CN210844665U - A closed-loop drug delivery system - Google Patents

Abstract

The utility model relates to a closed-loop drug delivery system. The closed-loop drug delivery system is implanted under the skin of a human body, and comprises: a drainage tube, a liquid reservoir, a detector, a flow regulator and a controller; the detector is arranged on the drainage tube and is used for It is used to detect the set body index of the patient; one end of the drainage tube is connected with the reservoir through the flow regulator, and the other end of the drainage tube directly reaches the preset drug injection area; The liquid container enters the drainage tube through the flow regulator, and finally reaches the preset drug injection area; the controller is connected with the detector and the flow regulator respectively, and is used to receive the set body index sent by the detector, and control the flow according to the set body index. The opening and closing and opening degree of the regulator; the flow regulator is used to control the flow rate of the preset medicine flowing into the drainage tube from the liquid reservoir. The above device can determine whether the preset medicine needs to be added according to the real-time set body index of the patient, and determine the addition amount of the medicine, thereby realizing the closed-loop intelligent control of the closed-loop medicine delivery system.

Description

A closed-loop drug delivery system

technical field

The utility model relates to the technical field of medical devices, in particular to a closed-loop drug delivery system.

Background technique

With the development of medical equipment, more and more medical equipment is now used in various medical fields. Example: Reservoir. In the process of disease treatment, some diseases require patients to inject drugs for a long time, and long-term injection of drugs requires frequent injection of drugs through syringes. In this way, patients suffer from pain every time they receive an injection, and patients are extremely pain. Therefore, in order to reduce the pain of the patient, the reservoir bag is used in the medical field. Implant the reservoir bag into the patient's body. When the patient needs to inject medicine, inject the medicine into the reservoir bag and enter the patient's body through the reservoir bag, so as to ensure that the patient does not need to inject medicine through a syringe every time. , Just implant the storage bag and inject the medicine into the storage bag, which greatly reduces the pain of the patient.

The liquid storage bag commonly used in the existing medical field is the ommaya liquid storage bag, the ommaya liquid storage bag is composed of a drainage tube and a liquid reservoir, the liquid storage bag is implanted into the human body, and when medicine needs to be injected, the medicine is injected into the liquid storage bag In the device, it enters the human body through the drainage tube. This kind of liquid storage bag can avoid the pain of needing needles for patients repeatedly. However, when this kind of liquid storage bag needs to inject medicine, it needs to inject medicine at one time, and the dosage of medicine cannot be accurately controlled, resulting in poor treatment effect.

Utility model content

In view of this, the purpose of the present invention is to overcome the deficiencies of the prior art and provide a closed-loop drug delivery system. The problem of artificial injection of drugs and inability to precisely control the amount of drugs is solved.

To achieve the above purpose, the utility model adopts the following technical solutions:

A closed-loop drug delivery system, the closed-loop drug delivery system is implanted subcutaneously in a human body, comprising:

Drainage tubes, reservoirs, detectors, flow regulators and controllers;

The detector is arranged on the drainage tube and is used to detect the set body index of the patient;

One end of the drainage tube is communicated with the liquid reservoir through the flow regulator, and the other end of the drainage tube directly reaches a preset drug injection area; the liquid reservoir is used for storing preset drugs, and the preset drug The medicine enters the drainage tube from the liquid reservoir through the flow regulator, and finally reaches the preset medicine injection area;

The controller is respectively connected with the detector and the flow regulator, and is used for receiving the set body index sent by the detector, and controlling the flow regulator according to the set body index. opening and closing and degree of opening;

The flow regulator is used to control the flow of the preset medicine flowing from the liquid reservoir into the drainage tube.

Optionally, the liquid storage device includes: a first liquid storage chamber and a second liquid storage chamber; the preset medicine includes a first preset medicine and a second preset medicine;

A first preset medicine is stored in the first liquid storage chamber, and a second preset medicine is stored in the second liquid storage chamber.

Optionally, the flow regulator includes: a micro valve or a micro pump.

Optionally, the shape of the first liquid storage chamber is different from the shape of the second liquid storage chamber.

Optionally, the first liquid storage chamber is square; the second liquid storage chamber is circular.

Optionally, the first preset drug is an antihypertensive drug, and the second preset drug is a blood pressure booster drug;

Alternatively, the first preset drug is a blood sugar-raising drug, and the second preset drug is a blood sugar-lowering drug;

Alternatively, the first preset drug is dopamine, and the second preset drug is a dopamine receptor blocker drug;

Alternatively, the second preset drug is an antagonist of the first preset drug.

