CN211068743U

CN211068743U - Soluble microneedle structure

Info

Publication number: CN211068743U
Application number: CN201921374119.XU
Authority: CN
Inventors: 不公告发明人
Original assignee: Youwei Zhuhai Biotechnology Co ltd
Current assignee: Youwei Zhuhai Biotechnology Co ltd
Priority date: 2019-08-22
Filing date: 2019-08-22
Publication date: 2020-07-24
Anticipated expiration: 2029-08-22

Abstract

The utility model discloses a soluble micro-needle structure, including the needle body, the needle body is the geometry that a pyramid was held back by at least a pair of plane that parallels, the plane perpendicular to pyramid's bottom surface, every pair of parallel plane distribution equal in the distance on pyramid's summit both sides and two planes and pyramid's summit. The micro-needle structure can pierce skin except the vertex of the pyramid, a plurality of side edges of the intercepted part of the pyramid and a plurality of side lines of the intersected plane and the side surface of the pyramid can assist in cutting and piercing skin, and the micro-needle is relatively integrally in a pyramid shape.

Description

Soluble microneedle structure

Technical Field

The utility model relates to a medical treatment and cosmetic field especially relate to a soluble micropin structure.

Background

The painless transdermal drug delivery of the microneedle is used as a novel drug delivery technology, can create a micron-sized drug delivery channel on the skin painlessly, enhances the permeability of the skin to active substances or drugs, particularly macromolecular drugs, and represents the development direction of the percutaneous in-vivo conduction of the drugs in the future due to the advantages of painless, safe, easy operation and the like.

The manufacturing process of the soluble microneedle at the present stage mainly comprises two main types, namely a mould shaping mode and a stretching shaping mode. For the stretching and shaping mode, the microneedle structure is formed by contacting and stretching viscous macromolecule liquid drops, and the shape of the manufactured microneedle cannot be freely controlled due to the fact that the manufacturing process utilizes the stretching and extending characteristics of viscous fluid; for the mold method, the viscous polymer material needs to be poured into the micro-needle mold of micron scale by using centrifugal or vacuum pumping and other external force methods, so the micro-needle mold needs to be designed to have a cross-sectional area of the bottom larger than that of the needle tip, so that the viscous solution can be easily and completely filled in the mold.

In consideration of the limitations of the manufacturing process, when designing a microneedle structure, the taper and volume of the microneedle are reduced as much as possible in order to easily pierce the skin, but a certain mechanical strength is lost, and if the mechanical strength of the microneedle is reduced, the microneedle is likely to bend and break when piercing the skin.

In addition, the cross section of the common microneedle structure is circular, except for a sharp point, no other sharp part exists, the skin gap is gradually enlarged along with the gradual penetration of the microneedle, and due to the natural elasticity and self-restoring force of the skin structure, the microneedle can be easily rebounded by the skin again after penetrating into a part of the skin, or the microneedle is bent and broken due to large resistance when continuously penetrating. Therefore, a microneedle structure with a reasonable shape and design is urgently needed.

SUMMERY OF THE UTILITY MODEL

The utility model aims to solve one of the technical problems existing in the prior art at least, and provide a soluble microneedle structure which is easy to pierce the skin and is difficult to bend and break.

The utility model provides a technical scheme that its technical problem adopted does:

soluble microneedle structure comprising a needle body in the form of a pyramid with a geometry intercepted by at least one pair of parallel planes perpendicular to the base of the pyramid, each pair of parallel planes being disposed on either side of the pyramid's apex and both planes being equidistant from the pyramid's apex.

As an improvement of the technical scheme, an included angle between each side edge of the pyramid and the bottom surface of the pyramid is larger than 45 degrees.

As an improvement of the technical scheme, the pyramid is a regular rectangular pyramid.

As an improvement of the technical scheme, each plane only intersects with one side edge of the regular rectangular pyramid and is parallel to a plane formed by two adjacent side edges of the regular rectangular pyramid.

As an improvement of the technical scheme, the needle body is a geometric body which is formed by a regular rectangular pyramid and is intercepted by a pair of parallel planes.

As an improvement to the above solution, each plane intercepts at most half of the side edges intersecting the plane.

As an improvement of the technical scheme, the needle body is a geometric body which is formed by intercepting a regular rectangular pyramid by two pairs of parallel planes, the two pairs of parallel planes comprise two parallel first planes and two parallel second planes, and the first planes are perpendicular to the second planes.

As an improvement of the above solution, the first plane is closer to the apex of the pyramid than the second plane.

As an improvement of the above technical solution, each first plane intercepts one third of the side edges intersecting with the first plane, and each second plane intercepts two thirds of the side edges intersecting with the second plane.

The beneficial effects of the utility model are that:

the needle body of the microneedle structure is a geometrical body of a pyramid which is intercepted by at least one pair of parallel planes, the planes are perpendicular to the bottom surface of the pyramid, each pair of parallel planes are distributed on two sides of the vertex of the pyramid, the distances between the two planes and the vertex of the pyramid are equal, except that the vertex of the pyramid can pierce the skin, a plurality of side edges of the intercepted part of the pyramid and a plurality of side lines of the intersection of the planes and the side surfaces of the pyramid can assist in cutting and piercing the skin, and the microneedle is in a pyramid state relatively to the whole.

Drawings

The present invention will be further described with reference to the accompanying drawings and specific embodiments, wherein:

fig. 1 is a schematic view of a first embodiment of the present invention to supplement a complete pyramid;

fig. 2 is a schematic structural diagram of a first embodiment of the present invention;

FIG. 3 is a schematic view of a second embodiment of the present invention to supplement a complete pyramid;

fig. 4 is a schematic structural diagram of a second embodiment of the present invention;

fig. 5 is a plan view of a second embodiment of the present invention.

Detailed Description

Referring to fig. 1 and 3, the present invention provides a soluble microneedle structure, including a needle body 1, the needle body 1 is a geometrical body that pyramid 2 is intercepted by at least a pair of parallel planes 3, wherein, plane 3 is perpendicular to pyramid's bottom surface 21, each pair of parallel planes 3 distribute in the both sides of pyramid's summit 22 and two planes 3 are equal with the distance of pyramid's summit 22, plane 3 intersects in many side lines 4 with the side of pyramid 2, except that pyramid's summit 22 can pierce the skin, pyramid 2 is assisted to cut, pierce the skin by many side arriss 23 and many side lines 4 of the part of intercepting.

In order to make it easier to penetrate the skin, each side edge 23 of the pyramid 2 is angled more than 45 ° relative to the base 21 of the pyramid. Compared with the microneedle which is integrally in a pyramid shape, the microneedle has the advantages that the cross sectional area is smaller, only little mechanical strength is sacrificed, the generated skin crack does not expand rapidly after reaching a certain depth, the resistance encountered during continuous puncturing is small, the microneedle is very easy to puncture the skin, and the microneedle is not easy to bend and break.

The pyramid 2 may be a triangular pyramid, a rectangular pyramid, a pentagonal pyramid, etc., and may be designed to be a more common regular triangular pyramid, a regular rectangular pyramid, a regular pentagonal pyramid, etc. for convenience of forming and manufacturing.

Referring to fig. 2, each plane 3 intersects with only one side edge 23 of the regular rectangular pyramid, and the plane formed by two adjacent side edges 23 parallel to the side edge ensures that the side edge 23 is always at the end, which is beneficial to incising and puncturing the skin, that is: the point at which any one of the side edges 23 is intersected by any cross section parallel to the base surface 21 is the end point of this cross section, since the plane 3 is generally aligned with the direction of penetration as the skin continues to be penetrated, the skin-contacting side of the plane 3 is no longer flared, and the skin is further incised by the adjacent two side edges 23.

The utility model discloses there are two embodiments to the number setting of plane 3.

First embodiment

Referring to fig. 1 and 2, the needle body 1 is a geometric body in which a regular rectangular pyramid is intercepted by a pair of parallel planes 3, and each plane 3 intercepts at most half of a side edge 23 intersecting with the plane 3, so that the needle body 1 is in a flattened shape, similar to a sword-shaped shape, and compared with a microneedle in a pyramid shape as a whole, the sword-shaped microneedle structure has a smaller cross-sectional area, and a plurality of side edges 23 and side lines 4 are very sharp, thereby being beneficial to piercing the skin.

