CN211244951U - Prefilled syringe - Google Patents

Abstract

The utility model discloses a embedment syringe in advance, the injection liquid of intussuseption in syringe and syringe, the syringe includes injection tube, piston, push rod, sealed cap etc. still includes the sleeve, the sleeve sets up injection tube rear end internal surface department, sleeve internal surface and its screw-thread fit injection tube internal surface parallel and level the sleeve with it has paraffin to fill between the push rod, be equipped with the capacity scale on the injection tube. The utility model provides a embedment syringe in advance, through at injection tube afterbody design sleeve, pack paraffin between sleeve and push rod, the problem that the sealed effect of the current injection tube afterbody of solution that can be fine is not good, this kind of design simple structure, reasonable, connect sealed reliable.

Description

Prefilled syringe

Technical Field

The utility model relates to a medicine preparation technical field especially relates to a embedment syringe in advance.

Background

In the operation process of the traditional injector, a solvent (injection water and the like) is firstly extracted by the injector, then a needle of the injector is pricked into a solute bottle (powder injection or water injection), then the solvent is pushed out to be mixed and dissolved with the solute, and finally the mixed liquid medicine is extracted into the injector to inject a human body or add medicine into an infusion bottle. The operation method has the disadvantages of complicated procedure, high labor intensity of nurses, and easy pollution caused by transferring the liquid medicine for several times. Most importantly, medical accidents caused by wrong administration of the medicines are easy to happen until the life safety of patients is endangered.

The pre-filled syringe is filled with the prepared medicine and then filled in the syringe, so that the problems caused by the operation of the traditional syringe are effectively avoided; however, the sealing structure at the tail of the injection tube of the prefilled syringe is used as a sterile guarantee barrier for the liquid medicine, and the sealing performance of the structure is particularly important. If the sealing effect of the part is not good, the pre-filled injection cannot be well sealed, so that the injection cannot be stored for a long time, and therefore, a pre-filled syringe with good sealing performance needs to be designed.

SUMMERY OF THE UTILITY MODEL

The utility model discloses a solve current technical defect, provide a embedment syringe in advance, through at injection tube afterbody design sleeve, it has paraffin to fill between sleeve and push rod, and this kind of design simple structure, reasonable connects sealed reliable, the current problem of sealed effect of injection tube afterbody of solution that can be fine.

The specific technical scheme is as follows: the utility model provides a embedment syringe in advance, the injection liquid of packing in syringe and syringe, the syringe includes injection tube, piston, push rod, sealed cap, the injection tube is made by polymer synthetic resin, the injection tube stack shell is the boss form, the injection tube front end is provided with the injection nozzle, the injection nozzle is the form of taper necking down, sealed cap detachable with the injection nozzle is connected, the assembly that the piston liquid-tight is in inside the injection tube, the push rod with the connection can be dismantled to the piston, still includes the sleeve, the sleeve sets up injection tube rear end internal surface department, the sleeve internal surface is rather than screw-thread fit injection tube internal surface parallel and level the sleeve with it has paraffin to fill between the push rod, be equipped with the capacity scale on the injection tube surface.

The utility model discloses among the technical scheme of preferred, the push rod comprises for columniform and cruciform two parts by the cross-section, the push rod is close to the piston end is cylindric, the cylindric partial length of push rod with sleeve length is the same, the push rod cross-section is provided with for crisscross rear end face and bulldozes the disc.

In the preferred technical solution of the present invention, the sealing cap is provided with a sealing sheet inside, one side of the sealing sheet is a plane structure, and the other side is close to the injection nozzle and is a convex structure.

The utility model discloses in the technical scheme of preferred the piston surface is provided with the sealing washer, sealing washer design quantity has threely.

The utility model discloses in the technical scheme of preferred the injection tube rear end periphery is provided with the annular handrail of oval ring to the vertical direction, the handrail is provided with the arch towards the one side of injection nozzle.

In the preferred technical scheme of the utility model, the piston the gasket the sealing washer is made by chlorinated butyl rubber.

The utility model has the advantages that: the utility model provides a embedment syringe in advance, through at injection tube afterbody design sleeve, it has paraffin to fill between sleeve and push rod, the problem that the sealed effect of the current injection tube afterbody of solution that can be fine is not good, the volume scale that sets up on the injection tube surface can audio-visual observation liquid medicine volume that the measurement was used, this kind of design simple structure, reasonable, connect sealed reliable.

Drawings

Fig. 1 is a schematic cross-sectional view of a pre-filled syringe according to an embodiment of the present invention;

fig. 2 is a schematic structural view of a pre-filled syringe according to an embodiment of the present invention;

fig. 3 is a schematic structural view of a sealing cap of a pre-filled syringe according to an embodiment of the present invention;

fig. 4 is a schematic view of a structure of a push rod of a pre-filled syringe according to an embodiment of the present invention;

fig. 5 is a schematic structural diagram of a sealing plate of a pre-filled syringe according to an embodiment of the present invention;

fig. 6 is a schematic structural view of the pre-filled and sealed syringe piston and the sealing ring according to the embodiment of the present invention.

