CN211384948U - Simple preparation device for exosome sustained-release gel - Google Patents
Simple preparation device for exosome sustained-release gel Download PDFInfo
- Publication number
- CN211384948U CN211384948U CN201921869931.XU CN201921869931U CN211384948U CN 211384948 U CN211384948 U CN 211384948U CN 201921869931 U CN201921869931 U CN 201921869931U CN 211384948 U CN211384948 U CN 211384948U
- Authority
- CN
- China
- Prior art keywords
- exosome
- injector
- sustained
- mixing device
- release gel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
Abstract
The utility model provides a simple exosome sustained-release gel preparation device, which comprises a plurality of injectors, a pushing injection base, a mixing device and a nozzle; the plurality of syringes are arranged in parallel, and the bottom surfaces of the syringes are fixedly connected with the injection base; the injection end of the injector is communicated with the feed end of the mixing device; mixing arrangement's discharge end is equipped with the nozzle to it is relatively more complicated to solve current gel preparation flow, has higher requirement to equipment and consumptive material and technique, promotes comparatively difficult problem clinically.
Description
Technical Field
The utility model relates to a medical equipment technical field especially relates to a simple and easy exosome sustained-release gel preparation facilities.
Background
Exosomes are nanoscale vesicles of cellular origin, about 30-150nm in diameter. Exosomes are composed of phospholipid bilayer membranes, membrane proteins, internal proteins, nucleic acids, and the like. The biological function of exosomes is the transmission of intercellular information. With the progress of related research and the deep knowledge of exosomes in recent years, the role of exosomes in the fields of tissue regeneration and tissue engineering is highlighted. Exosomes are now considered as the next generation of tissue repair tools following stem cells, i.e. "cell-free component" tissue regeneration techniques. Compared with the stem cell transplantation technology, the exosome transplantation technology has the advantages of no cell component in the graft, lower immunogenicity and higher safety. In addition, a great deal of research shows that the capacity of promoting tissue repair after the transplantation of the exosome derived from the stem cells is equivalent to the treatment effect of the direct transplantation of the stem cells derived from the exosome.
A large number of documents report that sodium alginate is an ideal exosome carrier. The sodium alginate has good biocompatibility and high safety, has certain anti-inflammatory effect, and is an ideal drug sustained-release system. The exosome wrapped by the sodium alginate is released in the process of degrading the sodium alginate. Compared with the direct use of the exosome, the exosome can be immobilized in a specific area to be released continuously in a certain time after being wrapped by sodium alginate gel. However, when the solution containing exosome is directly used, the problems of solution loss, rapid exosome release, short duration and the like may occur.
However, the exosome-containing sodium alginate gel in laboratory research is prepared by professional scientific researchers in an aseptic operation room by using equipment and consumables such as an aseptic operation table, an aseptic gun head, a liquid transfer device, a liquid transfer gun, an aseptic test tube and an aseptic culture dish. The preparation process is relatively complex and has high requirements on equipment, consumables and technology. These drawbacks make it difficult to popularize clinically.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a preparation exosome sodium alginate gel is simple and convenient to greatly reduced operation degree of difficulty reduces the simple and easy exosome slowly-releasing gel preparation facilities of preparation cost.
In order to achieve the purpose, the utility model provides a simple exosome sustained-release gel preparation device, which comprises a plurality of injectors, a pushing injection base, a mixing device and a nozzle;
the plurality of injectors are arranged in parallel, and the bottom surfaces of the injectors are fixedly connected with the injection base; the injection end of the injector is communicated with the feed end of the mixing device; the discharge end of the mixing device is provided with the nozzle.
Preferably, the syringe comprises three syringes: a sodium alginate injector, an exosome microinjector and a calcium chloride injector; the three injectors are arranged in parallel side by side.
Preferably, the three syringes are of uniform length; the ratio of the cross-sectional areas of the three injectors is equal to the ratio of the volumes required for mixing the solutions
Preferably, the injection section of the injector is communicated with the mixing device through a connecting pipe.
