annular protrusion 2611, a third bevel gear 262, a second stirring impeller 263, a vacuumizing device 3, a vacuum pump 31 and a connecting pipeline 32.
Detailed Description
To make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the embodiments of the present invention are combined to clearly and completely describe the technical solution in the embodiments of the present invention, and obviously, the described embodiments are some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.
Example one
As shown in fig. 1, the present embodiment discloses a liquid preparation synthesis reaction kettle based on irinotecan, specifically taking the orientation of fig. 1 as reference, comprising a reaction kettle body 1, a cross-flow stirring device 2 and a vacuum-pumping device 3. The cross-flow stirring device 2 is fixed on the reaction kettle body 1, and the output end of the cross-flow stirring device 2 extends into the reaction kettle body 1 and is rotationally connected with the reaction kettle body 1; the left side of the top of the reaction kettle body 1 is fixedly provided with a connector 11; the starting end of the connector 11 is communicated with the interior of the reaction kettle body 1, the input end of the vacuumizing device 3 is communicated with the terminating end of the connector 11, and the vacuumizing device 3 is used for reducing the boiling point of the liquid preparation in the reaction kettle body 1; the feed inlet 12 is arranged on the right side of the top of the reaction kettle body 1, and the discharge outlet 13 is arranged at the bottom of the reaction kettle body 1.
The utility model discloses when using, at first start cross-flow agitating unit 2, cross-flow agitating unit 2's output shaft rotates the mode that forms the convection current stirring in 1 inside of reation kettle body to start evacuating device 3 in the reaction process, be used for making the boiling point at the inside liquid preparation of reation kettle body reduce, thereby improve stirring efficiency.
As shown in fig. 1-2, the cross-flow stirring device 2 comprises a motor mounting frame 21, a rotating motor 22, a rotating shaft 23, a first bevel gear 24, a first stirring assembly 25 and a second stirring assembly 26; the motor mounting frame 21 is mounted at the upper end of the outer wall of the reaction kettle body 1 through bolts, and the rotating motor 22 is mounted on the motor mounting frame 21 through bolts; the input end of the rotating shaft 23 is welded and fixed with the end part of the output shaft of the rotating motor 22, and the output end of the rotating shaft 23 extends into the reaction kettle body 1 and is rotatably connected with the interior of the reaction kettle body 1; the first bevel gear 24 is coaxially fixed with the output end of the rotating shaft 23; the input end of the first stirring component 25 is in meshing transmission with the first bevel gear 24, the input end of the second stirring component 26 is in meshing transmission with the first bevel gear 24, and the output end of the second stirring component 26 is in rotating connection with the output end of the first stirring component 25.
As shown in fig. 2-3, the first stirring assembly 25 comprises a bearing 251, a stirring shaft 252, a second bevel gear 253 and a first stirring impeller 254; the outer ring of the bearing 251 is welded on the top wall of the reaction kettle body 1, and the top end of the stirring shaft 252 is coaxially fixed with the inner ring of the bearing 251; the second bevel gear 253 is coaxially fixed with the upper end of the stirring shaft 252, and the second bevel gear 253 is in meshing transmission with the first bevel gear 24; the first stirring impeller 254 is welded at the bottom of the stirring shaft 252; the output end of the second stirring assembly 26 is rotatably connected to the stirring shaft 252.
As shown in fig. 2-3, the second stirring assembly 26 includes a shaft sleeve 261, a third bevel gear 262 and a second stirring impeller 263; the shaft sleeve 261 is limited in the middle of the stirring shaft 252 and is rotationally connected with the stirring shaft 252; the third helical gear 262 is coaxially fixed with the upper end of the shaft sleeve 261, and the third helical gear 262 is in meshing transmission with the first helical gear 24; the second agitating impeller 263 is welded to the lower end of the sleeve 261.
The working principle of the embodiment is as follows: the utility model provides a liquid preparation synthesis reation kettle based on irinotecan, the utility model discloses when using, at first start rotating motor 22, the output shaft rotation of rotating motor 22 drives axis of rotation 23 and rotates, drives first helical gear 24 and rotates, and then drives second helical gear 253 and third helical gear 262 with its meshing transmission rotate, and second helical gear 253 drives (mixing) shaft 252 and rotates, and then drives first impeller 254 to rotate; and the third bevel gear 262 rotates to drive the shaft sleeve 261 to rotate, and then drives the second stirring impeller 263 to rotate, the first stirring impeller 254 and the second stirring impeller 263 reversely rotate to form a convection stirring manner, and the vacuum pumping device 3 is simultaneously turned on to reduce the boiling point of the liquid preparation inside the reaction kettle body 1, thereby improving the stirring efficiency.
Compared with the prior art, the utility model has the following advantages: the utility model improves the structure of the prior art, and utilizes the cross flow rotation mode of the opposite stirring device 2, thereby evenly mixing the liquid preparation; the utility model discloses still be provided with evacuating device 3 and improve the efficiency of stirring.
Example two
As shown in fig. 1, the present embodiment is different from the above embodiments in that: the vacuum pumping device 3 comprises a vacuum pump 31 and a connecting pipeline 32; the output end of the connecting pipeline 32 is communicated with the air inlet of the vacuum pump 31, and the input end of the connecting pipeline 32 is communicated with the termination end of the connector 13.
