CN211513496U

CN211513496U - A extraction element for extracting taxol in chinese yew

Info

Publication number: CN211513496U
Application number: CN201922407772.8U
Authority: CN
Inventors: 杜嵩生; 罗鸿皋
Original assignee: Yibin Haoyuan Biotechnology Co ltd
Current assignee: Yibin Haoyuan Biotechnology Co ltd
Priority date: 2019-12-27
Filing date: 2019-12-27
Publication date: 2020-09-18
Anticipated expiration: 2029-12-27

Abstract

The utility model provides an extraction element for draw taxol in taxus chinensis, including drawing the jar, the drain hole, extract and separating mechanism, it is equipped with and has open-ended inside cavity to draw the jar, the drain hole is located and is drawn the jar top, the drain hole is equipped with the through-hole of vertical direction, the through-hole communicates with each other with the inside cavity that draws the jar, the through-hole of taxus chinensis branch leaf powder accessible drain hole is placed in the inside cavity that draws the jar, it is equipped with the pureness thing after the extract distillation in the inside cavity of jar to draw, it is circular-arc structure to draw the cylinder bottom, circular-arc structure bottommost is equipped with separating mechanism, separating mechanism is used for separating taxol solution and taxus chinensis branch leaf powder residue, the existence among the prior art has been solved: the separation of taxus branch and leaf residues and paclitaxel solution is difficult, taxus resources are wasted, and the paclitaxel extraction rate is low.

Description

A extraction element for extracting taxol in chinese yew

Technical Field

The utility model belongs to the taxol in the chinese yew field of extracting, concretely relates to an extraction element for extracting taxol in chinese yew.

Background

Taxus chinensis, belonging to shallow root plants, has unobvious main roots and developed lateral roots, is a natural rare anti-cancer plant recognized in the world and endangered to extinction, is an ancient tree species left over from the fourth glacier, and has a history of 250 ten thousand years on the earth. Because the growth speed of the taxus chinensis is slow and the regeneration capability is poor under natural conditions, the taxol extracted from the branches and leaves of the taxus chinensis is the most excellent natural anticancer drug which is found at present, and is widely used for treating breast cancer, ovarian cancer, partial head and neck cancer and lung cancer in clinic. Because yew is very precious, yew branches and leaves usually need to be preliminarily extracted for many times in the process of extracting paclitaxel, in the prior art, the extraction process usually adopts the step of adding yew branch and leaf powder and an extracting solution into an extraction tank for extraction, the generated yew branch and leaf residues usually need to be extracted by other cleaning devices, and the added extracting solution does not contain impurities through purification treatment, so that the technical problems of difficulty in separating yew branch and leaf residues and an alcoholic solution of paclitaxel, waste of yew resources and low paclitaxel extraction rate exist.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide an extraction element for extracting taxol in chinese yew for solve the technical problem who exists among the prior art, if: the separation of taxus branch and leaf residues and paclitaxel solution is difficult, taxus resources are wasted, and the paclitaxel extraction rate is low.

In order to achieve the above object, the utility model adopts the following technical scheme:

the utility model provides an extraction element for drawing taxol in chinese yew, is including drawing jar, drain hole, extract and separating mechanism, it is equipped with to draw the jar and has open-ended inside cavity to draw the jar, the drain hole is located draw the jar top, the drain hole is equipped with the through-hole of vertical direction, the through-hole with draw the inside cavity intercommunication of jar each other, the branch and leaf powder of chinese yew accessible the through-hole of drain hole place in draw the inside cavity of jar, be equipped with in the inside cavity of drawing the jar the pureness thing after the extract distillation, it is circular-arc structure to draw the jar bottom, and circular-arc structure bottommost is equipped with separating mechanism, separating mechanism is used for separating taxol solution and the branch and leaf powder residue, separates out through separating mechanism and draws the taxol solution in the jar, draws the branch and leaf powder residue of chinese yew in the jar and can be used as the secondary extraction, the beneficial effect of saving the taxus chinensis resources is achieved.

