CN211426445U

CN211426445U - Semisolid preparation release experimental device

Info

Publication number: CN211426445U
Application number: CN201922004959.3U
Authority: CN
Inventors: 张双; 胡一波; 郑斌; 郭超
Original assignee: Shanghai General Pharmaceutical Co Ltd
Current assignee: Shanghai Zhengda General Pharmaceutical Co ltd
Priority date: 2019-11-18
Filing date: 2019-11-18
Publication date: 2020-09-04
Anticipated expiration: 2029-11-18

Abstract

The utility model relates to a medicine test field especially relates to a semisolid preparation releases experimental apparatus. The utility model provides a semisolid preparation release experimental device, which comprises a medicine feeder and a diffusion pool; the medicine applying device comprises a flat contact part, a holding part and a preparation dispersing part, wherein the contact part and the preparation dispersing part are respectively positioned at two ends of the holding part, and the preparation dispersing part comprises a smooth smearing surface; the diffusion cell comprises a base, a fixing column, a gasket and an upper cover, wherein the base comprises a membrane fixing groove with an upper opening. The utility model provides a semi-solid preparation release experimental apparatus can reduce the loss of medicine in research and development release experiment to avoid the destruction to experiment epidermis (or see through the membrane).

Description

Semisolid preparation release experimental device

Technical Field

The utility model relates to a medicine test field especially relates to a semisolid preparation releases experimental apparatus.

Background

The transdermal diffusion instrument and the equipment matched with the transdermal diffusion instrument are common devices in the release experiment of the semisolid preparation, and the equipment or tools matched with the Triew C12 instrument in the prior art have certain defects, such as: the medicine is lost, the smearing is not uniform, the medicine is easy to stick to the wall, the medicine feeding amount is not accurate, and the like. There is therefore a need to develop a new experimental device for the release of semisolid formulations to meet the further needs in the field and to remedy the drawbacks associated with the prior art.

SUMMERY OF THE UTILITY MODEL

In view of the above-mentioned shortcomings of the prior art, the present invention is directed to a semi-solid preparation release test device for solving the problems of the prior art.

In order to achieve the above objects and other related objects, the present invention provides a semisolid formulation release test device, comprising a drug applicator and a diffusion cell;

the medicine applying device comprises a flat contact part, a holding part and a preparation dispersing part, wherein the contact part and the preparation dispersing part are respectively positioned at two ends of the holding part, and the preparation dispersing part comprises a smooth smearing surface;

the diffusion cell comprises a base, a fixed column, a gasket and an upper cover, wherein the base comprises a membrane fixed groove with an upper opening, the bottom of the fixing column is matched with the shape of the membrane fixing groove and can be detachably extended into the membrane fixing groove, the gasket is positioned between the bottom surface of the membrane fixing groove and the fixing column, the shape of the gasket is matched with that of the membrane fixing groove, the fixing column and the gasket penetrate through the medicine carrying channel in the height direction, the upper cover is used for covering the medicine carrying channel, the upper cover is provided with at least one-way valve for air to flow into the medicine carrying channel and at least one-way valve for air to flow out of the medicine carrying channel, still be equipped with the diffusion cell on the bottom surface of membrane fixed slot (211), the position of medicine carrying channel cooperatees with the position of diffusion cell, still includes liquid input pipeline and the liquid output pipeline with the diffusion cell intercommunication.

In some embodiments of the invention, the grip portion is a cone.

In some embodiments of the present invention, the bottom of the fixing column is in threaded connection with the sidewall of the membrane fixing groove.

In some embodiments of the present invention, the fixing column is cylindrical, and the extending direction of the drug carrying channel is consistent with the extending direction of the fixing column.

In some embodiments of the present invention, the extending direction of the drug carrying channel is the same as the extending direction of the diffusion groove.

In some embodiments of the present invention, the membrane fixing groove is cylindrical.

In some embodiments of the invention, the diffusion channel is cylindrical.

In some embodiments of the present invention, a positioning member for fixing the gasket is disposed in the film fixing groove.

In some embodiments of the present invention, the liquid outlet of the liquid input pipeline and the liquid inlet of the liquid output pipeline are respectively located at both sides of the diffusion groove.

In some embodiments of the present invention, the coating surface is a convex surface, and the protruding direction is the same as the extending direction of the holding portion.

Drawings

Fig. 1 is a three-view of the applicator.

Description of the element reference numerals

1 medicine feeder

11 contact part

12 grip part

13 preparation dispersing part

131 smearing surface

2 diffusion cell

21 base

211 film fixing groove

212 diffusion cell

22 fixed column

221 drug loading channel

23 shim

24 upper cover

Detailed Description

The following description is provided for illustrative purposes, and other advantages and features of the present invention will become apparent to those skilled in the art from the following detailed description.

