CN210863754U - Preparation facilities of carbon-oxygen hemoglobin saturation - Google Patents
Preparation facilities of carbon-oxygen hemoglobin saturation Download PDFInfo
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- CN210863754U CN210863754U CN201921451949.8U CN201921451949U CN210863754U CN 210863754 U CN210863754 U CN 210863754U CN 201921451949 U CN201921451949 U CN 201921451949U CN 210863754 U CN210863754 U CN 210863754U
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Abstract
The utility model provides a preparation facilities of carboxyhemoglobin saturation. Comprises a gas generating device, a gas filtering device and a gas leading-in device; wherein the gas generating device comprises a reactor and a controller, and the reactor is connected with the gas filtering device through a first conduit; the gas filtering device is connected with the gas leading-in device through a second conduit. The preparation device of the utility model is simple and convenient, can be assembled and used at any time, and can simply and accurately control the generation amount of CO gas, the amount of the CO gas to be used and the preparation amount of the CO gas to be prepared by controlling the mixing amount of two chemical raw materials, and the CO gas can be prepared at any time, thus being simple, convenient and quick; when more samples need to be detected, the generation speed of CO gas can be increased, the time for introducing CO gas into each sample is shortened, a plurality of CO saturated samples are prepared quickly, then the enzyme-linked immunosorbent assay device can be used for simultaneous detection, the process of detecting by adopting a spectrophotometer one by one is avoided, and the detection efficiency of a plurality of samples is improved.
Description
Technical Field
The utility model relates to a carbon oxygen hemoglobin saturation detects technical field. And more particularly, to a device for preparing carboxyhemoglobin saturation.
Background
In forensic toxicology analysis, the blood of a deceased person is often subjected to carboxyhemoglobin saturation determination if the deceased person is due to gas poisoning, fire event or carbon monoxide poisoning. The method of measuring the saturation of carboxyhemoglobin (HbCO%) in blood is specified in the judicial identification technical specification file (accession number SF/Z JD 0107010-201). The principle is as follows: the measurement of HbCO% in blood by spectrophotometry is based on the fact that HbCO% is in direct proportion to the absorbance at a certain wavelength. By using a dual-wavelength method, two pairs of absorption points (two pairs of absorption points consisting of 530 nm, 583 nm and 569 nm) are selected from a system of normal human blood and CO saturated blood, the difference of the absorbance of the two pairs of absorption points of the sample blood and the sample blood introduced into the CO saturated blood is measured, and the HbCO% is obtained according to the ratio.
However, this approach has some problems, including: (1) the CO gas in the instrument and the reagent is pipeline gas, and when the pipeline gas is provided in the detection chamber, only bottled gas can be purchased, but the bottled gas usually has lower content of CO or more other impurities, and is inconvenient to use; (2) the gas is introduced for a long time of 15 minutes, and the detection efficiency is low; (3) in this method, the gas directly introduced into the sample solution may be changed to carbon monoxide gas produced from formic acid and concentrated sulfuric acid (carbon monoxide gas method in laboratory), but since the produced gas contains acidic gas, it is difficult to produce carboxyhemoglobin; in addition, it is difficult to control the amount of carbon monoxide produced, and it is difficult to form saturated carboxyhemoglobin, which causes a large error, if at all, and it is difficult to pollute the air.
Aiming at the problems, the preparation device and the determination method for identifying the carboxyhemoglobin in the technical specification file by the judicial method of the number SF/Z JD0107010-201 are improved.
Disclosure of Invention
The to-be-solved technical problem of the utility model is to overcome the CO that detection method exists in the current SF/Z JD0107010-201 file and supply with inconvenient and lower defect of detection efficiency and the technique not enough, provide a preparation facilities of carboxyhemoglobin saturation. The preparation facilities is simple and convenient, can assemble and use at any time, and the formation volume and the formation speed of the while accessible control CO, and then can shorten the access time of CO, can detect fast, has improved the detection efficiency of sample carbooxhemoglobin saturation.
The utility model discloses above-mentioned purpose is realized through following technical scheme:
a device for preparing the saturation of carboxyhemoglobin comprises a gas generating device, a gas filtering device and a gas introducing device; wherein the gas generating device comprises a reactor and a controller, and the reactor is connected with the gas filtering device through a first conduit; the gas filtering device is connected with the gas leading-in device through a second conduit.
