CN211534523U - Sampling capsule and sampling capsule system - Google Patents

Abstract

The utility model provides a sampling capsule and a sampling capsule system, wherein the sampling capsule comprises a shell, a sampling component, a membrane flora acquisition auxiliary component and a control module; the sampling assembly comprises a sampling pool arranged in the shell, an outer sampling port arranged on the shell, a communicating pipe for communicating the outer sampling port with the sampling pool, and a sampling switch for opening or closing the communicating pipe; the membrane flora acquisition auxiliary assembly comprises a vibration motor arranged in the shell and/or a counterweight arranged at the outer sampling port; the control module comprises a microprocessor which is in communication connection with the sampling switch and the vibration motor. The membrane flora collection auxiliary component can assist the sampling component to collect the membrane flora; and the communicating pipe can be opened/closed in time through the sampling switch, so that the sample introduction is more accurate, the sample can be prevented from leaking or being polluted, and the universality of the sampling capsule is improved.

Description

Sampling capsule and sampling capsule system

Technical Field

The application relates to the technical field of medical equipment, in particular to a sampling capsule and a sampling capsule system for collecting digestive tract membrane flora.

Background

A sampling capsule is an intelligent capsule which enters the alimentary canal to sample digestive juice. Taking sampling of intestinal digestive juice as an example, intestinal microorganisms are closely related to human health, and medical research finds that more and more diseases are related to the intestinal microorganisms, such as: cardiovascular diseases, obesity, diabetes, various intestinal diseases (IBD, IBS, CD, SIBO, etc.), liver diseases, anaphylaxis, immune diseases, nervous system diseases (autism, depression, senile dementia), cancer, hypertension, chronic nephropathy, etc. To further study the pathology of these diseases, the distribution and abundance of intestinal flora, especially in the large and small intestine, are receiving increasing attention.

The species and abundance of the large and small intestinal flora are significantly different, and therefore separate studies are required. Meanwhile, due to the self structure of the digestive tract and the characteristics of bacterial colony propagation, the intestinal flora can be divided into membrane flora or mucosal flora and luminal flora or intestinal luminal flora. The fluidity of the luminal flora is strong, so the abundance, distribution and species are different from those of the orthotopic membrane flora. The colonies of the membrane flora multiply colonize the mucus layer on the mucosa and the abundance of the flora on the membrane is relatively high. The research of the membrane flora has higher value.

The current more traditional methods for analyzing intestinal flora are as follows: enteroscopy suction, enteroscopy mucosa collection, feces analysis, hydrogen breath test and the like. However, these methods either require the use of an enteroscope, which is painful for the test person, or only analyze the flora in the posterior and rectal regions of the colon, and have few studies on the membrane flora of the small intestine, particularly the terminal ileum.

The intestinal microorganism collection technology based on the capsule endoscope has the advantages of comfort, full coverage of the digestive tract and the like, so that the intestinal microorganism collection technology becomes an effective tool for research in the field. Currently, there are many designs of collection systems based on capsule endoscopes, which can be roughly classified into: tissue sampling and fluid sampling systems.

The tissue sampling system has a large volume and a complex structure, and a collection Device, such as a blade, a Biopsy forceps, etc., needs to be extended from the capsule system during Biopsy, which may refer to "research on a capsule robotic Biopsy mechanism", "a nutritional microbial Device for the capsule end scope", "a non microbial for the microbial in the capsule end scope", "Shape medical assembled biological Device for the active biological in the capsule end scope", "Magnetic support spring for the tissue in the tissue Biopsy system", "Design of the Micro biological in the tissue end scope", etc. Because the control and positioning capacity of the capsule endoscope system is obviously weaker than that of the traditional intubation endoscope, the capsule endoscope system is difficult to fix during biopsy and cannot perform postoperative hemostasis and other treatments, the tissue sampling system has certain safety risk.

A liquid collection system, which generally sucks liquid in the digestive tract by some power, such as the adsorption force of a water absorption material, the suction force of a micropump, the vacuum suction force and the like, and analyzes flora in the liquid after recovery; specifically, reference may be made to "Ingetibeltweb scientific Sampling Devices: State-of-The-Art and Future orientations "," The term of a remote-controlled structured driver delivery and sampling system ", and The like. The system has high safety and acquisition success rate. However, these systems usually only absorb the liquid in the cavity, mainly analyzing the cavity flora, and have no effective scheme for the collection of the membrane flora.

In view of the above, there is a need for an improved sampling capsule and sampling capsule system to solve the above problems.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide a sampling capsule and sampling capsule system for gathering alimentary canal membrane fungus crowd.

In order to realize the purpose of the utility model, the utility model discloses following technical scheme of sampling:

a sampling capsule comprises a shell, a sampling component, a membrane flora acquisition auxiliary component and a control module; the sampling assembly comprises a sampling pool arranged in the shell, an outer sampling port arranged on the shell, a communicating pipe for communicating the outer sampling port with the sampling pool, and a sampling switch for opening or closing the communicating pipe; the membrane flora acquisition auxiliary assembly comprises a vibration motor arranged in the shell and/or a counterweight arranged at the outer sampling port; the control module comprises a microprocessor which is in communication connection with the sampling switch and the vibration motor.

As a further improvement, the sampling assembly includes a plurality of outer sampling ports on the shell, and is a plurality of the sampling chamber that outer sampling ports all communicate, communicating pipe with the sampling chamber is linked together.

As a further improvement of the utility model, a plurality of outer sampling ports are followed the circumferencial direction interval distribution of sampling capsule.

As a further improvement of the utility model, every the aperture of outer sample connection is less than the aperture of communicating pipe.

As a further improvement of the utility model, the sampling cavity is internally provided with a filtering structure.

As a further improvement of the utility model, the vibrating motor is a button type vibrating motor, a coreless motor and an eccentric device or a linear vibrating motor.

As a further improvement of the present invention, the vibrating motor is located at the center of the sampling capsule.

As a further improvement of the present invention, the weight is a magnetic member, and the gravity center of the magnetic member is biased toward the magnetic member is close to one side of the housing.

As a further improvement of the present invention, one side of the magnetic member is the arc surface matched with the housing, and the magnetic member is a radially magnetized magnetic member.

As a further improvement of the utility model, the magnetic part with the outer sampling opening is followed the axial of sampling capsule sets up side by side

As a further improvement of the utility model, the sampling capsule still includes the extraction subassembly, the extraction subassembly is including being located on the shell and with the extraction mouth of sampling pond intercommunication, with extraction mouth matched with mounting, assemble in silica gel stopper in the mounting.

As a further improvement of the present invention, the control module further comprises a sensor for collecting physiological parameters and/or image information in the digestive tract, the sensor is in communication connection with the microprocessor;

or the control module further comprises a sensor for acquiring physiological parameters and/or image information in the alimentary canal, a storage module for storing normal physiological parameters or image information of different parts in the alimentary canal and possible physiological parameters or image information during pathological changes, and the sensor and the storage module are both in communication connection with the microprocessor;

or the control module also comprises a sensor for collecting physiological parameters and/or image information in the alimentary canal, and a wireless transmission module which is in communication connection with an external processing terminal, wherein the sensor is in communication connection with the microprocessor.

As a further improvement of the present invention, the sensor is at least one of an image sensor, a pH sensor and an ultrasonic sensor; when the sensor comprises an image sensor, part of the shell is transparent; when the sensor comprises a pH sensor, the housing has a window thereon.

The utility model also provides a sampling capsule system, including above-mentioned sampling capsule, with the external processing terminal that the control module communication is connected.

Compared with the prior art, the beneficial effects of the utility model are that: the sampling capsule of the utility model can assist the sampling component to adopt the membrane flora through the membrane flora acquisition auxiliary component; the communicating pipe is opened/closed through the sampling switch to realize sample introduction, and after the sample introduction is finished, the communicating pipe is closed through the sampling switch to prevent the sample from leaking or being polluted; and by controlling the conduction state and the conduction time of the communicating pipe, the sampling volume can be accurately controlled. In addition, the sampling switch is used for actively controlling the connection or the closure of the communicating pipe, the communicating pipe is not influenced by the special environment of the digestive tract part, and the communicating pipe can be universally used for any digestive tract part and has high universality.

Drawings

Fig. 1 is a cross-sectional view of a sampling capsule according to a preferred embodiment of the present invention, taken along an axial direction;

FIG. 2 is a cross-sectional view of the sampling capsule of FIG. 1 taken in a radial direction;

FIG. 3 is a schematic structural view of a magnetic member in one embodiment that can be used with the sampling capsule shown in FIG. 1;

FIG. 4 is a schematic structural view of a magnetic member in another embodiment that can be used with the sampling capsule shown in FIG. 1;

FIG. 5 is a schematic structural view of a magnetic member in another embodiment that can be used with the sampling capsule shown in FIG. 1;

FIG. 6 is a schematic structural view of a magnetic member in another embodiment that can be used with the sampling capsule shown in FIG. 1;

FIG. 7 is a schematic structural view of a magnetic member in another embodiment that can be used with the sampling capsule shown in FIG. 1;

FIG. 8 is a schematic view of the sampling capsule of the present invention for membrane flora sampling;

fig. 9 is a schematic diagram of the present invention, which is based on a sampling capsule to define the direction.