Please refer to fig. 1. It should be understood that the structure, ratio, size and the like shown in the drawings attached to the present specification are only used for matching with the content disclosed in the specification, so as to be known and read by those skilled in the art, and are not used for limiting the limit conditions that the present invention can be implemented, so that the present invention has no technical essential meaning, and any structure modification, ratio relationship change or size adjustment should still fall within the scope that the technical content disclosed in the present invention can cover without affecting the function that the present invention can produce and the purpose that the present invention can achieve. Meanwhile, the terms such as "upper", "lower", "left", "right", "middle" and "one" used in the present specification are for convenience of description, and are not intended to limit the scope of the present invention, and changes or adjustments of the relative relationship thereof may be made without substantial technical changes, and the present invention is also regarded as the scope of the present invention.

As shown in fig. 1, the utility model provides a semisolid preparation release experimental device, which comprises a medicine applicator 1 and a diffusion cell 2; the applicator 1 comprises a flat contact part 11, a holding part 12 and a preparation dispersing part 13, the contact part 11 and the preparation dispersing part 13 are respectively positioned at two ends of the holding part 12, and the preparation dispersing part 13 comprises a smooth smearing surface 131; the diffusion cell 2 comprises a base 21, a fixing column 22, a gasket 23 and an upper cover 24, the base 21 comprises an upper opening membrane fixing groove 211, the shape of the bottom of the fixing column 22 is matched with the shape of the membrane fixing groove 211 and can be detachably extended into the membrane fixing groove 211, the gasket 23 is positioned between the bottom surface of the membrane fixing groove 211 and the fixing column 22, the shape of the gasket 23 is matched with the shape of the membrane fixing groove 211, a medicine carrying channel 221 is arranged in the fixing column 22 and the gasket 23 in a penetrating mode according to the height direction, the upper cover 24 is used for covering the medicine carrying channel 221, at least one-way valve capable of allowing gas to flow into the medicine carrying channel 221 and at least one-way valve capable of allowing gas to flow out of the medicine carrying channel 221 are arranged on the upper cover 24, a diffusion groove 212 is further arranged on the bottom surface of the membrane fixing, the medicine carrying channel 221 is matched with the diffusion groove 212 in position, and further comprises a liquid input pipeline and a liquid output pipeline which are communicated with the diffusion groove 212. When the semisolid preparation release experimental device is used, a release permeable membrane (usually a cellulose acetate membrane, a nylon membrane and the like which are changed by medicines, and also can be an artificial epidermis) to be tested can be laid at the bottom of the membrane fixing groove 211, the release permeable membrane can usually basically cover the port of the diffusion groove 212, but the outer diameter of the release permeable membrane is smaller than the inner diameter of the membrane fixing groove 211, then the gasket 23 can be placed on the surface of the release permeable membrane, and the outer diameter of the gasket 23 is usually matched with the inner diameter of the membrane fixing groove 211. Subsequently, the pad may be pressed while the preparation is placed on the release permeable membrane, the preparation may be dispersed by the smooth application surface 131 of the bulbous preparation dispersion portion 13 of the applicator to be uniformly distributed on the release permeable membrane, and the convex portion (e.g., edge portion) of the applied sphere may be improved by the flat contact portion 11 to make the distribution of the preparation more uniform. After the application is completed, the screw portion of the fixing post 22 may be coupled to the film fixing groove 211 such that the bottom of the fixing post 211 is in contact with the gasket 23, thereby fixing the release permeable film (or the epidermis) in the film fixing groove 211 through the fixing post 22. The upper cover 24 may be used to cover the fixing posts 22 from top to bottom to seal the drug carrying channel 221, and since the bottoms of the fixing posts 22 may be closed, the drug carrying channel 22 may be isolated from the outside, and the one-way valves on the upper cover 24 may be fitted with each other, thereby achieving replacement of the gas environment in the drug carrying channel 221, for example, inert gas (e.g., nitrogen, etc.) may be introduced into the drug carrying channel 221, forming an inert gas environment in the drug carrying channel 221. After the release permeation membrane and the preparation are loaded integrally, the whole device can be kept still for a period of time, and the upper cover can be covered when no bubble exists in the diffusion groove, so that the sample measurement is carried out. The upper cover 24, the fixing posts 22, the base 21, etc. are usually made of opaque materials (e.g., metal materials, etc.), so that light can be prevented from entering the drug carrying channel 221, which may affect the accuracy of the experiment.

