CN211324918U - Cystoscope capable of capturing cells - Google Patents

Abstract

The utility model provides a can catch cystoscope of cell, it has the image acquisition end that carries out image acquisition with can inserting the bladder, is provided with the cell capture unit in this image acquisition end, and the cell capture unit holds the insertion in the bladder along with image acquisition, and can constitute the discernment and the seizure to bladder epithelium cell in the bladder. The utility model discloses a cystoscope of cell can catch through setting up the cell capture unit of holding at image acquisition, can make this cell capture unit hold the insertion in the bladder along with image acquisition, and can realize directly gathering the urothelial cell in the bladder to can improve the reliability that the urothelial cell gathered.

Description

Cystoscope capable of capturing cells

Technical Field

The utility model relates to the field of medical equipment, in particular to a cystoscope capable of capturing cells.

Background

Currently, in diagnosis or treatment of many diseases, in order to accurately judge the cause of disease and to perform pathological culture, it is often necessary to collect human cells for corresponding detection. Currently, most of cell collection methods are to sample blood or urine of a human body first, and then collect cells in a sample and use the cells for detection processing. The above cell collection methods are low in sensitivity and selectivity, and the cells in the sample are inactivated, which leads to low reliability of the collected cells.

The cystoscope is a common tool for carrying out urological examination or operation, and when the cystoscope is used, the cystoscope is connected with an external host, an insertion tube of the cystoscope is inserted into the bladder of a human body through a urethra, and then a light source is turned on to obtain images in the bladder, so that the disease condition can be diagnosed according to the image conditions.

Bladder tumors are the most common tumors in the urinary system, with 95% of the bladder tumor tissue types being epithelial tumors, with over 90% of these migrating epithelial cancers, the most abundant in the lateral and posterior walls of the bladder, followed by the trigones and the roof, and the occurrence of bladder tumors can be multicentric. Bladder tumors can be accompanied with renal pelvis tumors, ureter tumors and urethral tumors sequentially or simultaneously, and the incidence rate of bladder tumors is second to that of prostate cancer in male genitourinary tumors, and is the second place, which is the first place in China. Wherein the incidence rate of the male is about 3-4 times that of the female, and the age is more than 50-70 years old.

In the diagnosis and treatment of bladder tumor, it is effective to collect bladder epithelial cells for the purpose of etiological observation and diagnosis, but in view of the shortcomings of the conventional cell collection methods, it is necessary to develop a method capable of directly collecting cells in the bladder of a human body by being combined with a cystoscope.

SUMMERY OF THE UTILITY MODEL

In view of the above, the present invention is directed to a cystoscope capable of capturing cells, so as to be used for capturing bladder epithelial cells in the bladder.

In order to achieve the above purpose, the technical scheme of the utility model is realized like this:

a cystoscope capable of capturing cells is provided with an image acquisition end which can be inserted into a bladder for image acquisition, a cell capture unit is arranged on the image acquisition end, and the cell capture unit can identify and capture bladder epithelial cells in the bladder along with the insertion of the image acquisition end into the bladder.

Further, the cell capturing unit comprises a substrate arranged at the image collecting end, one end of the substrate is provided with a capturing area which can extend out of the image collecting end, and the surface of the outer peripheral wall of the capturing area is provided with active molecules which can identify and capture bladder epithelial cells.

Further, the substrate is in a long-strip columnar shape.

Further, the cross section of the substrate is square, circular or polygonal, an organic coating or an inorganic coating is coated on the surface of the outer peripheral wall of the trapping region, and the active molecules are arranged on the organic coating or the inorganic coating.

Further, the active molecule is configured as a molecule that recognizes the EpCAM, E-cadherin, vemintin, CK18, CK19, CK20 and T53 sites.

Furthermore, the cystoscope capable of capturing cells further comprises an operating handle, and the image acquisition end comprises a soft tube connected with the operating handle and a hard tube inserted in the soft tube; an instrument channel, an illumination endoscopic channel and a liquid discharge channel are arranged in the hard tube, the base body is arranged in the instrument channel, and the trapping region is positioned at the tail end of the instrument channel.

Furthermore, a hose penetrates through the instrument channel, the trapping area is arranged on the hose, the base body is arranged in the hose, an outer convex part extending along the length direction of the hose is formed on the outer surface of the hose, and the outer convex part is abutted against the inner wall of the instrument channel.

Furthermore, one end of the hose is exposed relative to the operating handle, a limiting plate with a limiting hole is fixedly arranged on the operating handle, and the exposed end of the hose penetrates through the limiting hole and can be limited at the operating handle by the limiting plate.