Preferably, the surface of the bolus injection base is provided with a plurality of protrusions; a groove matched with the protrusion is preset on a piston handle at the end part of the piston of the injector; the protrusion is embedded in the groove, so that the push injection base is connected with the injector in a positioning mode.
Preferably, the mixing device is a turbulent mixing device, and two turbulent devices are erected in the turbulent mixing device; the two turbulence devices are alternately and repeatedly arranged along the long axis direction of the turbulence mixing device; the two turbulence devices comprise four turbulence arms, and the adjacent turbulence arms on the same turbulence device are vertically arranged; two vortex arms of the vortex device are arranged at an included angle of 45 degrees.
Preferably, the simple exosome sustained-release gel preparation device further comprises a holding handle, and the handle comprises a handle, a left wrapping edge and a right wrapping edge; the surface of the handle is provided with an embedding groove, and the left wrapping edge and the right wrapping edge are provided with clamping blocks matched with the embedding groove; the inner surfaces of the left wrapping edge and the right wrapping edge are provided with grooves matched with the periphery of the injector; the left edge covering and the right edge covering are wrapped on the periphery of the injector, and the left edge covering, the right edge covering and the handle are fixedly connected through the matching of the clamping block and the embedding groove.
Compared with the prior art, the utility model has the advantages that: the utility model discloses a simple and easy exosome sustained-release gel preparation facilities only need use the syringe of three customizations to extract sodium alginate solution, contain exosome's solution and calcium chloride solution respectively to install accessories such as base, handle, connecting pipe, mixing arrangement, nozzle can, install very simple.
After the injection device is installed, only the injection base needs to be pushed, three solutions in the injector flow into the turbulent flow mixing device according to a preset ratio, and the three solutions are fully mixed gel after flowing out of the nozzle. The device is simple and convenient to operate, after the components after sterilization are combined, the gel prepared according to the operation instruction is the sterile gel containing the exosome, the difficulty of exosome allocation is greatly reduced, a large number of devices do not need to be prepared, operation is not needed after training of professionals, and therefore the operation cost is correspondingly reduced.
Drawings
Fig. 1 is a schematic structural diagram of a simple exosome sustained-release gel preparation apparatus according to an embodiment of the present invention;
FIG. 2 is a cross-sectional view of a mixing device in a simple exosome sustained-release gel preparation device according to an embodiment of the present invention;
fig. 3 is a schematic view of a simple exosome sustained-release gel preparation device and a holding handle according to an embodiment of the present invention;
fig. 4 is a schematic view illustrating an assembly of a simple exosome sustained-release gel preparation device and a holding handle according to an embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention clearer, the technical solutions of the present invention will be further described below.
As shown in fig. 1, the utility model provides a simple exosome sustained-release gel preparation device, which comprises a plurality of injectors 1, a pushing injection base 2, a mixing device 3 and a nozzle 4;
the plurality of syringes 1 are arranged in parallel, and the bottom surfaces of the syringes 1 are fixedly connected with the injection base 2; the injection end of the injector 1 is communicated with the feed end of the mixing device 3; the discharge end of the mixing device 3 is provided with a nozzle 4.
In the present embodiment, the syringe 1 includes three syringes 1: a sodium alginate injector 11, an exosome microinjector 12 and a calcium chloride injector 13; the three injectors 1 are arranged in parallel side by side, and the lengths of the three injectors 1 are consistent; the ratio of the cross-sectional areas of the three syringes 1 is equal to the ratio of the volumes required for mixing the respective solutions.
Three syringe 1 absorbs corresponding sodium alginate solution, exosome solution and calcium chloride solution respectively, absorbs the back, and operating personnel only need promote to push injection base 2, can guarantee that three syringe 1 injects the solution to mixing arrangement 3 in step according to certain proportion volume, forms exosome slowly-releasing gel after mixing arrangement 3 mixes, from the blowout of nozzle 4.
