CN210815110U

CN210815110U - Micro liposome extruder

Info

Publication number: CN210815110U
Application number: CN201921386748.4U
Authority: CN
Inventors: 冯皓
Original assignee: Jiangsu Jingnuoze Biomedical Technology Co ltd
Current assignee: Jiangsu Jingnuoze Biomedical Technology Co ltd
Priority date: 2019-08-24
Filing date: 2019-08-24
Publication date: 2020-06-23
Anticipated expiration: 2029-08-24

Abstract

The utility model relates to a micro liposome extruder, which comprises a liposome extruding cylinder, two ends of the liposome extruding cylinder are connected with injectors, two clamps and an extruding device; the two clamps respectively clamp and fix an injector; the liposome extrusion cylinder is positioned between the two clamps; the extrusion device comprises an extrusion shell, and the two clamps are fixed on the same side of the extrusion shell; the extrusion shell is provided with an extrusion toothed bar penetrating through the extrusion shell, and the sliding direction of the extrusion toothed bar is parallel to the axis of the injector; a rack is arranged on one side of the extrusion rack rod, the extrusion shell is rotatably connected with a gear meshed with the rack, the gear is horizontally arranged, the upper end of a shaft of the gear extends upwards out of the shell and is externally fixed with a hand wheel, and the diameter of the hand wheel is larger than the reference circle diameter of the gear; the two ends of the extrusion toothed bar are provided with extrusion resisting bars, and the tail ends of the extrusion resisting bars are positioned on the extension line of the axis of the injector. The utility model discloses laborsaving effect when having the extrusion liposome.

Description

Micro liposome extruder

Technical Field

The utility model belongs to the technical field of the technique of liposome preparation and specifically relates to a trace liposome extruder is related to.

Background

The liposome is the core material of the existing nano-drugs, the medicament in the pharmaceutical industry has strict requirements on the particle size of the liposome, the particle size must meet within a certain unit, and the distribution is uniform, so the core for preparing the liposome is the nanocrystallization of the liposome and the precise control of the particle size of the liposome.

The first one is to use a closed glass syringe and make the material force to pass through the film in the matrix by using manual thrust, thereby obtaining uniform liposome nano-particles; the second is a liposome extruder driven by air pressure, which is low in price, but cannot continuously extrude, and has low pressure; the third type of liposome extruder uses a high pressure homogenizer as the high pressure source.

The above prior art solutions have the following drawbacks: during preparation, the liposome needs to pass through the film of the liposome extrusion cylinder back and forth; when the hand-operated preparation is carried out, the injector needs to be pressed back and forth manually, and the pressing force of the palm to the injector is large due to the nanometer-scale through holes of the film, so that the operation is inconvenient.

SUMMERY OF THE UTILITY MODEL

The utility model aims at providing a trace liposome extruder, it has laborsaving effect when extruding the liposome.

The above utility model discloses an above-mentioned utility model purpose can realize through following technical scheme:

a micro liposome extruder comprises a liposome extrusion barrel, injectors connected with two ends of the liposome extrusion barrel, two clamps and an extrusion device; the two clamps respectively clamp and fix an injector; the liposome extrusion cylinder is positioned between the two clamps; the extrusion device comprises an extrusion shell, and the two clamps are fixed on the same side of the extrusion shell; the extrusion shell is provided with an extrusion toothed bar penetrating through the extrusion shell, and the sliding direction of the extrusion toothed bar is parallel to the axis of the injector; a rack is arranged on one side of the extrusion rack rod, a gear meshed with the rack is rotatably connected to the extrusion shell, the gear is horizontally arranged, the upper end of a shaft of the gear extends upwards out of the shell and is externally fixed with a hand wheel, and the diameter of the hand wheel is larger than the reference circle diameter of the gear; the two ends of the extrusion toothed bar are provided with extrusion resisting bars, and the tail ends of the extrusion resisting bars are positioned on the extension line of the axis of the injector.

By adopting the technical scheme, when the two ends of the lipid extrusion cavity are well installed with the injector, the empty cylinder of the injector is fixed by the clamp. And the hand wheel is rotated forwards and backwards, and a gear at the lower end of the hand wheel drives the rack to drive the extrusion rack rod to slide back and forth along the gear. Meanwhile, extrusion abutting rods are fixed at two ends of the extrusion toothed rod, one end of each extrusion abutting rod is abutted against a piston handle of the injector, and the extrusion abutting rods move back and forth to push the piston handle of the injector to move back and forth so as to extrude the required materials. The diameter of the hand wheel is larger than the reference circle diameter of the gear, so that the operation is convenient and labor is saved during use.

