CN211477294U - Liquid level detection module and multichannel liquid-transfering device - Google Patents
Liquid level detection module and multichannel liquid-transfering device Download PDFInfo
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- CN211477294U CN211477294U CN202020521400.8U CN202020521400U CN211477294U CN 211477294 U CN211477294 U CN 211477294U CN 202020521400 U CN202020521400 U CN 202020521400U CN 211477294 U CN211477294 U CN 211477294U
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Abstract
The application discloses a liquid level detection module, which is used for a multi-channel liquid transfer device; the liquid level detection module is connected with a control module of the liquid transfer device and is used for realizing liquid level height detection of different channels; the liquid level detection module comprises a liquid level detection circuit, and the liquid level detection circuit comprises an air pressure sensing module. The application also discloses a multichannel pipetting device comprising the liquid level detection module. The liquid level detection module of this application is realized through the inside atmospheric pressure change of cavity that atmospheric pressure sensing module perception probe head tip contact liquid level brought. When the liquid-transferring head of the liquid-transferring device is close to the liquid surface, the air pressure in the cavity can be continuously changed, and when the air pressure reaches a set value, the control module sends an instruction to the motor. The air pressure sensing module is used, so that the detection sensitivity can be flexibly set, and high-density integration in multi-channel liquid transfer is facilitated; meanwhile, the sample does not need to be electrified, and the defect of capacitance detection is avoided.
Description
Technical Field
The utility model relates to a move liquid technical field that is used for medical treatment to detect and the high accuracy liquid of biotechnology trade shifts, specifically, relate to a liquid level detection module and multichannel move liquid device.
Background
With the rapid development of molecular biotechnology, the workload of biological laboratories has increased dramatically, and how to effectively improve the experimental work efficiency has become a popular topic today. A multi-channel and parallel-independent liquid transfer device is suitable for high-precision liquid transfer in medical detection and biotechnology industries. The labor intensity of the personnel in the biological laboratory is greatly improved by processing a large amount of repeated physical labor; the requirements of high reliability and high precision liquid transfer are met.
The liquid transfer is carried out by a gas replacement mode through a screw rod assembly (a screw rod) driven by a motor and causing a polished rod to move up and down in a piston. Each channel of the pipetting device corresponds to a separate motor so as to realize the parallel independent pipetting of multiple channels.
At present, the pipetting device detects the height of the liquid level of the sample in each channel through a liquid level detection module. The existing liquid level detection module uses a capacitance detection circuit. The capacitance detection circuit is complex, has a plurality of interference signals, and can change the sample property when the sample is electrified to influence the detection result.
Disclosure of Invention
In order to solve the above problems, the present application provides a liquid level detection module for a multi-channel pipetting device; the liquid level detection module is connected with a control module of the liquid transfer device and is used for realizing liquid level height detection of different channels; the liquid level detection module comprises a liquid level detection circuit, and the liquid level detection circuit comprises an air pressure sensing module.
Preferably, the liquid level detection circuit further comprises a first resistor and a filter circuit; the first end of the first resistor is respectively connected with the filter circuit and the control module of the pipetting device, and the second end of the first resistor is connected with the air pressure sensing module.
Preferably, the filter circuit comprises a second resistor and a capacitor connected in parallel across the second resistor.
Preferably, the air pressure sensing module is an air pressure sensing chip.
Preferably, the multi-channel pipetting device comprises M independent channels, and the liquid level detection module comprises liquid level detection circuits of the M independent channels; the M liquid level detection circuits are integrated on one circuit board.
Preferably, a first pin of the air pressure sensing chip is connected with +5V voltage, a second pin is connected with a first resistor R6, and a third pin is grounded;
the resistance of the first resistor R6 is 2K, the resistance of the capacitor C38 is 100p (pF), and the resistance of the second resistor R50 is 3.3K.
The application also provides a multichannel pipetting device, which comprises a direct current servo motor, a control module and the liquid level detection module.
Preferably, the liquid-transfering device also comprises a screw assembly and a piston, the direct current servo motor is connected with the screw assembly, and the screw assembly drives the piston; the liquid level detection module is arranged corresponding to the cavity of the piston.
