CN211487727U - Device for preparing paper-based microfluidic chip - Google Patents
Device for preparing paper-based microfluidic chip Download PDFInfo
- Publication number
- CN211487727U CN211487727U CN201922105156.7U CN201922105156U CN211487727U CN 211487727 U CN211487727 U CN 211487727U CN 201922105156 U CN201922105156 U CN 201922105156U CN 211487727 U CN211487727 U CN 211487727U
- Authority
- CN
- China
- Prior art keywords
- roller
- paper
- printing plate
- hydrophobic solution
- paper base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Abstract
The utility model discloses a device for preparing a paper-based microfluidic chip, which comprises a second roller and a printing plate, wherein a paper base is wound outside the second roller; the surface of the printing plate is provided with a protruding part, the surface of the printing plate is coated with a hydrophobic solution, and the printing plate is in contact with the paper base so as to coat the hydrophobic solution on the surface of the paper base. The surface of the printing plate in the utility model is provided with a convex part, the convex part is consistent with the pattern of the three-dimensional channel of the microfluidic chip to be prepared, and the pattern limits the hydrophobic area of the microfluidic chip to be prepared; when the hydrophobic solution is coated on the surface of the paper base by utilizing the attachment of the printing plate and the paper base, the hydrophobic solution can permeate into fiber pores of the paper base to form a hydrophobic wall after the hydrophobic solution is contacted with the paper base, and the part of the paper base which is not contacted with the hydrophobic solution still keeps hydrophilic and is used for forming a microfluidic channel.
Description
Technical Field
The utility model relates to a micro-fluidic chip's field, concretely relates to preparation paper base micro-fluidic chip's device.
Background
The paper-based micro-fluidic chip is a new micro-fluidic analysis technology platform, has the advantages of low cost, simple and easy processing, convenient use and carrying and the like, and has great application prospect in the application fields of clinical diagnosis, food quality control, environmental monitoring and the like. The paper-based microfluidic chip adopts paper as a substrate to replace materials such as silicon, glass, high polymer and the like, and the analysis device is called a micro laboratory on paper and is also called a microfluidic paper analysis device. It has wide application in clinical diagnosis, food quality, environment monitoring and other fields.
The preparation process of the paper-based microfluidic chip can be divided into physical-based and chemical-based methods. The physical process is mainly that a designed hydrophobic area is constructed on paper by methods of wax-spraying printing, laser cutting, drawing, ink-jet printing, stamp stamping and the like, so that fluid to be analyzed flows according to a set hydrophilic channel to realize various chemical analyses; the chemical process mainly realizes the flow control of the analysis sample by constructing a flow channel through photoetching, ultraviolet curing, plasma etching and the like. However, the physical and chemical-based preparation methods in the prior art require harsh preparation environments and precise instruments, so that the preparation cost of the paper-based microfluidic chip is high.
Disclosure of Invention
The to-be-solved technical problem of the utility model is to provide a device of preparation paper base micro-fluidic chip, it can be in a large number, low-cost ground preparation paper base micro-fluidic chip.
In order to solve the technical problem, the utility model provides a device for preparing a paper-based microfluidic chip, which comprises a second roller and a printing plate, wherein a paper base is wound outside the second roller; the surface of the printing plate is provided with a protruding part, the surface of the printing plate is coated with a hydrophobic solution, and the printing plate is in contact with the paper base so as to coat the hydrophobic solution on the surface of the paper base.
Further, the printing plate machine further comprises a first roller, and the printing plate is coated outside the first roller
Further, the drying device comprises a heating element
Further, the device for preparing the paper-based microfluidic chip further comprises a cooling roller, the paper base is wound on the surface of the cooling roller, and the drying device is positioned between the second roller and the cooling roller.
Furthermore, the device for preparing the paper-based microfluidic chip also comprises a feeding roller and a grid roller, wherein the feeding roller is adhered with a hydrophobic solution; the feeding roller and the grid roller are in contact and relatively rotate so as to coat the hydrophobic solution on the surface of the grid roller; the grid roller is contacted with the printing plate, and the grid roller and the first cylinder rotate relatively.
