CN211189193U - Extraction system for extracting natural paclitaxel - Google Patents
Extraction system for extracting natural paclitaxel Download PDFInfo
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- CN211189193U CN211189193U CN201922091253.5U CN201922091253U CN211189193U CN 211189193 U CN211189193 U CN 211189193U CN 201922091253 U CN201922091253 U CN 201922091253U CN 211189193 U CN211189193 U CN 211189193U
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- tower
- extraction system
- storage tank
- chromatography
- tank
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- 238000000605 extraction Methods 0.000 title claims abstract description 30
- 229930012538 Paclitaxel Natural products 0.000 title claims abstract description 26
- 229960001592 paclitaxel Drugs 0.000 title claims abstract description 26
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title claims abstract description 26
- 239000002904 solvent Substances 0.000 claims abstract description 30
- 238000002386 leaching Methods 0.000 claims abstract description 28
- 238000004587 chromatography analysis Methods 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000003756 stirring Methods 0.000 claims description 21
- 239000003480 eluent Substances 0.000 claims description 14
- 238000010438 heat treatment Methods 0.000 claims description 12
- 230000007246 mechanism Effects 0.000 claims description 11
- 238000007599 discharging Methods 0.000 claims description 10
- 238000012856 packing Methods 0.000 claims description 7
- 239000007787 solid Substances 0.000 claims description 6
- 239000012452 mother liquor Substances 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- 239000002893 slag Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 abstract description 10
- 241001149649 Taxus wallichiana var. chinensis Species 0.000 abstract description 9
- 230000009467 reduction Effects 0.000 abstract description 4
- 238000005516 engineering process Methods 0.000 abstract description 2
- 238000012545 processing Methods 0.000 abstract description 2
- 239000012535 impurity Substances 0.000 description 9
- 238000010828 elution Methods 0.000 description 8
- 238000011084 recovery Methods 0.000 description 8
- 238000000746 purification Methods 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 241001116500 Taxus Species 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000005086 pumping Methods 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 239000012156 elution solvent Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- 238000002791 soaking Methods 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000003808 methanol extraction Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229930000044 secondary metabolite Natural products 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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Abstract
The utility model relates to a chinese yew deep-processing technology field, concretely relates to draw natural taxol's extraction system. This extract natural taxol's extraction system includes the leaching tank, and the leaching tank has connected gradually the chromatography tower through the pipeline, vacuum concentration jar and crystallizer, is equipped with the shunt between chromatography tower and the vacuum concentration jar, and shunt one end is connected with the eluant storage tank, and the eluant storage tank is through first delivery pump and the inside intercommunication of chromatography tower, and there are condenser, oil-water separator and solvent storage tank at vacuum concentration tank top through the pipe connection, and the solvent storage tank is through the inside intercommunication of second delivery pump and chromatography tower. The utility model discloses to prior art's not enough, provide a reliable performance's extraction system of drawing natural taxol, solved the current problem that the equipment solvent consumption is big and the extraction rate is low of extracting, and can reduction in production cost.
Description
Technical Field
The utility model relates to a chinese yew deep-processing technology field, concretely relates to draw natural taxol's extraction system.
Background
Paclitaxel is a complex secondary metabolite in taxus plants, and is a worldwide recognized broad-spectrum and strong-activity anticancer drug. At present, taxol is mainly extracted from taxus plant raw materials. The process of extracting taxol from Chinese yew material includes crushing, soaking, concentrating, extracting to obtain coarse taxol product, and separating and purifying to obtain high purity taxol. In the production process of extracting taxol from taxus raw materials, taxus branches and leaves are put into an extraction tank, and extraction solvent such as methanol is added, and then extraction is carried out at normal temperature or by heating. The soaking and extracting method has the following defects: firstly, the solvent consumption is large, and the solvent in the elution stage and the concentration stage cannot be effectively recycled, so that the solvent consumption is high and the production cost is high. Secondly, the extraction process takes a long time, and the content of effective components in the extract is low.
SUMMERY OF THE UTILITY MODEL
The utility model discloses to prior art's not enough, provide a reliable performance's extraction system of drawing natural taxol, solved the current problem that the equipment solvent consumption is big and the extraction rate is low of extracting, and can reduction in production cost.
The technical scheme of the utility model is realized like this: the utility model provides an extract natural taxol's extraction system includes the leaching tank, its characterized in that, the leaching tank has connected gradually chromatography tower, vacuum concentration jar and crystallizer through the pipeline, be equipped with the shunt between chromatography tower and the vacuum concentration jar, shunt one end is connected with the eluant storage tank, the eluant storage tank is through first delivery pump and the inside intercommunication of chromatography tower, there are condenser, oil-water separator and solvent storage tank at vacuum concentration tank top through the pipe connection, the solvent storage tank is linked together through second delivery pump and chromatography tower inside.
The leaching tank comprises a leaching tank body, the upper part of the tank body is provided with a feed inlet, the bottom of the tank body is provided with a discharge outlet, the tank body is internally provided with a stirring mechanism and a filter plate, the lower surface of the tank body is wrapped by an annular jacket, the upper part of the jacket is provided with a steam inlet, the lower part of the jacket is provided with a steam outlet, and a slag discharging pipe is arranged above the filter plate.
The chromatography tower includes the tower body, tower body upper portion is equipped with sealed lid, and its bottom is equipped with the drain pipe, sealed top of covering is equipped with chromatography mother liquor inlet tube, eluant inlet tube and blast pipe, the blast pipe is connected with the vacuum pump, the tower body middle part is equipped with the silica gel packing layer, the packing layer below is equipped with psammitolite and solid fixed ring, the psammitolite joint is on solid fixed ring.
The vacuum concentration tank comprises a concentration tank body, wherein a feeding pipe and a vacuum pump are arranged above the concentration tank body, a discharging pipe is arranged below the concentration tank body, a steam heating cavity is arranged on the surface of the concentration tank body, a steam inlet pipe is arranged on the upper portion of one side of the steam heating cavity, and a condensed water outlet pipe is arranged on the lower portion of the other side of the steam heating cavity.
The stirring mechanism comprises a speed reducing motor, a stirring shaft and frame type stirring blades arranged on the stirring shaft.
The utility model provides an existing defect among the background art, have following beneficial effect:
the utility model provides an extract natural paclitaxel's extraction system simple structure is reasonable, has solved the big problem with the extraction rate is low of current extraction equipment solvent consumption, and can reduction in production cost. The utility model discloses a rabbling mechanism of leaching jar stirs the immersion fluid and presss from both sides the cover steam heating and go on simultaneously, has not only guaranteed to draw the taxus chinensis completely, can also accelerate extraction rate. In the course of carrying out crude elution separation in the chromatographic column, through carrying out stage recovery to the eluant, the eluant that anterior segment impurity content is high is concentrated, recycle after the condensation, the eluant that back end impurity content is low flows into the eluant storage tank, then the pumpconware supplies the elution of new round of production anterior segment to use in supplying, the purification solvent of concentrated recovery passes through the condenser cooling, separate with oil water separator, flow into at last and retrieve in the solvent basin, the further loss that has reduced the solvent, the service efficiency is improved, the solvent rate of recovery is more than 98%, and the production cost is saved.
Drawings
Fig. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic diagram of the configuration of the leaching tank of FIG. 1;
FIG. 3 is a schematic view of the structure of the chromatography column of FIG. 1;
FIG. 4 is a schematic view of the vacuum concentration tank of FIG. 1;
in the figure: 1-leaching tank, 2-chromatographic tower, 3-vacuum concentration tank, 4-crystallizing tank, 5-eluent storage tank, 6-condenser, 7-oil-water separator, 8-solvent storage tank, 9-flow divider, 10-first delivery pump, 11-second delivery pump, 12-leaching tank, 13-stirring mechanism, 14-jacket, 15-filter plate, 16-feeding port, 17-discharging port, 18-steam inlet, 19-steam outlet, 21-tower body, 22-chromatographic mother liquor inlet pipe, 23-eluent inlet pipe, 24-liquid outlet pipe, 25-packing layer, 26-sand core, 27-vacuum pump, 31-concentrating tank, 32-steam heating chamber, 33-vacuum pump and 34-discharging pipe, 35-a steam inlet pipe and 36-a condensed water outlet pipe.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.
