CN211051072U - Cross-linked sodium hyaluronate's concentrator - Google Patents
Cross-linked sodium hyaluronate's concentrator Download PDFInfo
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- CN211051072U CN211051072U CN201921971799.3U CN201921971799U CN211051072U CN 211051072 U CN211051072 U CN 211051072U CN 201921971799 U CN201921971799 U CN 201921971799U CN 211051072 U CN211051072 U CN 211051072U
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Abstract
The utility model discloses a concentration equipment of cross-linked sodium hyaluronate, which belongs to the technical field of concentration equipment, and solves the problem of complex production and operation process. The technical key points are as follows: including preceding stage filter tube and back level filter tube, preceding stage filter tube and back level filter tube intercommunication, be provided with the milipore filter in the back level filter tube, the booster pump is installed to back level filter tube, preceding stage filter tube detachably installs preceding stage filter equipment. The advantage of simpler production operation process is achieved.
Description
Technical Field
The utility model relates to a concentrator technical field, especially a concentrator of crosslinked sodium hyaluronate.
Background
The sodium hyaluronate belongs to macromolecular polysaccharide, can lubricate and nourish cells and organs and provides microenvironment for cell metabolism. The injection can promote cell regeneration and remove wrinkle. In order to ensure the use effect of the crosslinked sodium hyaluronate, the crosslinked sodium hyaluronate needs to be concentrated to obtain a crosslinked sodium hyaluronate gel with a higher concentration, and the crosslinked sodium hyaluronate gel with the higher concentration is coated on the surface of skin, so that a better skin care effect can be obtained.
In the existing production process of sodium hyaluronate, cockscomb is commonly used as a raw material, sodium hyaluronate is extracted after treatment, impurities are precipitated by ethanol, and then the sodium hyaluronate is crystallized and purified through multiple centrifugal separation, so that a sodium hyaluronate concentrated solution with high purity is obtained.
In the production process of concentrating and purifying the sodium hyaluronate by using the ethanol, a large amount of ethanol needs to be consumed, and the feeding speed of the ethanol needs to be controlled, so that the production operation process is complex and is not easy to control, and the mass production of the sodium hyaluronate is inconvenient. Therefore, the production equipment in the prior art has the problem of complex production operation process.
SUMMERY OF THE UTILITY MODEL
In order to overcome the above disadvantages of the prior art, the present invention provides a concentrating apparatus for cross-linked sodium hyaluronate, which has the advantage of simple operation.
The utility model provides a technical scheme that its technical problem adopted is:
the utility model provides a cross-linking sodium hyaluronate's concentrator, includes preceding stage filter tube and back level filter tube, preceding stage filter tube and back level filter tube intercommunication, be provided with the milipore filter in the back level filter tube, the booster pump is installed to back level filter tube, preceding stage filter tube detachably installs preceding stage filter equipment.
As a further improvement of the utility model: preceding stage filter equipment is including filtering frame, slip pipe and adapter sleeve, slip pipe and preceding stage filter pipe sliding connection, the adapter sleeve rotates with the preceding stage filter pipe to be connected and the axial linkage, adapter sleeve and slip pipe threaded connection, filter frame and slip pipe joint, filter frame fixed mounting has the fixed plate, the fixed plate is equipped with the smart filter bowl that link up the fixed plate, fixed plate fixed mounting has the essence board of straining that is located smart filter bowl department, the fixed plate edge laminates with the back level filter pipe.
As a further improvement of the utility model: the adapter sleeve includes first arc and second arc, first arc and second arc be the first connecting plate of fixedly connected with and the second connecting plate respectively, be equipped with the locking piece between first connecting plate and the second connecting plate, the length of filtering the frame is less than the distance between preceding stage filter tube and the back stage filter tube.
As a further improvement of the utility model: the utility model discloses a filter plate, including fixed cover and seal cover, fixed cover, essence groove, fixed cover and seal cover, the fixed cover of one side fixedly connected with and the seal cover that the fixed plate is close to the preceding stage filter tube, fixed cover is located the seal cover, the essence is strained the trench and is located between fixed cover and the seal cover, the one end fixedly connected with closing plate of fixed plate is kept away from to fixed cover, closing plate and seal cover fixed connection, fixed cover is equipped with the coarse strainer groove that link up fixed cover, fixed cover.