Detailed Description

The present application will now be described in detail with reference to specific embodiments thereof as illustrated in the accompanying drawings. These embodiments are not intended to limit the present application, and structural, methodological, or functional changes made by those skilled in the art according to these embodiments are included in the scope of the present application.

In the various illustrations of the present application, certain dimensions of structures or portions may be exaggerated relative to other structures or portions for ease of illustration and, thus, are provided to illustrate only the basic structure of the subject matter of the present application.

In addition, "and/or" as used herein means "or" and ", such as" M and/or N ", including M, or N, or both M and N.

Referring to fig. 1-2, a sampling capsule 100 according to a preferred embodiment of the present invention includes a housing 1, a sampling assembly 2 for sampling membrane flora, a membrane flora collection auxiliary assembly 3 for assisting in collecting membrane flora, and a control module 4. Wherein the control module 4 comprises a microprocessor communicatively connected to at least some of the other components to control and/or coordinate the operating state of the other components.

The housing 1 is biocompatible and will not be corroded by digestive fluids and may be transparent or opaque as required. And, the shell 1 is formed by splicing at least two parts, and the arrangement and installation of an internal structure are facilitated. For example, as shown in fig. 1, the housing 1 is composed of a first housing 11 and a second housing 12 distributed along the length direction of the sampling capsule 100, and the two parts are connected by screw threads, adhesive, etc.

The sampling assembly 2 comprises a sampling pool 21 arranged in the shell 1, an outer sampling port 22 arranged on the shell 1, a communicating pipe 23 for communicating the outer sampling port 22 with the sampling pool 21 and a sampling switch 24 for opening or closing the communicating pipe 23.

Specifically, the sampling capsule 100 further includes a partition wall 13 disposed in the housing 1, the partition wall 13 and the housing 1 located on the first side of the partition wall 13 are enclosed to form the sampling pool 21, the outer sampling port 22 is located on the second side of the partition wall 13, the sampling assembly 2 further includes an inner sampling port 25 disposed on the partition wall 13, and the communicating tube 23 communicates the outer sampling port 22 and the inner sampling port 25.

The partition wall 13 is integrally arranged with the shell 1 on the first side of the partition wall 13, so that the formed sampling pool 21 has better sealing property; or the partition wall 13 is separated from the housing 1 on the first side of the partition wall 13, and the joint between the two is sealed to ensure that the sampling cell 213 can maintain the required vacuum degree.

Prior to use, the sampling cell 21 is sterilized and the sampling cell 21 is under vacuum at an absolute pressure of 0hPa to 260 hPa. Methods of evacuating the sample cell 21 include, but are not limited to: before the manufacturing is completed, the communicating pipe 23 is opened, air in the sampling pool 21 is extracted through an air extraction element, and after the required vacuum degree is reached, the communicating pipe 23 is closed, so that the required vacuum degree is maintained in the sampling pool 21. Or before use, the sampling pool 21 is pumped to the required vacuum degree from the pumping assembly 7 through a pumping element.

The communicating pipe 23 is a hose, preferably a silicone tube. The communicating pipe 23 is connected to the partition wall 13 by a connector 26, so that the communicating pipe 23 is sealed and communicated with the inner sampling port 25.

The connecting piece 26 is made of UV glue, and the communicating pipe 23 is adhered to the peripheral wall forming the inner sampling port 25; or the connecting piece 26 is a rubber ring, the rubber ring is sleeved outside the communicating pipe 23 or nested in the inner sampling port 25, and after assembly, the rubber ring is in interference fit between the communicating pipe 23 and the inner sampling port 25 to play a role in sealing and connecting.

In addition, the sampling switch 24 is disposed at the middle position of the communication pipe 23, and the communication pipes 23 on both sides of the sampling switch 24 may be a silicone tube or two separate communication pipes 23.

The sampling switch 24 is a piezoelectric micro valve, a shape memory metal micro valve, a gas tube clamp, etc., wherein the opening and closing control of the communication tube 23 by the piezoelectric micro valve and the shape memory metal micro valve adopts the prior art, and is not described herein again; the gas tube clamp can be used for reference in patent applications 201811219936.8, 201811219926.4 and 201810617763.9, and is not described herein.