Further, the device for preparing the paper-based microfluidic chip further comprises a doctor blade, and the doctor blade is in contact with the surface of the grid roller to remove redundant hydrophobic solution.
Further, the doctor blade is tangent to the surface of the mesh roller.
Further, the hydrophobic solution includes polystyrene or polydimethylsiloxane.
The utility model has the advantages that:
the surface of the printing plate is provided with a convex part, the convex part is consistent with the pattern of the three-dimensional channel of the microfluidic chip to be prepared, and the pattern defines a hydrophobic area of the microfluidic chip to be prepared; when the hydrophobic solution is coated on the surface of the paper base by utilizing the attachment of the printing plate and the paper base, the hydrophobic solution can permeate into fiber pores of the paper base to form a hydrophobic wall after the hydrophobic solution is contacted with the paper base, and the part of the paper base which is not contacted with the hydrophobic solution still keeps hydrophilic and is used for forming a microfluidic channel;
the hydrophobic solution is coated on the paper base by utilizing the printing plate, and the paper base is wound outside the second roller, so that the printing plate can quickly and simply coat the hydrophobic solution on the surface of the paper base when the second roller rotates, and a large amount of paper base microfluidic chips can be prepared at low cost.
Drawings
FIG. 1 is a schematic diagram of an apparatus for preparing a paper-based microfluidic chip according to the present invention;
FIG. 2 is a schematic representation of the present invention in the context of printing plate and paper-based lamination;
FIG. 3 is a schematic representation of a hydrophobic barrier formed by a hydrophobic solution on a surface of a paper substrate;
FIG. 4 is a schematic view of a microfluidic channel;
fig. 5 is a block diagram of a paper-based microfluidic chip.
The reference numbers in the figures illustrate: 1. a hydrophobic solution; 2. a feeding roller; 3. a doctor blade; 4. a mesh roller; 5. a first drum; 51. a projection; 6. printing plate; 7. paper base; 8. a second drum; 9. a drying device; 10. and (5) cooling the roller.
Detailed Description
The present invention is further described with reference to the following drawings and specific embodiments so that those skilled in the art can better understand the present invention and can implement the present invention, but the embodiments are not to be construed as limiting the present invention.
Referring to fig. 1 to 5, an embodiment of the device for preparing a paper-based microfluidic chip according to the present invention includes a second cylinder 8 and a printing plate 6, wherein the surface of the printing plate 6 is provided with a protrusion 51, the protrusion 51 is consistent with a pattern of a three-dimensional channel of the microfluidic chip to be prepared, and the pattern defines a hydrophobic region of the microfluidic chip to be prepared. When the hydrophobic solution 1 is coated on the surface of the paper base 7 by utilizing the joint of the printing plate 6 and the paper base 7, the hydrophobic solution 1 can permeate into fiber pores of the paper base 7 to form hydrophobic walls after the hydrophobic solution 1 is contacted with the paper base 7, and the part of the paper base 7 which is not contacted with the hydrophobic solution 1 still keeps hydrophilic and is used for forming a microfluidic channel.
In this embodiment, the hydrophobic solution 1 may be hydrophobic materials such as polystyrene or polydimethylsiloxane; when polystyrene is included in the selected hydrophobic solution 1, the polystyrene solution needs to be in an organic solvent so as to coat the hydrophobic solution 1 on the surface of the printing plate 6 at a later stage. When the selected hydrophobic solution 1 includes polydimethylsiloxane, the prepolymer and the curing agent need to be mixed in advance according to a required ratio, and the hydrophobic solution 1 coated on the surface of the paper base 7 needs to be subjected to a curing treatment.
The paper base 7 is wound on the surface of the second roller 8, when the printing plate 6 is in contact with the paper base 7, the printing plate 6 can coat the hydrophobic solution 1 on the surface of the paper base 7, after the hydrophobic solution 1 is in contact with the paper base 7, the hydrophobic solution 1 can penetrate into fiber pores of the paper base 7 to form a hydrophobic wall, and the part of the paper base 7 not in contact with the hydrophobic solution 1 still keeps hydrophilic and is used for forming a microfluidic channel.