Preferably, the control module comprises a microprocessor module, an FPGA module, a motor speed regulation module, a CAN communication module, a motor zero position detection module and a motor driving module;
the microprocessor module is connected with the FPGA module, the liquid level detection module and the CAN communication module;
the FPGA module is connected with the motor driving module and the motor zero position detection module;
the motor driving module is connected with the direct current servo motor;
the motor speed regulation module is respectively connected with the microprocessor module and the motor driving module.
Preferably, the direct current servo motor is provided with a motor encoder, and the motor encoder is connected with the FPGA module; the FPGA module comprises a motor control module, an orthogonal counter module and a first communication module;
the first communication module is in communication with the microprocessor; the orthogonal counter module is connected with a motor encoder;
the number of the direct current servo motors is M; each direct current servo motor corresponds to one orthogonal counter module and one motor control module in the FPGA.
Compared with the prior art, the method has the following beneficial effects:
the liquid level detection module detects the tiny air pressure change in the piston cavity through the high-precision air pressure sensing probe of the air pressure sensing module, and the air pressure change in the cavity brought by the contact of the tip of the sensing probe head with the liquid level is achieved. When the liquid-moving head of the liquid-moving device approaches to the liquid surface, the air pressure in the cavity can be continuously changed, and when the air pressure reaches a set value, the control module sends an instruction to the motor (for example, the microprocessor sends the instruction to the FPGA, and finally triggers the motor driving module to work).
The air pressure sensing module is used, so that the detection sensitivity can be flexibly set, and high-density integration in multi-channel liquid transfer is facilitated; meanwhile, the sample does not need to be electrified, and the defect of capacitance detection is avoided.
Drawings
FIG. 1 is a schematic structural diagram of a control system of a multi-channel pipetting device provided by an embodiment of the application;
FIG. 2 is a schematic diagram of a circuit structure of a liquid level detection module according to a preferred embodiment of the present application;
fig. 3 is a schematic circuit diagram of a motor driving module according to an embodiment of the present disclosure.
Reference numerals:
the liquid level detection module 10, the motor zero position detection module 20, the motor speed regulation module 30, the microprocessor module 40, the CAN communication module 50, the FPGA module 60 and the motor driving module 70.
Detailed Description
In order to make the objects, technical solutions and advantages of the present application clearer, the present application will be described in further detail with reference to the accompanying drawings, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
The present application is further described with reference to the following figures and examples:
example (b):
as shown in FIG. 1, the present embodiment provides a multi-channel pipetting device including a motor, a control module, and a liquid level detection module 10.
The application is a liquid-transfering device of electronic piston formula. Wherein, the liquid transferring is carried out by a gas replacement mode through driving a screw rod assembly (a screw rod assembly) of the liquid transferring device by a motor and causing a polished rod to move up and down in a piston. The motor rotates forward or backward to drive the screw rod (screw rod) to rotate, the screw rod assembly is used for converting the rotation motion into up-and-down motion and driving the polished rod, and finally the polished rod changes the motion position of the piston to realize quantitative liquid suction or liquid spraying.
The control module is connected with the liquid level detection module 10 and is used for controlling the action of the motor.
And the liquid level detection module 10 is connected with the control module of the liquid-moving device and is used for realizing the detection of the liquid level heights of the samples in different channels and preparing for the subsequent liquid-moving action.
The control module of this application can be control chip, through a control chip control motor. Preferably, however, the control module of the present application includes a microprocessor module 40, an FPGA module 60, a motor speed regulation module 30, and a motor drive module 70.
The motor of the application is preferably a direct current servo motor, the torque density of the direct current servo motor is large, the size is small, the operation is stable, the positioning is accurate, and the motor is suitable for the field with strict requirements on displacement.
The liquid level detection module of the application is in a pneumatic detection mode. The liquid level detection module comprises a liquid level detection circuit, and the liquid level detection circuit comprises an air pressure sensing module. The piston assembly comprises a polished rod (pull rod), a piston head, a cavity and a liquid moving head which are sequentially connected from top to bottom. The polished rod is connected with the screw rod, and the screw rod is connected with the piston head and drives the piston head to move in the cavity. The liquid transferring head is extended out for sucking and spraying liquid. The liquid level detection module 10 is arranged corresponding to the cavity of the piston. The air pressure sensing module realizes liquid level height detection through air pressure change when the air pressure sensing module approaches the liquid level.