The utility model discloses further set up to: the clamp comprises a lower clamp body and an upper clamp body, the upper clamp body is rotatably connected with the lower clamp body, an upper placing groove for placing the injector is formed in the lower surface of the upper clamp body, and a lower placing groove for placing the injector is formed in the upper surface of the lower clamp body.

By adopting the technical scheme, the clamp comprises the lower clamp body and the upper clamp body, and the upper clamp body is rotatably connected with the lower clamp body, so that the clamp can be opened and closed conveniently; an upper placing groove and a lower placing groove are arranged so as to be convenient for placing the injector.

The utility model discloses further set up to: and rubber cushions with semicircular sections are respectively arranged in the upper placing groove and the lower placing groove.

Through adopting above-mentioned technical scheme, through set up the rubber packing ring in last standing groove and lower standing groove, make anchor clamps when centre gripping syringe, anchor clamps are not fragile syringe.

The utility model discloses further set up to: the upper clamp body and the lower clamp body are fixed through the movable fastener, and fastener grooves for accommodating the movable fastener are formed in the side faces of the upper clamp body and the lower clamp body.

By adopting the technical scheme, the upper clamp body is clamped and fixed by the movable fastener to surround the lower clamp body, so that the upper clamp body and the lower clamp body can be conveniently opened and closed, and the lipid extrusion cavity and the injector can be conveniently taken.

The utility model discloses further set up to: the movable fastener comprises a connecting rod and a buckle cap, one end of the connecting rod is hinged with the lower clamp body, and the other end of the connecting rod is in threaded connection with the buckle cap.

By adopting the technical scheme, the movable end of the connecting rod is turned to the upper end of the upper clamp body, the upper clamp body is tightly pressed through the buckle cap, and the injector can be fastened.

The utility model discloses further set up to: the extrusion tooth rod comprises a rod sleeve and a movable rod, the rack is positioned on one side of the rod sleeve, the movable rod is inserted at two ends of the rod sleeve, and bolt holes are uniformly distributed on the surface of the movable rod; meanwhile, the tail end of the rod sleeve is respectively provided with a fixed bolt which is in threaded connection with the bolt hole, and the extrusion resisting rod is vertically fixed with the movable rod.

Through adopting above-mentioned technical scheme, crowding the movable rod among the ratch, adjustable its elongation to it is fixed through the gim peg, thereby adjust and crowd and move the distance between the support rod.

The utility model discloses further set up to: one end of the extrusion abutting rod, which is far away from the movable rod, is provided with an abutting plate facing the upper placing groove, and the abutting plate is connected with the extrusion abutting rod through an abutting bolt penetrating through the extrusion abutting rod.

By adopting the technical scheme, the distance from the abutting plate to the piston rod of the injector can be finely adjusted by adjusting the abutting bolt, the fixing bolt is roughly adjusted, and then the abutting bolt is adjusted, so that the abutting plate can abut against the tail ends of the piston rods of the injectors of different models.

The utility model discloses further set up to: the lower surfaces of the clamp and the squeezing device are fixed with a bottom plate, and two ends of one side of the bottom plate are provided with fixing clamps which can be fixed with a desktop.

By adopting the technical scheme, the clamp and the extrusion device are fixed on the bottom plate, and the fixing clamp is arranged on the bottom plate, so that the bottom plate can be fixed with the desktop, the bottom plate is fixed, the hand wheel can stably rotate, and the operation is convenient.

To sum up, the utility model discloses a beneficial technological effect does:

1. the piston rod of the syringe is not directly pressed back and forth by hands; the pressing plate can drive a piston rod of the injector to move by rotating the hand wheel so as to finish the operation; and the diameter of the hand wheel is larger than the reference circle diameter of the gear below the hand wheel, so that the hand wheel is more labor-saving in operation.

2. When different types of injectors are used, the injectors with different thicknesses and lengths can be adapted by replacing the proper rubber cushion layer, roughly adjusting the fixed bolt and finely adjusting the stop bolt.

Drawings

Fig. 1 is a schematic structural diagram of the present invention;

FIG. 2 is a schematic view of the structure of the jig;

fig. 3 is a schematic view of the squeezing device.