Further, the cell capturing unit is located on the outer wall surface of the image acquisition end, and the cell capturing unit is an active molecule which is arranged on the outer wall surface of the image acquisition end and can identify and capture bladder epithelial cells.

Further, an organic coating or an inorganic coating is covered on the outer wall surface of the image acquisition end, and the active molecules are arranged on the organic coating or the inorganic coating.

Compared with the prior art, the utility model discloses following advantage has:

(1) a can catch cystoscope of cell, through setting up the cell capture unit on image acquisition holds, can make this cell capture unit hold the insertion in the bladder along with image acquisition, and can directly discern and catch the bladder epithelial cell in the bladder to can improve the reliability that bladder epithelial cell gathered.

(2) The cell capturing unit comprises a substrate, one end of the substrate is provided with a capturing area, the surface of the capturing area is provided with an antibody or polypeptide capable of identifying and capturing bladder epithelial cells, the cell capturing unit is sent into a bladder by using a cystoscope, and the capturing of the bladder epithelial cells is realized by the antibody or polypeptide on the capturing area of the cell capturing unit.

(3) The soft tube is wrapped outside the hard tube, so that the softness of the insertion tube is moderate, and meanwhile, the insertion guide head is arranged, so that the cystoscope is conveniently and smoothly inserted into the bladder during operation, and the pain of a patient is relieved.

(4) The flexible pipe is arranged in the instrument channel, the cell capturing unit can move in the instrument channel by drawing the flexible pipe, and the cell capturing unit can move to the proper position of the bladder so as to capture the bladder epithelial cells.

(5) An external convex part extending along the length direction of the hose is formed on the outer surface of the hose to prevent the trapping area of the cell capturing unit from being polluted due to the contact of the cell capturing unit and the inner wall of the instrument channel, so that the data reading and the diagnosis result of the cell capturing unit are influenced.

(6) A limiting plate at the exposed end of the hose is arranged on the operating handle to prevent the hose from being inserted too deeply or sliding out of the instrument channel.

Drawings

The accompanying drawings, which form a part hereof, are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the invention without undue limitation. In the drawings:

FIG. 1 is a schematic diagram of a cystoscope capable of capturing cells according to an embodiment of the present invention;

FIG. 2 is a cross-sectional view of a cystoscope capable of capturing cells according to embodiments of the present invention;

fig. 3 is a top view of the insertion guide head according to the embodiment of the present invention;

fig. 4 is a schematic structural diagram of a limiting plate according to an embodiment of the present invention;

FIG. 5 is a schematic diagram of a cell capture unit according to an embodiment of the present invention;

fig. 6 is a schematic structural diagram of a hose according to an embodiment of the present invention;

fig. 7 is a schematic structural view of a cross section of a hose according to an embodiment of the present invention;

FIG. 8 is a schematic view of a cystoscope capable of capturing cells according to an embodiment of the present invention;

description of reference numerals:

1-a flexible pipe, 2-a first rigid pipe, 3-a second rigid pipe, 4-a third rigid pipe, 5-an operating handle, 6-a cell capturing unit, 7-a flexible pipe, 8-a limiting plate and 9-a signal wire;

101-plug-in guide head, 201-LED lamp ring, 202-camera, 203-image sensor, 301-external convex part, 302-rubber plug, 501-rotation adjusting device, 502-mounting seat, 601-catching area, 801-limiting hole and 802-strip hole;

100-bladder, 200-illuminating endoscopic channel, 300-instrument channel, 400-drainage channel.

Detailed Description

It should be noted that, in the present invention, the embodiments and features of the embodiments may be combined with each other without conflict.

In the description of the present invention, the terms "first", "second" and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

The present invention will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.

The embodiment relates to a cystoscope capable of capturing cells, which is provided with an image acquisition end capable of being inserted into a bladder to acquire images, wherein a cell capture unit is arranged on the image acquisition end, and the cell capture unit can identify and capture bladder epithelial cells in the bladder along with the insertion of the image acquisition end into the bladder. The cystoscope capable of capturing cells of the utility model can realize the direct capture of the bladder epithelial cells from the bladder so as to improve the reliability of the collection of the bladder epithelial cells.

Based on the above design concept, an exemplary structure of a cystoscope capable of capturing cells according to the present embodiment is shown in fig. 1 and 2, and the cystoscope capable of capturing cells includes a central processing unit not shown in the drawings, an operation handle 5, a flexible tube 1 fixed on the operation handle 5, and a rigid tube inserted into the flexible tube 1, wherein the flexible tube 1 and the rigid tube form an image capturing end. The illumination endoscopic channel 200, the instrument channel 300 and the drainage channel 400 are arranged in the hard tube, and the trapping area is arranged at the tail end of the instrument channel 300.

