CN210863616U - Exhaled gas VOCs detection device - Google Patents
Exhaled gas VOCs detection device Download PDFInfo
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- CN210863616U CN210863616U CN201921100764.2U CN201921100764U CN210863616U CN 210863616 U CN210863616 U CN 210863616U CN 201921100764 U CN201921100764 U CN 201921100764U CN 210863616 U CN210863616 U CN 210863616U
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Abstract
The utility model discloses an expiratory air VOCs detection device can be used to the health continuous evaluation. The device comprises a main body exhaled air collecting bin, a hydrophobic membrane fixer, an exhalation nozzle, an array sensor, an exhaust fan, an information processing module, a valve, a display screen and other electronic components, wherein the array sensor measures exhaled air target VOCs signals, and the information processing module calculates changes of different target VOCs relative to last measurement results according to measured VOCs levels to reflect changes of health states. The exhaled gas VOCs detection device can realize high-frequency continuous evaluation of comprehensive health conditions in large-range crowds, and can be used for continuous monitoring and self-evaluation of sub-health states and disease degrees, drug treatment effect inspection, effectiveness evaluation of various intervention factors and the like.
Description
Technical Field
The utility model relates to an expired gas VOCs detection device that is arranged in human health to evaluate in succession, concretely relates to based on array sensor, detect in the expired gas that multiple diseases are relevant common Volatile Organic Compounds (VOCs), and then carry out the device of human health comprehensive evaluation, belong to medical instrument and make and application technical field.
Background
Analysis of the composition of VOCs in exhaled breath from humans is used to assess the health and disease state of humans. For example, acetone, dimethyl sulfide, isoprene, butanol, methyl nitrate, and some long-chain alkanes and benzene series have been found to present significant levels of abnormalities in exhaled breath in diabetic patients; benzene, ethanol, styrene, pentane, etc. were identified as potential markers for lung cancer in multiple studies; aldones such as heptanone and pentanone and alkanes such as butane and pentane are proved to have significant association with oxidative stress processes in vivo and various chronic diseases of the respiratory system, such as chronic pulmonary obstruction, pulmonary fibrosis, asthma and the like; levels of ammonia and hydrogen sulfide are closely related to digestive tract diseases such as chronic kidney disease and halitosis, respectively (Van Berkel, J.J., et al, Respir Med,2010.104(4): p.557-63; Saidi, T., et al, Sensors and Actuators B: Chemical,2017.257: p.178-188; Bajtarevic, A., et al, BMC cancer,2009: p.9: 348; Yoon, J.Y., et al. Lab on a chip,2017.17 (21)). Compared with the traditional invasive and extremely-high-cost physical examination method, the exhaled gas VOCs used for human health state evaluation have the main advantages of basically no harm to human bodies, rapidness and low cost, and are likely to become an important means for continuous health state monitoring and health intervention behavior effect evaluation in the future. In addition to cardiovascular disease, most chronic diseases lack effective means for continuous monitoring.
Currently, there are two main types of detection methods for exhaled gas VOCs: large-scale instrumentation and sensor methods. The advantage of large-scale instrumentation is that the accurate concentration of VOCs in exhaled Breath specific to various diseases can be analyzed simultaneously to determine the health status of human body, but the cost and operation difficulty are very high (Pizzini, A., et al, J Breath Res,2018.12(3): p.15; Zou, X., et al, J Gastroen Heastol, 2016.31(11): p.1837-1843), which is generally applied in large-scale medical institutions. Because the device is relatively more portable, the cost and operational difficulty of sensor methods for analyzing the concentration of target VOCs in exhaled breath from a human body is lower, and the method is more favorable for being developed into a commercial small health evaluation product for a continuous high-frequency health monitoring scene compared with a large instrument (Jalal, A.H., et al., Acs Sensors,2018.3(7): p.1246-1263).