The utility model discloses when using, through starting vacuum pump 31, vacuum pump 31 work is breathed in, and the air of 1 inside of reation kettle body enters into connecting tube 32 through connector 13 in, enters into vacuum pump 31 from connecting tube 32 again, and vacuum pump 31 discharges gas from its gas outlet department again, and the in-process of ware is taken out to vacuum pump 31, the pressure grow of 1 inside of reation kettle body, and then makes the boiling point of 1 inside liquid preparation at reation kettle body reduce to improve stirring efficiency.
EXAMPLE III
As shown in fig. 4, the present embodiment is different from the above embodiments in that: an annular groove 2521 is formed in the outer wall of the stirring shaft 252; an annular protrusion 2611 is welded on the inner wall of the shaft sleeve 261, the annular protrusion 2611 corresponds to the annular groove 2521, and the annular protrusion 2611 is sleeved in the annular groove 2521 and is in rotating fit with the annular groove 2521.
The above embodiments are only used to illustrate the technical solution of the present invention, and not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it should be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention in its corresponding aspects.
Claims (7)
1. A synthetic reation kettle of liquid preparation based on irinotecan which characterized in that: comprises a reaction kettle body, a cross flow stirring device and a vacuumizing device; the cross-flow stirring device is fixed on the reaction kettle body, and the output end of the cross-flow stirring device extends into the reaction kettle body and is rotationally connected with the reaction kettle body; the top of the reaction kettle body is fixedly provided with a connector; the connector initiating terminal with the inside intercommunication of reation kettle body, the connector termination end with evacuating device's input intercommunication.
2. The irinotecan-based liquid formulation synthesis reaction kettle of claim 1, characterized in that: the cross-flow stirring device comprises a motor mounting frame, a rotating motor, a rotating shaft, a first helical gear, a first stirring assembly and a second stirring assembly; the motor mounting frame is fixed at the upper end of the outer wall of the reaction kettle body, and the rotating motor is fixed on the motor mounting frame; the input end of the rotating shaft is fixed with the end part of the output shaft of the rotating motor, and the output end of the rotating shaft extends into the reaction kettle body and is rotationally connected with the interior of the reaction kettle body; the first helical gear is coaxially fixed with the output end of the rotating shaft; the input end of the first stirring component is in meshing transmission with the first bevel gear, the input end of the second stirring component is in meshing transmission with the first bevel gear, and the output end of the second stirring component is in rotating connection with the output end of the first stirring component.
3. An irinotecan-based liquid formulation synthesis reactor of claim 2, characterized in that: the first stirring assembly comprises a bearing, a stirring shaft second bevel gear and a first stirring impeller; the outer ring of the bearing is fixed on the top wall of the reaction kettle body, and the top end of the stirring shaft is coaxially fixed with the inner ring of the bearing; the second bevel gear is coaxially fixed with the upper end of the stirring shaft, and the second bevel gear is in meshing transmission with the first bevel gear; the first stirring impeller is fixed at the bottom of the stirring shaft; the output end of the second stirring component is rotationally connected with the stirring shaft.
4. An irinotecan-based liquid formulation synthesis reactor of claim 3, characterized in that: the second stirring assembly comprises a shaft sleeve, a third bevel gear and a second stirring impeller; the shaft sleeve is limited in the middle of the stirring shaft and is rotationally connected with the stirring shaft; the third helical gear is coaxially fixed with the upper end of the shaft sleeve and is in meshing transmission with the first helical gear; the second stirring impeller is fixed at the lower end of the shaft sleeve.
5. The irinotecan-based liquid formulation synthesis reaction kettle of claim 4, characterized in that: an annular groove is formed in the outer wall of the stirring shaft; the inner wall of the shaft sleeve is fixedly provided with an annular bulge, the annular bulge corresponds to the annular groove, and the annular bulge is sleeved in the annular groove and is in running fit with the annular groove.
6. The irinotecan-based liquid formulation synthesis reaction kettle of claim 1, characterized in that: the vacuumizing device comprises a vacuum pump and a connecting pipeline; the connecting pipeline output end is communicated with the air inlet of the vacuum pump, and the input end of the connecting pipeline is communicated with the termination end of the connector.
7. The irinotecan-based liquid formulation synthesis reaction kettle of claim 1, characterized in that: the feed inlet has been seted up on reation kettle body top right side, reation kettle body bottom has seted up the drain hole.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922373462.9U CN211537676U (en) | 2019-12-26 | 2019-12-26 | Synthetic reation kettle of liquid preparation based on irinotecan |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922373462.9U CN211537676U (en) | 2019-12-26 | 2019-12-26 | Synthetic reation kettle of liquid preparation based on irinotecan |
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| Publication Number | Publication Date |
|---|---|
| CN211537676U true CN211537676U (en) | 2020-09-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201922373462.9U Active CN211537676U (en) | 2019-12-26 | 2019-12-26 | Synthetic reation kettle of liquid preparation based on irinotecan |
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| CN (1) | CN211537676U (en) |
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