In the present embodiment, the injection section of the injector 1 communicates with the mixing device 3 via a connecting tube.
In this embodiment, the surface of the bolus base 2 is provided with a plurality of protrusions; a groove matched with the bulge is preset on a piston handle at the end part of the piston of the injector 1; the protrusion is embedded in the groove, so that the push injection base 2 is connected with the injector 1 in a positioning manner; the positioning between the injection base 2 and the injector 1 is realized by the matching of the groove and the bulge; the operator pushes the injection base 2 to realize the synchronous output of the solution in the three injectors 1.
As shown in fig. 2, in the present embodiment, the mixing device 3 is a turbulent mixing device 3, and two flow disturbing devices are erected in the turbulent mixing device 3; the two turbulence devices are alternately and repeatedly arranged along the long axis direction of the turbulence mixing device 3; the two turbulence devices comprise four turbulence arms, and adjacent turbulence arms on the same turbulence device are vertically arranged; the turbulence arms of the two turbulence devices are arranged at an included angle of 45 degrees; due to the arrangement of the turbulence device, three solutions can be promoted to form turbulence in the mixing device 3 to the greatest extent, and the uniform mixing of the liquids is promoted.
As shown in fig. 3 and 4, in this embodiment, the simple exosome sustained-release gel preparation device further comprises a holding handle 5, and the holding handle comprises a handle 51, a left covered edge 52 and a right covered edge 53; the surface of the handle 51 is provided with an embedding groove, and the left edge covering 52 and the right edge covering 53 are provided with clamping blocks matched with the embedding groove; the inner surfaces of the left edge-covering 52 and the right edge-covering 53 are both provided with grooves matched with the periphery of the injector 1; the left edge-covering 52 and the right edge-covering 53 are wrapped on the periphery of the injector 1, and the left edge-covering 52, the right edge-covering 53 and the handle 51 are fixedly connected through the matching of the fixture blocks and the embedding grooves; the setting of handle, first stability that can guarantee three syringe 1, the second can increase stability and convenient degree of operating personnel's operation.
The above description is only for the preferred embodiment of the present invention, and does not limit the present invention. Any technical personnel who belongs to the technical field, in the scope that does not deviate from the technical scheme of the utility model, to the technical scheme and the technical content that the utility model discloses expose do the change such as the equivalent replacement of any form or modification, all belong to the content that does not break away from the technical scheme of the utility model, still belong to within the scope of protection of the utility model.
Claims (7)
1. A simple preparation device for exosome sustained-release gel is characterized by comprising a plurality of injectors, a push injection base, a mixing device and a nozzle;
the plurality of injectors are arranged in parallel, and the bottom surfaces of the injectors are fixedly connected with the injection base; the injection end of the injector is communicated with the feed end of the mixing device; the discharge end of the mixing device is provided with the nozzle.
2. The simple exosome sustained-release gel preparation device according to claim 1, characterized in that said injector comprises three injectors: a sodium alginate injector, an exosome microinjector and a calcium chloride injector; the three injectors are arranged in parallel side by side.
3. The device for preparing a simple exosome sustained-release gel according to claim 2, wherein the three syringes are uniform in length; the ratio of the cross-sectional areas of the three injectors is equal to the ratio of the volumes required for mixing the respective solutions.
4. The device for preparing a simple exosome sustained-release gel according to claim 1, wherein the injection section of the injector is communicated with the mixing device through a connecting pipe.
5. The device for preparing the simple exosome sustained-release gel according to claim 1, wherein a plurality of protrusions are arranged on the surface of the bolus injection base; a groove matched with the protrusion is preset on a piston handle at the end part of the piston of the injector; the protrusion is embedded in the groove, so that the push injection base is connected with the injector in a positioning mode.
6. The device for preparing the simple exosome sustained-release gel according to claim 1, wherein the mixing device is a turbulent mixing device, and two flow disturbing devices are erected in the turbulent mixing device; the two turbulence devices are alternately and repeatedly arranged along the long axis direction of the turbulence mixing device; the two turbulence devices comprise four turbulence arms, and the adjacent turbulence arms on the same turbulence device are vertically arranged; two vortex arms of the vortex device are arranged at an included angle of 45 degrees.
7. The device for preparing the simple exosome sustained-release gel according to claim 1, further comprising a holding handle, wherein the handle comprises a handle, a left edge covering and a right edge covering; the surface of the handle is provided with an embedding groove, and the left wrapping edge and the right wrapping edge are provided with clamping blocks matched with the embedding groove; the inner surfaces of the left wrapping edge and the right wrapping edge are provided with grooves matched with the periphery of the injector; the left edge covering and the right edge covering are wrapped on the periphery of the injector, and the left edge covering, the right edge covering and the handle are fixedly connected through the matching of the clamping block and the embedding groove.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921869931.XU CN211384948U (en) | 2019-11-01 | 2019-11-01 | Simple preparation device for exosome sustained-release gel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921869931.XU CN211384948U (en) | 2019-11-01 | 2019-11-01 | Simple preparation device for exosome sustained-release gel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN211384948U true CN211384948U (en) | 2020-09-01 |
Family
ID=72228896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201921869931.XU Active CN211384948U (en) | 2019-11-01 | 2019-11-01 | Simple preparation device for exosome sustained-release gel |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN211384948U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110756128A (en) * | 2019-11-01 | 2020-02-07 | 上海市第六人民医院 | Simple preparation device for exosome sustained-release gel |
-
2019
- 2019-11-01 CN CN201921869931.XU patent/CN211384948U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110756128A (en) * | 2019-11-01 | 2020-02-07 | 上海市第六人民医院 | Simple preparation device for exosome sustained-release gel |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN211384948U (en) | Simple preparation device for exosome sustained-release gel | |
| BR0015832A (en) | Medical front injector and syringes, syringe interfaces, syringe adapters and syringe plungers for use with the same | |
| CN109055216B (en) | High-throughput 3D cell, tissue-like and organ-like dynamic culture system | |
| EP1647255A3 (en) | Method for preparing sclerosing foams and medical device for implementing said method | |
| CN110756128A (en) | Simple preparation device for exosome sustained-release gel | |
| CN208943252U (en) | A kind of double base mixer | |
| CN209098693U (en) | A kind of intermittent streaming electrotransfection device | |
| CN205031560U (en) | Nursing dispensing device | |
| CN214486683U (en) | Bone meal and rich platelet plasma, thrombase solution mixing arrangement | |
| CN205698521U (en) | A kind of cillin bottle drug dispensing component | |
| CN215250929U (en) | Umbilical cord mesenchymal stem cell culture is with annotating material device | |
| CN210886014U (en) | Easy operation type fluid infusion frame | |
| CN210301735U (en) | Combined syringe | |
| CN208943058U (en) | A kind of duplex mixing syringe with buckle structure | |
| CN213344085U (en) | Unmanned aerial vehicle fertilization dispensing device | |
| CN212247072U (en) | Micro-fluidic device for in-vitro 3D cell and tissue culture | |
| CN106010966B (en) | System is perfused in multi-direction organizational project porous material | |
| CN221061398U (en) | Novel mixing double-cavity injector | |
| CN214762653U (en) | Anti-aging medicament injector convenient for controlling injection dosage | |
| CN219398518U (en) | Multi-injection mixing injector | |
| CN210752579U (en) | Preparation device of core-shell structure microgel | |
| JP2007202430A (en) | Hollow yarn bundle module for cell culture | |
| CN2633332Y (en) | Injector for intervening therapeutic tumor | |
| CN219728598U (en) | Medicine partial shipment device for biological medicine production | |
| CN216419178U (en) | Single tube mixer and be convenient for operation's pair injection hybrid system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |