CN210846319U - Micro-embedding generating device for preparing calcium alginate microspheres in laboratory - Google Patents
Micro-embedding generating device for preparing calcium alginate microspheres in laboratory Download PDFInfo
- Publication number
- CN210846319U CN210846319U CN202020884549.2U CN202020884549U CN210846319U CN 210846319 U CN210846319 U CN 210846319U CN 202020884549 U CN202020884549 U CN 202020884549U CN 210846319 U CN210846319 U CN 210846319U
- Authority
- CN
- China
- Prior art keywords
- air
- sample
- calcium alginate
- laboratory
- nozzle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Medicinal Preparation (AREA)
Abstract
The utility model provides a micro-embedding generating device for preparing calcium alginate microspheres in a laboratory, which comprises a spray head, wherein a sample channel and an air channel are arranged in the spray head, a liquid inlet pipe communicated with an injection pump is arranged at the top of the sample channel, an air inlet pipe communicated with an air inlet bottle is arranged at the top of the air channel, the air inlet bottle is communicated with an air storage bottle storing high-pressure air through a pressure regulating box, a nozzle communicated with the sample channel and the air channel is arranged at the bottom of the spray head, a magnetic stirrer is arranged below the nozzle, and a reaction bottle containing curing liquid is arranged on the magnetic stirrer, the preparation method does not need any surfactant or organic solvent, and has the characteristics of simple preparation process, controllable particle size of the microspheres and high safety; and the structure and the preparation process of the required instrument are greatly simplified, and the method is particularly suitable for preparing the calcium alginate microspheres in a laboratory.
Description
Technical Field
The utility model belongs to the technical field of laboratory instrument technique and specifically relates to a little embedded generating device of laboratory preparation calcium alginate microballon is related to.
Background
Alginic acid is a natural polysaccharide, has the advantages of good biocompatibility and bioactivity, wide source, safety and no toxicity, can be solidified with various cations in seawater to form gel, and is often used as a stabilizer, a thickener and the like to be widely applied to the food and medicine industries. The calcium alginate microspheres can be obtained after reaction of alginic acid and calcium ions.
The existing calcium alginate preparation equipment mainly has the following problems: an organic solvent or a large amount of surfactant is required to be added in the preparation process, but the organic solvent and the surfactant have certain toxicity, and the organic solvent and the surfactant are removed through complex process operation in the subsequent process, so that the calcium alginate microspheres applied to the fields of food and medicine are safe and nontoxic; the devices are large-scale production devices, and if the large-scale devices are directly miniaturized for laboratories, the preparation process is extremely complex and is not suitable for the laboratories, so that a micro-embedding generating device special for preparing calcium alginate microspheres in the laboratories does not exist at present.
Therefore, a micro-embedding generating device for preparing calcium alginate microspheres in a laboratory, which can solve the above problems, is needed.
SUMMERY OF THE UTILITY MODEL
The utility model provides a little embedding generating device of preparation calcium alginate microballon in laboratory has utilized the principle of aerodynamics, can realize going on under the room temperature environment, and need not to use any surfactant active and organic solvent, has the characteristics that the preparation process is simple, the size of microballon particle diameter is controllable, the security is high; and the structure and the preparation process of the required instrument are greatly simplified, and the method is particularly suitable for preparing the calcium alginate microspheres in a laboratory.
The technical scheme of the utility model is realized like this:
micro-embedding generating device of laboratory preparation calcium alginate microballon, including a shower nozzle, be provided with sample passageway and the air passage of coaxial setting in the shower nozzle, the top of sample passageway is equipped with one and is used for holding the feed liquor pipe that the syringe pump of sample communicates mutually, the top of air passage is equipped with one and is used for letting in the intake pipe that the air inlet bottle of air communicates mutually, the air inlet bottle is linked together through pressure adjustment box and a storage bomb that has highly-compressed air, the bottom of shower nozzle be equipped with one with the nozzle that sample passageway and air passage are linked together, the below of nozzle is provided with a magnetic stirrers, be provided with a reaction flask of placing the solidification liquid on the magnetic stirrers.