An embodiment of an extraction system for extracting natural paclitaxel as shown in fig. 1, fig. 2, fig. 3 and fig. 4 comprises a leaching tank 1, the leaching tank 1 is sequentially connected with a chromatography tower 2, a vacuum concentration tank 3 and a crystallization tank 4 through pipelines, a flow divider 9 is arranged between the chromatography tower 2 and the vacuum concentration tank 3, one end of the flow divider 9 is connected with an eluent storage tank 5, the eluent storage tank 5 is communicated with the inside of the chromatography tower 2 through a first delivery pump 10, the top of the vacuum concentration tank 3 is connected with a condenser 6, an oil-water separator 7 and a solvent storage tank 8 through pipelines, and the solvent storage tank 8 is communicated with the inside of the chromatography tower 2 through a second delivery pump 11. The leaching tank 1 comprises a leaching tank body 12, a feeding port 16 is arranged at the upper part of the leaching tank body 12, a discharging port 17 is arranged at the bottom of the leaching tank body, a stirring mechanism 13 and a filter plate 15 are arranged in the leaching tank body 12, an annular jacket 14 is wrapped at the lower surface of the stirring mechanism, a steam inlet 18 is arranged at the upper part of the jacket 14, a steam outlet 19 is arranged at the lower part of the jacket 14, and a slag discharging pipe is arranged above the filter plate 15. Chromatography tower 2 includes tower body 21, and tower body 21 upper portion is equipped with sealed lid, and its bottom is equipped with drain pipe 24, and sealed lid top is equipped with chromatography mother liquor inlet tube 22, eluant inlet tube 23 and blast pipe, and the blast pipe is connected with vacuum pump 27, and tower body 21 middle part is equipped with silica gel packing layer 25, and packing layer 25 below is equipped with psammitolite 26 and solid fixed ring, and the psammitolite 26 joint is on solid fixed ring. The vacuum concentration tank 3 comprises a concentration tank body 31, a feeding pipe and a vacuum pump 33 are arranged above the concentration tank body 31, a discharging pipe 34 is arranged below the concentration tank body 31, a steam heating cavity 32 is arranged on the surface of the concentration tank body 1, a steam inlet pipe 35 is arranged at the upper part of one side of the steam heating cavity 32, and a condensed water outlet pipe 36 is arranged at the lower part of the other side of the steam heating cavity. The stirring mechanism 13 includes a speed reduction motor, a stirring shaft, and a frame-type stirring blade mounted on the stirring shaft.
The utility model discloses a working process is: when the extraction process is carried out, the feeding port 16 is opened, ground taxus chinensis branch and leaf scraps are fed into the extraction tank body 12, then an extraction solvent such as a methanol extraction solvent is pumped into the extraction tank, and taxus chinensis raw materials are soaked, wherein the pumping amount of the methanol is 5-7 times of the feeding amount of the taxus chinensis branch and leaf. The stirring mechanism 13 is started to stir the mixture, so that the materials do not move directionally or roll, and the taxus chinensis is fully extracted. The single leaching time is 4-8 hours, after the primary extraction is completed, the discharge hole 17 is opened, and the produced branch and leaf leaching liquor flows into the chromatographic column 2 for elution and separation. The crude paclitaxel is eluted by pumping dichloromethane through eluent inlet tube 23. The high initial-washing eluent containing impurities in the previous stage is shunted by a shunt 9 and flows into a vacuum concentration tank 3 for concentration and recovery treatment, and the concentrate containing the paclitaxel section is obtained. And after the subsequent stage of elution, obtaining a low eluent containing impurities, then flowing into an eluent storage tank 5 through a flow divider 9, pumping the eluent into the chromatographic tower 2 through a first delivery pump 10 for elution in a previous production stage, directly recycling the eluent with low impurity content, and collecting and concentrating and recycling the eluent when the impurity content is high. Thus, the eluent with low impurity content is concentrated and recovered twice, the recovery times are reduced, the use efficiency is improved, and the energy consumption is saved. The solvent is heated and boiled under vacuum by a vacuum concentration tank 3, the low boiling point solution steam is condensed by a condenser 6 and separated by an oil-water separator 7, and the obtained high purity solvent is stored in a solvent storage tank 8. The elution solvent recovered by concentration is sent back to the chromatography column 2 by the second transfer pump 11, and the subsequent elution solvent can be performed. The concentrate containing paclitaxel is fed into a crystallizing tank 4 for crystallization to obtain paclitaxel with high purity. Use the utility model discloses carry out taxol crude purification, its purification process is simple, and the purification solvent can recycle, and the material loss is low, and purification efficiency is high, and the purification is with low costs.