The separation mechanism comprises a discharge port, a spiral cover, an operating rod and a baffle plate, the discharge port is of a hollow structure provided with a through hole, the through hole is communicated with the inner cavity of the extraction cylinder, the spiral cover is provided with a cavity with an opening, one end of the spiral cover with the opening is detachably connected with one end of the discharge port, which is far away from the extraction cylinder, the other end of the spiral cover is provided with a filter hole only allowing liquid to pass through, the filter hole is communicated with the through hole of the discharge port, the operating rod comprises a handheld rod and a connecting rod, one end of the connecting rod is vertically and fixedly connected with the handheld rod, the other end of the connecting rod is fixedly connected with the baffle plate, the baffle plate is arranged in the through hole of the discharge port, the side surface of the baffle plate is attached to the inner wall of the through hole of the discharge, the handheld rod is arranged outside the discharge hole, and the baffle can limit the flow of the paclitaxel solution in the extraction cylinder which naturally falls from the through hole of the discharge hole by rotating the operating rod by related personnel.

The device comprises a distillation cylinder, a heating device and a transmission pipeline, wherein the distillation cylinder is provided with an internal cavity, the extracting solution is arranged in the internal cavity, the transmission pipeline comprises a horizontal pipe and two vertical pipes, the horizontal pipe and the two vertical pipes are respectively provided with a through hole which is communicated with each other, the two vertical pipes are respectively inserted at the tops of the distillation cylinder and the extraction cylinder, the through holes of the two vertical pipes are respectively communicated with the internal cavities of the distillation cylinder and the extraction cylinder, the height of the vertical pipe at one end of the distillation cylinder is larger than that of the vertical pipe at one end of the extraction cylinder, the heating device is used for keeping the extracting solution in the distillation cylinder at a boiling temperature, the extracting solution in the distillation cylinder can be boiled by the heating device and generates steam, and the purpose of purifying the extracting.

Further, the side face of the baffle is provided with a sealing strip, the sealing strip is attached to the inner wall of the through hole of the discharge port, and the sealing strip can block liquid from falling.

The collecting box is arranged under the discharge port, the opening of the collecting box is opposite to the discharge port, and the collecting box is used for collecting paclitaxel solution.

Furthermore, the extracting solution is methanol, and the taxol in the taxus chinensis powder can be dissolved in the methanol, so that the aim of primarily extracting the taxol is fulfilled.

Furthermore, the device also comprises a plurality of supporting legs, the bottom of the extraction cylinder is fixedly connected with one ends of the supporting legs, the other ends of the supporting legs are supported on the ground, and the extraction cylinder is supported on the ground through the supporting legs.

The injection opening is of a hollow structure with a through hole, one end of the injection opening is fixedly connected with the top of the distillation cylinder, the other end of the injection opening is detachably connected with a blocking cover, the blocking cover can completely block the through hole of the injection opening, the through hole of the injection opening is communicated with the inner cavity of the distillation cylinder, and the extracting solution can be added into the distillation cylinder from the injection opening.

Furthermore, the distillation device also comprises a plurality of support columns, the bottom of the distillation cylinder is fixedly connected with one ends of the support columns, the other ends of the support columns are supported on the ground, and the distillation cylinder is supported on the ground through the support columns.

The utility model has the advantages that:

(1) this an extraction element for extracting taxol in yew is provided with separating mechanism, separates out taxol branch and leaf residue and taxol solution through separating mechanism, has reached the simple effectual beneficial effect of taxol solution and the separation of taxol branch and leaf powder residue.

(2) This an extraction element for extracting taxol in chinese yew is provided with and draws jar and separating mechanism, and the taxol solution that draws in the jar through the separating mechanism separation lets the branch and leaf residue of chinese yew used twice, has reached the beneficial effect of practicing thrift the chinese yew resource.

(3) This an extraction element for extracting taxol in taxus chinensis is provided with distillation jar, heating device and transmission pipeline, can make the extract boiling in the distillation jar and produce steam through heating device, and then carries through transmission pipeline and draw in the jar, has played the purpose of purification extract, has reached the high beneficial effect of taxol extraction rate.

