CN210844665U - Closed-loop drug delivery system - Google Patents
Closed-loop drug delivery system Download PDFInfo
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- CN210844665U CN210844665U CN201921036966.5U CN201921036966U CN210844665U CN 210844665 U CN210844665 U CN 210844665U CN 201921036966 U CN201921036966 U CN 201921036966U CN 210844665 U CN210844665 U CN 210844665U
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Abstract
The utility model relates to a closed loop drug delivery system, closed loop drug delivery system implants human subcutaneous, include: the device comprises a drainage tube, a liquid storage device, a detector, a flow regulator and a controller; the detector is arranged on the drainage tube and used for detecting the set body index of the patient; one end of the drainage tube is communicated with the liquid storage device through the flow regulator, and the other end of the drainage tube directly reaches the preset medicine injection area; the liquid storage device is used for storing preset medicines, and the preset medicines enter the drainage tube from the liquid storage device through the flow regulator and finally reach the preset medicine injection area; the controller is respectively connected with the detector and the flow regulator and is used for receiving the set body index sent by the detector and controlling the opening and closing degree and the opening degree of the flow regulator according to the set body index; the flow regulator is used for controlling the flow of preset medicines flowing into the drainage tube from the liquid storage device. By adopting the device, whether the preset medicine needs to be added or not can be determined according to the real-time set body index of the patient, the addition amount of the medicine is determined, and the closed-loop intelligent control of the closed-loop medicine conveying system is realized.
Description
Technical Field
The utility model relates to the technical field of medical equipment, concretely relates to closed loop medicine conveying system.
Background
With the development of medical devices, more and more medical devices are now being applied to various medical fields. For example: a liquid storage bag. In the process of disease treatment, some diseases require long-term injection of medicines for patients, and the long-term injection of the medicines requires frequent injection of the medicines through a syringe, so that the patients suffer from pain once injection, and the patients suffer from great pain. Therefore, in order to reduce the pain of patients, the liquid storage bag is applied to the medical field. The liquid storage bag is implanted into a patient body, when the patient needs to inject the medicine, the medicine is injected into the liquid storage bag and enters the patient body through the liquid storage bag, so that the patient is ensured not to need to inject the medicine through the injector every time, only the liquid storage bag needs to be implanted, and the medicine is injected into the liquid storage bag, and the pain of the patient is greatly relieved.
The common liquid storage bag in the existing medical field is an ommaya liquid storage bag which consists of a drainage tube and a liquid storage device, the liquid storage bag is implanted into a human body, and when a medicine needs to be injected, the medicine is injected into the liquid storage device and enters the human body through the drainage tube. The liquid storage bag can avoid the pain of a patient who needs to prick the needle for the next time, but when the liquid storage bag needs to inject the medicine, the medicine needs to be injected manually at one time, the dosage of the medicine cannot be accurately controlled, and the treatment effect is poor.
SUMMERY OF THE UTILITY MODEL
In view of this, the present invention is directed to overcome the shortcomings of the prior art, and to provide a closed-loop drug delivery system. The problem that the dosage of the medicine can not be accurately controlled due to the fact that the medicine is injected manually is solved.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
a closed-loop drug delivery system implanted subcutaneously in a human comprising:
the device comprises a drainage tube, a liquid storage device, a detector, a flow regulator and a controller;
the detector is arranged on the drainage tube and used for detecting the set body index of the patient;
one end of the drainage tube is communicated with the liquid storage device through the flow regulator, and the other end of the drainage tube directly reaches a preset medicine injection area; the liquid storage device is used for storing preset medicines, and the preset medicines enter the drainage tube from the liquid storage device through the flow regulator and finally reach the preset medicine injection area;
the controller is respectively connected with the detector and the flow regulator and is used for receiving the set body index sent by the detector and controlling the opening and closing and opening degree of the flow regulator according to the set body index;
the flow regulator is used for controlling the flow of the preset medicine flowing into the drainage tube from the liquid storage device.
Optionally, the reservoir comprises: a first reservoir and a second reservoir; the preset medicines comprise a first preset medicine and a second preset medicine;
a first preset medicine is stored in the first liquid storage chamber, and a second preset medicine is stored in the second liquid storage chamber.
Optionally, the flow regulator includes: a microvalve or a micropump.
Optionally, the shape of the first reservoir is different from the shape of the second reservoir.
Optionally, the first liquid storage chamber is square; the second liquid storage chamber is circular.