The application principle of preparation facilities does: the mixing amount of two chemical raw materials is controlled through a reactor and a controller, so that the generation amount and the generation speed of CO are controlled by controlling the generation amount of chemical reaction, the generated CO gas enters a gas filtering device through a first conduit to be filtered, the filtered CO gas enters a gas introduction device through a second conduit, the gas introduction device extends into a sample to be detected, the CO gas is smoothly introduced into the sample to be detected, the CO saturated sample is obtained, the light absorption values of the CO saturated sample at the positions with the wavelengths of 530 nm, 583 nm and 569nm are detected according to the specification in an SF/Z JD0107010-201 file, and accurate detection results can be obtained through calculation.
The preparation device can simply and accurately control the generation amount, the consumption amount and the preparation amount of the CO gas by controlling the mixing dosage of the two chemical raw materials, and the preparation can be carried out at any time, so that the preparation device is simple, convenient and quick; when more samples need to be detected, the generation speed of the CO gas can be increased, and the time for introducing the CO gas into each sample is shortened.
Preferably, the reactor is detachably and hermetically connected with the controller and the first conduit respectively.
Preferably, the controller is used for controlling the dropping rate of the raw materials.
Preferably, the reactor is sealed by adopting an elastic material; the controller and the first conduit are both in communication with the reactor by interposing an elastomeric material.
Because the CO gas that produces is toxic gas, in order to avoid producing the safety problem, consequently whole device has the requirement to the leakproofness, seals through elastic material, and is sealed effectual on the one hand, and on the other hand, dismouting is simple, convenient between each part.
Preferably, the controller is made of elastic materials and is provided with a liquid storage part and a flow guide part.
Preferably, the controller is communicated with the reactor by inserting the elastic material through the flow guide part.
Preferably, the reactor is used for containing concentrated sulfuric acid; the liquid storage part of the controller is used for containing formic acid.
Preferably, the gas filtering device is filled with filtering liquid, and an elastic material is adopted to seal the opening.
Preferably, the first conduit is detachably and hermetically connected with the gas filtering device, and one end of the first conduit penetrates through the elastic material and is inserted into the filtering liquid.
Preferably, the filtrate is an alkaline solution; more preferably, the filtrate is a sodium hydroxide solution.
Preferably, the mass concentration of the sodium hydroxide solution is 20%.
Preferably, the second conduit is connected with the gas filtering device and the gas introducing device and the detachable seal respectively.
Preferably, one end of the gas leading-in device is a gas guide tube, and the other end of the gas leading-in device is a needle tube.
Preferably, the preparation device further comprises a fixing bottom plate for fixedly placing the gas generating device and the gas filtering device.
Preferably, the preparation apparatus further comprises a sample detection plate; more preferably, the sample detection plate may be a multi-well plate, and contains a plurality of samples at the same time; more preferably, the sample detection plate is a 24-well plate or a 48-well plate.
Because the preparation facilities lets in the gaseous speed of CO very fast, and consequently the preparation speed of CO saturated sample is fast, can adopt the perforated plate, and a plurality of samples of splendid attire simultaneously can adopt the ELIASA to detect simultaneously after preparing a plurality of CO saturated samples fast, has avoided adopting the spectrophotometer to carry out the process that detects one by one, has improved the detection efficiency of a plurality of samples.
The utility model discloses following beneficial effect has:
the preparation device of the utility model is simple and convenient, can be assembled and used at any time, and can simply and accurately control the generation amount of CO gas, the amount of the CO gas to be used and the preparation amount of the CO gas to be prepared by controlling the mixing amount of two chemical raw materials, and the CO gas can be prepared at any time, thus being simple, convenient and quick; when more samples need to be detected, the generation speed of CO gas can be increased, the time for introducing CO gas into each sample is shortened, a plurality of CO saturated samples are prepared quickly, then the enzyme-linked immunosorbent assay device can be used for simultaneous detection, the process of detecting by adopting a spectrophotometer one by one is avoided, and the detection efficiency of a plurality of samples is improved.
Drawings
Fig. 1 is a schematic structural diagram of an apparatus for producing carboxyhemoglobin saturation according to example 1.
Detailed Description
The present invention will be further described with reference to the following drawings and specific examples, which are not intended to limit the invention in any way. Unless otherwise indicated, the reagents, methods and apparatus employed in the present invention are conventional in the art.
Unless otherwise indicated, reagents and materials used in the present invention are commercially available.
Example 1
A device for preparing carboxyhemoglobin saturation, the overall structure schematic diagram of which is shown in figure 1, comprises a gas generating device 1, a gas filtering device 2 and a gas introducing device 3; wherein the gas generating device 1 comprises a reactor 11 and a controller 12, the reactor 11 is connected with the gas filtering device 2 through a first conduit 4; the gas filter device 2 is connected to the gas introduction device 3 via a second conduit 5.
The application principle of the preparation device in this embodiment is as follows: the mixing amount of the two chemical raw materials is controlled through the reactor 11 and the controller 12, so that the generation amount and the generation speed of CO are controlled by controlling the generation amount of chemical reaction, then the generated CO gas enters the gas filtering device 2 through the first conduit 4 for filtering, the filtered CO gas enters the gas introducing device 3 through the second conduit 5, then the gas introducing device 3 extends into a sample to be detected, the CO gas is smoothly introduced into the sample to be detected, so that a CO saturated sample is obtained, the light absorption values of the CO saturated sample at the positions with the wavelengths of 530 nm, 583 nm and 569nm are detected according to the specification in the SF/Z JD0107010-201 file, and accurate detection results are obtained through calculation.
The preparation device can simply and accurately control the generation amount, the consumption amount and the preparation amount of the CO gas by controlling the mixing dosage of the two chemical raw materials, and the preparation can be carried out at any time, so that the preparation is simple, convenient and quick; when more samples need to be detected, the generation speed of the CO gas can be increased, and the time for introducing the CO gas into each sample is shortened.
The reactor 11 is detachably and hermetically connected with the controller 12 and the first conduit 4 respectively.
The controller 12 is used to control the dropping rate of the raw material.
The reactor 11 is sealed by adopting elastic material; the controller 12 and the first conduit 4 are both in communication with the reactor 11 by interposing an elastomeric material.
Because the CO gas that produces is toxic gas, in order to avoid producing the safety problem, consequently whole device has the requirement to the leakproofness, seals through elastic material, and is sealed effectual on the one hand, and on the other hand, dismouting is simple, convenient between each part.
The controller 12 is made of an elastic material and has a liquid storage portion 121 and a flow guide portion 122.
The controller 12 is communicated with the reactor 11 by inserting the elastic material through the guide portion 122.
The reactor 11 is used for containing concentrated sulfuric acid; the liquid storage part 121 of the controller 12 is used for containing formic acid.
From the viewpoint of cost saving, in this manufacturing apparatus of the present embodiment, the reactor 11 is a transparent glass bottle, and is sealed by a rubber stopper; the controller 12 is a rubber dropper, which is convenient for storing the formic acid solution and dropping the formic acid into the reactor 11.
The gas filtering device 2 is filled with filtering liquid and sealed by adopting an elastic material.
The first conduit 4 is detachably connected with the gas filtering device 2 in a sealing way, and one end of the first conduit 4 penetrates through the elastic material and is inserted into the filtering liquid.
The filtrate is alkaline solution; sodium hydroxide solution may be used, with a mass concentration of 20%.
The second conduit 5 is respectively connected with the gas filtering device 2 and the gas leading-in device 3 in a detachable and sealed mode.
One end of the gas leading-in device 3 is a gas guide tube, and the other end is a needle tube.
The gas filtering device 2 is also a transparent glass bottle and is sealed by a rubber stopper; the first catheter 4 and the second catheter 5 can be universal disposable infusion tubes or other catheters; one end of the gas introducing means 3 is a needle tube having a small diameter.
The preparation device also comprises a sample detection plate 6; in order to facilitate the simultaneous detection of a plurality of samples, the sample detection plate 6 may be a multi-well plate; the most common are 24-well plates or 48-well plates.
Because the speed that this embodiment preparation facilities let in CO gas is very fast, therefore the preparation speed of CO saturated sample is fast, can adopt the perforated plate, and a plurality of samples of splendid attire simultaneously after preparing a plurality of CO saturated samples fast, can adopt the ELIASA to carry out simultaneous detection, avoided adopting the spectrophotometer to carry out the process that detects one by one, improved the detection efficiency of a plurality of samples.
The preparation device also comprises a fixed bottom plate 7 for fixedly placing the gas generating device 1 and the gas filtering device 2.
The fixed bottom plate 7 can be made of foam, and is simple, convenient and fast and convenient to disassemble and assemble.
The preparation device is simple and convenient, can be assembled and used at any time, and can simply and accurately control the generation amount, the consumption amount and the preparation amount of the CO gas by controlling the mixing amount of the two chemical raw materials, and the preparation can be carried out at any time, so that the preparation device is simple, convenient and quick; when more samples need to be detected, the generation speed of CO gas can be increased, the time for introducing CO gas into each sample is shortened, a plurality of CO saturated samples are prepared quickly, then the enzyme-linked immunosorbent assay device can be used for simultaneous detection, the process of detecting by adopting a spectrophotometer one by one is avoided, and the detection efficiency of a plurality of samples is improved.
It should be finally noted that the above embodiments are only intended to illustrate the technical solutions of the present invention, and not to limit the scope of the present invention, and that those skilled in the art can make variations or modifications in other different forms based on the above description and thought, and all embodiments need not be exhaustive. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.
Claims (10)
1. The device for preparing the saturation of the carboxyhemoglobin is characterized by comprising a gas generating device (1), a gas filtering device (2) and a gas introducing device (3); wherein the gas generating device (1) comprises a reactor (11) and a controller (12), the reactor (11) is connected with the gas filtering device (2) through a first conduit (4); the gas filter device (2) is connected with the gas leading-in device (3) through a second conduit (5).
2. The apparatus for preparing carboxyhemoglobin saturation according to claim 1, wherein the reactor (11) is detachably and hermetically connected to the controller (12) and the first conduit (4), respectively.
3. The carboxyhemoglobin saturation production apparatus of claim 2, wherein said controller (12) is configured to control a dropping rate of the raw material.
4. The apparatus for preparing carboxyhemoglobin saturation according to claim 3, wherein said reactor (11) is hermetically sealed with an elastic material; the controller (12) and the first conduit (4) are both in communication with the reactor (11) by interposing an elastomeric material.
5. The apparatus for preparing carboxyhemoglobin saturation according to claim 4, wherein said controller (12) is made of an elastic material and has a liquid storage part (121) and a flow guide part (122).
6. The apparatus for preparing saturated hydrocarbon hemoglobin according to claim 1, wherein the gas filtering device (2) is filled with a filtering liquid and sealed with an elastic material.
7. The apparatus for preparing carboxyhemoglobin saturation according to claim 6, wherein said first conduit (4) is detachably and hermetically connected to said gas filtering means (2), and one end of said first conduit (4) is inserted into said filtering liquid through said elastic material.
8. The apparatus for preparing carboxyhemoglobin saturation according to claim 1, wherein said second conduit (5) is detachably and hermetically connected to said gas filtering means (2) and said gas introducing means (3), respectively.
9. The apparatus for preparing carboxyhemoglobin saturation according to claim 1, wherein said gas introducing means (3) has a gas guiding tube at one end and a needle tube at the other end.
10. The carboxyhemoglobin saturation production apparatus of claim 1, further comprising a sample detection plate (6).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921451949.8U CN210863754U (en) | 2019-09-02 | 2019-09-02 | Preparation facilities of carbon-oxygen hemoglobin saturation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921451949.8U CN210863754U (en) | 2019-09-02 | 2019-09-02 | Preparation facilities of carbon-oxygen hemoglobin saturation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210863754U true CN210863754U (en) | 2020-06-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201921451949.8U Expired - Fee Related CN210863754U (en) | 2019-09-02 | 2019-09-02 | Preparation facilities of carbon-oxygen hemoglobin saturation |
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| Country | Link |
|---|---|
| CN (1) | CN210863754U (en) |
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2019
- 2019-09-02 CN CN201921451949.8U patent/CN210863754U/en not_active Expired - Fee Related
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| GR01 | Patent grant | ||
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Granted publication date: 20200626 Termination date: 20210902 |