As a preferable technical solution, the sample passage is disposed at a central position of the nozzle head, and the air passage is annularly disposed at an outer side of the sample passage.
As a preferred technical scheme, the spray head is made of stainless steel materials.
By adopting the technical scheme, the beneficial effects of the utility model are that:
the utility model discloses in utilized the principle of aerodynamics, laboratory staff can promote the syringe pump to let in the sample passageway in the shower nozzle through the feed liquor pipe in to the sample, the air in the gas bomb lets in the air passage in the shower nozzle through gas inlet cylinder and intake pipe, sample passageway and air passage are coaxial setting in the shower nozzle to make the air in the air passage produce certain pressure to the sample in the sample passageway; when the sample flows out from a nozzle at the bottom of the spray head at a certain speed, the air blown out from the air channel breaks the sample liquid column into small droplets by utilizing the shearing action of the coaxial air flow, the formed small droplets are collected in the reaction bottle and react with the 5 percent calcium chloride solution in the reaction bottle to be solidified into microspheres.
The utility model discloses in, utilized the principle of aerodynamics and coaxial air current's shearing action, under the effect of atmospheric pressure, with sample liquid column breakage to the microballon that the footpath is lighter than nozzle aperture 10 times, make the utility model discloses the particle diameter of the calcium alginate microballon that prepares is little, and the distribution range of particle size is narrower, and the preparation process is very simple moreover, can go on under the room temperature environment, need not to use any surfactant active and organic solvent, has avoided leading to the fact the calcium alginate microballon to have toxicity because of surfactant active and organic solvent remove thoroughly, has improved the security that calcium alginate microballon used; laboratory personnel can change the sample feeding speed of the sample by adjusting the speed of pushing the injection pump according to requirements, and can also control the air pressure through a pressure adjusting box so as to control the particle size of the prepared calcium alginate microspheres; simultaneously the utility model provides an instrument is small and simple structure, and the flow of preparation transformation calcium acid microballon is simple, accords with the development trend of current laboratory paraphernalia miniaturization, integration and portability completely.
Because the shower nozzle adopts the stainless steel to make, the shower nozzle that stainless steel material made can bear most chemical reagent and high temperature, can recycle after disinfection or ultrasonic cleaning in addition, has reduced the preparation cost input of calcium alginate microballon.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without inventive exercise.
Fig. 1 is a schematic structural diagram of the present invention.
Wherein: 1. a spray head; 2. a sample channel; 3. an air passage; 4. an injection pump; 5. a liquid inlet pipe; 6. feeding a gas cylinder; 7. a pressure regulating box; 8. a gas cylinder; 9. a nozzle; 10. a magnetic stirrer; 11. a reaction bottle; 12. 5% calcium chloride solution; 13. a sample liquid column; 14. calcium alginate microspheres; 15. an air inlet pipe.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.
As shown in fig. 1, the micro-embedding generating device for preparing calcium alginate microspheres in a laboratory comprises a nozzle 1, a sample channel 2 and an air channel 3 which are coaxially arranged are arranged in the nozzle 1, a liquid inlet pipe 5 communicated with an injection pump 4 for containing samples is arranged at the top of the sample channel 2, an air inlet pipe 15 communicated with an air inlet bottle 6 for introducing air is arranged at the top of the air channel 3, the air inlet bottle 6 is communicated with an air storage bottle 8 storing high-pressure air through a pressure adjusting box 7, a nozzle 9 communicated with the sample channel 2 and the air channel 3 is arranged at the bottom of the nozzle 1, a magnetic stirrer 10 is arranged below the nozzle 9, a reaction bottle 11 for placing curing liquid is arranged on the magnetic stirrer 10, in this embodiment, the syringe pump 4 is a micro syringe pump of model WZ-50C6, and the magnetic stirrer 10 is a multi-head magnetic heating stirrer of model HJ-6A.
Wherein, the solidified liquid in the reaction bottle 11 adopts a 5 percent calcium chloride solution 12.
The sample channel 2 is provided at the center of the head 1, and the air channel 3 is provided around the outside of the sample channel 2.
In addition, the spray head 1 is the spray head 1 made of stainless steel materials, the spray head 1 made of stainless steel materials can bear most of chemical reagents and high temperature, and can be repeatedly used after being disinfected or ultrasonically cleaned, so that the preparation cost investment of the calcium alginate microspheres 14 is reduced.
The method of the utility model is as follows:
firstly, weighing a certain amount of polyvinyl alcohol, putting the polyvinyl alcohol into a conical flask, adding a proper amount of distilled water, stirring for 20 minutes at a constant temperature of 20 ℃, and then putting the mixture into a flask and stirring for at least 40 minutes at a temperature of 80 ℃ until the polyvinyl alcohol is completely dissolved to form a polyvinyl alcohol solution;
secondly, weighing quantitative sodium alginate, adding the sodium alginate into the polyvinyl alcohol solution, and then fully stirring, uniformly mixing and dissolving the sodium alginate and the polyvinyl alcohol solution by using a magnetic stirrer 10 to form a sodium alginate-polyvinyl alcohol blending solution as a sample;
thirdly, taking a certain amount of the sample by using an injection pump 4, connecting the injection pump 4 with a liquid inlet pipe 5, pouring a 5% calcium chloride solution 12 serving as a curing liquid into a reaction bottle 11, and placing the reaction bottle 11 on a magnetic stirrer 10;
fourthly, adjusting the pressure of the pressure adjusting box 7 to a proper value, as shown in fig. 1, the direction of an arrow indicates the flowing direction of air, the air in the gas storage cylinder 8 is introduced into the air channel 3 in the spray head 1 through the gas inlet cylinder 6 and the gas inlet pipe 15, the magnetic stirrer 10 is started, then laboratory personnel can push the injection pump 4, the sample is introduced into the sample channel 2 in the spray head 1 through the liquid inlet pipe 5, and the air in the air channel 3 generates a certain pressure on the sample in the sample channel 2;
fifthly, when the sample flows out from the nozzle 9 at the bottom of the spray head 1 at a certain speed, the air blown out from the air channel 3 breaks the sample liquid column 13 into small droplets by utilizing the shearing action of the coaxial air flow, and the formed small droplets are collected in the reaction bottle 11 and react with the 5% calcium chloride solution 12 in the reaction bottle 11 to be solidified into microspheres.
In the utility model, the principle of aerodynamics and the shearing action of coaxial air flow are utilized, under the action of air pressure, the sample liquid column 13 is crushed into microspheres with the particle size being 10 times smaller than the aperture of the nozzle 9, so that the calcium alginate microspheres 14 prepared by the utility model have small particle size and narrow distribution range of the particle size, and the preparation process is very simple, can be carried out in a room temperature environment without using any surfactant and organic solvent, thereby avoiding toxicity in the calcium alginate microspheres 14 caused by incomplete removal of the surfactant and the organic solvent, and improving the safety of the use of the calcium alginate microspheres 14; laboratory personnel can change the sample feeding speed of the sample by adjusting the speed of pushing the injection pump 4 according to requirements, and can also control the size of air pressure through the pressure adjusting box 7 so as to control the particle size of the prepared calcium alginate microspheres 14; simultaneously the utility model provides an instrument is small and simple structure, and the flow of preparation transformation calcium acid microballon is simple, accords with the development trend of current laboratory paraphernalia miniaturization, integration and portability completely.
To sum up, the micro-embedding generating device for preparing calcium alginate microspheres 14 provided by the utility model utilizes the principle of aerodynamics, can be implemented in room temperature environment, does not need to use any surfactant and organic solvent, and has the characteristics of simple preparation process and controllable size of microsphere particle diameter; and the structure and the preparation process of the required instrument are greatly simplified, and the method is particularly suitable for preparing the calcium alginate microspheres in a laboratory.
The above description is only a preferred embodiment of the present invention, and should not be taken as limiting the invention, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (3)
1. Micro-embedding generating device of preparation calcium alginate microballon in laboratory, its characterized in that, including a shower nozzle, be provided with sample passageway and the air passage of coaxial setting in the shower nozzle, the top of sample passageway is equipped with one and is used for holding the feed liquor pipe that the syringe pump of sample communicates mutually, the top of air passage is equipped with one and the intake pipe that is used for letting in the air bottle that admits air and communicates mutually, the air bottle is linked together through pressure regulation box and a storage bomb that has highly-compressed air, the bottom of shower nozzle be equipped with one with the nozzle that sample passageway and air passage are linked together, the below of nozzle is provided with a magnetic stirrers, be provided with a reaction flask of placing the solidification liquid on the magnetic stirrers.
2. The micro-embedding generating device for preparing calcium alginate microspheres in laboratory according to claim 1, wherein the sample channel is arranged at the center of the nozzle, and the air channel is annularly arranged at the outer side of the sample channel.
3. The micro-embedding generating device for preparing the calcium alginate microspheres in the laboratory according to claim 1, wherein the spray head is made of stainless steel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020884549.2U CN210846319U (en) | 2020-05-25 | 2020-05-25 | Micro-embedding generating device for preparing calcium alginate microspheres in laboratory |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020884549.2U CN210846319U (en) | 2020-05-25 | 2020-05-25 | Micro-embedding generating device for preparing calcium alginate microspheres in laboratory |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210846319U true CN210846319U (en) | 2020-06-26 |
Family
ID=71301635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202020884549.2U Active CN210846319U (en) | 2020-05-25 | 2020-05-25 | Micro-embedding generating device for preparing calcium alginate microspheres in laboratory |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN210846319U (en) |
-
2020
- 2020-05-25 CN CN202020884549.2U patent/CN210846319U/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL370303A1 (en) | Supercritical fluids processing: preparation of protein microparticles and their stabilisation | |
| CN105853391A (en) | Preparation method of sodium alginate/chitosan/nutgall external antibacterial microcapsule | |
| CN110639450A (en) | Device and method for preparing calcium alginate microspheres by using microreactor and application of device | |
| Conner et al. | Scalable Formation of Concentrated Monodisperse Lignin Nanoparticles by Recirculation‐Enhanced Flash Nanoprecipitation | |
| CN108855055A (en) | A kind of preparation method of the high activity hydroxide palladium carbon based on microreactor | |
| CN210846319U (en) | Micro-embedding generating device for preparing calcium alginate microspheres in laboratory | |
| EP1412473B1 (en) | Bioreactor provided with equipment with flexible walls | |
| US20180200801A1 (en) | Preparation Method for the Nano-silver Particles | |
| Kobayashi et al. | Microbubble generation with rapid dissolution of ammonia (NH3)-hydrogen (H2) mixed gas fed from a nozzle into water | |
| EP1292385A1 (en) | Method and facility for producing micromembrane capsules | |
| CN104686812B (en) | Coated nano vitamin D for feed3Preparation method of (1) | |
| Ma et al. | A mild method for encapsulation of citral in monodispersed alginate microcapsules | |
| CN104707240A (en) | Method for manufacturing magnetic guiding nanometer connection porous microneedle array | |
| JP5149479B2 (en) | Bioreactor | |
| CN105326809B (en) | One kind containing CaCO3The preparation method of the composite natral high molecule microcapsule of particle | |
| DE102012215476B4 (en) | Method and device for the selective feeding of gases or gas mixtures into a liquid, suspension or emulsion in a reactor | |
| CN110408374B (en) | Method and device for preparing nano-coated oil displacement agent by adopting micro-flow field reaction technology | |
| CN102431996A (en) | Preparation method of monodisperse large size carbon ball | |
| CN208661155U (en) | A kind of Oscillatory Flow Reactor | |
| CN108101091B (en) | Method and device for producing calcium carbonate by dynamic carbonization method | |
| CN111229097A (en) | Preparation method of monodisperse full-aqueous-phase Pickering emulsion and microfluidic device thereof | |
| Hu et al. | Improved Spherical Particle Preparation of Ceftriaxone Sodium via Membrane-Assisted Spherical Crystallization | |
| CN207958380U (en) | A kind of cell technique vaccine manufacture system | |
| CN214636163U (en) | Novel film emulsification can be in succession quick device | |
| CN107163264B (en) | A method of chitosan microball is prepared to break out nucleation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |