CN210873230U - Catheter with polycation compound coating - Google Patents

Abstract

The utility model relates to a catheter with polycation compound coating. The catheter comprises a catheter substrate, an activation layer and a functional layer, wherein the activation layer is coated on the inner surface and the outer surface of the catheter substrate, and the functional layer is coated on the surface of the activation layer; the functional layer is a polycationic coating. The catheter is made of silica gel or latex, after the inner surface and the outer surface of a catheter body are treated by low-temperature plasma, a negatively charged hydroxyl or carboxyl functional group coating is formed on the surface of the catheter body by electron energy bombardment, and the coating absorbs an agglomerated cationic compound under the action of electrostatic force to form a functional outermost layer. The outermost functional coating formed by the polycation compound has the functions of moisture retention, antibiosis and the like. In clinical use, the composition has a lubricating effect, reduces the friction force with mucosa in the urethra, has excellent antibacterial performance and can prevent urinary tract infection of patients.

Description

Catheter with polycation compound coating

Technical Field

The utility model belongs to the technical field of medical instrument, concretely relates to catheter of polycation compound coating.

Background

Microbial pathogens have become the chief culprit in the worldwide harm to human health, resulting in disease and even death. Drug-resistant superbacteria, which have been known for a long time to be abused with antibiotics, have raised human beings with a potential threat of global infection. The development of novel broad-spectrum efficient and drug-resistance-free antibacterial agents is urgent. The quaternary ammonium salt bactericide has excellent properties of low toxicity, broad spectrum, high-efficiency antibiosis and the like, and is widely applied to the fields of materials, cosmetics, textile, medical treatment, industrial water treatment and the like. However, these small molecule antibacterial agents have the disadvantages of unstable performance, easy volatilization, difficult processing and the like, and are easy to permeate and diffuse to cause toxic residues. The polycation quaternary ammonium salt polymer material has better antibacterial activity than micromolecule quaternary ammonium salt, is safe to use, cannot permeate into human or animal epidermis, has the advantages of high selectivity, long service life, no residual toxicity and the like, and is widely concerned by researchers. The catheter is a medical instrument commonly used in clinical medical care, most of the existing products are common latex or silica gel catheters, related infections are easily caused during indwelling catheterization of a patient, the number of the infections caused by long-term indwelling of the catheter accounts for 5-10% of total infection cases in a hospital, and no effective method is available for the infections caused by the catheter at present. Therefore, it is necessary to provide a functional catheter with convenient operation, high use comfort and low toxic and side effects.

Disclosure of Invention

Be difficult to satisfy the demand clinically to current product, the utility model aims to provide a catheter of polycation compound coating, this catheter preparation process is simple, and the cost is lower, can reduce the infection rate of clinical medical catheter under the no medicine condition, increases the catheter and keeps somewhere the time in vivo. Meanwhile, the catheter has certain moisturizing effect, and can relieve bladder irritation and urethral mucosa injury during catheterization, catheterization and indwelling.

The above technical problem of the present invention can be solved by the following technical solutions:

the utility model provides a catheter with polycation compound coating, which comprises a catheter base, an activation layer and a functional layer, wherein the inner surface and the outer surface of the catheter base are coated with the activation layer, and the surface of the activation layer is coated with the functional layer; the functional layer is a polycationic coating.

The utility model discloses in, the catheter base adopts the body that latex or silica gel material formed.

The utility model discloses in, the active layer relies on electron energy bombardment for in the low temperature vacuum plasma handles the operating mode, at catheter base surface form the unimolecular coating of the hydroxyl or the carboxyl functional group of negative charge.

The utility model discloses in, adsorb the equipment through electrostatic force between functional layer and the activation layer and form.

The beneficial effects of the utility model reside in that: the utility model discloses a catheter of polycation compound coating in the use, can be under the no medicine prevention infection, and the coating combines firmly with the body, and is little to the mucous membrane damage, characteristics such as use comfort level height.

Drawings

To more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following description of the embodiments or the prior art will be briefly described using the accompanying drawings.

Fig. 1 is a schematic structural view of the present invention;

reference numbers in the figures: 1 is catheter base, 2 is activation layer, 3 is functional layer.

Detailed Description

Preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings so that the advantages and features of the invention can be more easily understood by those skilled in the art.

Example 1: as shown in figure 1, the catheter with the polycation compound coating comprises a catheter substrate 1, wherein an activated layer 2 subjected to low-temperature vacuum plasma treatment is arranged on the inner surface and the outer surface of the catheter substrate 1, and a functional layer 3 composed of a polycation compound is adsorbed on the outer surface of the activated layer 2.

The catheter substrate 1 is made of latex or silica gel (silicon rubber).

The activating layer 2 is bombarded by plasma electron energy, and a negatively charged carboxyl functional group monomolecular layer is formed on the surface of the catheter body of the catheter tube substrate 1, is positioned on the surface of the catheter tube substrate 1, and plays a role of connecting the functional layer 3 by electrostatic force.

The functional layer 3 is composed of polyquaternary ammonium salt (dimethyldiallylammonium chloride-acrylamide copolymer).

When the catheter is manufactured, a catheter made of silica gel or latex is placed in a cavity of vacuum low-temperature plasma treatment equipment, glow discharge treatment is carried out for 3-10 minutes to obtain a monolayer activation layer 2 rich in carboxyl functional groups, then the catheter substrate 1 with the activation layer 2 is immersed in an aqueous phase solution composed of dimethyl diallyl ammonium chloride-acrylamide copolymer for 3 hours to obtain a functional layer 3. The prepared catheter with the polycation compound coating has the advantages of firm combination of the coating and the catheter body substrate, difficult falling off, convenient operation, small damage to mucous membranes, high use comfort level and antibacterial and infection prevention functions.

The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that are not thought of through the creative work should be covered within the scope of the present invention. Therefore, the protection scope of the present invention should be subject to the protection scope defined by the claims.

Claims (4)

1. A polycation compound coated catheter, which comprises a catheter substrate, an activation layer and a functional layer, and is characterized in that: the catheter base is characterized in that the inner surface and the outer surface of the catheter base are coated with an activation layer, and the surface of the activation layer is coated with a functional layer; the functional layer is a polycationic coating.

2. A polycation coated urinary catheter according to claim 1, wherein: the catheter base is a tube body made of latex or silica gel.

3. A polycation coated urinary catheter according to claim 1, wherein: the activating layer is a monomolecular coating with negatively charged hydroxyl or carboxyl functional groups formed on the surface of the pipe body by electron energy bombardment under the working condition of low-temperature vacuum plasma treatment.

4. A polycation coated urinary catheter according to claim 1, wherein: the outermost functional layer and the activated coating layer are assembled by electrostatic force adsorption.

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