In this embodiment, the cell capturing unit 6 is inserted into the instrument channel 300, the cell capturing unit 6 includes a long columnar substrate, and one end of the substrate has a capturing region, and the outer peripheral wall surface of the capturing region is provided with active molecules capable of recognizing and capturing bladder epithelial cells. In addition, a light source, a camera 202 and an image sensor 203 connected to a central processing unit are provided in the illumination endoscopic channel 200.

It should be noted that the cell capturing unit 6 may be disposed on the outer wall surface of the image capturing end directly in addition to the one end of the substrate, and the cell capturing unit 6 is an active molecule that is disposed on the outer wall surface of the image capturing end and can recognize and capture the bladder epithelial cells, and of course, an organic coating or an inorganic coating may be disposed on the outer wall surface of the image capturing end, and the active molecule is disposed on the organic coating or the inorganic coating.

In this embodiment, the rigid tube includes a first rigid tube 2, a second rigid tube 3, and a third rigid tube 4, which are coaxially arranged, in a cross section of the rigid tube, a central connection line of the first rigid tube 2, the second rigid tube 3, and the third rigid tube 4 is triangular, a cavity in the first rigid tube 2 forms the illumination endoscopic channel 200, a cavity in the second rigid tube 3 forms the instrument channel 300, a cavity in the third rigid tube 4 forms the liquid discharge channel 400, the rigid tube has an outer extending end extending out of the flexible tube 1, and an insertion guide head 101 is sleeved on the outer extending end.

Specifically, as shown in fig. 1 and 2, the soft tube 1 is fixed on the operation handle 5, and the hard tube is inserted into the soft tube 1, the hard tube is a stainless steel snake bone tube and includes a first hard tube 2, a second hard tube 3 and a third hard tube 4 which are coaxially arranged, on the cross section of the hard tube, the central connecting line of the first hard tube 2, the second hard tube 3 and the third hard tube 4 is triangular, and the structural schematic diagram is shown in fig. 3. The inner cavity of the first hard tube 2 forms an illumination endoscopic channel 200, the inner cavity of the second hard tube 3 forms an instrument channel 300, the inner cavity of the third hard tube 4 forms a liquid discharge channel 400, the hard tube is provided with an extending end extending out relative to the soft tube 1, and the extending end is sleeved with an insertion guide head 101 so as to be beneficial to the smooth insertion of the image acquisition end into the bladder.

In the embodiment, the soft tube 1 is used for wrapping the hard tube, so that the softness of the insertion tube is moderate, the pain born by a patient is relieved, the inserted guide head 101 is convenient to insert the cystoscope into the urethra smoothly with small force during operation, and the urination intention and the distending pain of the patient are further relieved.

Meanwhile, cavities communicated with the illumination endoscopic channel 200, the instrument channel 300 and the liquid discharge channel 400 are respectively formed in the operation handle 5, the other end of the cavity communicated with the illumination endoscopic channel 200 is connected with a signal wire 9, and the signal wire 9 is connected with the central processing unit so as to transmit signals to the central processing unit. The other end of the cavity communicated with the instrument channel 300 is provided with a mounting seat 502, and a limiting plate 8 with a limiting hole 801 is fixedly arranged on the mounting seat 502.

The limiting plate 8 of this embodiment is a plastic sheet, and its structure is shown in fig. 4, and in addition, the limiting plate 8 is provided with a long hole 802 screwed with the mounting seat 502, and through the bolt connection assembly, the limiting plate 8 is mounted on the mounting seat 502, and through different positions of the bolt connection assembly screwed in the long hole 802, so as to realize different positions of the limiting plate 8 on the operating handle 5.

The exposed end of the hose 7 passes through the limiting hole 801, and the limiting plate 8 is moved upward and fastened, so that the hose 7 is deformed and clamped at the narrow part of the limiting hole 801, and the limiting of the hose 7 by the limiting plate 8 is realized. So configured, the hose 7 is effectively prevented from being inserted too far or slipping out of the instrument channel 300. In addition, a rubber plug 302 is arranged at the exposed end of the hose 7 to seal the port of the hose 7 and reduce pollution, thereby improving the accuracy of cell detection after capture.