In the figure, 1, a liposome extrusion cylinder; 2. an injector; 3. a clamp; 31. an upper clamp body; 311. an upper placing groove; 32. a lower clamp body; 321. placing the tank down; 33. a rubber cushion layer; 34. a movable fastener; 341. a connecting rod; 342. buckling a cap; 35. a fastener slot; 4. a squeezing device; 41. extruding the shell; 42. squeezing the rack bar; 421. a rod sleeve; 4211. a rack; 4212. a fixing bolt; 422. a movable rod; 4221. a keyhole; 43. a gear; 44. a hand wheel; 45. squeezing the abutting rod; 451. stopping the plug; 452. a resisting plate; 5. a base plate; 51. and (4) fixing clips.

Detailed Description

The present invention will be described in further detail with reference to the accompanying drawings.

Referring to fig. 1 and 2, for the utility model discloses a micro liposome extruder, including liposome extrusion cylinder 1, syringe 2, anchor clamps 3, extrusion device 4 and bottom plate 5. The two clamps 3 and the squeezing device 4 are bolted on the upper surface of the bottom plate 5, and the two ends of one side of the bottom plate 5 are respectively welded with a fixing clamp 51 fixed with the desktop. The squeezing device 4 includes a squeezing housing 41, and the two clamps 3 are located at both ends of the same side of the squeezing device 4. The liposome extrusion cylinder 1 is positioned between two clamps 3, the two ends of the liposome extrusion cylinder 1 are respectively inserted with the syringes 2, and the two clamps 3 respectively clamp the empty cylinder of one syringe 2.

Referring to fig. 1 and 2, the clamp 3 includes a lower clamp body 32 and an upper clamp body 31, and the upper clamp body 31 and the lower clamp body 32 are rectangular solids. The lower surface of the upper clip body 31 is provided with an upper placing groove 311 for placing an empty syringe 2, and the upper surface of the lower clip body 32 is provided with a lower placing groove 321 for placing an empty syringe 2. The upper placing groove 311 and the lower placing groove 321 are semicircular grooves, and rubber cushions 33 with semicircular sections are respectively arranged in the grooves. The upper clamp body 31 is hinged to the lower clamp body 32, and the hinged end thereof is located at the end far away from the squeeze housing 41. The upper clamp body 31 and the lower clamp body 32 are fixed by a movable fastener 34, and a fastener groove 35 for mounting the movable fastener 34 is arranged on one side of the upper clamp body 31 and one side of the lower clamp body 32. The movable fastener 34 includes a connecting rod 341 and a fastening cap 342, wherein one end of the connecting rod 341 is hinged with the lower clamp body 32, and the other end is in threaded connection with the fastening cap 342.

Referring to fig. 2 and 3, the pressing housing 41 is provided with a pressing rack 42 penetrating through and slidable on the pressing housing 41 in a direction parallel to the axis of the lower seating groove 321. The squeezing rack 42 includes a rack 421 and two movable rods 422, one side of the rack 421 is provided with a rack 4211, and the two movable rods 422 are inserted into two ends of the rack 421. Bolt holes 4221 are uniformly distributed on the surface of the movable rod 422, two ends of the rod sleeve 421 are respectively provided with a fixing bolt 4212 which is connected with the bolt holes 4221 in a threaded manner, and the extending length of the movable rod 422 is fixed through the fixing bolts 4212. One side of the rod sleeve 421 is a rack 4211. The extrusion case 41 is provided with a gear 43 engaged with the rack 4211, and the gear 43 is horizontally disposed and fixed in the extrusion case 41 by the rotation of the gear 43 shaft. The upper end of the shaft of the gear 43 extends upwards out of the shell, a hand wheel 44 is welded at the upper end of the shaft of the gear 43, and the rotating diameter of the hand wheel 44 is larger than the reference circle diameter of the gear 43.

Referring to fig. 2 and 3, the protruding end of the movable rod 422 is welded with the squeezing resisting rod 45 perpendicular thereto, and the end of the squeezing resisting rod 45 passes through the extension line of the axis of the upper placing groove 311. The pushing and abutting rod 45 is in threaded connection with an abutting bolt 451 at the extension line of the axis of the upper placing groove 311, and the abutting bolt 451 penetrates through the pushing and abutting rod 45. The abutting plate 452 is welded at one end of the abutting bolt 451 close to the clamp 3, and the plane of the abutting plate 452 is perpendicular to the extension line of the axis of the upper placing groove 311.