The utility model discloses a 13 of rabbling mechanism of leaching jar 1 stir the soak solution and press from both sides 14 steam heating of cover and go on simultaneously, have not only guaranteed to draw the taxus chinensis completely, can also accelerate extraction rate. In the course of carrying out crude elution separation in chromatographic column 2, through carrying out stage recovery to the eluant, the eluant that anterior segment impurity content is high is concentrated, recycle after the condensation, the eluant that back end impurity content is low flows into eluant storage tank 5, then the pump is gone into in chromatographic column 2 and supplies the elution of new round of production anterior segment to use, the purification solvent of concentrated recovery passes through condenser 8 cooling, separate with oil water separator 7, flow into the recycle in solvent basin 8 at last, the further loss that has reduced the solvent, the availability factor has been improved, the solvent rate of recovery is more than 98%, and the production cost is saved.
The above description is only a preferred embodiment of the present invention, and should not be taken as limiting the invention, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (5)
1. The utility model provides an extract natural paclitaxel's extraction system, includes leaching tank (1), its characterized in that, leaching tank (1) has connected gradually chromatography tower (2), vacuum concentration jar (3) and crystallizer (4) through the pipeline, be equipped with shunt (9) between chromatography tower (2) and vacuum concentration jar (3), shunt (9) one end is connected with eluent storage tank (5), eluent storage tank (5) are through first delivery pump (10) and the inside intercommunication of chromatography tower (2), there are condenser (6), oil water separator (7) and solvent storage tank (8) at vacuum concentration jar (3) top through the pipe connection, solvent storage tank (8) are linked together through second delivery pump (11) and chromatography tower (2) inside.
2. The extraction system for extracting natural paclitaxel according to claim 1, wherein: the leaching tank (1) comprises a leaching tank body (12), the upper part of the leaching tank body (12) is provided with a feeding port (16), the bottom of the leaching tank body is provided with a discharging port (17), the interior of the leaching tank body (12) is provided with a stirring mechanism (13) and a filtering plate (15), the lower surface of the leaching tank body is wrapped by an annular jacket (14), the upper part of the jacket (14) is provided with a steam inlet (18), the lower part of the jacket is provided with a steam outlet (19), and a slag discharging pipe is arranged above the filtering plate (15).
3. The extraction system for extracting natural paclitaxel according to claim 1 or 2, wherein: chromatography tower (2) are including tower body (21), tower body (21) upper portion is equipped with sealed lid, and its bottom is equipped with drain pipe (24), sealed top of the covering is equipped with chromatography mother liquor inlet tube (22), eluant inlet tube (23) and blast pipe, the blast pipe is connected with vacuum pump (27), tower body (21) middle part is equipped with silica gel packing layer (25), packing layer (25) below is equipped with psammitolite (26) and solid fixed ring, psammitolite (26) joint is on solid fixed ring.
4. The extraction system for extracting natural paclitaxel according to claim 3, wherein: vacuum concentration jar (3) is including the concentrated jar body (31), the concentrated jar body (31) top is equipped with pan feeding pipe and vacuum pump (33), and its below is equipped with discharging pipe (34), and the concentrated jar body (31) surface is equipped with steam heating chamber (32), steam heating chamber (32) one side upper portion is equipped with steam and advances pipe (35), and the opposite side lower part is equipped with comdenstion water exit tube (36).
5. The extraction system for extracting natural paclitaxel according to claim 2, wherein: the stirring mechanism (13) comprises a speed reducing motor, a stirring shaft and frame type stirring blades arranged on the stirring shaft.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922091253.5U CN211189193U (en) | 2019-11-28 | 2019-11-28 | Extraction system for extracting natural paclitaxel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922091253.5U CN211189193U (en) | 2019-11-28 | 2019-11-28 | Extraction system for extracting natural paclitaxel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN211189193U true CN211189193U (en) | 2020-08-07 |
Family
ID=71847850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201922091253.5U Expired - Fee Related CN211189193U (en) | 2019-11-28 | 2019-11-28 | Extraction system for extracting natural paclitaxel |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN211189193U (en) |
-
2019
- 2019-11-28 CN CN201922091253.5U patent/CN211189193U/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20200807 |