In addition, the operating handle 5 is further provided with a rotary adjusting device 501, the soft tube 1 is fixed in the rotary adjusting device 501, and the soft tube 1 can axially rotate through the rotary adjusting device 501, so that the position of the camera 202 can be changed conveniently, and the inside of the bladder can be observed comprehensively.

In this embodiment, an LED light ring 201 and a CMOS image sensor 203 are fixedly disposed at the front end of the illuminating endoscopic channel 200, a camera 202 is disposed at the center of the LED light ring 201, the LED light ring 201 is covered with a sterile film, a central processing unit is used to realize signal conversion and working state control of the image sensor 203, the LED light ring 201 and a display, and the image sensor 203 and a light source are electrically connected to the central processing unit through a signal line 9, so as to provide light rays required for examination and collect images and transmit the images to the display to display a diagnosis result. Meanwhile, in order to facilitate the discharge of the residual urine in the bladder 100, the drainage channel 400 is further provided in the present embodiment, so as to facilitate the cell capturing unit 6 to better capture the bladder epithelial cells.

In addition, a cell capturing unit 6 is inserted into the instrument channel 300, and the schematic configuration thereof is shown in fig. 4, wherein the cell capturing unit 6 includes a long columnar substrate, one end of the substrate is configured as a capturing region 601, and active molecules capable of recognizing and capturing bladder epithelial cells are provided on the outer peripheral surface of the capturing region 601. The cross section of the base body of the present embodiment may be square or circular, and may have a regular cross-sectional shape such as a triangle, an ellipse, or other polygons instead of the square or circular shape. The material of the base may be one of metal, nylon, polyester, and polypropylene, and stainless steel is preferably used in the case of metal.

In this embodiment, in order to facilitate the placement of the antibody or polypeptide in the trapping region 601, an organic coating or an inorganic coating may be coated on the outer peripheral wall surface of the trapping region 601, so that the antibody or polypeptide is disposed on the organic coating or the inorganic coating. Among them, when an organic coating is used, a polymer layer such as polyacrylamide hydrogel or the like can be used as the organic coating, and when an inorganic coating is used, a metal coating such as nanogold or the like can be used as the inorganic coating.

In addition, the antibody or polypeptide of this embodiment is further configured to recognize EpCAM, E-cadherin, vemintin, CK18, CK19, CK20 and T53 alleles, and when an antibody is used, the antibody may be, for example, Anti-EpCAM antibody or Anti-CK20antibody, and when a polypeptide is used, the polypeptide may be a polypeptide that recognizes one or more molecules.

In this embodiment, in order to facilitate the movement of the cell capture unit 6 within the instrument channel 300 and to the bladder 100 to a desired location for capturing bladder epithelial cells, it is shown in fig. 2 and 5 in conjunction with fig. 6. A hose 7 is arranged in the instrument channel 300 in a penetrating manner, the cell capturing unit 6 is inserted in the hose 7, one end of the cell capturing unit 6 with the capturing area 601 extends out of the hose 7, and the movement of the cell capturing unit 6 in the instrument channel 300 is realized by drawing the hose 7. The other end of the hose 7 is exposed relative to the operating handle 5, and can be limited and fixed by the limiting plate 8 which is fixed on the operating handle and is provided with the limiting hole 801.

In order to prevent the cell capturing unit 6 from contacting the inner wall of the instrument channel 300 to cause the capture area 601 of the cell capturing unit 6 to be polluted, thereby affecting the accuracy of the data of the cell capturing unit 6, an outer convex part 301 extending along the length direction of the hose 7 is formed on the outer surface of the hose 7, and the outer convex part 301 is three parts which are approximately trapezoidal in cross section and evenly distributed on the outer surface of the hose 7. The external protrusion 301 may be a plurality of ribs having a ring-shaped cross section and arranged along the length direction of the hose 7, besides the structure of the embodiment. In order to smoothly insert or remove the tube 7 into or from the instrument channel 300, guide surfaces into which the tube 7 is inserted are formed on the inner walls of both ends of the second rigid tube 3.

When the device is operated and used, the hose 7 sequentially passes through the limiting hole 801 on the limiting plate 8, the cavity on the handle, which is communicated with the instrument channel 300, and a part of the hose extends out of the instrument channel 300, then the cell capturing unit 6 is inserted into the hose 7 of the extending part, and the cell capturing unit 6 enters the instrument channel 300 along with the hose 7 and clamps the hose 7 in the limiting plate 8 for limiting by drawing the hose 7.