The sampling switch 24 is normally closed, and maintains the vacuum degree in the sampling cell 21 and the communicating tube 23 connected between the sampling cell 21 and the sampling switch 24, so that it can withstand at least one atmospheric pressure. After the microprocessor receives the sampling instruction transmitted by wireless, the microprocessor controls the sampling switch 24 to open the communicating pipe 23 for sampling. After sampling is finished, the sampling switch 24 is controlled to be closed, and the sample is prevented from leaking or being polluted by substances in the downstream of the digestive tract.

Further, as shown in fig. 1, especially fig. 2, the sampling assembly 2 includes a plurality of outer sampling ports 22 opened on the housing 1, and a sampling chamber 22 'communicated with the plurality of outer sampling ports 22, and the communicating tube 23 is communicated with the sampling chamber 22' so as to be indirectly communicated with the outer sampling ports 22. The gas and liquid in the alimentary canal enter the sampling cavity 22' through the outer sampling port 22 and are gathered in the communicating pipe 23, even if the outer sampling port 22 is blocked, part of the gas and liquid is still kept in conduction, and the sampling is not influenced. In addition, the digestive juice entering through each outer sampling port 22 can be mixed and buffered through the sampling cavity 22', and the uniform and smooth sampling is ensured.

The plurality of outer sampling ports 22 are distributed at intervals along the circumferential direction of the sampling capsule 100, and preferably, the plurality of outer sampling ports 22 are arranged at equal intervals. In this embodiment, be equipped with 3 ~ 5 on the shell 1 outer sample connection 22 can guarantee smoothly to sample, and does not influence the intensity of shell 1.

Preferably, the aperture of each outer sampling port 22 is smaller than the aperture of the communicating tube 23, so that the substance entering the sampling chamber 22' through the outer sampling port 22 does not block the communicating tube 23.

Further, the sampling chamber 22' has a filtering structure (not shown), such as but not limited to a filter screen, etc., inside to prevent food debris from blocking the communicating tube 23, and the filtering structure can refer to the structural design for anti-blocking and anti-inhaling air in the digestive juice sampling capsule 100 system of patent application 201811330328.4.

In any one of the above sampling assemblies 2, the membrane flora collecting auxiliary assembly 3 includes a vibration motor 31 disposed in the housing 1 and/or a weight 32 disposed at the outer sampling port 22.

In general, the sampling capsule 100 can be used to sample when it is located in a portion of the digestive tract to be examined or when it reaches a portion of the digestive tract having a lesion. When the sampling capsule 100 reaches the alimentary canal site to be sampled, the sampling capsule 100 is immersed into the digestive juice by the weight 32, and the outer sampling port 22 faces and is close to the wall of the alimentary canal; or as shown in fig. 8, the vibration motor 31 is turned on to make the sampling capsule 100 vibrate to disturb the digestive juice in the digestive tract, so that the membrane flora enters the digestive juice; or the weight 32 and the vibration motor 31 work simultaneously, then the communicating pipe 23 is opened through the sampling switch 24, and the digestive juice with membrane flora enters the sampling pool 21 through the outer sampling port 22 and the communicating pipe 23 under the pressure difference between the inner pressure and the outer pressure, so that the sample introduction is realized. After the sample introduction is finished, the communicating pipe 23 is closed through the sampling switch 24, so that the sample is prevented from leaking or being polluted; and by controlling the on state and on time of the communication pipe 23, the sample volume can be accurately controlled. In addition, the sampling switch 24 actively controls the connection or the closure of the communicating pipe 23, is not influenced by the special environment of the digestive tract part, can be universally used for any digestive tract part, and has high universality.

When the vibration motor 31 is started, the sampling capsule 100 can vibrate in the digestive tract, so that on one hand, the surrounding liquid environment can be disturbed, and bacterial colonies in part of mucus layers can enter digestive juice in the intestinal cavity; on the other hand, the vibrating capsule more easily breaks the folds of the digestive tract, so that the sampling capsule 100 is attached to the inner wall of the digestive tract, and the outer sampling port 22 contacts the mucus layer.

Preferably, the vibration motor 31 is located at the center of the sampling capsule 100, and can drive the sampling capsule 100 to vibrate more smoothly, so as to avoid the deviation; and its vibration is easy to control. The "center position" herein is not a geometrically symmetric center point, but a small area range centered on the symmetric center point, as long as the sampling capsule 100 can be smoothly vibrated, for example, at the center position of the vibration motor 31 along the axial direction of the sampling capsule 100.