Drawings

Fig. 1 is the overall structure schematic diagram of the extraction device for extracting paclitaxel from taxus chinensis of the utility model.

Fig. 2 is the schematic view of the structure of the operating rod and the baffle of the extraction device for extracting paclitaxel from taxus chinensis.

Fig. 3 is a schematic view of the matching relationship between the condensation sleeve and the transmission pipeline of the extraction device for extracting paclitaxel from taxus chinensis.

FIG. 4 is a schematic view of the relationship between the discharge port and the baffle of the device for extracting paclitaxel from Taxus chinensis.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to fig. 1-4 of the present invention, and it should be apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

An extraction device for extracting paclitaxel in taxus chinensis, includes and draws jar 9, drain hole 8, extract 1 and separating mechanism draws jar 9 to support through its bottom fixed connection's supporting leg 15 subaerial, it is equipped with and has open-ended inside cavity to draw jar 9, drain hole 8 is located draw jar 9 top, drain hole 8 is equipped with the through-hole of vertical direction, the through-hole with draw the inside cavity intercommunication of jar 9, taxus chinensis branch and leaf powder accessible draw the through-hole of drain hole 8 place in draw the inside cavity of jar 9, be equipped with in the inside cavity of jar 9 the pureness after extract 1 distills, extract 1 is the methyl alcohol, and the taxol in the taxus chinensis powder is soluble in the methyl alcohol, so reached the preliminary purpose of extracting taxol, it is circular-arc structure to draw jar 9 bottom, circular-arc structure bottommost is equipped with separating mechanism, the separation mechanism is used for separating paclitaxel solution and the taxus chinensis branch and leaf powder residues, paclitaxel solution in the extraction cylinder is separated through the separation mechanism, and the taxus chinensis branch and leaf powder residues in the extraction cylinder can be used for secondary extraction, so that the beneficial effect of saving taxus chinensis resources is achieved.

The separating mechanism comprises a discharge port 10, a spiral cover 13, an operating rod 11 and a baffle 12, the discharge port 10 is of a hollow structure provided with a through hole, the through hole is communicated with the inner cavity of the extraction cylinder 9, the spiral cover 13 is provided with a cavity with an opening, the spiral cover 13 is provided with one end with an opening which is detachably connected with the discharge port 10, the other end of the discharge port 10 is far away from one end of the extraction cylinder 9, the other end of the spiral cover 13 is provided with a filter hole which can only pass through liquid, the filter hole is communicated with the through hole of the discharge port 10, the operating rod 11 comprises a handheld rod and a connecting rod, one end of the connecting rod is vertically and fixedly connected with the handheld rod, the other end of the connecting rod is fixedly connected with the baffle 12, the baffle 12 is arranged in the through hole of the discharge port 10, the side surface of the baffle 12 is attached to the, the connecting rod is rotatably connected with the discharge port 10, the central axis of the connecting rod is mutually vertical to the central axis of the through hole of the discharge port 10, the hand-held rod is arranged outside the discharge port 10, a collecting box 14 is arranged under the discharge port 10, the collecting box 14 is provided with a cavity with an opening, the opening of the collecting box 14 is opposite to the discharge port 10, the baffle 12 can limit the natural falling flow of the taxol solution in the extracting cylinder 9 from the through hole of the discharge port 10 by rotating the operating rod 11 by related personnel, when the baffle 12 is attached to the inner wall of the through hole of the discharge port 10, the taxol solution does not fall, because the mixture of the extracting solution 1 and the taxus chinensis branch and leaf powder needs to be kept still for a certain time in the process of extracting the taxol, the aim of keeping still for a certain time can be realized by the baffle 12, make baffle 12 no longer laminate with the inner wall of the through-hole of discharge gate 10, because discharge gate 10 bottom is equipped with spiral cover 13 that only can pass through liquid again, so only taxol solution falls naturally and is collected by collecting box 14 from discharge gate 10 this moment, and after taxol solution no longer falls, relevant personnel pull down spiral cover 13, taxol branch leaf powder residue falls and is collected from discharge gate 10, taxol solution and taxol branch leaf powder residue can separate, whole process only needs relevant personnel to operate action bars 11 and spiral cover 13, the simple and separation efficiency of process has been reached taxol solution and the simple effectual beneficial effect of taxol branch leaf powder residue separation.