Optionally, the first preset medicine is a pressure reducing medicine, and the second preset medicine is a pressure increasing medicine;
or the first preset medicine is a blood sugar increasing medicine, and the second preset medicine is a blood sugar reducing medicine;
or the first preset medicine is dopamine, and the second preset medicine is a dopamine receptor blocker medicine;
alternatively, the second predetermined drug is an antagonist of the first predetermined drug.
Optionally, the detector specifically includes:
a blood glucose detector and/or a blood pressure detector and/or a blood lipid detector and/or a dopamine concentration detector.
Optionally, the detector is a blood glucose detector and/or a blood pressure detector and/or a blood lipid detector, and the preset medicine injection area is a set position on the abdomen or a set position at the neck of the patient;
or the detector is a dopamine concentration detector, and the preset medicine injection area is a nerve nucleus mass in the brain of the patient.
Optionally, the setting the physical index specifically includes: the blood glucose level of the patient and/or the blood pressure of the patient and/or the blood lipid level of the patient and/or the dopamine concentration of the patient.
Optionally, the drainage tube is a medical silicone tube.
The technical scheme provided by the application can comprise the following beneficial effects:
disclosed in this application is a closed loop drug delivery system, this closed loop drug delivery system implants the human subcutaneous, includes: the device comprises a drainage tube, a liquid storage device, a detector, a flow regulator and a controller; one end of the drainage tube is communicated with the liquid storage device through the flow regulator, the other end of the drainage tube directly reaches the preset medicine injection area, the detector is arranged on the drainage tube and used for detecting the set body index of a patient and sending the set body index to the controller, the controller controls the opening and closing degree of the flow regulator according to the set body index, and the flow regulator further realizes the flow of the preset medicine. Adopt above-mentioned closed loop drug delivery system can learn the information of patient's settlement health index according to the detector, the controller is according to the switching and the degree of opening of this information control flow regulator, the injection volume of predetermineeing the medicine in having realized according to patient health intelligent control reservoir, closed loop drug delivery system's closed loop control is realized, simultaneously because the injection volume of predetermineeing the medicine according to patient health control, the appearance of the too much or too little problem of dosage has been avoided, treatment is greatly improved.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
Fig. 1 is a schematic structural diagram of a closed-loop drug delivery system according to an embodiment of the present invention;
fig. 2 is a schematic structural diagram of a closed-loop drug delivery system according to another embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention clearer, the technical solutions of the present invention will be described in detail below. It is to be understood that the embodiments described are only some embodiments of the invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.
Fig. 1 is a schematic structural diagram of a closed-loop drug delivery system according to an embodiment of the present invention. Referring to fig. 1, a closed loop drug delivery system implanted subcutaneously in a human comprising:
a drainage tube 101, a reservoir 102, a detector 103, a flow regulator 1055 and a controller 104;
the detector 103 is arranged on the drainage tube 101 and used for detecting a set body index of a patient; wherein, the set physical index comprises the blood sugar content of the patient and/or the blood pressure of the patient and/or the blood fat of the patient and/or the concentration of dopamine of the patient and/or some other monitoring index. It should be noted that the selection of the set physical index in this embodiment is not only, and may include several physical indexes indicated in this embodiment, or may include other physical indexes, as long as the physical index can judge the physical condition of the patient according to the index and further has an instruction effect on medication, and the physical index may be preset according to a user or a merchant. Wherein, the drainage tube 101 and the reservoir 102 in this embodiment are made of silica gel. It should be noted that the material selection of drainage tube and reservoir is not limited to and the silica gel material, can preset according to the demand, as long as to be harmless to the human body, and can arrange the material in vivo for life.
One end of the drainage tube 101 is communicated with the liquid reservoir 102 through the flow regulator 105, and the other end of the drainage tube 101 directly reaches a preset medicine injection area; the liquid storage device 102 is used for storing preset medicines, and the preset medicines enter the drainage tube 101 from the liquid storage device 102 through the flow regulator 105 and finally reach the preset medicine injection area; the controller 104 is connected to the detector 103 and the flow regulator 105 through connection lines, and is configured to receive the set body index sent by the detector 103, and control the opening and closing of the flow regulator 105 and the opening degree according to the set body index; wherein the micro regulator comprises a micro valve or a micro pump. The micro valve or the micro pump in the embodiment is made of metal materials with nuclear magnetism resistance, has no side effect on a human body, and can be permanently remained in the body. It should be noted that the model of the micro valve or the micro pump in this embodiment is not limited, and may be preset according to the user's requirement, as long as the micro switch device can realize the control function of the switch.