The liquid level detection module 10 of the present application can be realized by detecting the tiny air pressure change in the piston cavity through the high-precision air pressure inductive probe. When the pipetting head of the pipetting device approaches to the liquid surface, the air pressure in the cavity can be continuously changed,
this application liquid level atmospheric pressure sensing module can set up detectivity in a flexible way, and the high density integration of being convenient for moves liquid in the multichannel moreover. Meanwhile, the sample is not required to be electrified, so that the defect of capacitance detection is overcome.
As shown in fig. 2, the liquid level detection module is a schematic circuit structure diagram, and the liquid level air pressure sensing module includes an air pressure sensor. The air pressure sensor of the present application is preferably an air pressure sensing chip J1. The liquid level air pressure sensing module comprises a sensor, a first resistor R6 and a filter circuit.
The first end of the first resistor R6 is respectively connected with the control module and the filter circuit, and the second end of the first resistor R6 is connected with the air pressure sensing chip. The filter circuit comprises a second resistor R50 and a capacitor C38 connected in parallel across the second resistor R50.
The first pin of the air pressure sensing chip J1 is connected with +5V voltage, the second pin is connected with the first resistor R6, and the third pin is grounded.
One end of the second resistor R50, which faces away from the first resistor R6, is grounded.
As a preferred embodiment, the liquid level detection circuit for the multi-channel pipetting device has the first resistor R6 with the resistance of 2K, the capacitor C38 with the resistance of 100p (pF) and the second resistor R50 with the resistance of 3.3K.
The air pressure sensing chip J1 includes a high precision air pressure sensing probe. The air pressure induction probe is provided with a probe head tip.
The liquid level detection module of this application detects the tiny atmospheric pressure change in the piston cavity through atmospheric pressure response chip J1's high accuracy atmospheric pressure inductive probe, and the inside atmospheric pressure change of cavity that the tip contact liquid level of perception spy rifle head brought realizes. When the pipetting head of the pipetting device approaches the liquid surface, the air pressure in the cavity can be continuously changed.
The air pressure sensing chip J1 sends the detected information to the control module, and when the liquid level air pressure sensing detection module-the air pressure sensing chip J1 detects that the air pressure reaches a set value, the control module sends an instruction to the motor.
The multichannel pipetting device in this application implementation includes M independent channels (independent liquid channel), and correspondingly, the liquid level detection module can include the liquid level detection circuit of M independent channels. Wherein, M liquid level detection circuits are integrated on a circuit board. The liquid level detection module circuit used by the invention has a highly compact circuit structure, greatly reduces the circuit area, can be completely integrated on one circuit board, and has obvious effect on occasions with higher installation requirements.
A multi-channel pipetting device of the present application, a microprocessor module 40, such as an MCU unit.
A plurality of motors corresponding to the multiple channels of the pipetting device.
And a motor driving module 70 connected to the motor and driving the motor through the dc motor driving circuit.
And the motor speed regulation module 30 is connected with the motor driving module 70, and the motor speed regulation module 30 is connected with the 24V input.
The motor speed regulating module 30 is respectively connected with the microprocessor module 40 and the motor driving module 70.
The microprocessor module 40 is also connected with the liquid level detection module 10, and the liquid level detection module 10 sends the detected information to the microprocessor module 40.
The FPGA module 60 is connected with the microprocessor module 40 and receives microprocessor instructions, and the FPGA module 60 is connected with the motor driving module 70. The microprocessor module 40 sends a user instruction to the FPGA module 60, and the FPGA module 60 is used to control the motor driving module 70 to drive the motor, so as to control the position of the motor.
According to the control system of the multichannel pipetting device, the FPGA module 60 is in a logic gate control mode, and a plurality of control modules can be realized through software codes inside the FPGA. According to the control method and the control device, the FPGA logic gate is used for controlling, the multi-motor synchronous control can be realized only by copying the control module inside, extra circuit design is not needed, and the stability of the system is enhanced while the circuit is simplified. In addition, compared with the structure that a soft core is built in the FPGA, the structure that the microprocessor and the FPGA are combined is more flexible, debugging and maintenance are more rapid and reliable, and updating programs can be independently carried out without mutual interference.