Preferably, the vibration amplitude of the vibration motor 31 is adjustable, so that a suitable vibration amplitude can be adopted according to specific conditions, and better acquisition of the membrane flora is facilitated. Specifically, the vibration motor 31 is in communication connection with the microprocessor, an external device can send an instruction to the sampling capsule 100 by wireless, and the microprocessor adjusts the output frequency and the rotation speed of the vibration motor 31 according to the instruction, so as to adjust the vibration amplitude, specifically, the vibration amplitude can be achieved by adjusting the input voltage or current of the motor; for example, the adjustment can be performed using pwm (pulse Width modulation) technology.

Specifically, the vibration motor 31 may be a button type vibration motor, a coreless motor plus an eccentric device, or a linear vibration motor. A button type vibration motor is preferably selected, the thickness is minimum, and the occupied space is small; in addition, the vibration direction of the linear vibration motor is adjusted to a direction perpendicular to the outer sampling port 22.

Referring to fig. 9, the direction of the outer sampling port 22 is defined as X direction: taking the center of the sampling capsule 100 as an origin, when the number of the outer sampling ports 22 is 1, the direction in which the origin points to the outer sampling ports 22 is the X direction; when there are a plurality of the outer sampling ports 22, the outer sampling port 22 located at the center is used as an end point, and the direction pointing from the origin to the end point is the X direction, for example, when there are 3 outer sampling ports 22, the second is the end point; for example, if there are 4 outer sampling ports 22, the middle two midpoints are the end points. The direction of the long axis of the sampling capsule 100 is defined as the Z direction, and both the Y direction and the X direction are along the diameter direction of the sampling capsule 100, wherein the vibration direction of the linear vibration motor may be perpendicular to the X direction along the Y direction or the Z direction.

The weight 32 makes the gravity center of the sampling capsule 100 bias towards the outer sampling port 22, when the sampling capsule 100 enters the position to be sampled, the sampling capsule 100 is immersed into the digestive juice under the action of the weight 32, so that the outer sampling port 22 faces and is close to the wall of the digestive tract, and the membrane flora is convenient to collect.

Preferably, as shown in fig. 3 to 7, the weight member 32 is a magnetic member, and the gravity center of the magnetic member is biased to one side of the magnetic member close to the housing 1, so as to function as the weight member 32, and control the movement or posture of the capsule through an external magnetic field, so that the outer sampling port 22 can be aligned with the wall of the digestive tract. When the sampling capsule 100 contains the vibration motor 31 and the vibration motor also contains a magnet, the magnetization direction of the magnet is consistent with that of the magnetic member as much as possible, so that the magnetic control effect is prevented from being influenced.

Specifically, one surface of the magnetic element is an arc surface matched with the shell 1, so that the magnetic element can be close to the shell 1 as much as possible when being installed, and the gravity center of the magnetic element is closer to the shell 1; and is easily controlled by an external magnetic field.

Furthermore, the magnetic part is a magnetic part which is magnetized in the radial direction, and the control of the magnetic part by the external magnetic field is facilitated.

For example, the magnetic member is a radially magnetized neodymium iron boron permanent magnet of a ring shape, a sector shape or a partial ring shape.

When the magnetic member is in the shape of a sector or a partial circular ring, the center of gravity of the magnetic member is offset from the center of the circle and is biased to one side of the outer sampling port 22, which has the effect of a counterweight, i.e., the center of gravity of the magnetic member is located between the axis of the sampling capsule 100 and the outer sampling port 22. And, the shorter the length of the magnetic member is, the smaller the opening angle thereof is, and the closer the center of gravity thereof is to the outer sampling port 22.

Preferably, the fan angle of the magnetic member is the same as the fan angle of the outer sampling port 22. The fan angle of the outer sampling port 22 refers to a fan-shaped fan angle formed by connecting two ends of the outer sampling port 22 along the circumferential direction of the sampling capsule 100 with the central axis of the sampling capsule 100 along the radial direction; when the sampling capsule 100 includes a plurality of the outer sampling ports 22, the fan angle of the outer sampling ports 22 refers to a fan angle formed by connecting the end portions of two outer sampling ports 22 at both ends of the sampling capsule 100 in the circumferential direction with the central axis of the sampling capsule 100 in the radial direction.