In the early stage of skin penetration, starting from the apex 22 of the pyramid, four side edges 23 cut the skin in four directions and expand the skin tear; in the later stage of skin penetration, two side edges 23 and four side lines 4 continue to enlarge the skin gap along the respective transverse directions, while the other two side edges 23 and the plane 3 do not expand the skin gap any more, and only need to go deeper, and the acting force on the skin is smaller, so that the resistance is smaller, the mechanical strength is sufficient, and the needle body 1 is difficult to bend and break.

Second embodiment

With reference to fig. 3, 4 and 5, the needle body 1 is a geometric body of a regular rectangular pyramid intercepted by two pairs of parallel planes 3, the two pairs of parallel planes 3 comprising two parallel first planes 31 and two parallel second planes 32, the first planes 31 being perpendicular to the second planes 32, wherein the first planes 31 are closer to the apex 22 of the pyramid than the second planes 32, in particular each first plane 31 intercepts one third of the side edges 23 intersecting the first plane 31, each second plane 32 intercepts two thirds of the side edges 23 intersecting the second planes 32.

The needle body 1 is also in a flattened shape, has a smaller cross section area, is provided with more side edges 23 and side lines 4, is very sharp and is beneficial to puncturing the skin. In the first third of the skin penetration, starting from the apex 22 of the pyramid, the four lateral edges 23 cut through the skin in four directions and dilate the skin tear; during the middle third period of skin penetration, the four side lines 4 of two side edges 23 and the first plane 31 continue to enlarge the skin gap in the respective transverse directions, while the other two side edges 23 and the first plane 31 do not expand the skin gap any longer, but only need to go deeper, and are subjected to less skin force; in the latter third of the skin penetration period, the split is not rapidly enlarged any more by means of the four side lines 4 of the first plane 31 and the four side lines 4 of the second plane 32 in the respective transverse directions, but is slowly enlarged and gradually penetrates into the deep layer of the skin, but the resistance is not so large and the mechanical strength is sufficient that the needle body 1 is difficult to bend and break.

The above description is only a preferred embodiment of the present invention, but the present invention is not limited to the above embodiments, and the technical effects of the present invention should be all included in the protection scope of the present invention as long as the technical effects are achieved by any of the same or similar means.

Claims

1. A soluble microneedle structure characterized by: the needle body is a geometrical body which is a pyramid and is intercepted by at least one pair of parallel planes, the planes are perpendicular to the bottom surface of the pyramid, each pair of parallel planes are distributed on two sides of the vertex of the pyramid, and the distances between the two planes and the vertex of the pyramid are equal.

2. The dissolvable microneedle structure of claim 1, wherein: and the included angle between each side edge of the pyramid and the bottom surface of the pyramid is more than 45 degrees.

3. The dissolvable microneedle structure of claim 1 or 2, wherein: the pyramid is a regular rectangular pyramid.

4. The dissolvable microneedle structure of claim 3, wherein: each plane is intersected with only one side edge of the regular rectangular pyramid and is parallel to a plane formed by two adjacent side edges of the regular rectangular pyramid.

5. The dissolvable microneedle structure of claim 4, wherein: the needle body is a geometric body which is a regular rectangular pyramid and is intercepted by a pair of parallel planes.

6. The dissolvable microneedle structure of claim 5, wherein: each plane intercepts at most half of the side edges that intersect the plane.

7. The dissolvable microneedle structure of claim 4, wherein: the needle body is a geometric body which is formed by intercepting a regular rectangular pyramid by two pairs of parallel planes, the two pairs of parallel planes comprise two parallel first planes and two parallel second planes, and the first planes are perpendicular to the second planes.

8. The dissolvable microneedle structure of claim 7, wherein: the first plane is closer to the apex of the pyramid than the second plane.

9. The dissolvable microneedle structure of claim 8, wherein: each first plane intercepts one third of the side edges intersecting the first plane and each second plane intercepts two thirds of the side edges intersecting the second plane.