CN210583224U - Low-adsorption and antibacterial-colony-deposition catheter - Google Patents
Low-adsorption and antibacterial-colony-deposition catheter Download PDFInfo
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- CN210583224U CN210583224U CN201920876441.6U CN201920876441U CN210583224U CN 210583224 U CN210583224 U CN 210583224U CN 201920876441 U CN201920876441 U CN 201920876441U CN 210583224 U CN210583224 U CN 210583224U
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Abstract
The utility model relates to a low sedimentary catheter that adsorbs, antibiotic colony. The catheter comprises a catheter substrate, an activated hydrophilic layer and a natural protein or amino acid polymer functional layer, wherein the activated hydrophilic layer is coated on the inner surface and the outer surface of the catheter substrate, and the natural protein or amino acid polymer functional layer is coated on the surface of the activated hydrophilic layer. The thickness of the natural protein or amino acid polymer functional layer is between 10 micrometers and 20 nanometers. The catheter has simple preparation process and lower cost, and can reduce the infection rate of the clinical medical catheter and increase the indwelling time of the catheter in vivo under the condition of no medicine.
Description
Technical Field
The utility model belongs to the technical field of medical instrument is relevant, concretely relates to low sedimentary catheter that adsorbs, antibiotic colony.
Background
The urinary catheter is a medical instrument commonly used in clinic, and related infection is easily caused during indwelling catheterization. Among the common infections in hospitals, urinary tract infection accounts for 35-50%, 75-80% of the urinary tract infection is caused by catheters, and the number of infections caused by long-term catheter retention accounts for about 5-10% of the total infection cases in hospitals. There is currently no effective method for catheter-induced infection. The utility model discloses a low catheter of inhaling absorption, antibiotic subsides has that the preparation process is simple, and the cost is lower, can reduce the infection rate of clinical medical catheter under the no medicine condition, increases advantages such as catheter indwelling time in vivo.
Disclosure of Invention
Be difficult to satisfy the characteristics of clinical prevention infection requirement to current product, the utility model aims to provide a low catheter that adsorbs, antibiotic colony deposit, this catheter preparation process is simple, and the cost is lower, can reduce the infection rate of clinical medical catheter under the no medicine condition, increases the catheter and keeps somewhere the time in vivo.
The above technical problem of the present invention can be solved by the following technical solutions:
the utility model provides a catheter with low adsorption and antibacterial colony deposition, which comprises a catheter substrate, an activated hydrophilic layer and a natural protein or amino acid polymer functional layer, wherein the inner surface and the outer surface of the catheter substrate are coated with the activated hydrophilic layer, and the surface of the activated hydrophilic layer is coated with the natural protein or amino acid polymer functional layer; the thickness of the natural protein or amino acid polymer functional layer is between 10 micrometers and 20 nanometers.
The utility model discloses in, the catheter base adopts the body that latex or silica gel material formed.
In the utility model, the activated hydrophilic layer is a functional group layer which is rich in any one of hydroxyl, carboxyl or amino and is formed on the surface of the pipe body of the latex catheter by bombarding silica gel or the surface of the pipe body of the latex catheter by a low-temperature plasma method.
In the utility model, the functional layer of natural protein or amino acid polymer is natural protein or amino acid polymer adsorbed by intermolecular force.
In the present invention, the natural protein or amino acid polymer is a water-soluble related polymer, which is polymerized from a single or multiple basic amino acid units.
The beneficial effects of the utility model reside in that: the utility model discloses a low catheter of inhaling absorption, antibiotic subsides has that the preparation process is simple, and the cost is lower, can reduce the infection rate of clinical medical catheter under the no medicine condition, increases advantages such as catheter indwelling time in vivo.
Drawings
To more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following description of the embodiments or the prior art will be briefly described using the accompanying drawings.
Fig. 1 is a schematic structural view of the present invention;
reference numbers in the figures: 1 is a catheter substrate, 2 is an activated hydrophilic layer, and 3 is a natural protein or amino acid polymer functional layer.
Detailed Description
Preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings so that the advantages and features of the invention can be more easily understood by those skilled in the art.