However, there are several problems with devices that use exhaled breath VOCs sensors for health assessment: (1) since the levels of VOCs associated with health assessment in exhaled breath are low (1-100ppb), the accuracy and stability of the sensor itself is insufficient to accurately quantify them, and health assessment based on a few VOCs cannot be performed as with large instruments (Jaisutti, r., et al, Acs Applied Materials & Interfaces,2017.9(10): p.8796-8804). Improving the performance of sensors for analysis of target exhaled breath VOCs is a major research direction at present, but the progress is still very limited (Righettoni, m., et al., analytical Chimica Acta,2012.738: p.69-75.). (2) The exhaled gas contains various VOCs and has high concentration, and the reaction of different VOCs and a single sensor has serious mutual interference. A single disease typically has a variety of characteristic VOCs, and the number of incorporated VOCs is reduced due to defects of the sensor, which further reduces the accuracy of health assessment equipment based on assessing the accurate concentration of VOCs. (3) The array sensor can be used for identifying diseases on the basis of the relative difference of the concentrations of different VOCs, and the concentration of each VOCs does not need to be accurately analyzed, so that the defect of the performance of the existing sensor is avoided to a certain extent. However, the development of an exhaled breath health assessment device developed based on an array sensor requires the use of statistical methods to obtain as many as possible indiscriminate disease-characteristic VOCs to incorporate information on level differences between them, which greatly increases the interference factor for the measurement of VOCs. Currently, the component and level heterogeneity of exhaled breath VOCs related to the same disease, which are screened by different research statistics, are high, and the accuracy of the exhaled breath array sensor health assessment product for a single disease applied to different populations is still very large (Nakhleh, M.K., et al., ACS Nano,2017.11(1): p.112-125; Saidi, T.et al., Sensors and Actuators B: Chemical,2017.257: p.178-188). (4) The basis for the evaluation of health status of currently developed exhaled breath-based health assessment products is whether the concentration or relative difference of certain VOCs differs from the normal level in healthy humans (Saidi, T., et al, Sensors and Actuators B: Chemical,2017.257: p.178-188; Righettoni, M., et al, analytical chip Acta,2012.738: p.69-75.). However, these references are derived from the average values obtained from population study statistics and cannot be guaranteed to be applicable to each individual. In addition, to determine if there are normal levels that are different from healthy individuals, the sensors are required to measure relatively accurate absolute concentrations or inter-component differences of exhaled breath VOCs, which increases the need for health assessment product calibration times, as well as the cost of operation and use. (5) Few devices consider excluding the effects of external VOCs inhalation on health-related low-concentration exhaled Breath VOCs concentrations and relative differences in composition (Van Berkel, J.J., et al., Respir Med,2010.104(4): p.557-63; Phillips, C.O., et al., J Breath Res, 2012.6.). (6) Health problems often arise without independence. At present, more accurate evaluation of single-type diseases is pursued by exhaled gas VOCs health evaluation equipment, and the evaluation of comprehensive conditions of human health is ignored. This not only wastes the physiological information that VOCs have, but also greatly exacerbates the difficulty of development.
Several representative techniques for health status assessment based on exhaled breath VOCs are described below.
Kim et al used a gold-modified ferric oxide nanotube sensor for the analysis of acetone in exhaled breath for the continuous monitoring of diabetes (Kim, d.h., et al, Sensors and actors B-Chemical,2018.274: p.587-594.). The sensor can reach 304ppb only by the detection limit under the working environment of 350 ℃, has potential to be developed into a sensor for large-scale disease diagnosis, but is difficult to be transformed into portable health continuous monitoring equipment and is easily interfered by ethanol in exhaled air. At present, research is carried out in a sensor development stage, the influence of individual difference on diagnosis efficiency is not considered, and the interference of inhaling external VOCs on the sensor is not eliminated.