As a further improvement of the utility model: the bottom of the coarse filter plate is higher than the fixed plate.
As a further improvement of the utility model: the fixed sleeve is fixedly connected with a baffle ring which inclines downwards along the direction close to the inside of the fixed sleeve.
As a further improvement of the utility model: sealed cover is equipped with blowdown and leads to groove and third seal groove, the blowdown leads to the groove and is located between third seal groove and the fixed plate, the third sealing member that is located third seal groove department is installed to the seal cover, third sealing member and back stage filter tube butt.
As a further improvement of the utility model: the filter frame is equipped with first seal groove, the filter frame is installed and is located the first sealing member of first seal groove department, first sealing member and sliding tube butt.
As a further improvement of the utility model: the fixed plate is provided with a second sealing groove, a second sealing element located at the second sealing groove is installed on the fixed plate, and the second sealing element is abutted to the rear-stage filter pipe.
Compared with the prior art, the beneficial effects of the utility model are that:
the booster pump drives the sodium hyaluronate liquid to flow from the preceding stage filter tube to the post stage filter tube, can effectively improve whole concentration efficiency, simultaneously, can provide sufficient pressure for the milipore filter and filter. Impurities in the sodium hyaluronate are filtered through the pre-stage filtering device and the ultrafiltration membrane, so that the purity and concentration of the sodium hyaluronate can be rapidly improved, and the effect of concentrating the sodium hyaluronate is realized. The method has the advantages that the ethanol does not need to be added additionally, the adding amount of the ethanol does not need to be controlled, the cost in the production operation process can be reduced to a certain extent, the complexity in the production operation process is reduced, and the advantage of simpler production operation process is achieved.
The liquid is filtered twice through the coarse filter plate and the fine filter plate, and the impurities with large volume in the liquid can be effectively reduced, so that the speed of the ultrafiltration membrane polluted by the impurities is reduced, the filtration speed and the service life of the ultrafiltration membrane are improved, the impurities in the sodium hyaluronate can be effectively reduced, and the effect of improving the concentration of the sodium hyaluronate is achieved.
When needs wash thick filter plate and smart filter plate, remove the locking state of locking piece, demolish first connecting plate and second connecting plate from the advanced filtration pipe to can be directly on the advanced filtration pipe to the direction removal slip tube of keeping away from the filter stand, and take out the filter stand from between advanced filtration pipe and the back filter pipe, thereby can be convenient clear up rough filter plate and smart filter plate. Reduce the impurity of adhering to on rough filter plate and the fine filtration board, play the effect that improves filtering speed, realize adapter sleeve detachable function.
Drawings
Fig. 1 is a schematic structural diagram of a concentrating apparatus for cross-linked sodium hyaluronate according to an embodiment of the present application;
FIG. 2 is an enlarged view taken at A in FIG. 1;
fig. 3 is a schematic structural diagram of a connecting sleeve in the embodiment of the present application.
Reference numerals: 11. a pre-stage filter tube; 12. a sliding tube; 13. connecting sleeves; 14. a first arc-shaped plate; 15. a first connecting plate; 16. a second arc-shaped plate; 17. a second connecting plate; 18. a locking member; 21. a filter frame; 22. a fixing plate; 23. fixing a sleeve; 24. sealing sleeves; 25. a sealing plate; 26. a baffle ring; 31. a fine filter tank; 32. fine filtering the plate; 33. a coarse filtration tank; 34. coarse filter plate; 41. a first seal groove; 42. a first seal member; 43. a second seal groove; 44. a second seal member; 45. a third seal groove; 46. a third seal member; 47. a pollution discharge through groove; 48. a fourth seal member; 51. a post-stage filter tube; 52. ultrafiltration membranes; 53. a booster pump.