The utility model provides an among the semi-solid preparation release experimental apparatus, the portion of gripping 12 is the straight line extension usually, and its shape can be the cylindricality on the whole, and the portion of gripping 12 is close to the cross section of contact portion 11 and can be slightly littleer, and the portion of gripping 12 is close to the cross section of preparation dispersion portion 13 and can be slightly big. The contact portion 11 is generally flat and has a width dimension generally matching the dimension of the drug loading channel 221 so that the formulation can be applied through the contact portion 11 when the pad 23 is pressed against the release permeable membrane, typically consisting of a 4mm by 2.5mm by 3mm rectangular solid and a 4mm by 2.5mm by 2mm irregular conical body. The holding direction of the rod is basically 30-90 degrees with the horizontal of the membrane in the process of medicine application (which can be changed by personal habits). The preparation dispersing part 13 comprises a smooth coating surface 131, the coating surface 131 may be a convex surface, the protruding direction of the coating surface may generally coincide with the extending direction of the holding part 12, the diameter of the preparation dispersing part 13 (i.e. the dimension perpendicular to the extending direction of the holding part 12) generally matches with the dimension of the drug loading channel 221, so that the preparation can be coated through the preparation dispersing part 13 when the gasket 23 is pressed on the release permeable membrane, generally, the preparation dispersing part 13 comprises a cylinder with a diameter of 8mm and a thickness of 1mm, one end surface of the cylinder is connected with the holding part 12, and the other end surface of the cylinder forms an arc-shaped protrusion, and the protrusion has a dimension of about 2mm (center) to form a spherical segment. The holding part 12 is a cone with an upper bottom diameter of 3mm, a lower bottom diameter of 5mm and a height of 50 mm.

In the semi-solid preparation release experimental apparatus provided by the utility model, the bottom of fixed column 22 can be connected with the lateral wall screw thread of membrane fixed slot 211. For example, the side wall of the bottom of the fixing column 22 and the side wall of the film fixing groove 211 may be provided with screw threads that are engaged with each other, so that the bottom of the fixing column 22 may be at least partially screwed into the film fixing groove 211 to achieve fixing.

The utility model provides an among the semi-solid preparation release experimental apparatus, fixed column 22 can be the cylinder, membrane fixed slot 211 also can be the cylinder, gasket 23 also can be irregular cylinder, and the external diameter of fixed column 22, gasket 23 cooperatees with the internal diameter of membrane fixed slot 211 usually, the external diameter 40mm of fixed column 22, high 30mm, spiral cover one end threaded is connected with the circular recess in the diffusion cell main part, and hole diameter 20mm, high 30 mm. The gasket 3 of the gasket 23 is made of polytetrafluoroethylene, and has an outer diameter of about 40mm, an inner diameter of 20mm and a thickness of about 3-4 mm. The extending direction of the medicine carrying channel 221 is consistent with the extending direction of the fixing column 22, the medicine carrying channel 221 can be generally cylindrical, the medicine carrying channel 221 can generally comprise hollow parts of the fixing column 22 and the gasket 23, a circular groove with the diameter of 40mm and the depth of 10mm is arranged in the main body part, threads are arranged on the wall of the circular groove, a diffusion hole with the aperture of 20mm is formed in the middle of the groove, and a space capable of containing receiving liquid is formed by hollowing below the diffusion hole.

The utility model provides an among the semi-solid preparation release experimental apparatus, the extending direction of diffusion groove 212 can be unanimous with the extending direction of medicine carrying channel 221, diffusion groove 212 also can be the cylinder, and the diameter of its cross section can be generally the same basically with the diameter of medicine carrying channel 221 cross section to can guarantee that the release sees through the membrane upper portion when experimental and the basic equivalence of lower part condition, the diameter of diffusion groove 212 cross section is 40mm, the groove height 15 mm.

The utility model provides an among the semi-solid preparation release experimental apparatus, can be equipped with in membrane fixed slot 211 and be used for fixing gasket 23's setting element, for example, can be equipped with the protruding portion on membrane fixed slot 211's the bottom surface edge and/or the inside wall, can be equipped with on the gasket 23 with protruding portion complex breach to can arrange the gasket in membrane fixed slot 211 steadily, prevent the random removal of gasket 23.