Chinese patent application publication CN109001445A provides an exhaled air detection reaction apparatus for lung cancer diagnosis based on porphyrin array sensors. The device considers the influence of the temperature and humidity difference of the exhaled air on the diagnosis effect, and the gas control device is used for ensuring the sufficient contact between the sensor and the gas. However, the method only aims at one disease of lung cancer, and considers the influence of other respiratory diseases of the same type; only the use of an array sensor is explained, the types of the screened VOCs are not explained, and the reliability cannot be evaluated; the equipment development carries out lung cancer diagnosis according to the VOCs level of the average level of the crowd, the factors of individual difference are not considered sufficiently, and the guarantee of high-frequency calibration is needed; the effect of the inhaled ambient air on the relative difference in exhaled VOCs is not considered.
Nakhleh et al detected the exhaled breath VOCs of 1404 subjects with different diseases (cancer, gastrointestinal disease, Parkinson's disease, etc.) using an array sensor array of 17 gold nanoparticles and 3 carbon nanotube sensors (Nakhleh, M.K., et al, ACS Nano,2017.11(1): p.112-125.). The results show that people with lung cancer, gastrointestinal diseases, Parkinson's disease and other diseases have characteristic ' exhaled breath footprints ', and the accuracy rate of disease discrimination by using the sensor array is highest and can reach 86%. However, the basis of disease diagnosis in the research is relative difference data of VOCs levels of 1404 subjects, the types of the screened VOCs are not verified in other groups, and the accuracy of the product applied to other groups cannot be guaranteed; the product does not consider the influence of individual difference factors on the diagnosis efficiency, and needs the guarantee of high-frequency calibration; the effect of the inhaled ambient air on the relative difference in exhaled VOCs is not considered. Other prior art methods also suffer from one or more of the problems described above.
The portable exhaled breath type health continuous self-evaluation device and the use method thereof are required to be higher in adaptability of different crowds, capable of comprehensively evaluating the health state of a human body, small in influence of individual difference on diagnosis results and relatively low in calibration requirement.
SUMMERY OF THE UTILITY MODEL
The utility model relates to a part of terminology as shown in the following table:
the utility model aims at providing a be applicable to the china area crowd on a large scale, individual difference and outside air influence the evaluation efficiency lower, simple and convenient quick, accurate, low use cost, can be used to synthesize healthy in succession and comment the exhaled breath VOCs detection device by oneself.
The technical scheme of the utility model as follows:
a detection device for VOCs (volatile organic compounds) in exhaled breath can be used for continuous self-evaluation of human health and is characterized by comprising a main exhaled breath collection bin, a hydrophobic membrane fixer, an exhalation nozzle, an array sensor, an exhaust fan and an electronic component, wherein the electronic component comprises a display screen, an information processing module, a valve A, a valve B and a valve C, and the valve A is arranged on the top surface of the main exhaled breath collection bin; a drain membrane is arranged in the drain membrane fixer, one end of the drain membrane fixer is connected with the valve A, and the other end of the drain membrane fixer is connected with an exhalation nozzle positioned outside the main body exhaled air collection bin; the valve C is arranged on the side wall of the main body exhaled air collection bin, the valve B is arranged at the bottom of the main body exhaled air collection bin, and the outer side of the valve B is connected with the exhaust fan; the array sensor and the information processing module are arranged inside the main body exhaled air collection bin, and the display screen is arranged on the surface of the main body exhaled air collection bin; the array sensor, the display screen, the valve A, the valve B, the valve C and the exhaust fan are respectively connected with the information processing module through signal transmission lines, and the opening of the valve A, the valve B, the valve C and the exhaust fan and the display content of the display screen are controlled by the information processing module; the array sensor measures the concentration of target VOCs in the main body exhaled air collection bin, and the information processing module records, evaluates and calculates signals measured by each sensor and displays the signals on the display screen.
Above-mentioned can be used to healthy continuous expired air VOCs detection device who assesses oneself, the array sensor is preferably resistance type array sensor, comprises a plurality of resistance type sensors to different target VOCs classification, has selected 15 resistance type sensors to different target VOCs classification to constitute the array in the embodiment of the utility model, these VOCs are the relevant volatile organic compounds of commonality of disease.
In the exhaled gas VOCs detection apparatus applicable to health continuous self-evaluation, the main body exhaled gas collection bin is preferably cylindrical and is preferably a bin body made of polytetrafluoroethylene or other low-adsorption materials convenient to mold, so as to reduce the influence of residual VOCs on subsequent measurement.
Above-mentioned can be used to healthy continuous self-evaluation's exhaled gas VOCs detection device, the drum that hydrophobic membrane fixer was made for polytetrafluoroethylene or other fashioned low adsorption material of being convenient for to the maximize reduces the absorption of device material to VOCs.
The interior of the bin body needs to be quickly cleaned before and after the exhaled air is measured. The array sensor is arranged at the bottom of the main body exhaled air collection bin, the valve B is arranged at the bottom of the main body exhaled air collection bin close to the array sensor, and the valve C is arranged on the side wall of the main body exhaled air collection bin close to one side of the array sensor. During sampling, the valves A and B are opened simultaneously to enable air to be discharged from the bottom, the valve C is added to enable ambient air to better pass through the surface of the sensor during cleaning, and the cleaning efficiency of the array sensor is improved. The designs ensure that the measurement process has no influence of VOCs residues on subsequent measurement.
The exhaled gas VOCs detection device capable of being used for health continuous self-evaluation is provided with an on-off key, a test key and a review key for controlling the information processing module, wherein the on-off key controls the on-off of the exhaled gas VOCs detection device; the test key controls the opening of all valves and exhaust fans; and the recall key controls the display screen to display the test results of the previous times.
The exhaled breath VOCs detection device is used for continuously testing the exhaled breath of a human body, so that the concentration change conditions of various VOCs in the exhaled breath of the human body, particularly the concentration change conditions of common VOCs related to various diseases, are obtained, and the health state of the human body can be judged. When the test is started, all valves and exhaust fans are opened, ambient air enters the main body exhaled air collection bin through the exhalation nozzle and the drain film, and the array sensor and the interior of the collection bin are quickly cleaned; closing all valves, and measuring target VOCs signals of ambient air by the array sensor; opening a valve A and a valve B, enabling the exhaled air to enter a main body exhaled air collecting bin from an exhalation nozzle and a hydrophobic membrane, closing the valve A and the valve B, and measuring target VOCs signals of the exhaled air by an array sensor; all valves and exhaust fans are opened, and the interior of the collection bin is rapidly cleaned again; the information processing module calculates the changes of different target VOCs relative to the last measurement result according to the VOCs level measured by the array sensor, and can further judge the health state according to the change conditions.
The above-described array sensor target VOCs selection concept does not encompass as many incorporation-relevant VOCs as possible for a disease, but rather selects "robust common VOCs"; and the information processing module jointly judges the health state by using the accumulated change amplitude of the 'robust common VOCs' and the number of the VOCs with changes. The design reduces the requirements on the measurement detection limit and precision of the sensor, reduces the probability of judgment errors, and realizes the comprehensive evaluation of the health state. "robust consensus VOCs" refers to exhaled VOCs that have a high degree of scientific evidence and high consistency of conclusion, appear in a diverse group of disease-associated VOCs, and have large horizontal variation among healthy and diseased populations. The embodiment of the utility model provides a select acetone (rise in diabetes and other metabolic diseases, healthy and disease crowd's gap can reach 1000ppb), ethanol (rise in lung cancer and other respiratory system diseases, the level difference can reach 300ppb), pentane (internal inflammation, the level difference can reach 10ppb), butane (internal inflammation, the level difference can reach 50ppb), styrene (rise in diseases such as ovarian cancer, lung cancer, senile dementia, the level difference can reach 50ppb), ethylbenzene (rise in lung cancer and other respiratory system diseases, the level difference can reach 10ppb), hydrogen sulfide (rise in digestive tract diseases such as halitosis, the level difference can reach 10ppb), ammonia (nephropathy and asthma, the level difference can reach 10 ppb).
The above concept of design choice of target VOCs of array sensor is not limited to the VOCs in the example, and can be further improved with the increase of sensor level and the increase of the number of "robust common VOCs", and has great growth potential.
The hydrophobic membrane is suitable in pore size, preferably the hydrophobic membrane made of PTFE and other materials with the pore size of 5-10 microns, so that the influence of humidity of exhaled breath on the sensor is avoided, and the influence of too high impact flow rate of the exhaled breath on the sensor is reduced.
The exhaled gas VOCs signal acquisition process, the cleaning process before and after acquisition and the calculation process of the information processing module are integrally controlled, and a user only needs to exhale inwards when the valve A is opened; the cleaning process before the exhaled gas VOCs is collected is combined with the ambient air VOCs signal measurement process. These designs reduce the difficulty of use and measurement time, reducing the possibility of errors due to out-of-specification use.
Further, before measuring the exhaled breath, the sensor measures the target VOCs concentration of the ambient air; and the information processing module deducts the target VOCs concentration of the ambient air from the VOCs concentration of the exhaled air during each calculation. These designs reduce the effect of inhaled VOCs on exhaled breath VOCs concentration.
Furthermore, the information processing module does not depend on the absolute concentration of the VOCs in the exhaled air to judge the health state, and different VOCs are compared with the relative change of the concentration of the corresponding VOCs measured last time to judge. The design uses the user as a reference, reduces the influence caused by errors (such as expiratory air temperature and humidity) among individuals, and reduces the requirement on high-frequency calibration.
The following steps are carried out by utilizing the exhaled gas VOCs detection device to continuously self-evaluate the health state of the human body:
1) long press switch key to open the device.
2) After the test key is pressed for a short time, all the valves and the exhaust fan are opened, and the valves and the exhaust fan are closed after being cleaned for a certain time (such as 5 seconds); the information processing module records signals measured by each sensor in the sensor group as corresponding signals of target VOCs in ambient air; when the valves A and B are opened, the display screen prompts a user to breathe one breath into the breathing mouth deeply for diseases; the valves A and B are closed, and the information processing module records signals measured by each sensor as corresponding signals of target VOCs in the exhaled breath; all valves and fans are turned on and cleaned for a certain period of time (e.g., 5 seconds).
3) The information processing module calculates whether each target VOCs in the exhaled breath has changed significantly using the following formula:
in the formula (1), inciThe change of the concentration of the ith VOCs relative to the last measurement result; signibAnd signieThe comprehensive signal values corresponding to the ith VOCs in the current exhaled breath and the ambient air are respectively obtained by calculating current signal values measured by a plurality of sensors; siglibAnd siglieRespectively indicating the comprehensive signal values corresponding to the ith VOCs in the exhaled air and the ambient air last time; k is a radical ofiAnd biThe regression slope and intercept of the concentration were calculated for the corresponding integrated signal values using VOCs, respectively.
4) The more the number of the raised target VOCs comprehensive signals is, the larger the amplitude is, and the more the display screen displays that the comprehensive health state becomes worse; conversely, the more the overall health status becomes better.
5) And pressing a review key for a short time, and displaying the test results of the previous times on a display screen.
6) And long-time pressing of a switch key to shut down the computer.
The utility model discloses an exhaled breath VOCs detection device can realize synthesizing the high-frequency continuous evaluation of health status in crowd on a large scale, can be used to the continuous monitoring of sub-health state and sick degree and self-assessment, the validity evaluation of drug therapy effect inspection, various intervention factors etc..
The utility model discloses an expiratory air VOCs detection device and application method target are for solving a plurality of problems in expiratory gas class health condition evaluation equipment development and the use: the characteristic that the array sensor jointly judges results by using a plurality of signals is reserved, but the idea of selecting target VOCs is adjusted from surrounding single diseases to using 'robust common VOCs', so that the measurement stability of the array sensor is further improved, the comprehensive evaluation of the health state is realized, and a certain disease problem is not considered in an isolated manner; the health state is evaluated by taking the user as a contrast, so that the influence of individual difference and environmental factors on a test result is reduced, and the calibration requirement and the probability of occurrence of misjudgment are further reduced; the device is simple and portable, the cost is low, the test method is quick and noninvasive, the operation process is integrated, the user acceptance degree is high, and the device is suitable for the standardized test of large-range crowds in different areas; the influence of the environment background of the VOCs with higher content in China on the VOCs with low concentration in the exhaled breath is avoided as much as possible.
Drawings
Fig. 1 is a schematic structural diagram of an exhaled air VOCs detection apparatus for health continuous self-evaluation according to an embodiment of the present invention;
fig. 2 is a cross-sectional view of the exhaled breath VOCs detection apparatus of fig. 1 in the direction a-a;
FIG. 3 is a top view of the exhaled breath VOCs detection apparatus shown;
FIG. 4 is a bottom view of the exhaled breath VOCs detection apparatus shown;
in fig. 1 to 4: 1-exhalation nozzle, 2-hydrophobic membrane, 3-hydrophobic membrane fixer, 4-valve A, 5-main body exhaled gas collection bin, 6-valve B, 7-valve C, 8-array sensor, 9-exhaust fan, 10-display screen, 11-review key, 12-on-off key, 13-information processing module and 14-test key.
Figure 5 shows the response of an array sensor of the device according to an embodiment to a gradual cumulative increase in different target VOCs in exhaled breath.
Detailed Description
The invention will be described in further detail below by way of examples with reference to the accompanying drawings, without limiting the scope of the invention in any way.
As shown in fig. 1 to 4, the device for detecting VOCs in exhaled breath for continuous self-evaluation of health of the present invention mainly comprises six parts: the main body exhaled air collecting bin 5, the hydrophobic membrane fixer 3, the exhalation nozzle 1, the array sensor 8, the exhaust fan 9 and the electronic component, wherein the electronic component comprises a display screen 10 and a built-in information processing module 13, and a review key 11, an on-off key 12 and a test key 14 are arranged on the external interface of the electronic component; and a valve A4, a valve B6 and a valve C7 which are respectively arranged on the top surface, the bottom surface and the side surface of the main body exhaled air collecting bin 5; the valves and the exhaust fan 9 are connected with the information processing module 13 through signal transmission lines.
The hydrophobic membrane fixer 3 is internally provided with a hydrophobic membrane 2, is connected with the exhalation nozzle 1 and the valve A4 and is used for reducing the influence of humidity and impact force of exhaled breath on the array sensor 8; the wall surface of the main exhaled air collection bin 5 is made of polytetrafluoroethylene or other low-VOCs adsorbing materials, so that the influence of residual VOCs on subsequent measurement is reduced; before and after the exhaled air is measured, the information processing module 13 controls the opening of the valve A4, the valve B6, the valve C7 and the exhaust fan 9, and the inner bin of the main body exhaled air collection bin 5 is cleaned, so that adjacent measurement results are prevented from being interfered with each other. In particular, the valve C7 is arranged on the side wall of the main body exhaled air collecting bin 5 and is positioned on one side of the array sensor 8, so that the cleaning effect of the array sensor 8 is improved. . The array sensor 8 selects the exhaled gas VOCs group which has sufficient scientific evidence, is closely associated with various diseases and has large horizontal difference among healthy and diseased crowds as a main target of measurement, so that the requirements on the measurement detection limit and precision of the sensor are reduced, the probability of judgment errors is reduced, and the comprehensive evaluation on the health state is realized. Before the exhaled breath is measured, the information processing module 13 records the concentration of the target VOCs in the ambient air measured by the array sensor 8, and is used for calculating and eliminating the interference of the target VOCs concentration measurement in the exhaled breath. In this embodiment, the array sensor 8 is a resistive array sensor.
By the method, the exhaled air VOCs detection device for health continuous self-evaluation realizes process integrated control, reduces use difficulty and measurement time, and reduces the possibility of error caused by non-standard use; the influence of individual differences and environmental factors on the health status evaluation results is reduced by using the subject itself as a reference object. The method comprises the following steps:
(1) pressing the switch key 12 for a long time, turning on the device, and displaying on the screen prompt "please perform the health test at a fixed time every day! ".
(2) The test key 14 is pressed for a short time, the information processing module 13 controls all valves and the exhaust fan 9 to be opened, the main body expired air collection bin is cleaned for 5 seconds, and then the main body expired air collection bin is closed after 5 seconds; the information processing module 13 records the signal of each sensor in the array sensor 8 as a target VOCs signal in the ambient air; the information processing module 13 controls the valve A4 and the valve B6 to be opened, controls the display screen 10 to display that 'please inhale a breath deeply and rapidly breathe the breath into the breathing mouth forcefully', and prompts a user to breathe a breath deeply into the breathing mouth 1 and then control the valve to be closed; the information processing module 13 records the signal of each sensor in the array sensor 8 as a target VOCs signal in the exhaled breath; the information processing module 13 controls all valves and the exhaust fan 9 to be opened, the main body exhaled air collecting bin 5 is cleaned, and the air collecting bin is closed after 5 seconds.
(3) The information processing module 13 controls the display screen 10 to calculate and display the comprehensive health status of the user according to the formula (1). The more the number of the rising of the comprehensive signals of the target VOCs is, the larger the amplitude is, the worse the comprehensive health state becomes; conversely, the better the overall health status becomes.
(4) The review key 11 is pressed for a short time, and the display screen 10 displays the test results of the previous times.
(5) And a long press of a switch key 12 turns off the machine.
In this embodiment, acetone (elevated in diabetes and other metabolic diseases, the difference between healthy and diseased people may reach 1000ppb), ethanol (elevated in lung cancer and other respiratory diseases, and the difference in level may reach 300ppb), pentane (internal inflammation, and the difference in level may reach 10ppb), butane (internal inflammation, and the difference in level may reach 50ppb), styrene (elevated in ovarian cancer, lung cancer, senile dementia, and other diseases, and the difference in level may reach 50ppb), ethylbenzene (elevated in lung cancer and other respiratory diseases, and the difference in level may reach 10ppb), hydrogen sulfide (elevated in digestive tract diseases such as halitosis, and the difference in level may reach 10ppb), ammonia (kidney disease and asthma, and the difference in level may reach 10ppb), are selected as "robust common cs" included in the array sensor 8.
In the embodiment, the air exhaust amount is 6.5 liters/second when the exhaust fan 9 is started; the volume of the main body expired air collection bin 5 is 6.5 liters, and the cleaning time is 5 seconds each time; the measurement time of the array sensor 8 is 5 minutes each time, and the array sensor is composed of 15 single-point resistance sensors; the diameter of the mouthpiece 1 is 4 cm.
Next, exhaled breath of different compositions was tested using the above-described exhaled breath VOCs detection apparatus. The experimental method comprises the following steps:
a. 1 subject is recruited to test the corresponding current signal value of the exhaled breath;
b. in the exhaled breath of the subject, 309ppb acetone was added using a gas distribution apparatus to prepare a new exhaled breath "a 1".
c. In the new expired gas "a 1", air distribution devices were used to add (56ppb styrene +12ppb ethylbenzene) and (56ppb styrene +12ppb ethylbenzene), respectively, to make new expired gases "B1" and "B2".
d. In the new expired gas "B2", new expired gases "C1" and "C2" were prepared by adding (11ppb pentane +52ppb butane +10ppb hydrogen sulfide +11ppb ammonia) and (22ppb pentane +104ppb butane +20ppb hydrogen sulfide +22ppb ammonia), respectively, using a gas distribution device.
e. In the new expired gas "C2", 313ppb ethanol and 626ppb ethanol were added using a gas distribution device, respectively, to prepare new expired gases "D1" and "D2".
f. Use the utility model discloses expiratory gas VOCs detection device tests new expiratory gas "A1", "B1", "B2", "C1", "C2", "D1", "D2".