Detailed Description
The invention will now be further described with reference to the accompanying drawings, in which:
example (b):
a concentrating apparatus of cross-linked sodium hyaluronate, as shown in fig. 1, 2 and 3, comprises a pre-stage filtering pipe 11 and a post-stage filtering pipe 51, wherein the pre-stage filtering pipe 11 is communicated with the post-stage filtering pipe 51, an ultrafiltration membrane 52 is arranged in the post-stage filtering pipe 51, a booster pump 53 is arranged on the post-stage filtering pipe 51, and a pre-stage filtering device is detachably arranged on the pre-stage filtering pipe 11.
Preceding stage filter equipment is including filtering frame 21, sliding tube 12 and adapter sleeve 13, sliding tube 12 and 11 sliding connection of preceding stage filter tube, preceding stage filter tube 11 install with the fourth sealing member 48 of sliding tube 12 butt, fourth sealing member 48 is the fourth sealing washer of rubber material, adapter sleeve 13 rotates with preceding stage filter tube 11 to be connected and axial linkage, adapter sleeve 13 and sliding tube 12 threaded connection, filtering frame 21 and sliding tube 12 joint, filtering frame 21 fixed mounting has fixed plate 22, fixed plate 22 is equipped with the fine filtration groove 31 that link up fixed plate 22, fixed plate 22 fixed mounting has the fine filtration board 32 that is located fine filtration groove 31 department, fixed plate 22 edge and the laminating of back level filter tube 51.
The connecting sleeve 13 comprises a first arc-shaped plate 14 and a second arc-shaped plate 16, the first arc-shaped plate 14 and the second arc-shaped plate 16 are fixedly connected with a first connecting plate 15 and a second connecting plate 17 respectively, a locking piece 18 is arranged between the first connecting plate 15 and the second connecting plate 17, the locking piece 18 is a bolt penetrating through the first connecting plate 15 and the second connecting plate 17, and the length of the filter frame 21 is smaller than the distance between the pre-stage filter pipe 11 and the post-stage filter pipe 51.
One side of the fixing plate 22 close to the pre-stage filter tube 11 is fixedly connected with a fixing sleeve 23 and a sealing sleeve 24, the fixing sleeve 23 is positioned in the sealing sleeve 24, the fine filter groove 31 is positioned between the fixing sleeve 23 and the sealing sleeve 24, one end of the fixing sleeve 23 far away from the fixing plate 22 is fixedly connected with a sealing plate 25, the sealing plate 25 is fixedly connected with the sealing sleeve 24, the fixing sleeve 23 is provided with a coarse filter groove 33 penetrating through the fixing sleeve 23, and the fixing sleeve 23 is fixedly connected with a coarse filter plate 34 positioned at the coarse filter groove 33.
The bottom of the coarse filter plate 34 is higher than the fixed plate 22.
The retaining sleeve 23 is fixedly connected with a stop ring 26 inclined downwards in a direction close to the inside of the retaining sleeve 23.
The sealing sleeve 24 is provided with a pollution discharge through groove 47 and a third sealing groove 45, the pollution discharge through groove 47 is positioned between the third sealing groove 45 and the fixing plate 22, the sealing sleeve 24 is provided with a third sealing element 46 positioned at the third sealing groove 45, the third sealing element 46 is a third sealing ring made of rubber, and the third sealing element 46 is abutted to the rear-stage filter pipe 51.
The filter frame 21 is provided with a first seal groove 41, the filter frame 21 is provided with a first seal member 42 located in the first seal groove 41, the first seal member 42 is a first seal ring made of rubber, and the first seal member 42 is abutted against the slide pipe 12.
The fixing plate 22 is provided with a second seal groove 43, a second seal 44 located in the second seal groove 43 is attached to the fixing plate 22, the second seal 44 is a second seal ring made of rubber, and the second seal 44 abuts against the post-stage filter pipe 51.
The embodiment has the following advantages:
the booster pump 53 drives the sodium hyaluronate solution to flow from the prefilter pipe 11 to the postfilter pipe 51, so that the overall concentration efficiency can be effectively improved, and at the same time, sufficient pressure can be provided for the ultrafiltration membrane 52 to perform filtration. Impurities in the sodium hyaluronate are filtered through the pre-stage filtering device and the ultrafiltration membrane 52, so that the purity and concentration of the sodium hyaluronate can be rapidly improved, and the effect of concentrating the sodium hyaluronate is realized. The method has the advantages that the ethanol does not need to be added additionally, the adding amount of the ethanol does not need to be controlled, the cost in the production operation process can be reduced to a certain extent, the complexity in the production operation process is reduced, and the advantage of simpler production operation process is achieved.
The connecting sleeve 13 in threaded connection with the sliding pipe 12 is rotated to drive the sliding pipe 12 to approach the filter frame 21 and tightly abut against the filter frame 21, so that the gap between the filter frame 21 and the preceding stage filter pipe 11 is reduced, and liquid can be prevented from leaking from the gap between the filter frame 21 and the preceding stage filter pipe 11 to a certain extent. The edge of the fixing plate 22 is attached to the inner wall of the post-stage filtering pipe 51, so that the gas and the liquid can be prevented from passing through the gap between the fixing plate 22 and the post-stage filtering pipe 51, the liquid can be prevented from leaking, and the gas can be prevented from entering the post-stage filtering pipe 51.
When the coarse filter plate 34 and the fine filter plate 32 need to be cleaned, the locking state of the locking member 18 is released, and the first connecting plate 15 and the second connecting plate 17 are detached from the front stage filter tube 11, so that the filter frame 21 can be taken out from between the front stage filter tube 11 and the rear stage filter tube 51, and the coarse filter plate 34 and the fine filter plate 32 can be conveniently cleaned. Reduce the impurity that adheres to on rough filter plate 34 and the fine filtration board 32, play the effect that improves the filtration speed, realize adapter sleeve 13 detachable function. Impurities attached to the fine filter plate 32 can be conveniently cleaned through the pollution discharge through groove 47.
The liquid is filtered twice through the coarse filter plate 34 and the fine filter plate 32, and the impurities with large volume in the liquid can be effectively reduced, so that the speed of the ultrafiltration membrane 52 polluted by the impurities is reduced, the filtering speed and the service life of the ultrafiltration membrane 52 are improved, the impurities in the sodium hyaluronate can be effectively reduced, and the effect of improving the concentration of the sodium hyaluronate is achieved.
The impurities filtered by the coarse filter plates 34 are sunk on the fixed plates 22 by gravity, and the bottom of the coarse filter plates 34 is higher than the fixed plates 22, so that the impurities precipitated on the fixed plates 22 cannot block the coarse filter plates 34, thereby improving the filtering efficiency of the coarse filter plates 34. When the filter frame 21 is removed, the impurities stored between the impurity fixing plate 22 and the coarse filter plate 34 can be cleaned conveniently, and the effect of convenient use is achieved.
The baffle ring 26 can block the impurities moving to the coarse filter plate 34, so that the impurities can move to the middle of the fixing plate 22, the impurities attached to the coarse filter plate 34 can be reduced, and the effect of improving the filtering efficiency of the coarse filter plate 34 is achieved. Effectively reduces impurities in the sodium hyaluronate, thereby achieving the effect of improving the concentration of the sodium hyaluronate.
The third seal 46 blocks the gap between the sealing sleeve 24 and the post-stage filter tube 51, and prevents air and sodium hyaluronate from passing through the gap between the sealing sleeve 24 and the post-stage filter tube 51, thereby improving the sealing performance.
The first seal member 42 blocks the gap between the filter frame 21 and the preceding filter tube 11, and prevents air and sodium hyaluronate from passing through the gap between the filter frame 21 and the preceding filter tube 11, thereby improving the sealing property.
The second sealing member 44 blocks the gap between the fixing plate 22 and the second-stage filtering tube 51, and prevents sodium hyaluronate from passing through the gap between the fixing plate 22 and the second-stage filtering tube 51, thereby improving sealability.
In conclusion, after the ordinary skilled in the art reads the document of the present invention, according to the present invention, the technical solution and technical concept of the present invention do not need creative mental labor to make other various corresponding transformation schemes, which all belong to the protection scope of the present invention.