For a partial circular ring structure, if the thickness and the radius are the same, the larger the circular ring is, the larger the opening angle is, and the closer the center of gravity is to the center of a circle; the smaller the ring is, the smaller the opening angle is, and the more the center of gravity deviates from the center of a circle. However, the smaller the opening angle is, the smaller the size of the magnetic part is, and correspondingly, the magnetic moment intensity is reduced, and the magnetic control capability is weakened; meanwhile, the weight is reduced, and the influence on the gravity center distribution of the whole capsule is weakened, so that the opening angle design with the best magnetic control and weight balancing effects needs to be selected according to the weight and volume design of the whole capsule.

The magnetic part is installed in the place that is close to outer sample connection 22, specifically the magnetic part with outer sample connection 22 is followed sampling capsule 100's axial sets up side by side, like this sampling capsule 100's focus is partial to sampling connection one end, plays the counter weight effect, and accessible external magnetic field controls the capsule motion or changes the gesture simultaneously.

At the time of sampling, the sampling capsule 100 is controlled by the external magnetic field to be close to the intestinal wall and to change the posture so that the outer sampling port 22 faces the mucosa of the intestinal wall (see fig. 2). In a natural state, the outer sampling port 22 is more easily oriented downward and submerged below the liquid level. Thus, when the external magnetic control is difficult to affect the capsule, such as too far distance leading to too weak magnetic force, the external sampling port 22 is still easy to immerse in the liquid for easy sampling.

In addition, the sampling capsule 100 further comprises a pressure sensor 5 disposed in the sampling cell 21, which has the following functions: 1. before taking the sampling capsule 100, detecting whether the sampling capsule 100 is effective; 2. before sending a sampling instruction, detecting whether the sampling capsule 100 is valid; 3. determining whether sampling is performed normally; 4. the end of sampling is determined.

Preferably, the absolute pressure measuring range of the pressure sensor 5 is 260hPa to 1260hPa or 300hPa to 1100 hPa. If the chip of 260 hPa-1260 hPa is selected, the 260hPa is still displayed when the pressure is lower than 260 hPa. Therefore, after the sampling cell 21 is vacuumized, the pressure value is observed, and if the pressure value is displayed as 260hPa, the absolute pressure is less than or equal to 260hPa, namely 0 hPa-260 hPa. If the chip of 300-1100 hPa is selected, when the actual pressure is lower than 300hPa, the chip still gives a measured value, such as 80hPa, but the measured value is not accurate enough, and only the actual pressure can be qualitatively judged to be less than or equal to 300 hPa.

The sampling capsule 100 further comprises a temperature sensor 6 positioned in the shell 1, the temperature measuring range is 0-80 ℃, and the temperature sensor is used for detecting the temperature of the sampling capsule 100 during working so as to ensure that the sampling capsule 100 works normally and cannot cause harm to human bodies. When the temperature sensor 6 detects that the temperature exceeds a certain safety threshold, the machine needs to be stopped for cooling in time. The safety threshold is 55-60 ℃ so as not to cause harm to human bodies.

Preferably, the temperature sensor 6 is located on the second side of the partition wall 13, on the one hand without contaminating the sampling cell 21; on the other hand, the elements that generate heat during operation of the sampling capsule 100 are located substantially on the second side of the separation wall 13, which provides for better detection of the temperature of the sampling capsule 100.

The temperature sensor 6 is mainly used for monitoring the temperature of the sampling switch 24. Depending on the implementation of the sampling switch 24, such as shape memory microvalves, motor-based valves, etc., heat is generated during operation.

The control module 4 further comprises a sensor 42 for acquiring physiological parameters and/or image information within the digestive tract, the sensor 42 being in communication with the microprocessor. The sensor 42 is at least one of an image sensor, or a pH sensor, or an ultrasonic sensor; when the sensor 42 comprises an image sensor, part of the shell 1 is transparent; when the sensor 42 comprises a pH sensor, the housing 1 has a window therein. The position of the sampling capsule 100 in the digestive tract is determined according to the image and the pH value obtained by the sensor 42, and the specific determination method may be any method in the prior art, which is not described herein again.

Of course, the control module 4, together with the sensor 42, may further include a storage module for storing normal physiological parameters or image information of different parts in the digestive tract, and physiological parameters or image information of possible lesions, and the storage module is communicatively connected to the microprocessor. After the sensor 42 collects physiological parameters and/or image information within the alimentary tract, the microprocessor compares the information with the information in the storage module to determine whether the sampling capsule 100 has reached the location to be sampled.

Or, the control module 4 includes the sensor 42 and also includes a wireless transmission module for communicating with an external processing terminal, when the sensor 42 collects physiological parameters and/or image information in the alimentary tract, the information is transmitted to the external processing terminal, and the external processing terminal analyzes the information and determines whether the sampling capsule 100 reaches the position to be sampled.