The implementation principle of the embodiment is as follows: when both ends of the liposome extrusion cylinder 1 are well installed with the syringe 2, the empty cylinder of the syringe 2 is fixed by the upper placing groove 311 and the lower placing groove 321. When the hand wheel 44 is rotated forward and backward, the gear 43 at the lower end of the hand wheel 44 drives the rack 4211 to slide back and forth along the gear 43 driving the extrusion rack 42. The two ends of the extrusion toothed bar 42 are fixed with extrusion resisting bars 45, one end of the extrusion resisting bar 45 is abutted against the piston handle of the injector 2, and the extrusion resisting bar 45 moves back and forth to push the piston handle of the injector 2 to move back and forth so as to extrude the required materials. Moreover, the distance between the resisting plates 452 can be adjusted to adapt to the syringes 2 with different lengths by adjusting the fixing bolts 4212 and the resisting bolts 451.

The embodiment of this specific implementation mode is the preferred embodiment of the present invention, not limit according to this the utility model discloses a protection scope, so: all equivalent changes made according to the structure, shape and principle of the utility model are covered within the protection scope of the utility model.

Claims

1. The utility model provides a trace liposome extruder, includes liposome extrusion section of thick bamboo (1), and liposome extrusion section of thick bamboo (1) both ends are connected with syringe (2), its characterized in that: the device also comprises two clamps (3) and a squeezing device (4); the two clamps (3) respectively clamp and fix a syringe (2); the liposome extrusion cylinder (1) is positioned between the two clamps (3); the extrusion device (4) comprises an extrusion shell (41), and the two clamps (3) are fixed on the same side of the extrusion shell (41); the squeezing shell (41) is provided with a squeezing rack (42) penetrating through the squeezing shell (41), and the sliding direction of the squeezing rack is parallel to the axis of the injector (2); a rack (4211) is arranged on one side of the extrusion rack rod (42), a gear (43) meshed with the rack (4211) is rotatably connected to the extrusion shell (41), the gear (43) is horizontally arranged, the upper end of the shaft of the gear (43) extends upwards out of the shell and is externally fixed with a hand wheel (44), and the diameter of the hand wheel (44) is larger than the reference circle diameter of the gear (43); the two ends of the extrusion rack bar (42) are provided with extrusion resisting bars (45), and the tail ends of the extrusion resisting bars (45) are positioned on the extension line of the axis of the injector (2).

2. A microliposome extruder according to claim 1, wherein: the clamp (3) comprises a lower clamp body (32) and an upper clamp body (31), the upper clamp body (31) is rotatably connected with the lower clamp body (32), an upper placing groove (311) for placing the injector (2) is formed in the lower surface of the upper clamp body (31), and a lower placing groove (321) for placing the injector (2) is formed in the upper surface of the lower clamp body (32).

3. A liposome microscale extrusion device according to claim 2, wherein: rubber cushion layers (33) with semicircular sections are respectively arranged in the upper placing groove (311) and the lower placing groove (321).

4. A liposome microscale extrusion device according to claim 2, wherein: the upper clamp body (31) and the lower clamp body (32) are fixed through a movable fastener (34), and fastener grooves (35) for accommodating the movable fastener (34) are formed in the side faces of the upper clamp body (31) and the lower clamp body (32).

5. A liposome microscale extrusion device according to claim 4, wherein: the movable fastener (34) comprises a connecting rod (341) and a buckle cap (342), one end of the connecting rod (341) is hinged with the lower clamp body (32), and the other end of the connecting rod is in threaded connection with the buckle cap (342).

6. A microliposome extruder according to claim 1, wherein: the extrusion toothed bar (42) comprises a bar sleeve (421) and two movable bars (422), a rack (4211) is positioned at one side of the bar sleeve (421), the two movable bars (422) are respectively inserted at two ends of the bar sleeve (421), and bolt holes (4221) are uniformly distributed on the surface of each movable bar (422); two ends of the rod sleeve (421) are respectively provided with a fixed bolt (4212) which is connected with the bolt hole (4221) in a threaded manner, and the extrusion resisting rod (45) is vertically fixed with the movable rod (422).

7. A microliposome extruder according to claim 1, wherein: one end of the extrusion abutting rod (45) far away from the movable rod (422) is provided with an abutting plate (452) facing the upper placing groove (311), and the abutting plate (452) is connected with the extrusion abutting rod (45) through an abutting bolt (451) penetrating through the extrusion abutting rod (45).

8. A microliposome extruder according to claim 1, wherein: the lower surfaces of the clamp (3) and the extrusion device (4) are fixed with a bottom plate (5), and two ends of one side of the bottom plate (5) are provided with fixing clamps (51).