Example 1 as shown in fig. 1, a low adsorption and anti-bacterial colony deposition catheter comprises a catheter substrate 1, an activated hydrophilic layer 2 which is coated on the inner surface and the outer surface of the catheter substrate 1 and is subjected to low-temperature plasma treatment, wherein the activated hydrophilic layer 2 mainly comprises a monomolecular layer 2 formed by amino functional groups, and a natural protein or amino acid polymer functional layer 3 which is coated on the surface of the activated hydrophilic layer 2 and adsorbs natural protein or amino acid polymer through intermolecular forces, wherein the natural protein or amino acid polymer functional layer 3 is specifically a poly aspartic acid functional layer.
The catheter base 1 is made of latex or silica gel (silicon rubber).
The activated hydrophilic layer 2 treated by the low-temperature plasma is a monomolecular layer rich in amino functional groups on the surface of the catheter substrate 1, so that the hydrophilic and hydrophobic properties of the substrate material are improved, and the intermolecular interaction force between the activated hydrophilic layer 2 and electrolyte in water-phase macromolecules is enhanced. The natural protein or amino acid polymer functional layer 3 is specifically composed of poly-aspartic acid. At pH =7, the surface is negatively charged under neutral conditions, and the repulsion force against bacterial attachment is generated by coulomb force.
When the catheter is manufactured, a catheter substrate 1 made of silica gel or latex is placed in a cavity of vacuum low-temperature plasma treatment equipment, glow discharge treatment is carried out for 5-30 minutes to obtain an activated hydrophilic layer 2, then the catheter substrate is immersed in an electrolyte aqueous phase solution prepared from poly aspartic acid, and the natural protein or amino acid polymer functional layer 3 is obtained after the catheter substrate is immersed for a certain time (10 minutes to 48 hours). The prepared low-absorption adsorption and antibacterial colony deposition coating catheter has the advantages of simple preparation process, lower cost, reduction of the infection rate of clinical medical catheters under the condition of no medicine, increase of the indwelling time of the catheter in vivo and the like.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that are not thought of through the creative work should be covered within the scope of the present invention. Therefore, the protection scope of the present invention should be subject to the protection scope defined by the claims.
Claims (5)
1. A low-adsorption and antibacterial colony deposition catheter is characterized in that: the catheter comprises a catheter substrate, an activated hydrophilic layer and a natural protein or amino acid polymer functional layer, wherein the inner surface and the outer surface of the catheter substrate are coated with the activated hydrophilic layer, and the surface of the activated hydrophilic layer is coated with the natural protein or amino acid polymer functional layer; the thickness of the natural protein or amino acid polymer functional layer is between 10 micrometers and 20 nanometers.
2. A low sorption, anti-microbial colony catheter as recited in claim 1, wherein: the catheter base is a tube body made of latex or silica gel.
3. A low sorption, anti-microbial colony catheter as recited in claim 1, wherein: the activated hydrophilic layer is a functional group layer which is rich in any one of hydroxyl, carboxyl or amino and is formed on the surface of the silica gel or latex catheter body by a low-temperature plasma method.
4. A low sorption, anti-microbial colony catheter as recited in claim 1, wherein: the functional layer of natural protein or amino acid polymer is natural protein or amino acid polymer adsorbed by intermolecular force.
5. A low sorption, anti-microbial colony-depositing urinary catheter according to claim 4, wherein: natural proteins or amino acid polymers are polymerized from single or multiple basic amino acid units.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920876441.6U CN210583224U (en) | 2019-06-12 | 2019-06-12 | Low-adsorption and antibacterial-colony-deposition catheter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920876441.6U CN210583224U (en) | 2019-06-12 | 2019-06-12 | Low-adsorption and antibacterial-colony-deposition catheter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210583224U true CN210583224U (en) | 2020-05-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920876441.6U Active CN210583224U (en) | 2019-06-12 | 2019-06-12 | Low-adsorption and antibacterial-colony-deposition catheter |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN210583224U (en) |
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2019
- 2019-06-12 CN CN201920876441.6U patent/CN210583224U/en active Active
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