Optionally, the detector specifically includes:

Blood glucose level detector and/or blood pressure detector and/or blood lipid detector and/or dopamine concentration detector.

Optionally, the detector is a blood sugar content detector and/or a blood pressure detector and/or a blood lipid detector, and the preset drug injection area is a set position on the patient's abdomen or a set position on the neck;

Alternatively, the detector is a dopamine concentration detector, and the preset drug injection area is a nerve nucleus in the patient's brain.

Optionally, the set body index specifically includes: the blood sugar level of the patient and/or the blood pressure of the patient and/or the blood lipid of the patient and/or the dopamine concentration of the patient.

Optionally, the drainage tube is a medical silicone tube.

The technical solution provided by this application can include the following beneficial effects:

The present application discloses a closed-loop drug delivery system. The closed-loop drug delivery system is implanted subcutaneously in a human body, and includes: a drainage tube, a liquid reservoir, a detector, a flow regulator and a controller; one end of the drainage tube is connected to the flow regulator through the flow regulator. The liquid reservoir is connected, and the other end is directly connected to the preset drug injection area. The detector is set on the drainage tube to detect the set body index of the patient, and sends the set body index to the controller, and the controller according to the setting The body index controls the opening and closing and the degree of opening of the flow regulator, and the flow regulator further realizes the flow of the preset medicine. By adopting the above closed-loop drug delivery system, the information of the set body index of the patient can be obtained according to the detector, and the controller can control the opening and closing and the opening degree of the flow regulator according to the information, so as to realize the intelligent control of the preset in the liquid reservoir according to the physical condition of the patient. The injection volume of the drug realizes the closed-loop control of the closed-loop drug delivery system. At the same time, the pre-set injection volume of the drug is controlled according to the patient's physical condition, which avoids the problem of too much or too little medication, and greatly improves the treatment effect.

Description of drawings

In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the following briefly introduces the accompanying drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description These are just some embodiments of the present invention, and for those of ordinary skill in the art, other drawings can also be obtained from these drawings without creative effort.

1 is a schematic structural diagram of a closed-loop drug delivery system provided by an embodiment of the present invention;

2 is a schematic structural diagram of a closed-loop drug delivery system provided by another embodiment of the present invention.

Detailed ways

In order to make the objectives, technical solutions and advantages of the present invention more clear, the technical solutions of the present invention will be described in detail below. Obviously, the described embodiments are only a part of the embodiments of the present invention, but not all of the embodiments. Based on the embodiments of the present invention, all other implementations obtained by those of ordinary skill in the art without creative work fall within the scope of protection of the present invention.

FIG. 1 is a schematic structural diagram of a closed-loop drug delivery system provided by Embodiment 1 of the present invention. Referring to Figure 1, a closed-loop drug delivery system, the closed-loop drug delivery system implanted under the skin of a human body, includes:

Drainage tube 101, reservoir 102, detector 103, flow regulator 1055 and controller 104;

The detector 103 is arranged on the drainage tube 101 and is used to detect the set body index of the patient; wherein, the set body index includes the blood sugar level of the patient and/or the blood pressure of the patient and/or the blood lipid of the patient and/or the dopamine concentration of the patient / or some other monitoring indicator. It should be noted that the choice of setting the physical index in this embodiment is not unique, and may include several types indicated in this embodiment, and may also include other physical indicators, as long as the physical condition of the patient can be judged according to the index, and then The body index that has an indication effect on the medication can be used, and it can be preset according to the user or the merchant. Wherein, the drainage tube 101 and the liquid reservoir 102 in this embodiment are made of silica gel. It should be noted that the material selection of the drainage tube and the liquid reservoir is not limited to the silicone material, and can be preset according to the needs, as long as it is harmless to the human body and can be placed in the body for life.

One end of the drainage tube 101 is communicated with the reservoir 102 through the flow regulator 105, and the other end of the drainage tube 101 is directly connected to a preset drug injection area; the reservoir 102 is used for storing preset The preset drug enters the drainage tube 101 from the liquid reservoir 102 through the flow regulator 105, and finally reaches the preset drug injection area; the controller 104 is connected to the The detector 103 and the flow regulator 105 are connected to receive the set body index sent by the detector 103, and control the opening, closing and opening of the flow regulator 105 according to the set body index. degree; wherein the micro-regulator includes a micro-valve or a micro-pump. The micro-valve or micro-pump in this embodiment is made of metal material with anti-NMR, has no side effect on the human body, and can be permanently indwelled in the body. It should be noted that the selection of the model of the microvalve or the micropump in this embodiment is not unique, and can be preset according to user requirements, as long as it is a microswitch device that can realize the control function of the switch.