In another embodiment, the device for preparing microfluidic chips further comprises a first cylinder 5, the printing plate 6 being coated on the outside of the first cylinder 5 such that the projections 51 are arranged facing the outside. The printing plate 6 is capable of applying the hydrophobic solution 1 to the surface of the paper substrate 7 while the first cylinder 5 and the second cylinder 8 are relatively rotated. When the first roller 5 and the second roller 8 rotate relatively, the hydrophobic solution 1 can be quickly and simply coated on the surface of the paper base 7, and the paper base 7 microfluidic chip can be prepared in a large amount at low cost. The hydrophobic solution 1 attached to the surface of the printing plate 6 may be sprayed directly or applied by other means.
In the application, the hydrophobic solution 1 is coated on the paper base 7 by using the printing plate 6 coated outside the first roller 5, and the paper base 7 is wound outside the second roller 8, so that the hydrophobic solution 1 can be quickly and simply coated on the surface of the paper base 7 when the first roller 5 and the second roller 8 rotate relatively, and thus, the micro-fluidic chip of the paper base 7 can be prepared in a large amount at low cost. The first roller 5 and the second roller 8 rotate to realize the attachment of the printing plate 6 and the paper base 7, and the hydrophobic solution 1 adhered to the convex part 51 can be accurately coated on the surface of the paper base 7 in the process of coating the hydrophobic solution 1, so that the hydrophobic solution 1 is prevented from being adhered to other parts of the paper base 7, and the consistency of a hydrophobic area on the microfluidic chip and the convex part 51 on the surface of the printing plate 6 is ensured. Of course, it is also possible to directly cover the printing plate 6 on the surface of the paper base 7 to coat the hydrophobic solution 1 on the surface of the paper base 7.
In another embodiment, the device for preparing the paper-based microfluidic chip further comprises a feeding roller 2, a grid roller 4 and a doctor blade 3, wherein the hydrophobic solution 1 is adhered to the surface of the feeding roller 2, and when the feeding roller 2 and the grid roller 4 are in contact and relatively rotate, the feeding roller 2 can coat the hydrophobic solution 1 adhered to the surface of the grid roller 4. In this embodiment, the hydrophobic solution 1 is placed under the loading roller 2 while the lower end portion of the loading roller 2 is immersed in the hydrophobic solution 1, so that the loading roller 2 coats the hydrophobic solution 1 on the surface of the mesh roller 4. It is of course also possible to spray the hydrophobic solution 1 directly onto the surface of the applicator roll 2. The grid roller 4 is in contact with the printing plate 6 and can rotate relative to the first cylinder 5, thus enabling the hydrophobic solution 1 on its surface to be applied to the printing plate 6. The material of the mesh roller 4 in this embodiment is preferably ceramic or metal. Continuous coating of the surface of the printing plate 6 is achieved by means of contact and rotation of the feeding roller 2 and the grid roller 4, then the hydrophobic solution 1 on the surface of the printing plate 6 can be continuously coated on the surface of the paper base 7 by means of relative rotation of the first cylinder 5 and the second cylinder 8, and then continuous conveying of the paper base 7 is achieved by means of rotation of the second cylinder 8, so that continuous coating and conveying of the paper base 7 are achieved. Therefore, the paper-based 7 microfluidic chip can be prepared quickly, massively and at low cost when the microfluidic chip is prepared by using the method.
Further, the doctor blade 3 is in contact with the surface of the mesh roller 4, so that the excess hydrophobic solution 1 on the surface of the mesh roller 4 can be removed by the doctor blade 3. In the embodiment, the surface of the doctor blade 3 and the surface of the grid roller 4 are tangent, and the tangent position of the doctor blade 3 and the grid roller 4 is positioned above the hydrophobic solution 1, so that the redundant hydrophobic solution 1 can be recovered. When the doctor blade 3 is tangent to the grid roller 4, the contact area of the doctor blade 3 and the grid roller 4 can be reduced, so that the damage to the grid roller 4 is reduced; meanwhile, the doctor blade 3 is vertically arranged to remove redundant hydrophobic solution 1 more easily, so that the hydrophobic solution 1 is prevented from being adhered to the surface of the grid roller 4 due to inertia effect when the grid roller 4 rotates.