In the figure:

10. an injector; 101. an injection tube; 1011. an injection nozzle; 1012. a handrail; 102. a piston; 103. a push rod; 1031. pushing and pressing the disc; 104. a sealing cap; 20. an injection solution; 30. a sleeve; 40. paraffin wax; 50. sealing the sheet; 60. and (5) sealing rings.

Detailed Description

The invention will be described in further detail with reference to the accompanying drawings, which are simplified schematic drawings and only schematically illustrate the basic structure of the invention, and the direction of the present embodiment is based on the direction of fig. 1.

In the description of the present invention, it is to be understood that the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on those shown in the drawings, and are merely for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically limited otherwise.

In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," and "fixed" are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meaning of the above terms in the present invention can be understood according to specific situations by those skilled in the art.

Fig. 1-2 exemplarily show a prefilled syringe provided by the present invention, which includes a syringe 10 and an emulsion injection 20 filled in the syringe, wherein the syringe 10 includes a syringe 101, a piston 102, a push rod 103, and a sealing cap 104, the syringe 101 is made of polymer synthetic resin, a barrel of the syringe 101 is in a boss shape, an injection nozzle 1011 is disposed at a front end of the syringe 101, the injection nozzle 1011 is in a tapered necking shape, the sealing cap 104 is detachably connected to the injection nozzle 1011, the piston 104 is liquid-tightly assembled inside the syringe 101, the push rod 103 is detachably connected to the piston 104, the syringe further includes a sleeve 30, the sleeve 30 is disposed at an inner surface of a rear end of the syringe 101, an inner surface of the sleeve 30 is flush with an inner surface of the syringe 101 in threaded fit, and paraffin 40 is filled between the sleeve 30 and the push rod 103, the outer surface of the injection cylinder 101 is provided with a capacity scale.

The working process of the example is as follows: the sleeve 30 is detachably connected with the inner surface of the rear end of the injection tube 101 through threads, paraffin 40 is filled between the sleeve 30 and the push rod 103, in the using process, the sleeve 30 is held, the push rod 103 is rotated to separate the paraffin 40 between the sleeve 30 and the push rod 103, the push disc 1031 is pushed, quantitative injection liquid medicine is observed according to a capacity scale arranged on the outer surface of the injection tube 101, and after the sleeve 30 and the push rod 103 rotate, the paraffin between the sleeve 30 and the push rod 103 has clear opening marks, so that secondary use of products is prevented. The front end of the piston 102 is shaped to correspond to the inner surface of the front end of the syringe barrel 101, the portion of the sleeve 30 protruding out of the syringe barrel 101 can limit the feed movement of the push rod, and when the piston 102 moves to the inner surface of the front end of the syringe barrel 101, the push disc 1031 is in contact with the sleeve 30 close to the surface of the syringe barrel 101, and the push rod 103 is prevented from moving forward.

Fig. 3 is a schematic diagram illustrating a structure of a sealing cap of a pre-filled syringe, in which a spiral groove is formed inside the sealing cap 104, and the spiral groove can be in threaded fit with a spiral protrusion at the front end of the syringe 101, and a mesh indentation is formed on the outer surface of the sealing cap 104 to increase contact friction.

Preferably, the push rod 103 is composed of two parts with a cylindrical and cross-shaped cross section, the push rod 103 is close to the end of the piston 102 and is cylindrical, the cylindrical part of the push rod 103 is as long as the sleeve 30, the cross section of the push rod 103 is a cross-shaped rear end face and is provided with a pushing disc 1031, and the push rod 103 is close to the end of the piston 102 and is designed into a cylindrical shape so as to facilitate the rotation separation of the paraffin 40 when in use.

Preferably, the outer surface of the piston 102 is provided with three sealing rings 60, and the number of the sealing rings 60 is three, so that the injection liquid is prevented from permeating out from the outer surface of the piston 102, and meanwhile, the injection liquid 20 is prevented from contacting the paraffin 40, and the sealing performance of the device is improved.

Preferably, an elliptical ring-shaped handrail 1012 is disposed on the outer circumference of the rear end of the syringe 101 in a vertical direction, and a protrusion is disposed on a surface of the handrail facing the injection nozzle, so as to increase friction force and facilitate handling. Preferably, the syringe 101 is made of transparent material, preferably transparent polymer synthetic resin, which can be synthetic resin such as PP, PE, PS, PA, PC, PVC, ABS, PET, etc.

Preferably, the piston 102, the sealing sheet 50, and the sealing ring 60 are made of chlorinated butyl rubber, since the injection solution is generally stably preserved in an aqueous solution having a pH of about 4.5, a piston made of a general rubber is easily deformed by long-term exposure to such an acidic condition, while a piston made of a chlorinated butyl rubber is not easily deformed, and the stored injection solution is stably preserved for a long time.