When the liquid level detection module 10 detects that the liquid level reaches a certain value, the microprocessor sends an instruction to the FPGA, the FPGA controls the motor driving module 70 to stop the motor and sends liquid level height data to the upper computer, so that detection of liquid levels of different samples is realized, and preparation is made for subsequent liquid transferring actions.
As a further preferred solution, the motor is provided with an encoder, which is connected to the FPGA module 60. The encoder is, for example, a magnetic encoder, and is configured to feed back an encoding signal of the motor to the FPGA module 60; the FPGA module 60 implements accurate position control by the encoded signal fed back from the encoder. The position control of the motor is realized by feeding back a coding signal to the FPGA through a magnetic encoder.
Preferably, the FPGA module 60 of the present application includes a motor control module, a quadrature counter module, and a first communication module. The motor control module and the orthogonal counter module are realized by logic programming, the first communication module is communicated with the microprocessor, and the orthogonal counter module is connected with the motor encoder.
The two modules, the motor control module and the quadrature counter module, may control one motor. When a plurality of motors need to be controlled, only two modules, namely the motor control module and the orthogonal counter module, need to be duplicated. When the number of channels of the multi-channel pipetting device is M and the number of corresponding motors is M, each motor corresponds to one motor control module and one orthogonal counter module; a total of M motor control modules and M quadrature counter modules are required.
The control system of the present application further includes a CAN communication module 50, and the CAN communication module 50 is connected with the microprocessor module 40. The CAN communication module 50 is used for connecting a CAN bus of the system and receiving a control instruction of an external upper computer. CAN communication module 50 CAN convert external communication to microprocessor module 40, and CAN communication module 50 receives the instruction of outside host computer through with external communication, includes: a motor zero return instruction, a motor speed instruction, a motor position instruction and a liquid level detection instruction. The motor control module inside the FPGA module 60 may trigger the motor driving module 70 to operate according to the position information of the motor encoder and the instruction information of the upper computer.
The control system of the application further comprises a motor zero position detection module 20, and the motor zero position detection module 20 is connected with the FPGA module 60. Since both the pipetting head and the piston of the pipetting device have to define zero positions as starting coordinates in order to achieve an accurate positional displacement.
The motor drive module 70 of the present application, including the motor drive circuit, can drive more than ten motors simultaneously in a particular embodiment, so that only one drive module is required for multiple motors.
An FPGA, i.e., a Field Programmable Gate Array (Field Programmable Gate Array). The FPGA module of the application is, for example, an LCMXO2-4000HC model FPGA chip on the market.
The motor driving module 70 of the present application is preferably an RZ7899 driving module, and fig. 3 is a schematic diagram of a motor driving circuit of the RZ7899 driving module.
Compared with the prior art, the method has the following beneficial effects:
the liquid level detection module detects the tiny air pressure change in the piston cavity through the high-precision air pressure sensing probe of the air pressure sensing module, and the air pressure change in the cavity brought by the contact of the tip of the sensing probe head with the liquid level is achieved. When the liquid-transferring head of the liquid-transferring device is close to the liquid surface, the air pressure in the cavity can be continuously changed, and when the air pressure reaches a set value, the microprocessor sends an instruction to the FPGA.
The air pressure sensing module is used, so that the detection sensitivity can be flexibly set, and high-density integration in multi-channel liquid transfer is facilitated; meanwhile, the sample does not need to be electrified, and the defect of capacitance detection is avoided.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the embodiments of the present application and not for limiting the same, and although the embodiments of the present application are described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the embodiments of the present application, and these modifications or equivalent substitutions cannot make the modified technical solutions depart from the scope of the technical solutions of the embodiments of the present application.
Claims (10)
1. A liquid level detection module is used for a multi-channel pipetting device; the device is characterized in that the liquid level detection module is connected with a control module of the liquid transfer device and is used for realizing liquid level height detection of different channels;
the liquid level detection module comprises a liquid level detection circuit, and the liquid level detection circuit comprises an air pressure sensing module.
2. The fluid level detection module of claim 1, wherein the fluid level detection circuit further comprises a first resistor and a filter circuit; the first end of the first resistor is respectively connected with the filter circuit and the control module of the pipetting device, and the second end of the first resistor is connected with the air pressure sensing module.
3. The fluid level detection module of claim 2, wherein the filter circuit comprises a second resistor and a capacitor connected in parallel across the second resistor.
4. The liquid level detection module of claim 3, wherein the air pressure sensing module is an air pressure sensing chip.
5. The level detection module of claim 1, wherein the multi-channel pipetting device comprises M independent channels, the level detection module comprising M independent channel level detection circuits; the M liquid level detection circuits are integrated on one circuit board.
6. The liquid level detection module as claimed in claim 4, wherein a first pin of the air pressure sensing chip is connected with +5V voltage, a second pin is connected with a first resistor R6, and a third pin is grounded;
the resistance of the first resistor R6 is 2K, the resistance of the capacitor C38 is 100p, and the resistance of the second resistor R50 is 3.3K.
7. A multi-channel pipetting device comprising a DC servo motor, a control module, and a liquid level detection module according to any one of claims 1 to 6.
8. The multi-channel pipetting device of claim 7, wherein the pipetting device further comprises a screw assembly, a piston, the DC servo motor is connected to the screw assembly, and the screw assembly drives the piston; the liquid level detection module is arranged corresponding to the cavity of the piston.
9. The multi-channel pipetting device of claim 7, wherein the control module comprises a microprocessor module, an FPGA module, a motor speed regulation module, a CAN communication module, a motor zero detection module, and a motor drive module;
the microprocessor module is connected with the FPGA module, the liquid level detection module and the CAN communication module;
the FPGA module is connected with the motor driving module and the motor zero position detection module;
the motor driving module is connected with the direct current servo motor;
the motor speed regulation module is respectively connected with the microprocessor module and the motor driving module.
10. Multi-channel pipetting device according to claim 9, wherein the dc servo motor is provided with a motor encoder, which is connected to the FPGA module; the FPGA module comprises a motor control module, an orthogonal counter module and a first communication module;
the first communication module is in communication with the microprocessor; the orthogonal counter module is connected with a motor encoder;
the number of the direct current servo motors is M; each direct current servo motor corresponds to an orthogonal counter module and a motor control module which is realized by logic programming in the FPGA.
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| CN202020521400.8U CN211477294U (en) | 2020-04-10 | 2020-04-10 | Liquid level detection module and multichannel liquid-transfering device |
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| CN202020521400.8U CN211477294U (en) | 2020-04-10 | 2020-04-10 | Liquid level detection module and multichannel liquid-transfering device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112473760A (en) * | 2020-11-14 | 2021-03-12 | 上海硕控电子科技有限公司 | Air pressure type liquid level detection method and device by blowing and sucking method |
| CN114749223A (en) * | 2022-04-19 | 2022-07-15 | 英诺维尔智能科技（苏州）有限公司 | Multi-channel parallel pipetting unit with single channel capable of being independently operated |
-
2020
- 2020-04-10 CN CN202020521400.8U patent/CN211477294U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112473760A (en) * | 2020-11-14 | 2021-03-12 | 上海硕控电子科技有限公司 | Air pressure type liquid level detection method and device by blowing and sucking method |
| CN114749223A (en) * | 2022-04-19 | 2022-07-15 | 英诺维尔智能科技（苏州）有限公司 | Multi-channel parallel pipetting unit with single channel capable of being independently operated |
| CN114749223B (en) * | 2022-04-19 | 2023-09-08 | 英诺维尔智能科技（苏州）有限公司 | Multichannel parallel pipetting unit with single channel capable of being independently operated |
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Effective date of registration: 20210730 Address after: 528323 one of 502, building 2, Shunde Leliu Photoelectric Industrial Center, 85 Lianfu 1st Road, Chonghe village committee, Leliu sub district office, Shunde District, Foshan City, Guangdong Province Patentee after: Foshan Desong Scientific Instrument Co.,Ltd. Address before: 528325 one of 601, building 7, Shunde Zhifu garden, No. 8, Second Ring Road, Gaozan village committee, Xingtan town, Shunde District, Foshan City, Guangdong Province Patentee before: Foshan Shunli Cheng Biotechnology Co.,Ltd. |