When it is necessary to adjust the amount of the hydrophobic solution 1 coated on the paper base 7 by the printing plate 6, it can be achieved by adjusting the rotation speed between the feeding roller 2 and the mesh roller 4. When the speed difference between the two is large, the amount of the hydrophobic solution 1 coated on the surface of the printing plate 6 is reduced; when the difference in the speed between the two is small, the amount of the hydrophobic solution 1 coated on the surface of the printing plate 6 is increased.
The device for preparing the paper-based microfluidic chip further comprises a drying device 9 and a cooling roller 10, wherein the drying device 9 comprises heating elements, and the heating elements can be hot air pipes, infrared emission pipes and the like. The cooling roll 10 is provided with cooling water or cooling air along its axial direction, but other cooling methods may be used. The drying device 9 is arranged between the second roller 8 and the cooling roller 10, after the paper base 7 coated with the hydrophobic solution 1 passes through the drying device 9 and the cooling roller 10 in sequence, the drying device 9 can solidify the hydrophobic solution 1 on the surface of the hydrophilic paper base 7, and then the cooling roller 10 is used for realizing the sizing.
The preparation process comprises the following steps:
s0, coating the printing plate 6 outside the first cylinder 5;
s11, the feeding roller 2 coats the hydrophobic solution 1 on the surface of the grid roller 4 contacted with the feeding roller;
s12, the doctor blade 3 contacts with the surface of the grid roller 4 to remove the redundant hydrophobic solution 1 on the grid roller 4;
s13, the grid roller 4 is contacted with the printing plate 6 coated outside the first roller 5 to coat the hydrophobic solution 1 on the surface of the printing plate 6;
s21, winding the paper base 7 outside the second roller 8;
s22, the first cylinder 5 and the second cylinder 8 rotate relatively, and the printing plate 6 is pressed on the paper base 7;
s23, at the position where the printing plate 6 is attached to the paper base 7, the hydrophobic solution 1 penetrates into fiber gaps of the paper base 7 to form hydrophobic walls so as to limit hydrophobic areas;
s3, drying and cooling the paper substrate 7.
The above-mentioned embodiments are merely preferred embodiments for fully illustrating the present invention, and the scope of the present invention is not limited thereto. Equivalent substitutes or changes made by the technical personnel in the technical field on the basis of the utility model are all within the protection scope of the utility model. The protection scope of the present invention is subject to the claims.
Claims (8)
1. The device for preparing the paper-based microfluidic chip is characterized by comprising a second roller and a printing plate, wherein the paper base is wound outside the second roller; the surface of the printing plate is provided with a protruding part, the surface of the printing plate is coated with a hydrophobic solution, and the printing plate is in contact with the paper base so as to coat the hydrophobic solution on the surface of the paper base.
2. The device for preparing paper-based microfluidic chip according to claim 1, further comprising a first roller, wherein the printing plate is coated outside the first roller.
3. The device for preparing paper-based microfluidic chip according to claim 1, further comprising a drying device, wherein the drying device comprises a heating element.
4. The device for preparing the paper-based microfluidic chip according to claim 3, wherein the device for preparing the paper-based microfluidic chip further comprises a cooling roller, the paper is wound on the surface of the cooling roller, and the drying device is positioned between the second roller and the cooling roller.
5. The device for preparing the paper-based microfluidic chip according to claim 2, further comprising a feeding roller and a grid roller, wherein the feeding roller is adhered with a hydrophobic solution; the feeding roller and the grid roller are in contact and relatively rotate so as to coat the hydrophobic solution on the surface of the grid roller; the grid roller is contacted with the printing plate, and the grid roller and the first cylinder rotate relatively.
6. The device for preparing the paper-based microfluidic chip according to claim 5, wherein the device for preparing the paper-based microfluidic chip further comprises a doctor blade, and the doctor blade is in contact with the surface of the grid roller to remove the excess hydrophobic solution.
