CN210990334U

CN210990334U - Quantitative blood collection plate for dry blood spot capillary

Info

Publication number: CN210990334U
Application number: CN201921203926.5U
Authority: CN
Inventors: 陈启; 周楚涵; 蒋云灏; 陈清宁; 蒋云涵; 陶妍希
Original assignee: Hangzhou Pusheng Detection Technology Co ltd
Current assignee: Hangzhou Pusheng Detection Technology Co ltd
Priority date: 2019-07-29
Filing date: 2019-07-29
Publication date: 2020-07-14
Anticipated expiration: 2029-07-29

Abstract

The utility model relates to a blood board is adopted to dry blood spot capillary ration solves traditional dry blood spot sampling and can not accurate ration, uses the professional requirement height, is unsuitable for the problem of using by oneself. This device includes the base plate, is provided with the capillary blood sampling passageway of a plurality of ration blood samplings on the base plate side by side, capillary blood sampling passageway both ends are the import that is used for the blood sampling respectively and one be used for printing the blood sample to the export on filter paper, import and the capacity of the capillary blood sampling passageway between the export be the ration volume of taking a blood sample, the import setting of capillary blood sampling passageway is at the side of base plate, the export setting of capillary blood sampling passageway is in the front of base plate. The utility model discloses the ration blood sampling degree of accuracy is high, and the blood sampling operation degree of difficulty is little, can use the completion by the patient by oneself, also can accomplish the blood sampling by the patient in being in and send to the inspection center inspection, need not the patient and queue up the blood sampling to the hospital, makes things convenient for the patient, has also reduced the people stream of hospital, reduces disease infection hidden danger.

Description

Quantitative blood collection plate for dry blood spot capillary

Technical Field

The utility model belongs to the field of medical equipment, a dry blood spot blood sampling device is related to, in particular to dry blood spot capillary quantitative blood sampling board.

Background

Dry Blood Spot (DBS) method, i.e. collecting a whole blood sample on a card paper to form a dry blood spot, and inspecting the card paper. The method needs less blood, and the examination requirement can be met as long as a plurality of microliters to dozens of microliters of blood form a circular dry blood spot with proper size on the filter paper; the blood sampling mode has low operation difficulty, does not need qualified sampling places and operation of sampling personnel, and can be operated by patients or non-professional personnel; infectious pathogens (e.g., HIV, hepatitis b virus, etc.) cannot survive in the dry plaque environment; the tested object is stable in the environment of dry blood spots, and does not need refrigeration. Therefore, the dried blood spots can be transported to a hospital or a testing institution for testing in an express way without adopting a professional medical cold chain.

However, the traditional dry spotting method does not strictly require the amount of blood collected. Circular holes with a diameter of 3.2mm are usually made in well-soaked sheets of filter paper, corresponding to 3.42. mu.l of blood. However, due to the difference in the viscosity coefficient of blood of each person, the difference in the hematocrit, the chromatographic effect of the filter paper, etc., the filter paper sheet that is laid down cannot be in a stable proportional relationship with the blood volume. Therefore, the traditional dry blood spot method has weak quantitative capability, is only suitable for carrying out some semi-quantitative and qualitative detection items, and is not suitable for the detection items needing accurate quantification. In addition, hospitals and laboratories often use venous blood for testing items with high quantitative requirements. The mode needs high operation difficulty and needs professional blood collection qualification, so the application range is narrow.

Disclosure of Invention

The utility model aims to solve the problem that traditional dry blood spot sampling can not be accurate ration to and although professional venous blood is quantitative can the height, the operation degree of difficulty is big, can't be by the problem that the patient gathered by oneself, provide a dry blood spot capillary ration blood sampling board. Simultaneously this application has simplified the blood sampling operation, has reduced the degree of difficulty of capillary blood sampling, is fit for using by oneself.

The utility model provides a technical scheme that its technical problem adopted is: a dry blood spot capillary quantitative blood sampling plate is characterized in that: including the base plate, be provided with the capillary blood sampling passageway of a plurality of ration blood samplings on the base plate side by side, capillary blood sampling passageway both ends are one import and one be used for with the blood sample print on the filter paper export, import and the capacity of the capillary blood sampling passageway between the export be the ration volume of taking a blood sample respectively, the import setting of capillary blood sampling passageway is at the side of base plate, the export setting of capillary blood sampling passageway is in the front of base plate. This device convenient to use, the operation degree of difficulty is low, during the use, prick the finger with disposable medical blood taking needle, extrude the blood drop from finger breach department, gather the import of the capillary blood sampling passageway of base plate to blood drop department, utilize capillary action to draw the blood drop to the capillary blood sampling passageway in, until blood is full of whole capillary blood sampling passageway and spreads to the exit of capillary blood sampling passageway, the volume of taking a blood sample of capillary blood sampling passageway and capillary blood sampling passageway this moment predetermine the capacity identical, be 5 to 10 microliters usually. When each capillary blood collection channel finishes blood collection, the front surface of the substrate is printed on the dry blood spot filter paper, the outlet of the capillary blood collection channel is attached to the dry blood spot filter paper, the suction force of the dry blood spot filter paper can suck all blood samples from the outlet of the capillary blood collection channel onto the dry blood spot filter paper to form a circular dry blood spot, and the blood volume of one circular dry blood spot is completely the same as the preset volume of the capillary blood collection channel and is usually 5-10 microliters. The device is provided with a plurality of capillary blood sampling channels, and can repeatedly take blood for a plurality of times to form a plurality of samples. After the blood spots are dried, the dried blood spot filter paper can be sent to a hospital or a laboratory in a common express way. And (4) the whole dried blood spot is punched by a puncher by an inspector, and then extraction, detection and other operations are carried out. On the basis of ensuring quantitative blood sampling, the device reduces the difficulty of blood sampling operation and can be used by a patient by self; the dry blood spots do not have the risk of infectious pathogeny, the blood can be collected by the patient at home and sent to an inspection center for inspection in a common express way, the patient does not need to queue up to collect blood in a hospital, the patient is convenient, the flow of people in the hospital is reduced, and the hidden danger of disease infection is reduced.