The whole device also comprises a distillation cylinder 2, a heating device 16 and a transmission pipeline 5, wherein the distillation cylinder 2 is supported on the ground through a support column 17 fixedly connected with the bottom of the distillation cylinder 2, the top of the distillation cylinder 2 is provided with an injection port 18, the injection port 18 is of a hollow structure with a through hole, one end of the injection port 18 is fixedly connected with the top of the distillation cylinder 2, the other end of the injection port 18 is detachably connected with a blocking cover, the blocking cover can completely block the through hole of the injection port 18, the through hole of the injection port 18 is mutually communicated with the inner cavity of the distillation cylinder 2, an extracting solution 1 is added into the inner cavity of the distillation cylinder 2 through the through hole of the injection port 18, the distillation cylinder 2 is provided with the inner cavity, the extracting solution 1 is arranged in the inner cavity, the transmission pipeline 5 comprises a horizontal pipe and two vertical pipes, the horizontal pipe and the two vertical pipes are respectively provided with mutually communicated, the through holes of the two vertical pipes are respectively communicated with the internal cavities of the distillation cylinder 2 and the extraction cylinder 9, the height of the vertical pipe at one end of the distillation cylinder 2 is greater than that of the vertical pipe at one end of the extraction cylinder 9, the heating device 16 is used for keeping the extracting solution 1 in the distillation cylinder 2 at a boiling temperature, the extracting solution 1 in the distillation cylinder 2 can be boiled and generate steam through the heating device 16, and the purpose of purifying the extracting solution 1 is achieved, the liquid-cooling type distillation device further comprises a condensation sleeve 3, a cooling liquid 4, a water outlet 7 and a water inlet 6, the condensation sleeve 3 is of a hollow structure with through holes, a transverse pipe of the transmission pipeline 5 is inserted into the through hole of the condensation sleeve 3, the condensation sleeve 3 is provided with an internal cavity, the cooling liquid 4 is arranged in the internal cavity, the transverse pipe of the transmission pipeline 5 is completely covered by the internal cavity of the condensation sleeve 3, and the water outlet 7 and the water inlet 6, the water outlet 7 and the water inlet 6 are both provided with through holes communicated with the inner cavity of the condensation sleeve 3, a water pump is connected between the water outlet 7 and the water inlet 6, the cooling liquid 4 can circularly flow under the action of the water pump, the condensation effect on the extracting liquid 1 is achieved through the circular flow of the cooling liquid 4, the extracting liquid 1 in the distillation cylinder 2 is condensed into liquid to flow to the extracting cylinder 9 from the transmission pipeline 5 after boiling, and the extracting liquid 1 flowing to the extracting cylinder 9 from the distillation cylinder 2 is a purified extract of the extracting liquid 1 after distillation, so that the purity of the extracting liquid is high, and the beneficial effect of high paclitaxel extraction rate is achieved.

In the description of the present invention, it should be understood that the terms "counterclockwise", "clockwise", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description of the present invention, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention.

Claims

1. An extraction device for extracting paclitaxel in yew is characterized by comprising an extraction cylinder (9), a discharge hole (8), an extracting solution (1) and a separation mechanism, the extraction cylinder (9) is provided with an inner cavity with an opening, the discharge hole (8) is arranged at the top of the extraction cylinder (9), the discharging hole (8) is provided with a through hole in the vertical direction, the through hole of the discharging hole (8) is communicated with the inner cavity of the extracting cylinder (9), the taxus chinensis branch and leaf powder can be placed in the inner cavity of the extracting cylinder (9) through the through hole of the discharging hole (8), the inner cavity of the extraction cylinder (9) is provided with the purified substance of the distilled extracting solution (1), the bottom of the extraction cylinder (9) is of an arc-shaped structure, the separation mechanism is arranged at the bottommost end of the arc-shaped structure, and the separation mechanism is used for separating paclitaxel solution and taxus chinensis branch and leaf powder residues;