Figure 5 shows the response of 15 different single-point sensors in the array sensor 8 due to the increased concentration and number of "robust common VOCs" in the exhaled breath. It is found that the signals from the different single point sensors can be combined to form a composite signal of the target VOCs, for example, the signal rises of sensors 2, 3, 5, 7, 8, 10, 12, 13, 15 constitute a composite rise signal of acetone; the combination of the fall of sensors 1, 6, 9, 11 and the rise of sensors 2, 3, 5, 7, 12, 15 forms a combined rise signal for styrene and ethylbenzene; the combination of the falling of the sensors 4 and 9 and the rising of the sensors 1 and 6 forms a comprehensive rising signal of alkane, hydrogen sulfide and ammonia; the rise of the sensors 1, 2, 3, 4, 5, 6, 7, 8, 9, 13 and 15 are combined to form an ethanol comprehensive rise signal. In addition, the gradual accumulation of the signals, which reflect the increase in the levels and types of target VOCs, can be used to determine changes in overall health level, such as the rise in styrene, acetone, and ethanol that would cause the rise in sensors 2, 3, 5, 7, and 15, and the continued rise in these sensor levels, without species discrimination, can reflect a decrease in overall health.
Claims (8)
1. The utility model provides an expiratory gas VOCs detection device, its characterized in that, includes that storehouse, hydrophobic membrane fixer, exhale mouth, array sensor, exhaust fan and electronic component are collected to main part expiratory gas, electronic component includes display screen, information processing module, valve A, valve B and valve C, wherein: the valve A is arranged on the top surface of the main body expired air collection bin; a drain membrane is arranged in the drain membrane fixer, one end of the drain membrane fixer is connected with the valve A, and the other end of the drain membrane fixer is connected with an exhalation nozzle positioned outside the main body exhaled air collection bin; the valve C is arranged on the side wall of the main body exhaled air collection bin, the valve B is arranged at the bottom of the main body exhaled air collection bin, and the outer side of the valve B is connected with the exhaust fan; the array sensor and the information processing module are arranged inside the main body exhaled air collection bin, and the display screen is arranged on the surface of the main body exhaled air collection bin; the array sensor, the display screen, the valve A, the valve B, the valve C and the exhaust fan are respectively connected with the information processing module through signal transmission lines, and the opening of the valve A, the valve B, the valve C and the exhaust fan and the display content of the display screen are controlled by the information processing module; the array sensor measures the concentration of target VOCs in the main body exhaled air collection bin, and the information processing module records, evaluates and calculates signals measured by each sensor and displays the signals on the display screen.
2. The apparatus of claim 1, wherein the array sensor is a resistive array sensor comprising a plurality of resistive sensors for different classes of target VOCs.
3. The exhaled breath VOCs detection apparatus of claim 1, wherein the main body exhaled breath collection chamber is cylindrical.
4. The exhaled breath VOCs detection apparatus of claim 1, wherein the main body exhaled breath collection chamber is a chamber made of teflon or other low-sorption material.
5. The exhaled breath VOCs detection apparatus of claim 1, wherein the hydrophobic membrane holder is a cylinder made of teflon or other low sorption material.
6. The exhaled breath VOCs detection apparatus of claim 1, wherein the array sensor is disposed at the bottom of the main body exhaled breath collection chamber, the valve B is disposed at a position near the bottom of the main body exhaled breath collection chamber of the array sensor, and the valve C is disposed on a side wall of the main body exhaled breath collection chamber near a side of the array sensor.
7. The apparatus according to claim 1, wherein the apparatus is provided with an on/off key, a test key, and a review key for controlling the information processing module.
8. The exhaled breath VOCs detection apparatus of claim 1, wherein the hydrophobic membrane has a pore size of 5-10 microns.
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