7. The device for preparing paper-based microfluidic chip according to claim 6, wherein the doctor blade is tangent to the surface of the grid roller.
8. The device for preparing paper-based microfluidic chip according to claim 1, wherein the hydrophobic solution comprises polystyrene or polydimethylsiloxane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922105156.7U CN211487727U (en) | 2019-11-29 | 2019-11-29 | Device for preparing paper-based microfluidic chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922105156.7U CN211487727U (en) | 2019-11-29 | 2019-11-29 | Device for preparing paper-based microfluidic chip |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN211487727U true CN211487727U (en) | 2020-09-15 |
Family
ID=72412348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201922105156.7U Active CN211487727U (en) | 2019-11-29 | 2019-11-29 | Device for preparing paper-based microfluidic chip |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN211487727U (en) |
-
2019
- 2019-11-29 CN CN201922105156.7U patent/CN211487727U/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Yang et al. | A twice electrochemical-etching method to fabricate superhydrophobic-superhydrophilic patterns for biomimetic fog harvest | |
| CN110975952B (en) | Paper-based microfluid chip and preparation method and application thereof | |
| Sousa et al. | Patterned superhydrophobic paper for microfluidic devices obtained by writing and printing | |
| EP2034318B1 (en) | Flow cell and process for manufacturing the same | |
| JP5136997B2 (en) | Microelectrode system for electrochemical measurement with optical microscope observation function | |
| Kim et al. | Enriching libraries of high-aspect-ratio micro-or nanostructures by rapid, low-cost, benchtop nanofabrication | |
| CN104321271A (en) | Microfluidic surface processing device and method | |
| Chatterjee et al. | Precise liquid transport on and through thin porous materials | |
| CN105802290B (en) | A kind of preparation method of super dewatering titanium oxide coating material and its application in terms of paper substrate microfluidic device is constructed | |
| CN103885300A (en) | Hydrophobic surface photoetching process | |
| CN211487727U (en) | Device for preparing paper-based microfluidic chip | |
| CN112756233A (en) | Method for preparing large-size micro-groove bionic anti-fouling coating by template imprinting method | |
| CN110711615A (en) | Method and device for preparing paper-based micro-fluidic chip | |
| US20090266713A1 (en) | Channelless fluidic sample transport medium | |
| Wu et al. | Micro‐Patterning Wettability in Very Large Scale Microfluidic Integrated Chips for Double Emulsion Generation | |
| JP2013524258A (en) | Cantilever for adhesion | |
| Zhao et al. | Liquid imbibition in ceramic-coated carbon nanotube films | |
| KR20110119665A (en) | Large area, homogeneous array fabrication including controlled tip loading vapor deposition | |
| US9034277B2 (en) | Surface preparation for a microfluidic channel | |
| Wang et al. | Beech wood cross sections as natural templates to fabricate superhydrophobic surfaces | |
| CN111013679A (en) | Preparation method of paper-based micro-fluidic chip and paper-based micro-fluidic chip | |
| KR20140036827A (en) | Microfluidic channel detection kit and manufacturing method of the same | |
| CN108490736B (en) | Functional layer for realizing liquid drop self-driving based on shape gradient and preparation method thereof | |
| Yang et al. | A liquid molding method for the fabrication of microfluidic devices based on a drop-on-demand generation of patterned substrates | |
| Burgoyne et al. | Screening conditions for rationally engineered electrodeposition of nanostructures (SCREEN): Electrodeposition and applications of polypyrrole nanofibers using microfluidic gradients |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20201223 Address after: Room C309, South third floor, huanxiuhu building, high speed rail new town, Xiangcheng District, Suzhou City, Jiangsu Province Patentee after: Suzhou WeiPai Medical Technology Co.,Ltd. Address before: 215000 South 3rd and 4th Floors of Huanxiuhu Building, Xiangcheng High-speed Railway New Town, Suzhou City, Jiangsu Province Patentee before: JIANGSU JICUI MICRO-NANO AUTOMATION SYSTEM AND EQUIPMENT TECHNOLOGY RESEARCH INSTITUTE Co.,Ltd. |
|
| TR01 | Transfer of patent right |