The emulsion injection of the utility model comprises the following raw materials by mass volume fraction: 1% of flurbiprofen axetil, 5% of medium-chain triglyceride, 5% of long-chain triglyceride, 2.5% of phospholipid mixture, 2.25% of glycerol, 0.05% of disodium hydrogen phosphate and the balance of water for injection.

The phospholipid mixture comprises the following components in percentage by weight: 80% of phosphatidylcholine, 14% of phosphatidylethanolamine, 1% of lysophosphatidylethanolamine, 1% of sphingomyelin, 1% of phosphatidylinositol, 1% of dioleoyl lecithin, 1% of dioleoylphosphatidylglycerol DOPG, and 78% of dipalmitoylphosphatidylserine DPPS 1.

A preparation method of a pre-encapsulation injection preparation of an emulsion injection comprises the following steps:

1) mixing the flurbiprofen axetil, the medium-chain triglyceride, the long-chain triglyceride, the phosphatidylcholine, the phosphatidylethanolamine, the lysophosphatidylethanolamine, the sphingomyelin, the phosphatidylinositol, the dioleoyl lecithin, the dioleoyl phosphatidylglycerol DOPG and the dipalmitoyl phosphatidylserine DPPS according to the proportion at a high speed of 40-75 ℃ to form a solution;

2) stirring and mixing the solution obtained in the step 1), glycerol and an injection water solution at the temperature of 20-40 ℃, adjusting the pH to 8 by using sodium dihydrogen phosphate, and then forming primary emulsion by using a homogenizer;

3) continuously homogenizing the primary emulsion obtained in the step 2) for 5 times under high pressure (keeping the pressure of 500kg/cm 2-600 kg/cm 2);

4) encapsulating the obtained emulsion obtained in step 3) into the syringe 10 of the utility model, and sterilizing at 115 deg.C for 30 min.

To the emulsion injection (experimental group) in the pre-filled and sealed syringe of the utility model and the emulsion injection (control group) in the pre-filled and sealed syringe on the market, the sealing and oxygen-isolating tests are carried out according to the guiding principle about the sealing test of 'the Chinese pharmacopoeia is 2015 edition'. The samples were placed in a constant temperature and humidity chamber at 40 ℃ and 25% relative humidity for 0, 1, 2, 3 and 6 months, respectively, and the results are shown in Table 1:

TABLE 1 tightness test of emulsion injection in prefilled syringes of the present invention

As can be seen from Table 1, the anisidine value, the particle size and the related substances of the injection in the pre-filled and sealed syringe of the utility model accelerated for 6 months did not change significantly compared with the control group. The pre-filling and sealing injector of the utility model has better sealing performance. The oxidation condition of the raw and auxiliary materials in the production, storage and preparation processes can be indirectly known by measuring the anisidine value, and the change value can also be known from the anisidine value, so that the oxygen barrier property is good.

While the invention has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof without departing from the spirit and scope of the invention. The present invention is not to be limited by the specific embodiments disclosed herein, and other embodiments that fall within the scope of the claims of the present application are intended to be within the scope of the present invention.

Claims (6)

1. The utility model provides a embedment syringe in advance, includes syringe and the injection liquid of syringe intussuseption, the syringe includes injection tube, piston, push rod, sealing cap, the injection tube is made by polymer synthetic resin, the injection tube stack body is the boss form, the injection nozzle is provided with at the injection tube front end, the injection nozzle is the form of taper necking down, sealing cap detachable with the injection nozzle is connected, the assembly that the piston is liquid-tight is in inside the injection tube, the push rod with the piston detachable connection, its characterized in that still includes the sleeve, the sleeve sets up in injection tube rear end internal surface department, the sleeve internal surface is rather than screw-thread fit's injection tube internal surface parallel and level, it has paraffin to fill between sleeve and the push rod, be equipped with the capacity scale on the injection tube external surface.

2. A pre-filled syringe as claimed in claim 1, wherein: the push rod comprises cylindrical and cross-shaped sections, the push rod is close to the piston end and is cylindrical, the length of the cylindrical section of the push rod is equal to that of the sleeve, and the cross-shaped section of the push rod is provided with a pushing disc for the rear end face of the cross-shaped section.

3. A pre-filled syringe as claimed in claim 1, wherein: the sealing cap is internally provided with a sealing sheet, one side of the sealing sheet is of a plane structure, and the other side of the sealing sheet is close to the injection nozzle and is of a convex structure.

4. A pre-filled syringe as claimed in claim 3, wherein: the outer surface of the piston is provided with three sealing rings, and the number of the sealing rings is three.

5. A pre-filled syringe as claimed in claim 1, wherein: an elliptical ring-shaped handrail is arranged on the periphery of the rear end of the injection tube in the vertical direction, and a protrusion is arranged on one surface, facing the injection nozzle, of the handrail.

6. The pre-filled syringe of claim 4, wherein: the piston, the sealing piece and the sealing ring are all made of chlorinated butyl rubber.

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