Optionally, the detector 103 in this embodiment specifically includes:

Blood glucose level detector and/or blood pressure detector and/or blood lipid detector and/or dopamine concentration detector/or detector of some other monitoring index. It should be noted that the selection of detectors in this application is not unique, and can be preset according to user needs. The selection of detectors here corresponds to the above-mentioned set physical indicators, as long as it can detect and set physical indicators. The corresponding detector can be. The detector in this embodiment can select a sensor.

When the detector in this embodiment is a dopamine concentration detector, the closed-loop drug delivery system is implanted at the nerve nucleus in the patient's brain, and the dopamine concentration detector is used to detect the dopamine concentration in the experience.

When the detector is a blood glucose level detector and/or a blood pressure detector and/or a blood lipid detector, the closed-loop drug delivery system is arranged in the subcutaneous artery of the patient, such as implanted in the patient's carotid artery or implanted in the patient's femoral artery, and the blood glucose The content detector detects the blood sugar of the patient, the blood pressure detector detects the blood pressure of the patient, and the blood lipid detector detects the blood lipid of the patient;

Optionally, when the detector is a blood sugar content detector and/or a blood pressure detector, the closed-loop drug delivery system can also be set in the patient's brain ventricle, the blood sugar content detector is used to detect the glucose content in the patient's body fluid, and the blood pressure detector detects the patient's blood pressure. brain pressure.

It should be noted that the selection of the implantation position of the closed-loop drug delivery system is not limited to the positions in the embodiments of this application, and the implantation position of the closed-loop drug delivery system can be determined according to the type of the detector, which can selected.

Further, when the detector is a blood glucose level detector and/or a blood pressure detector and/or a blood lipid detector, and the closed-loop drug delivery system is set at the patient's femoral artery, the preset drug injection area is the one on the patient's abdomen. Set the position; it can be the position of the patient's left lower quadrant or the patient's right lower quadrant. When the closed-loop drug delivery system is set in the carotid artery of the patient, the preset drug injection area is a set position at the neck. It should be noted that the specific position selection of the preset drug injection area is not unique, and can be selected according to the implantation position of the closed-loop drug delivery system.

Alternatively, the detector is a dopamine concentration detector, and the preset drug injection area is a nerve nucleus in the patient's brain.

The flow regulator 105 is used to control the flow of the preset medicine flowing into the drainage tube 101 from the liquid reservoir 102 .

The controller 104 in this embodiment compares the set body index with the preset standard index, and controls the opening and closing of the flow regulator 105 when the set body index is greater or less than the preset body index. The magnitude of the difference between the standard indicators determines the opening degree of the flow regulator 105 . When the difference between the two is large, it means that the patient's physical condition is poor. At this time, more preset drugs are required for intervention treatment. Therefore, it is necessary to ensure that the flow regulator is at a large opening degree at this time, so that more If the preset drug flows into the drainage tube, on the contrary, the opening degree of the flow regulator is adjusted to reduce the flow rate of the preset drug flowing into the drainage tube.

Here, the controller 104 selects an 8051 single-chip microcomputer. It should be noted that the selection of the model of the controller in this embodiment is not limited to the 8051 single-chip microcomputer, and can be preset according to requirements, as long as the single-chip microcomputer can realize the comparison of the data size.

In this embodiment, the detector detects the set body index of the patient, and sends the set body index to the controller, and the controller further determines the size of the set body index and the preset standard index according to the detected set body index of the patient, Determine the opening and closing of the flow regulator and the degree of opening according to the comparison result. When the flow regulator is in the open state, the preset drug in the closed-loop drug delivery system flows into the drainage tube, and the preset drug goes directly to the preset drug injection area through the drainage tube.

In this implementation, according to the real-time physical condition of the patient, the flow rate of the preset drug flowing into the drainage tube in the liquid reservoir can be regulated, so as to realize the intelligent closed-loop control of the drug in the closed-loop drug delivery system, and it can avoid the overdose of the drug. The occurrence of too many or too few problems greatly improves the treatment effect.