Claims (9)
1. A cross-linked sodium hyaluronate's concentrator which characterized in that: including preceding stage filter tube (11) and back level filter tube (51), preceding stage filter tube (11) and back level filter tube (51) intercommunication, be provided with milipore filter (52) in back level filter tube (51), booster pump (53) are installed in back level filter tube (51), preceding stage filter tube (11) detachably installs preceding stage filter equipment.
2. The concentrating device of crosslinked sodium hyaluronate according to claim 1, characterized in that: preceding stage filter equipment is including filtering frame (21), sliding tube (12) and adapter sleeve (13), sliding tube (12) and preceding stage filter tube (11) sliding connection, adapter sleeve (13) rotate with preceding stage filter tube (11) and are connected and axial linkage, adapter sleeve (13) and sliding tube (12) threaded connection, filter frame (21) and sliding tube (12) joint, filter frame (21) fixed mounting has fixed plate (22), fixed plate (22) are equipped with essence filter tank (31) that link up fixed plate (22), fixed plate (22) fixed mounting has essence filter plate (32) that is located essence filter tank (31) department, fixed plate (22) edge laminates with back level filter tube (51).
3. The concentrating device of crosslinked sodium hyaluronate according to claim 2, characterized in that: connecting sleeve (13) include first arc (14) and second arc (16), first arc (14) and second arc (16) are fixedly connected with first connecting plate (15) and second connecting plate (17) respectively, be equipped with locking piece (18) between first connecting plate (15) and second connecting plate (17), the length of filtering frame (21) is less than the distance between preceding stage filter tube (11) and back stage filter tube (51).
4. The concentrating device of crosslinked sodium hyaluronate according to claim 2, characterized in that: fixed cover (23) and seal cover (24) of one side fixedly connected with that fixed plate (22) are close to preceding stage filter tube (11), fixed cover (23) are located seal cover (24), smart filter bowl (31) are located between fixed cover (23) and seal cover (24), the one end fixedly connected with closing plate (25) of fixed plate (22) are kept away from to fixed cover (23), closing plate (25) and seal cover (24) fixed connection, fixed cover (23) are equipped with coarse filtration groove (33) that link up fixed cover (23), fixed cover (23) fixedly connected with is located coarse filtration board (34) of coarse filtration groove (33) department.
5. The concentrating device of crosslinked sodium hyaluronate according to claim 4, characterized in that: the bottom of the coarse filter plate (34) is higher than the fixed plate (22).
6. The concentrating device of crosslinked sodium hyaluronate according to claim 4, characterized in that: the fixed sleeve (23) is fixedly connected with a baffle ring (26) which inclines downwards along the direction close to the inner part of the fixed sleeve (23).
7. The concentrating device of crosslinked sodium hyaluronate according to claim 4, characterized in that: seal cover (24) are equipped with blowdown and lead to groove (47) and third seal groove (45), blowdown is led to groove (47) and is located between third seal groove (45) and fixed plate (22), third sealing member (46) that are located third seal groove (45) department are installed to seal cover (24), third sealing member (46) and back level filter tube (51) butt.
8. The concentrating device of crosslinked sodium hyaluronate according to claim 2, characterized in that: the filter frame (21) is provided with a first sealing groove (41), a first sealing element (42) located at the first sealing groove (41) is installed on the filter frame (21), and the first sealing element (42) is abutted to the sliding pipe (12).
9. The concentrating device of crosslinked sodium hyaluronate according to claim 2, characterized in that: the fixed plate (22) is provided with a second sealing groove (43), a second sealing element (44) located at the second sealing groove (43) is installed on the fixed plate (22), and the second sealing element (44) is abutted to the rear-stage filtering pipe (51).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921971799.3U CN211051072U (en) | 2019-11-15 | 2019-11-15 | Cross-linked sodium hyaluronate's concentrator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921971799.3U CN211051072U (en) | 2019-11-15 | 2019-11-15 | Cross-linked sodium hyaluronate's concentrator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN211051072U true CN211051072U (en) | 2020-07-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201921971799.3U Active CN211051072U (en) | 2019-11-15 | 2019-11-15 | Cross-linked sodium hyaluronate's concentrator |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN211051072U (en) |
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2019
- 2019-11-15 CN CN201921971799.3U patent/CN211051072U/en active Active
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