In addition, the control module further includes a battery for supplying power to other components, and the microprocessor, the wireless transmission module and the battery are all integrated on the same circuit board 41.

The use of the sampling capsule 100 will be described in detail below.

Referring to fig. 8 in conjunction with fig. 1 to 7, taking the collection of the membranous flora in the intestinal tract as an example, after the capsule system reaches a specified intestinal cavity 801, an external magnet 901 can be used to approach the human body from below, so that the external sampling port 22 faces downward to approach the intestinal wall. Because the magnetic member is a ring-shaped radial magnetizing magnet or a sector-shaped radial magnetizing magnetic member distributed only on one side of the outer sampling port 22, an operator can control the sampling capsule 100 to rotate along the axial direction of the capsule with reference to the image, so that one end of the outer sampling port 22 faces the intestinal wall 802. However, the outer sampling port 22 may not be in close contact with the mucus layer 803 due to wrinkles in the intestinal wall 802, insufficient adsorption force due to an excessively long distance between magnets, and the like; the "shock" command may be sent to the sampling capsule 100 by an external control device; after receiving the instruction, the vibration motor 31 will drive the whole sampling capsule 100 to vibrate at high frequency, especially along the direction perpendicular to the outer sampling port 22, keeping the outer sampling port 22 facing the intestinal wall 802; in this way, sampling capsule 100 may be brought closer to intestinal wall 802, while agitating mucus layer 803 and fluid in intestinal lumen 801, allowing some of the bacteria in mucus layer 803 to enter the lumen fluid. After a period of time, a sampling instruction may be sent through the external processing terminal 902, at which point the sampling capsule 100 will collect a liquid containing a higher concentration of membrane flora. During sampling, the digestive tract environment at the side of the outer sampling port 22 can be judged through images all the time, and the liquid at the side is ensured to be full during sampling. In this way, by the combined control of the vibration motor 31, the magnetic member, and the external magnet 901, the sampling success rate of the sampling capsule 100 and the concentration of the membrane flora can be significantly improved by the closed-loop control in which the image obtained by the image sensor 42 is fed back.

In order to collect higher concentration of membrane flora, the vibration function of the sampling capsule 100 can be independently used without an external magnet, and the sampling capsule 100 automatically finishes the sampling work: when the sampling capsule 100 reaches the collection area, the vibration mode is started to disturb the surrounding intestinal environment and improve the concentration of liquid membrane flora in the cavity. After a period of time, the vibration is stopped, and after the sampling capsule 100 is still, the outer sampling port 22 is downward close to the intestinal wall 802 under the influence of the weight of the magnetic member, submerged in the liquid, and then the sampling is started, so that a similar effect can be achieved.

Additionally, when the sampling capsule 100 is removed from the body, the protocol for removing the digestive juices includes, but is not limited to: the communicating pipe 23 is opened through the sampling switch 24 to be in a conducting state, and the digestive juice flows out through the communicating pipe 23 and the outer sampling port 22 for pathological analysis.

Or, the sampling capsule 100 further includes an extraction assembly 7 which is matched with the sampling pool 21 to realize vacuum pumping and sampling, and the extraction assembly 7 includes an extraction port 71 which is located on the first side of the partition wall 13 and is communicated with the sampling pool 21 and is arranged on the shell 1, a fixing member 72 which is matched with the extraction port 71, and a silicon plug 73 which is assembled in the fixing member 72. Specifically, the fixing member 72 is fixed to the housing 1, and the silicone plug 73 is in interference fit with the fixing member 72. Through the extraction assembly 7, a user can penetrate the silica gel plug 73 by using a syringe or the like, and the sampling pool 21 is pumped to form vacuum or a sample in the sampling pool 21 is taken out to realize sampling.

It will be understood by those skilled in the art that any of the above-mentioned sampling assemblies 2, any of the membrane flora collecting auxiliary assemblies 3, and any of the control modules 4 can be combined to form the sampling capsule 100.

The utility model also provides a sampling capsule 100 system, including above-mentioned arbitrary sampling capsule 100 and with the external processing terminal that 4 communications of control module are connected. Specifically, the communication connection between the control module 4 and the external processing terminal is implemented by any one of the prior art, which is not described herein again.

The utility model also provides a control method of sampling capsule 100 based on above-mentioned sampling capsule 100, including following step: judging whether sampling is needed, if so, opening the communicating pipe 23 by the sampling switch 24; after sampling, the sampling switch 24 closes the communication pipe 23. The determination of whether sampling is required can be performed by any of the above-described manners, which is not described herein again. The manner of opening or closing the communicating tube 23 by the sampling switch 24 is any one of the above manners, and details thereof are not repeated herein.