On the basis of the above embodiment, in order to introduce the closed-loop drug delivery system in the present application in more detail, another embodiment is also provided, and the details are as follows:

2 is a schematic structural diagram of a closed-loop drug delivery system provided by another embodiment of the present invention. 2, a closed-loop drug delivery system, the closed-loop drug delivery system is implanted subcutaneously in a human body, including: a drainage tube 201, a liquid reservoir, a detector 203, a flow regulator and a controller 204;

The detector 203 is arranged on the drainage tube 201 and is used to detect the set body index of the patient;

One end of the drainage tube 201 is communicated with the liquid reservoir through the flow regulator, and the other end of the drainage tube 201 directly reaches the preset drug injection area; the liquid reservoir is used for storing preset drugs, and the The preset drug enters the drainage tube 201 from the liquid reservoir through the flow regulator, and finally reaches the preset drug injection area;

The controller 204 is respectively connected with the detector 203 and the flow regulator through the connecting line 206, and is used to receive the set body index sent by the detector, and control the body according to the set body index. The opening and closing and opening degree of the flow regulator;

The flow regulator is used to control the flow of the preset medicine flowing from the liquid reservoir into the drainage tube.

Wherein, the liquid storage device includes: a first liquid storage chamber 2021 and a second liquid storage chamber 2022, and the shapes of the first liquid storage chamber 2021 and the second liquid storage chamber 2022 are different. The first liquid storage chamber 2021 is square, and the second liquid storage chamber 2022 is circular. The preset medicine includes a first preset medicine and a second preset medicine; the flow regulator includes a first flow regulator 2051 and a second flow regulator 2052; the first liquid storage chamber 2021 stores the first preset medicine, the said The second liquid storage chamber 2022 stores the second preset medicine. When the liquid accumulator includes two liquid storage chambers, the end of the drainage pipe that communicates with the liquid accumulator is provided with two drainage branch pipes: a first drainage branch pipe and a second drainage branch pipe; the first flow regulator 2051 is arranged in the first storage On the first drainage branch pipe between the liquid chamber 2021 and the drainage pipe 201, the second flow regulator 2052 is arranged on the second drainage branch pipe between the second liquid storage chamber 2022 and the drainage pipe 201; it should be noted that the first preset medicine and the second preset standard may be the same drug or different drugs, and specific conditions may be preset according to requirements. At the same time, it should be noted that the liquid storage device in this embodiment is not limited to including two liquid storage chambers, and can have multiple liquid storage chambers, which can be used to store a variety of different medicines, depending on the specific situation. At the same time, the number of drainage branch pipes of the drainage pipe in this embodiment is not limited to the two in this embodiment. The number of drainage branch pipes cannot be less than the number of liquid storage chambers, and the number of drainage branch pipes can be set according to actual needs. .

Further, the second preset drug in this application is an antagonist of the first preset drug;

Specifically, the first preset drug is an antihypertensive drug, and the second preset drug is a blood pressure booster drug;

Or, the first preset drug is a blood sugar-raising drug, and the second preset drug is a blood sugar-lowering drug;

Alternatively, the first preset drug is dopamine, and the second preset drug is a dopamine receptor blocker drug.

The functions of the first preset drug and the second preset drug have opposite effects. For example, when an overdose of antihypertensive drugs causes the patient's blood pressure to be too low, the blood pressure can be increased by injecting a vasopressor to avoid overdose. cause irreversible effects.

Now, the solution of this embodiment is described in detail by taking the pressure-boosting medicine stored in the first liquid storage chamber and the antihypertensive medicine stored in the second liquid storage chamber as an example.

The blood pressure detector detects the blood pressure of the patient in real time, and sends the detected blood pressure of the patient to the controller, and the controller compares the blood pressure of the patient with the normal value of blood pressure, and then judges the physical condition of the patient. When the patient's blood pressure is greater than the normal value of blood pressure, it is necessary to inject antihypertensive drugs into the patient to reduce blood pressure. At this time, the controller controls the second flow regulator to open, so that the antihypertensive drugs in the second liquid storage chamber can enter the patient's body through the drainage tube , to achieve the function of reducing pressure. If the patient's blood pressure is lower than the normal value of blood pressure, it is necessary to inject a booster drug into the patient to boost the pressure. At this time, the controller controls the first flow regulator to turn on, so that the booster drug in the first liquid storage chamber enters the patient's body, so as to achieve boost effect.

In this embodiment, the shape of the first liquid storage chamber is different from the shape of the second liquid storage chamber. When the first preset medicine and the second preset medicine are different medicines, since the shape of the first liquid storage chamber is different from the shape of the second liquid storage chamber, the situation of using the wrong medicine is avoided. Greatly ensure the safety of patients' lives and improve the practicability of the product. It should be noted that when the first liquid storage chamber is square, the corners of the liquid storage chamber are polished and curved corners to prevent the sharp edge design from causing damage to the patient. At the same time, the liquid reservoir in this embodiment is designed in the form of a compartment, which can realize the injection of various medicines, which greatly improves the practicability of the device.

In this embodiment, the liquid reservoir is arranged in the form of a compartment, which can avoid the situation that the body of the patient is threatened due to excessive drug injection. This greatly ensures the health of the patient and improves the practicability of the device.

It can be understood that, the same or similar parts in the above embodiments may refer to each other, and the content not described in detail in some embodiments may refer to the same or similar content in other embodiments.

It should be noted that, in the description of the present invention, the terms "first", "second" and the like are only used for the purpose of description, and cannot be understood as indicating or implying relative importance. Furthermore, in the description of the present invention, unless otherwise specified, the meaning of "plurality" means at least two.

In the description of this specification, description with reference to the terms "one embodiment," "some embodiments," "example," "specific example," or "some examples", etc., mean specific features described in connection with the embodiment or example , structure, material or feature is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

Although the embodiments of the present invention have been shown and described above, it should be understood that the above embodiments are exemplary and should not be construed as limitations of the present invention, and those of ordinary skill in the art are within the scope of the present invention Variations, modifications, substitutions and variations can be made to the above-described embodiments.

Claims (10)

1. A closed-loop drug delivery system implanted subcutaneously in a human comprising:

the device comprises a drainage tube, a liquid storage device, a detector, a flow regulator and a controller;

the detector is arranged on the drainage tube and used for detecting the set body index of the patient;

one end of the drainage tube is communicated with the liquid storage device through the flow regulator, and the other end of the drainage tube directly reaches a preset medicine injection area; the liquid storage device is used for storing preset medicines, and the preset medicines enter the drainage tube from the liquid storage device through the flow regulator and finally reach the preset medicine injection area;

the controller is respectively connected with the detector and the flow regulator and is used for receiving the set body index sent by the detector and controlling the opening and closing and opening degree of the flow regulator according to the set body index;

the flow regulator is used for controlling the flow of the preset medicine flowing into the drainage tube from the liquid storage device.

2. The closed-loop drug delivery system of claim 1, wherein the reservoir comprises: a first reservoir and a second reservoir; the preset medicines comprise a first preset medicine and a second preset medicine;

a first preset medicine is stored in the first liquid storage chamber, and a second preset medicine is stored in the second liquid storage chamber.

3. The closed-loop drug delivery system of claim 1, wherein the flow regulator comprises: a microvalve or a micropump.

4. The closed loop drug delivery system of claim 2, wherein the shape of the first reservoir is different from the shape of the second reservoir.

5. The closed loop drug delivery system of claim 4, wherein the first reservoir is square; the second liquid storage chamber is circular.

6. The closed-loop drug delivery system of claim 2, wherein the first predetermined drug is a pressure reducing drug and the second predetermined drug is a pressure increasing drug;

or the first preset medicine is a blood sugar increasing medicine, and the second preset medicine is a blood sugar reducing medicine;

or the first preset medicine is dopamine, and the second preset medicine is a dopamine receptor blocker medicine;

alternatively, the second predetermined drug is an antagonist of the first predetermined drug.

7. Closed loop drug delivery system as claimed in claim 1, characterized in that the detector in particular comprises:

a blood glucose detector and/or a blood pressure detector and/or a blood lipid detector and/or a dopamine concentration detector.

8. The closed loop drug delivery system of claim 7 wherein the detector is a blood glucose detector and/or a blood pressure detector and/or a blood lipid detector and the pre-set drug injection zone is a set location on the abdomen or a set location at the neck of the patient;

or the detector is a dopamine concentration detector, and the preset medicine injection area is a nerve nucleus mass in the brain of the patient.

9. Closed loop drug delivery system as claimed in claim 1, characterized in that the setting of body indices in particular comprises: the blood glucose level of the patient and/or the blood pressure of the patient and/or the blood lipid level of the patient and/or the dopamine concentration of the patient.

10. The closed loop drug delivery system of claim 1, wherein the drain tube is a medical silicone tube.

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