the separating mechanism comprises a discharge port (10), a rotary cover (13), an operating rod (11) and a baffle plate (12), the discharge port (10) is of a hollow structure provided with a through hole, the through hole of the discharge port (10) is communicated with an inner cavity of the extraction cylinder (9), the rotary cover (13) is provided with an open cavity, one end of the rotary cover (13) with an opening is detachably connected with one end of the discharge port (10) far away from the extraction cylinder (9), the other end of the rotary cover (13) is provided with a filter hole only allowing liquid to pass through, the filter hole is communicated with the through hole of the discharge port (10), the operating rod (11) comprises a handheld rod and a connecting rod, one end of the connecting rod is vertically and fixedly connected with the handheld rod, the other end of the connecting rod is fixedly connected with the baffle plate (12), the baffle plate (12) is arranged in the through hole of the discharge port (10), baffle (12) side with the laminating of the through-hole inner wall of discharge gate (10), connecting rod rotationally connect discharge gate (10), the connecting rod center pin with the center pin mutually perpendicular of discharge gate (10) through-hole, handheld pole set up in outside discharge gate (10).

2. The extraction device for extracting paclitaxel from Taxus chinensis as claimed in claim 1, it is characterized by also comprising a distillation cylinder (2), a heating device (16) and a transmission pipeline (5), the distillation cylinder (2) is provided with an inner cavity, the extracting solution (1) is arranged in the inner cavity, the transmission pipeline (5) comprises a horizontal pipe and two vertical pipes, the horizontal pipe and the two vertical pipes are respectively provided with through holes which are communicated with each other, the two vertical pipes are respectively inserted at the tops of the distillation cylinder (2) and the extraction cylinder (9), the through holes of the two vertical pipes are respectively communicated with the internal cavities of the distillation cylinder (2) and the extraction cylinder (9), the height of a vertical pipe at one end of the distillation cylinder (2) is greater than that of a vertical pipe at one end of the extraction cylinder (9), the heating device (16) is used for keeping the extracting solution (1) in the distillation cylinder (2) at a boiling temperature.

3. The extraction device for extracting paclitaxel in taxus chinensis according to claim 1, characterized in that the side surface of the baffle (12) is provided with a sealing strip, and the sealing strip is attached to the inner wall of the through hole of the discharge hole (10).

4. The extraction device for extracting paclitaxel in taxus chinensis according to claim 1, further comprising a collection box (14), wherein the collection box (14) is provided with a cavity with an opening, the collection box (14) is arranged right below the discharge port (10) and the opening is opposite to the discharge port (10).

5. The extraction device for extracting paclitaxel from taxus chinensis as claimed in claim 1, wherein said extracting solution (1) is methanol.

6. The extraction device for extracting paclitaxel in taxus chinensis as claimed in claim 1, further comprising a plurality of support legs (15), wherein the bottom of said extraction cylinder (9) is fixedly connected with one end of said support legs (15), and the other end of said support legs (15) is supported on the ground.

7. The extraction device for extracting paclitaxel from taxus chinensis as claimed in claim 2, further comprising an injection port (18), wherein said injection port (18) is a hollow structure with a through hole, one end of said injection port (18) is fixedly connected to the top of said distillation cylinder (2), the other end of said injection port (18) is detachably connected with a blocking cover, said blocking cover can completely block the through hole of said injection port (18), and the through hole of said injection port (18) is communicated with the internal cavity of said distillation cylinder (2).

8. The extraction device for extracting paclitaxel in taxus chinensis as claimed in claim 2, further comprising a plurality of support columns (17), wherein the bottom of said distillation cylinder (2) is fixedly connected with one end of said support columns (17), and the other end of said support columns (17) is supported on the ground.