The cystoscope body with the cell capture unit 6 can be inserted into the urethra to reach the bladder 100, the cell capture unit 6 can be moved in the instrument channel 300 by pulling the hose 7, so that the trapping area 601 on the cell capture unit 6 can be shown in fig. 8, when the cystoscope is withdrawn after the trapping of the cell capture unit 6 is completed, the trapping area 601 on the cell capture unit 6 is returned to the instrument channel 300 along with the hose 7 by pulling the hose 7, when the trapping area 601 is returned, the trapping area 601 can be provided with a space in the instrument channel 300 through the retraction of the hose 7, and the convex part 301 on the hose 7 avoids the contact between the trapping area 601 and the inner wall of the instrument channel 300, and then the cystoscope is withdrawn.

In addition, after the cystoscope is inserted into the bladder 100 through the urethra, in order to prevent the residual urine in the bladder 100 from affecting the trapping of the bladder epithelial cells by the cell trapping unit 6, the drainage channel 400 communicated with the operation handle 5 may be opened to drain the residual urine.

When cystoscopy is performed, the insertion tube of the cystoscope needs to be inserted into a human body, so the existing cystoscope can be used only after strict disinfection, and the cleaning and disinfection steps of the cystoscope are complicated, the required time is long, and cross infection is easy to occur after repeated use. The low-cost image sensor 203 adopted in the embodiment can be used for pulling out the signal wire 9 and discarding the insertion tube together with the operating handle 5 after the cystoscope is used. The disposable use mode can reduce the risk of infection and is beneficial to protecting the health of patients.

The above description is only a preferred embodiment of the present invention, and should not be taken as limiting the invention, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (10)

1. A cystoscope capable of capturing cells, which is provided with an image acquisition end capable of being inserted into a bladder to acquire images, is characterized in that the cystoscope comprises a cell capturing unit (6) arranged on the image acquisition end, and the cell capturing unit (6) can identify and capture bladder epithelial cells in the bladder along with the insertion of the image acquisition end in the bladder.

2. A cystoscope for capturing cells as claimed in claim 1 wherein: the cell capturing unit (6) comprises a substrate arranged in the image acquisition end, one end of the substrate is provided with a capturing area (601) which can extend out of the image acquisition end, and the surface of the outer peripheral wall of the capturing area (601) is provided with active molecules which can identify and capture bladder epithelial cells.

3. A cystoscope for capturing cells as claimed in claim 2 wherein: the substrate is in a strip column shape.

4. A cystoscope for capturing cells as claimed in claim 2 wherein: the cross section of the substrate is square, circular or polygonal, an organic coating or an inorganic coating is coated on the surface of the outer peripheral wall of the trapping region (601), and the active molecules are arranged on the organic coating or the inorganic coating.

5. A cystoscope for capturing cells as claimed in claim 4, wherein: the active molecule is configured to recognize molecules at the EpCAM, E-cadherin, vemintin, CK18, CK19, CK20 and T53 sites.

6. A cell-capturing cystoscope according to any one of claims 2-5, wherein: the cystoscope capable of capturing cells is provided with an operating handle (5), and the image acquisition end comprises a soft tube (1) connected with the operating handle (5) and a hard tube inserted in the soft tube (1); an instrument channel (300), an illumination endoscopic channel (200) and a liquid discharge channel (400) are arranged in the hard tube, the substrate is arranged in the instrument channel, and the trapping region (601) is positioned at the tail end of the instrument channel (300).

7. A cystoscope for capturing cells as claimed in claim 6, wherein: the flexible pipe (7) penetrates through the instrument channel (300), the base body is arranged in the flexible pipe (7), an outer convex portion (301) extending along the length direction of the flexible pipe (7) is formed on the outer surface of the flexible pipe (7), and the outer convex portion (301) abuts against the inner wall of the instrument channel (300).

8. A cystoscope for capturing cells as claimed in claim 7, wherein: one end of the hose (7) is exposed relative to the operating handle (5), a limiting plate (8) with a limiting hole (801) is fixedly arranged on the operating handle (5), one end of the hose (7) exposed penetrates through the limiting hole (801), and the limiting plate (8) is limited at the operating handle (5).

9. A cystoscope for capturing cells as claimed in claim 1 wherein: the cell capturing unit (6) is positioned on the outer wall surface of the image acquisition end, and the cell capturing unit (6) is an active molecule which is arranged on the outer wall surface of the image acquisition end, can identify and capture bladder epithelial cells.

10. A cystoscope for capturing cells as claimed in claim 9 wherein: an organic coating or an inorganic coating is covered on the outer wall surface of the image acquisition end, and the active molecules are arranged on the organic coating or the inorganic coating.

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