In the semi-solid preparation release experimental device provided by the utility model, the liquid outlet of the liquid input pipeline (i.e. the opening that the liquid input pipeline is located one end of the diffusion groove 212) and the liquid inlet of the liquid output pipeline (i.e. the opening that the liquid output pipeline is located one end of the diffusion groove 212) are respectively located at both sides of the diffusion groove 212, and more particularly can be located at the lower part of the diffusion groove 212. The liquid inlet of the liquid inlet conduit, which leads the liquid to the lower portion of the diffuser trough 212, is typically located outside the base 21 and the liquid outlet of the liquid inlet conduit, which leads the liquid to the lower portion of the diffuser trough 212, may be located within the diffuser trough 212, and more particularly, in the lower portion of the diffuser trough 212. The liquid outlet of the liquid outlet conduit may be located outside the base 21 so that liquid may be drawn out from the lower portion of the diffusion tank 212. The openings of the liquid input pipe and the liquid output pipe in the diffusion tank 212 may be respectively located at both sides of the diffusion tank 212 to allow a sufficient residence time of the liquid introduced into the diffusion tank 212 in the diffusion cell. The outlet of the liquid inlet line is typically lower than the inlet of the liquid outlet line, e.g., at the bottom of the diffusion cell 212, so that the liquid in the bottom of the diffusion cell 212 is free of the drug, and the inlet of the liquid outlet line is located at the lower portion of the diffusion cell 212 near the release permeable membrane to be tested.

The utility model provides a semi-solid preparation release experimental apparatus can reduce the loss of medicine in research and development release experiment to avoid the destruction to experiment epidermis (or see through the membrane), in the experimentation, the degree of consistency of preparation also can be further increased, and can avoid hand and medicine contact, make the experiment more simple and convenient, high-efficient. To sum up, the utility model discloses various shortcomings in the prior art have effectively been overcome and high industry value has.

The above embodiments are merely illustrative of the principles and effects of the present invention, and are not to be construed as limiting the invention. Modifications and variations can be made to the above-described embodiments by those skilled in the art without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which may be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.

Claims

1. A semi-solid preparation release experimental device is characterized by comprising a medicine applicator (1) and a diffusion pool (2);

the medicine applying device (1) comprises a flat contact part (11), a holding part (12) and a preparation dispersing part (13), the contact part (11) and the preparation dispersing part (13) are respectively positioned at two ends of the holding part (12), and the preparation dispersing part (13) comprises a smooth smearing surface (131);

the diffusion cell (2) comprises a base (21), a fixing column (22), a gasket (23) and an upper cover (24), wherein the base (21) comprises an upper open membrane fixing groove (211), the shape of the bottom of the fixing column (22) is matched with the shape of the membrane fixing groove (211) and can detachably extend into the membrane fixing groove (211), the gasket (23) is positioned between the bottom surface of the membrane fixing groove (211) and the fixing column (22), the shape of the gasket (23) is matched with the shape of the membrane fixing groove (211), a medicine carrying channel (221) is arranged in the fixing column (22) and the gasket (23) in a penetrating mode according to the height direction, the upper cover (24) is used for covering the medicine carrying channel (221), at least one-way valve capable of allowing a gas to flow into the medicine carrying channel (221) and at least one-way valve capable of allowing the gas to flow out of medicine carrying channel (221) are arranged on the upper, still be equipped with diffusion groove (212) on the bottom surface of membrane fixed slot (211), the position of medicine carrying channel (221) cooperatees with the position of diffusion groove (212), still includes liquid input pipeline and the liquid output pipeline with diffusion groove (212) intercommunication.

2. The semi-solid formulation release testing device of claim 1, wherein the grip portion (12) is cylindrical.

3. The semi-solid formulation release assay device of claim 1, wherein the bottom of the fixed post (22) is threaded to the sidewall of the membrane fixation slot (211).

4. The semi-solid formulation release test device according to claim 1, wherein the fixing posts (22) are cylindrical, and the extension direction of the drug-loading channel (221) is consistent with the extension direction of the fixing posts (22).

5. The semi-solid formulation release test device according to claim 1, wherein the drug-loaded channel (221) extends in a direction that coincides with the extension direction of the diffusion groove (212).

6. The semi-solid formulation release assay device of claim 1, wherein the membrane-fixation groove (211) is cylindrical.

7. The semi-solid formulation release assay device of claim 1, wherein the diffusion channel (212) is cylindrical.

8. The semi-solid preparation release assay device of claim 1, wherein a positioning member for fixing the spacer (23) is disposed in the membrane fixing groove (211).

9. The semi-solid formulation release assay device of claim 1, wherein the liquid outlet of the liquid input conduit and the liquid inlet of the liquid output conduit are located on opposite sides of the diffusion cell (212).

10. The semi-solid formulation release test device of claim 1, wherein the spreading surface (131) is convex and protrudes in a direction corresponding to the extension direction of the grip portion (12).