Optionally, in this embodiment, the detector 103 specifically includes:
a blood glucose detector and/or a blood pressure detector and/or a blood lipid detector and/or a dopamine concentration detector and/or some other monitoring indicator. It should be noted that the selection of the detector in the present application is not exclusive, and may be preset according to the user's requirement, and the selection of the detector herein corresponds to the set body index, and may be any corresponding detector capable of detecting the set body index. The detector in this embodiment may be a sensor.
When the detector in this embodiment is a dopamine concentration detector, the closed-loop drug delivery system is implanted at the nerve nuclei in the brain of the patient, and the dopamine concentration detector is used to detect the dopamine concentration during the experience.
When the detector is a blood glucose detector and/or a blood pressure detector and/or a blood lipid detector, the closed loop drug delivery system is arranged in an artery under the skin of the patient, such as a carotid artery implanted in the patient or a femoral artery implanted in the patient, so that the blood glucose detector detects the blood glucose of the patient, the blood pressure detector detects the blood pressure of the patient, and the blood lipid detector detects the blood lipid of the patient;
optionally, when the detector is a blood glucose detector and/or a blood pressure detector, the closed loop drug delivery system may also be disposed in a ventricle of the brain of the patient, the blood glucose detector being configured to detect a glucose level in a body fluid of the patient, and the blood pressure detector being configured to detect a brain pressure of the patient.
It should be noted that the selection of the implantation position of the closed loop drug delivery system is not limited to the position in the embodiments of the present application, and the implantation position of the closed loop drug delivery system may be determined according to the type of the detector, i.e. may be selected according to the actual situation.
Furthermore, when the detector is a blood glucose detector and/or a blood pressure detector and/or a blood lipid detector and the closed loop drug delivery system is arranged at the femoral artery of the patient, the preset drug injection area is a set position on the abdomen of the patient; the position of the left lower abdomen of the patient can be the position of the right lower abdomen of the patient. When the closed-loop drug delivery system is arranged in the carotid artery of a patient, the preset drug injection area is a set position at the neck. It should be noted that the specific location of the pre-set drug injection zone is not unique and may be selected based on the implantation location of the closed loop drug delivery system.
Or the detector is a dopamine concentration detector, and the preset medicine injection area is a nerve nucleus mass in the brain of the patient.
The flow regulator 105 is used to control the flow of the preset medicine flowing from the reservoir 102 into the drain 101.
The controller 104 in this embodiment compares the set physical index with the preset standard index, and when the set physical index is greater than or less than the preset physical index, controls the flow rate controller 105 to open and close, and determines the opening degree of the flow rate controller 105 according to the difference between the set physical index and the preset standard index. When the difference between the two is great, it is relatively poor to represent patient's health, needs more preset medicine to intervene the treatment this moment, so need guarantee that the flow modulator is in great degree of opening this moment to make more preset medicine flow in the drainage tube, otherwise, then turn down the degree of opening of flow modulator, reduce the flow of the preset medicine that flows in the drainage tube.
The controller 104 here selects an 8051 single chip microcomputer. It should be noted that the selection of the model of the controller in this embodiment is not limited to the 8051 single chip, and may be preset according to the requirement, as long as the single chip can implement comparison of the data size.
In this embodiment, the detector detects a set physical index of the patient and sends the set physical index to the controller, and the controller further determines the size of the set physical index and a preset standard index according to the set physical index of the patient, and determines the opening and closing and the opening degree of the flow regulator according to the comparison result. When the flow regulator is in an open state, preset medicines in the closed-loop medicine conveying system flow into the drainage tube, and the preset medicines directly reach the preset medicine injection area through the drainage tube.
Adopt this in implementation can be according to patient's real-time health condition, regulate and control the flow of the predetermined medicine that flows into the drainage tube in the reservoir to realize the intelligent closed-loop control of medicine among the closed-loop medicine conveying system, and can, avoided the appearance of the too much or too little problem of dosage, greatly improved treatment.
On the basis of the above embodiments, in order to describe the closed-loop drug delivery system in the present application in more detail, another embodiment is provided, which is as follows:
fig. 2 is a schematic structural diagram of a closed-loop drug delivery system according to another embodiment of the present invention. Referring to fig. 2, a closed-loop drug delivery system implanted subcutaneously in a human comprising: a drainage tube 201, a liquid storage device, a detector 203, a flow regulator and a controller 204;
the detector 203 is arranged on the drainage tube 201 and used for detecting a set body index of a patient;
one end of the drainage tube 201 is communicated with the liquid reservoir through the flow regulator, and the other end of the drainage tube 201 directly reaches a preset medicine injection area; the liquid storage device is used for storing preset medicines, and the preset medicines enter the drainage tube 201 from the liquid storage device through the flow regulator and finally reach the preset medicine injection area;
the controller 204 is connected to the detector 203 and the flow controller through a connection line 206, and is configured to receive the set body index sent by the detector, and control the opening and closing of the flow controller according to the set body index;
the flow regulator is used for controlling the flow of the preset medicine flowing into the drainage tube from the liquid storage device.
Wherein, the reservoir includes: the first reservoir 2021 and the second reservoir 2022, and the first reservoir 2021 and the second reservoir 2022 are different in shape. The first reservoir 2021 is square and the second reservoir 2022 is circular. The preset medicines comprise a first preset medicine and a second preset medicine; the flow regulators include a first flow regulator 2051 and a second flow regulator 2052; the first liquid storage chamber 2021 stores a first preset medicine, and the second liquid storage chamber 2022 stores a second preset medicine. When the reservoir included two stock solution rooms, the one end that the drainage tube was linked together with the reservoir was equipped with two drainage branch pipes: the first branch drainage pipe and the second branch drainage pipe; the first flow regulator 2051 is arranged on a first drainage branch pipe between the first liquid storage chamber 2021 and the drainage pipe 201, and the second flow regulator 2052 is arranged on a second drainage branch pipe between the second liquid storage chamber 2022 and the drainage pipe 201; it should be noted that the first preset drug and the second preset drug may be the same drug or different drugs, and the specific conditions may be preset according to the requirements. It should be noted that the liquid storage device in this embodiment is not limited to two liquid storage chambers, and may have a plurality of liquid storage chambers, and may be used to store a plurality of different medicines, as the case may be. Simultaneously the quantity of the branch drainage pipe of drainage tube in this embodiment also is not only limited to two in this embodiment, and the quantity of branch drainage pipe can not be less than the quantity of stock solution room, can set for the quantity of branch drainage pipe according to actual demand.
Further, the second predetermined drug is an antagonist of the first predetermined drug;
specifically, the first preset medicine is a hypotensor, and the second preset medicine is a booster;
or the first preset medicine is a blood sugar increasing medicine, and the second preset medicine is a blood sugar reducing medicine;
or the first preset medicine is dopamine, and the second preset medicine is a dopamine receptor blocker medicine.
The functions of the first preset medicine and the second preset medicine play opposite roles, for example, when the blood pressure of a patient is too low due to the fact that the blood pressure reducing medicine is overdosed, the blood pressure of the patient can be increased through injecting the boosting medicine, and the situation that the irrecoverable influence is caused due to the fact that the medicine is overdosed is avoided.
The embodiment will be described in detail by taking the case that the first liquid storage chamber stores the pressure increasing medicine and the second liquid storage chamber stores the pressure decreasing medicine.
The blood pressure detector detects the blood pressure of a patient in real time, the detected blood pressure of the patient is sent to the controller, and the controller compares the blood pressure of the patient with a normal blood pressure value to judge the physical condition of the patient. When the blood pressure of the patient is larger than the normal blood pressure value, the patient needs to be injected with the pressure reducing medicine to reduce the pressure, and at the moment, the controller controls the second flow regulator to be opened, so that the pressure reducing medicine in the second liquid storage chamber enters the body of the patient through the drainage tube, and the function of reducing the pressure is realized. If the blood pressure of the patient is smaller than the normal blood pressure value, the pressure boosting medicine needs to be injected into the patient to boost the pressure, and the controller controls the first flow regulator to be started at the moment so that the pressure boosting medicine in the first liquid storage chamber enters the body of the patient to achieve the effect of boosting the pressure.
In this embodiment, the shape of the first reservoir is different from the shape of the second reservoir. When the first preset medicine and the second preset medicine are different medicines, the appearance of wrong medicines is avoided due to the fact that the shape of the first liquid storage chamber is different from that of the second liquid storage chamber. Greatly ensuring the life safety of the patient and improving the practicability of the product. It should be noted that, when the first liquid storage chamber is square, the corners of the liquid storage chamber are all the corners with radian after polishing treatment, so as to prevent the sharp corners from damaging the patient. Meanwhile, the liquid storage device in the embodiment adopts a design of a separating chamber, so that injection of various medicines can be realized, and the practicability of the device is greatly improved.
In the embodiment, the liquid reservoir is provided in the form of the component compartment, so that the situation that the drug is injected excessively to cause threat to the body of a patient can be avoided. Greatly ensuring the health of the patient and improving the practicability of the device.
It is understood that the same or similar parts in the above embodiments may be mutually referred to, and the same or similar parts in other embodiments may be referred to for the content which is not described in detail in some embodiments.
It should be noted that, in the description of the present invention, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance. In addition, in the description of the present invention, "a plurality" means at least two unless otherwise specified.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
Although embodiments of the present invention have been shown and described, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that variations, modifications, substitutions and alterations can be made to the above embodiments by those of ordinary skill in the art without departing from the scope of the present invention.
Claims (10)
1. A closed-loop drug delivery system implanted subcutaneously in a human comprising:
the device comprises a drainage tube, a liquid storage device, a detector, a flow regulator and a controller;
the detector is arranged on the drainage tube and used for detecting the set body index of the patient;
one end of the drainage tube is communicated with the liquid storage device through the flow regulator, and the other end of the drainage tube directly reaches a preset medicine injection area; the liquid storage device is used for storing preset medicines, and the preset medicines enter the drainage tube from the liquid storage device through the flow regulator and finally reach the preset medicine injection area;
the controller is respectively connected with the detector and the flow regulator and is used for receiving the set body index sent by the detector and controlling the opening and closing and opening degree of the flow regulator according to the set body index;
the flow regulator is used for controlling the flow of the preset medicine flowing into the drainage tube from the liquid storage device.
2. The closed-loop drug delivery system of claim 1, wherein the reservoir comprises: a first reservoir and a second reservoir; the preset medicines comprise a first preset medicine and a second preset medicine;
a first preset medicine is stored in the first liquid storage chamber, and a second preset medicine is stored in the second liquid storage chamber.
3. The closed-loop drug delivery system of claim 1, wherein the flow regulator comprises: a microvalve or a micropump.
4. The closed loop drug delivery system of claim 2, wherein the shape of the first reservoir is different from the shape of the second reservoir.
5. The closed loop drug delivery system of claim 4, wherein the first reservoir is square; the second liquid storage chamber is circular.
6. The closed-loop drug delivery system of claim 2, wherein the first predetermined drug is a pressure reducing drug and the second predetermined drug is a pressure increasing drug;
or the first preset medicine is a blood sugar increasing medicine, and the second preset medicine is a blood sugar reducing medicine;
or the first preset medicine is dopamine, and the second preset medicine is a dopamine receptor blocker medicine;
alternatively, the second predetermined drug is an antagonist of the first predetermined drug.
7. Closed loop drug delivery system as claimed in claim 1, characterized in that the detector in particular comprises:
a blood glucose detector and/or a blood pressure detector and/or a blood lipid detector and/or a dopamine concentration detector.
8. The closed loop drug delivery system of claim 7 wherein the detector is a blood glucose detector and/or a blood pressure detector and/or a blood lipid detector and the pre-set drug injection zone is a set location on the abdomen or a set location at the neck of the patient;
or the detector is a dopamine concentration detector, and the preset medicine injection area is a nerve nucleus mass in the brain of the patient.
9. Closed loop drug delivery system as claimed in claim 1, characterized in that the setting of body indices in particular comprises: the blood glucose level of the patient and/or the blood pressure of the patient and/or the blood lipid level of the patient and/or the dopamine concentration of the patient.
10. The closed loop drug delivery system of claim 1, wherein the drain tube is a medical silicone tube.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201921036966.5U CN210844665U (en) | 2019-07-04 | 2019-07-04 | Closed-loop drug delivery system |
| PCT/CN2019/110357 WO2021000441A1 (en) | 2019-07-04 | 2019-10-10 | Closed-loop medicine delivery system |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201921036966.5U CN210844665U (en) | 2019-07-04 | 2019-07-04 | Closed-loop drug delivery system |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110180054A (en) * | 2019-07-04 | 2019-08-30 | 山西医科大学 | A kind of closed loop drug delivery systems |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110180054A (en) * | 2019-07-04 | 2019-08-30 | 山西医科大学 | A kind of closed loop drug delivery systems |
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