CN211318330U - High-precision liquid chromatograph - Google Patents
High-precision liquid chromatograph Download PDFInfo
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- CN211318330U CN211318330U CN201922400855.4U CN201922400855U CN211318330U CN 211318330 U CN211318330 U CN 211318330U CN 201922400855 U CN201922400855 U CN 201922400855U CN 211318330 U CN211318330 U CN 211318330U
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- sample injector
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Abstract
The utility model relates to a high-precision liquid chromatograph, which comprises a liquid storage device, a vacuum pump, a mixing bin, a sample injector, a chromatographic column, a detector and a recorder, wherein the liquid storage device, the mixing bin, the sample injector, the chromatographic column and the detector are sequentially connected to form liquid phase circulation, and the recorder is used for generating the analysis chromatogram of the detector; the mixing bin comprises a bin body, the top of the bin body is respectively provided with a liquid inlet and an evacuation port, the bottom of the bin body is provided with a liquid outlet, the liquid inlet is communicated with a liquid storage device, the evacuation port is connected with a vacuum pump, and the liquid outlet is communicated with a sample injector; the liquid inlet and the liquid outlet are respectively provided with a first electromagnetic valve and a second electromagnetic valve; still include a control panel, control panel is provided with the on-off state and the positive and negative rotation of vacuum pump that are used for controlling first solenoid valve and second solenoid valve, and this scheme can effectively avoid the air to form the bubble in sample liquid to improve the analytical accuracy.
Description
Technical Field
The utility model relates to a liquid chromatograph, concretely relates to high accuracy liquid chromatograph.
Background
The liquid chromatograph is an instrument which firstly separates a mixture and then analyzes and identifies the mixture by utilizing the difference of the distribution ratio of the mixture between two liquids which are liquid-solid or immiscible. The system consists of a liquid storage device, a pump, a sample injector, a chromatographic column, a detector, a recorder and the like. The mobile phase in the reservoir is pumped into the system by a high pressure pump, the sample solution enters the mobile phase through the sample injector, and is loaded into the chromatographic column (stationary phase) by the mobile phase, because each component in the sample solution has different distribution coefficients in the two phases, when the two phases move relatively, through the distribution process of repeated adsorption-desorption, each component generates a large difference in the moving speed, and is separated into single components which flow out of the column in sequence, when passing through the detector, the sample concentration is converted into an electric signal and transmitted to the recorder, and the data is printed in the form of a map, and the schematic diagram of the system can be referred to as fig. 1.
The disadvantages of the existing systems are: the existing high-pressure pump is connected between the liquid storage device and the sample injector and used for pumping the sample into the sample injector, and in the process, due to the high-speed negative pressure difference generated by the utilization, part of air is introduced into the sample injector when the sample is pumped, so that bubbles are formed in the sample liquid and enter the chromatographic column, and finally the analysis result is deviated.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to overcome prior art not enough, provide a high accuracy liquid chromatograph, can effectively avoid the air to form the bubble in the sample liquid to improve the analytical accuracy.
The purpose of the utility model is realized through the following technical scheme:
a high-precision liquid chromatograph comprises a liquid storage device, a vacuum pump, a mixing bin, a sample injector, a chromatographic column, a detector and a recorder, wherein the liquid storage device, the mixing bin, the sample injector, the chromatographic column and the detector are sequentially connected to form liquid phase circulation, and the recorder is used for generating an analysis chromatogram of the detector;
the mixing bin comprises a bin body, the top of the bin body is respectively provided with a liquid inlet and an evacuation port, the bottom of the bin body is provided with a liquid outlet, the liquid inlet is communicated with a liquid storage device, the evacuation port is connected with a vacuum pump, and the liquid outlet is communicated with a sample injector;
the liquid inlet and the liquid outlet are respectively provided with a first electromagnetic valve and a second electromagnetic valve;
the vacuum pump further comprises a control panel, and the control panel is provided with a switch state for controlling the first electromagnetic valve and the second electromagnetic valve and positive and negative rotation of the vacuum pump.
Compare the direct suction of sample liquid sample injector with traditional utilization pump, this scheme utilizes the vacuum pump to form the negative pressure storehouse, make and form a complete vacuum in the mixing storehouse, then through first solenoid valve of control panel control and second solenoid valve, make not fill up sample liquid in the mixing storehouse, then close first solenoid valve and second solenoid valve and make the air in the sample liquid separate out, then control vacuum pump direction pressure boost, force sample liquid to get into the sample injector, thereby the bubble has been eliminated completely, the analysis precision is improved.
Further, the liquid inlet is positioned on the side surface of the top of the bin body. This design can avoid the sample liquid to get into the vacuum pump.
Further, the evacuation port is positioned at the top of the bin body and is vertically upward.
Furthermore, the bin body is a closed transparent cavity or is provided with a liquid level observation window. The liquid level in the mixing bin can be conveniently controlled, the overflow is prevented, and enough cavities are reserved for air separation.
Furthermore, the control panel is provided with an upper computer for sending control instructions, or is directly controlled by manpower. The scheme provides two control modes for the user to select.
Further, the volume of the cartridge body is more than twice the volume of the sample injector. The design ensures that the mixing bin has enough cavities to separate out air, and simultaneously ensures that the mixed sample liquid is enough for the analysis of the chromatographic column.
The utility model has the advantages that:
(1) the vacuum pump is used for manufacturing negative pressure bin drainage, and compared with the traditional direct drainage, the vacuum pump avoids the rolling of sample liquid, so that the air mixed with the sample liquid can be reduced;
(2) a semi-vacuum state of the semi-sample liquid is built in the mixing bin, so that gas in the sample liquid can be completely separated out, and the sample liquid is fed into the sample injector by utilizing reverse pressurization, so that air in the sample liquid is completely eliminated, bubble formation is avoided, and the analysis precision is improved.
Drawings
FIG. 1 is a schematic diagram of the composition of a liquid chromatograph system;
FIG. 2 is a schematic diagram of the system of the present invention;
fig. 3 is a schematic diagram of a mixing bin structure.
Detailed Description
The technical solution of the present invention is described in further detail below with reference to the accompanying drawings, but the scope of the present invention is not limited to the following description.
As shown in fig. 2, a high-precision liquid chromatograph comprises a liquid reservoir, a vacuum pump, a mixing chamber, an injector, a chromatographic column, a detector and a recorder. The above components except the mixing chamber are integrated by the components of the existing product, and the present embodiment will not describe the above components in detail for reducing the description space, but those skilled in the art will understand that any number of components of the liquid chromatograph can be used in the present solution. As shown in fig. 2, the liquid reservoir, the mixing chamber, the sample injector, the chromatographic column and the detector are connected in sequence to form liquid phase circulation, and the recorder is used for generating the analytical chromatogram of the detector; meanwhile, the detector also discharges the waste liquid after analysis, and a desirable recovery bottle or recovery tank can be arranged in order to ensure no environmental pollution. As a further preferred embodiment of the present invention, as shown in fig. 3, the mixing bin includes a bin body 1, a liquid inlet 2 and an evacuation port 4 are respectively arranged at the top of the bin body 1, a liquid outlet 3 is arranged at the bottom of the bin body 1, the liquid inlet 2 is communicated with the liquid storage device, the evacuation port 4 is connected with a vacuum pump, and the liquid outlet 3 is communicated with the sample injector; the liquid inlet 2 and the liquid outlet 3 are respectively provided with a first electromagnetic valve 6 and a second electromagnetic valve 5; the vacuum pump further comprises a control panel, and the control panel is provided with a switch state for controlling the first electromagnetic valve 6 and the second electromagnetic valve 5 and positive and negative rotation of the vacuum pump. In other words, in this embodiment, the vacuum pump is not used to directly pump the sample into the sample injector, but the vacuum pump is used to reduce or increase the pressure of the mixing chamber, which may be specifically divided into three stages, where the first stage is regarded as manufacturing a negative pressure chamber, the vacuum pump is used to vacuumize the mixing chamber, and the first electromagnetic valve 6 and the second electromagnetic valve 5 are closed in the process; the second stage is regarded as a stage of gas separation of the sample liquid, at the moment, the first electromagnetic valve 6 is opened, the sample liquid enters the mixing bin under negative pressure, the first electromagnetic valve 6 is closed when more than half of the mixing bin is filled and the rest of the cavity is filled, then the state is maintained for tens of seconds, so that the gas in the sample liquid is separated out under vacuum negative pressure, then the third stage is carried out, the vacuum pump pressurizes the mixing bin and simultaneously opens the second electromagnetic valve 5, the sample liquid enters the sample injector, the process realizes the gas purification of the sample liquid, and the control can be manually controlled or automatically controlled by setting corresponding action time according to the volume of the mixing bin and the flow of the first electromagnetic valve 6 and the second electromagnetic valve 5 by the upper computer. In some embodiments, as shown in FIG. 3, the liquid inlet 2 is located on the top side of the cartridge body 1, and the drain 4 is located on the top of the cartridge body 1 and faces vertically upward. Preferably, the bin body 1 is a closed transparent cavity or is provided with a liquid level observation window. The control panel is provided with an upper computer used for sending control instructions or is directly controlled by manpower. The volume of the cartridge body 1 is more than twice the volume of the sample injector.
The foregoing is merely a preferred embodiment of the invention, it is to be understood that the invention is not limited to the forms disclosed herein, but is not intended to be exhaustive or to limit the invention to other embodiments, and to various other combinations, modifications, and environments and may be modified within the scope of the inventive concept as described herein by the teachings or the skill or knowledge of the relevant art. But that modifications and variations may be effected by those skilled in the art without departing from the spirit and scope of the invention, which is to be limited only by the claims appended hereto.
Claims (6)
1. A high-precision liquid chromatograph is characterized by comprising a liquid storage device, a vacuum pump, a mixing bin, a sample injector, a chromatographic column, a detector and a recorder, wherein the liquid storage device, the mixing bin, the sample injector, the chromatographic column and the detector are sequentially connected to form liquid phase circulation, and the recorder is used for generating an analysis chromatogram of the detector;
the mixing bin comprises a bin body (1), the top of the bin body (1) is respectively provided with a liquid inlet (2) and an evacuation port (4), the bottom of the bin body (1) is provided with a liquid outlet (3), the liquid inlet (2) is communicated with a liquid storage device, the evacuation port (4) is connected with a vacuum pump, and the liquid outlet (3) is communicated with a sample injector;
the liquid inlet (2) and the liquid outlet (3) are respectively provided with a first electromagnetic valve (6) and a second electromagnetic valve (5);
the vacuum pump further comprises a control panel, and the control panel is provided with a switch state for controlling the first electromagnetic valve (6) and the second electromagnetic valve (5) and positive and negative rotation of the vacuum pump.
2. A high accuracy liquid chromatograph according to claim 1, characterized in that said inlet (2) is located on the top side of the cartridge body (1).
3. A high accuracy liquid chromatograph according to claim 2, characterized in that said evacuation port (4) is located at the top of the cartridge body (1) and faces vertically upwards.
4. A high accuracy liquid chromatograph according to claim 1, characterized in that said chamber body (1) is a closed transparent cavity or is provided with liquid level observation windows.
5. A high accuracy liquid chromatograph according to claim 1, wherein said control panel is provided with a host computer for sending control instructions, or is directly controlled by a human.
6. A high accuracy liquid chromatograph according to claim 1, characterized in that said cartridge body (1) has a volume greater than twice the volume of the sample injector.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922400855.4U CN211318330U (en) | 2019-12-27 | 2019-12-27 | High-precision liquid chromatograph |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922400855.4U CN211318330U (en) | 2019-12-27 | 2019-12-27 | High-precision liquid chromatograph |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN211318330U true CN211318330U (en) | 2020-08-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201922400855.4U Active CN211318330U (en) | 2019-12-27 | 2019-12-27 | High-precision liquid chromatograph |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN211318330U (en) |
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2019
- 2019-12-27 CN CN201922400855.4U patent/CN211318330U/en active Active
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