Preferably, the capillary blood sampling channel is a capillary blood sampling groove formed in the back surface of the base plate, and a cover plate for closing the back surface of the capillary blood sampling groove is further attached and fixedly arranged on the back surface of the base plate. The base plate fluting adopts the apron to seal and forms capillary blood sampling passageway, and capillary blood sampling groove processing is convenient, and can the accurate processing of constant volume.

Preferably, the back surface of the substrate is provided with an inner concave part corresponding to the shape of the cover plate, and the cover plate is embedded in the inner concave part. The joint of the base plate and the cover plate is provided with an inward concave area, so that the cover plate is convenient to position.

Preferably, the capacity of the capillary blood collection channel is 5-10 microliter quantitative setting.

Preferably, the front surface of the substrate is provided with an upward convex thickened area surrounding the outlet of the capillary blood sampling channel, and the thickened area is circular. When the dry blood spot filter paper is attached to the outlet of the capillary blood sampling channel, the thickened area is abutted against the dry blood spot filter paper, so that the compression of other positions of the substrate on the dry blood spot filter paper is reduced, the dry blood spots are rounded, and the dry blood spots formed by adjacent blood samples are prevented from irregularly spreading and interfering with each other.

Preferably, the side edge of the base plate protrudes outwards at the inlet position of the capillary blood collection channel to form a raised blood collection end. The raised blood sampling end is convenient to aim at the blood drop.

Preferably, the inlets of the capillary blood collection channels are disposed on the same side of the base plate.

Preferably, the middle part of the capillary blood sampling channel is provided with a U-shaped bend. The outlets of the adjacent capillary blood sampling channels are kept at an enough interval, so that enough space is ensured between dried blood spots on the dried blood spot filter paper, the dried blood spots cannot be crossed with each other, and the space of the adjacent capillary blood sampling channels can be fully utilized due to the U-shaped bend.

Preferably, the side edge of the base plate, which is provided with the inlet of the capillary blood sampling channel, is provided with a notch which is convenient for the cover plate to be attached.

Preferably, the substrate is a transparent plastic plate. The transparent material of the substrate makes the blood sampling condition of the capillary blood sampling channel visible. The cover plate can be designed to be transparent, and can also be designed to be a background color which is obviously contrasted with the color of blood, such as white.

The utility model discloses the ration blood sampling degree of accuracy is high, and the blood sampling operation degree of difficulty is little, can use the completion by the patient by oneself, also can accomplish the blood sampling by the patient in being in and send to the inspection center inspection, need not the patient and queue up the blood sampling to the hospital, makes things convenient for the patient, has also reduced the people stream of hospital, reduces disease infection hidden danger.

Drawings

The present invention will be further explained with reference to the accompanying drawings.

Fig. 1 is a schematic diagram of a blood sampling plate structure of the present invention.

Fig. 2 is a schematic view of the structure a-a in fig. 1 according to the present invention.

Fig. 3 is a schematic structural view of the dried blood spot filter paper used with the blood sampling plate of the present invention.

In the figure: 1. the blood sampling device comprises a base plate, 2, a cover plate, 3, a capillary blood sampling channel, 4, an inlet, 5, an outlet, 6, a thickened area, 7, a groove gap, 8, a blood sampling card, 9 and dry blood spot filter paper.

Detailed Description

The present invention will be further described with reference to the following specific embodiments and accompanying drawings.