In summary, the sampling capsule 100 of the present application can assist the sampling component 2 to sample membrane flora through the membrane flora collection auxiliary component 3; the communicating pipe 23 is opened/closed through the sampling switch 24 to realize sample introduction, and after the sample introduction is finished, the communicating pipe 23 is closed through the sampling switch 24 to prevent the sample from leaking or being polluted; and by controlling the on state and on time of the communication pipe 23, the sample volume can be accurately controlled. In addition, the sampling switch 24 actively controls the connection or the closure of the communicating pipe 23, is not influenced by the special environment of the digestive tract part, can be universally used for any digestive tract part, and has high universality.

It should be understood that although the present description refers to embodiments, not every embodiment contains only a single technical solution, and such description is for clarity only, and those skilled in the art should make the description as a whole, and the technical solutions in the embodiments can also be combined appropriately to form other embodiments understood by those skilled in the art.

The above list of details is only for the concrete description of the feasible embodiments of the present application, they are not intended to limit the scope of the present application, and all equivalent embodiments or modifications that do not depart from the technical spirit of the present application are intended to be included within the scope of the present application.

Claims (14)

1. A sampling capsule, comprising:

a housing;

the sampling assembly comprises a sampling pool arranged in the shell, an outer sampling port arranged on the shell, a communicating pipe for communicating the outer sampling port with the sampling pool, and a sampling switch for opening or closing the communicating pipe;

the membrane flora collecting auxiliary assembly comprises a vibration motor arranged in the shell and/or a counterweight arranged at the outer sampling port;

and the control module comprises a microprocessor which is in communication connection with the sampling switch and the vibration motor.

2. The sampling capsule of claim 1, wherein: the sampling subassembly is including offering in a plurality of outer sample connection on the shell, with a plurality of the sampling chamber that outer sample connection all communicates, communicating pipe with the sampling chamber is linked together.

3. The sampling capsule of claim 2, wherein: the outer sampling ports are distributed at intervals along the circumferential direction of the sampling capsule.

4. The sampling capsule of claim 2, wherein: the aperture of each outer sampling port is smaller than that of the communicating pipe.

5. The sampling capsule of claim 2, wherein: the sampling cavity is internally provided with a filtering structure.

6. The sampling capsule of claim 1, wherein: the vibration motor is a button type vibration motor, a hollow cup motor and an eccentric device or a linear vibration motor.

7. The sampling capsule of claim 1, wherein: the vibration motor is located at the center of the sampling capsule.

8. The sampling capsule of claim 1, wherein: the weight piece is a magnetic piece, and the gravity center of the magnetic piece is deviated to one side, close to the shell, of the magnetic piece.

9. The sampling capsule of claim 8, wherein: one surface of the magnetic part is an arc surface matched with the shell, and the magnetic part is a magnetic part magnetized in the radial direction.

10. The sampling capsule of claim 8, wherein: the magnetic part and the outer sampling port are arranged side by side along the axial direction of the sampling capsule.

11. The sampling capsule of claim 1, wherein: the sampling capsule further comprises an extraction assembly, wherein the extraction assembly comprises an extraction port, a fixing piece and a silica gel plug, the extraction port is positioned on the shell and communicated with the sampling pool, the fixing piece is matched with the extraction port, and the silica gel plug is assembled in the fixing piece.

12. A sampling capsule according to any one of claims 1 to 11, wherein: the control module also comprises a sensor for acquiring physiological parameters and/or image information in the alimentary canal, and the sensor is in communication connection with the microprocessor;

or the control module further comprises a sensor for acquiring physiological parameters and/or image information in the alimentary canal, a storage module for storing normal physiological parameters or image information of different parts in the alimentary canal and possible physiological parameters or image information during pathological changes, and the sensor and the storage module are both in communication connection with the microprocessor;

or the control module also comprises a sensor for collecting physiological parameters and/or image information in the alimentary canal, and a wireless transmission module which is in communication connection with an external processing terminal, wherein the sensor is in communication connection with the microprocessor.

13. The sampling capsule of claim 12, wherein: the sensor is at least one of an image sensor, a pH sensor and an ultrasonic sensor; when the sensor comprises an image sensor, part of the shell is transparent; when the sensor comprises a pH sensor, the housing has a window thereon.

14. A sampling capsule system comprising a sampling capsule according to any one of claims 1 to 13 and an external processing terminal in communication with the control module.

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