Example (b): a quantitative blood collecting plate for dry blood spot capillary is shown in figures 1 and 2. The device comprises a substrate 1 which is a transparent plastic plate. A plurality of capillary blood sampling channels 3 are arranged on the base plate 1 in parallel, the capillary blood sampling channels are uniformly processed to have the same structure, and blood is quantitatively sampled, wherein each capillary blood sampling channel is 10 microliters of quantitative blood sampling. The two ends of the capillary blood taking channel are respectively provided with an inlet 4 for taking blood and an outlet 5 for printing the blood sample on the filter paper. The inlet 4 of each capillary blood collection channel 3 is arranged on the same side of the base plate 1. An outlet 5 of the capillary blood collection channel 3 is arranged on the front surface of the base plate 1, and a circular thickened area 6 which protrudes upwards is arranged on the front surface of the base plate 1 around the outlet of the capillary blood collection channel. The outlets 5 of the capillary blood collection passages 3 are arranged along the same straight line. Because the outlet 5 of the capillary blood sampling channel 3 needs to have enough space, the middle part of the capillary blood sampling channel 3 is provided with a U-shaped bend, and the gap between the adjacent capillary blood sampling channels 3 is fully utilized. As shown in fig. 2, the capillary blood sampling channel is a capillary blood sampling groove formed on the back surface of a base plate 1, a cover plate 2 for closing the back surface of the capillary blood sampling groove is further attached and fixedly arranged on the back surface of the base plate, and the cover plate is made of transparent plastic material. The back of the base plate is provided with a rectangular inner concave part at the position where the capillary blood sampling channel is arranged, and the cover plate is matched with the shape of the inner concave part and is embedded in the inner concave part. The side edge of the base plate 1 protrudes outwards at the position of the inlet 4 of the capillary blood collection channel to form a convex blood collection end. The side edge of the inward concave part of the base plate 1, which is provided with the capillary blood sampling channel inlet 4, is provided with a groove notch 7 which is convenient for the cover plate 2 to be attached, and the groove notch is clamped and adjusted when the cover plate is convenient to be attached.

As shown in figure 3, the device comprises a matched blood sampling card 8 which is a double-layer paper board, wherein a window is arranged in the middle of the blood sampling card, dry blood spot filter paper 9 is embedded in the window, and the dry blood spot filter paper is clamped between the double-layer paper board. After the blood collection of the capillary blood collection channel is completed by the dry blood spot capillary blood collection plate of the device, the blood of the capillary blood collection channel needs to be printed on the dry blood spot filter paper 9 from the outlet of the capillary blood collection channel to form a circular dry blood spot, and marks can be made on the blood collection card at the aligned position of each dry blood spot, wherein the marks comprise information such as a blood collection object, blood collection time and the like.

When the device is used, a finger is punctured by a disposable medical blood taking needle, a blood drop is squeezed out from a finger laceration, an inlet of a capillary blood taking channel of the substrate is gathered to the blood drop, the blood drop is absorbed into the capillary blood taking channel by utilizing the capillary action until the whole capillary blood taking channel is filled with blood and spreads to an outlet of the capillary blood taking channel. The device has small difficulty in blood sampling operation, can be used by a patient by self, can also be used by the patient at home to finish blood sampling and send the blood to an inspection center for inspection, does not need the patient to queue up for blood sampling in a hospital, is convenient for the patient, reduces the flow of people in the hospital and reduces the hidden danger of disease infection.

Claims

1. A dry blood spot capillary quantitative blood sampling plate is characterized in that: including the base plate, be provided with the capillary blood sampling passageway of a plurality of ration blood samplings on the base plate side by side, capillary blood sampling passageway both ends are one import and one be used for with the blood sample print on the filter paper export, import and the capacity of the capillary blood sampling passageway between the export be the ration volume of taking a blood sample respectively, the import setting of capillary blood sampling passageway is at the side of base plate, the export setting of capillary blood sampling passageway is in the front of base plate.

2. The dry blood spot capillary quantitative blood collection plate according to claim 1, wherein: the capillary blood sampling channel is a capillary blood sampling groove formed in the back surface of the base plate, and a cover plate for closing the back surface of the capillary blood sampling groove is further pasted and fixedly arranged on the back surface of the base plate.

3. The dry blood spot capillary quantitative blood collection plate according to claim 2, wherein: the back of the substrate is provided with an inner concave part corresponding to the shape of the cover plate, and the cover plate is embedded in the inner concave part.

4. A dry plaque capillary quantification blood collection sheet as claimed in claim 1, 2 or 3 wherein: the capacity of the capillary blood sampling channel is quantitatively set to be 5-10 microliter.

5. A dry plaque capillary quantification blood collection sheet as claimed in claim 1, 2 or 3 wherein: the front surface of the base plate is provided with an upward convex thickened area surrounding the outlet of the capillary blood sampling channel, and the thickened area is circular.

6. A dry plaque capillary quantification blood collection sheet as claimed in claim 1, 2 or 3 wherein: the side edge of the base plate protrudes outwards at the inlet position of the capillary blood sampling channel to form a raised blood sampling end.

7. A dry plaque capillary quantification blood collection sheet as claimed in claim 1, 2 or 3 wherein: the inlets of the capillary blood sampling channels are arranged on the same side of the base plate.

8. A dry plaque capillary quantification blood collection sheet as claimed in claim 1, 2 or 3 wherein: the middle part of the capillary blood sampling channel is provided with a U-shaped bend.

9. A dry plaque capillary quantification blood collection sheet as claimed in claim 1, 2 or 3 wherein: the side edge of the base plate, which is provided with the inlet of the capillary blood sampling channel, is provided with a notch which is convenient for the cover plate to be attached.

10. A dry plaque capillary quantification blood collection sheet as claimed in claim 1, 2 or 3 wherein: the substrate is a transparent plastic plate.