CN112169400A - Manual liposome extruder - Google Patents
Manual liposome extruder Download PDFInfo
- Publication number
- CN112169400A CN112169400A CN202011192390.9A CN202011192390A CN112169400A CN 112169400 A CN112169400 A CN 112169400A CN 202011192390 A CN202011192390 A CN 202011192390A CN 112169400 A CN112169400 A CN 112169400A
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- CN
- China
- Prior art keywords
- extruder
- manual
- liposome
- cavity
- piston
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002502 liposome Substances 0.000 title claims abstract description 33
- 239000000463 material Substances 0.000 claims abstract description 25
- 238000001125 extrusion Methods 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000004321 preservation Methods 0.000 claims abstract description 4
- 238000007789 sealing Methods 0.000 claims description 17
- 239000012528 membrane Substances 0.000 claims description 13
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 230000001174 ascending effect Effects 0.000 abstract description 3
- 230000007547 defect Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
- B01D29/01—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements
- B01D29/05—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements supported
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D35/00—Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
- B01D35/18—Heating or cooling the filters
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a manual liposome extruder, which comprises a fixed frame and an extruder erected on the fixed frame, wherein the bottom of the extruder is provided with a discharge hole communicated with a material cavity of the extruder, the extruder is externally sleeved with a temperature control jacket, the temperature control jacket is provided with a water inlet and a water outlet communicated with a heat preservation cavity, the outer wall of the extruder is provided with a feed inlet communicated with the material cavity, the material cavity of the extruder is internally provided with an extrusion piston capable of ascending and descending along the inner wall of the extruder, the extrusion piston is fixedly connected with a handle positioned outside the extruder through a piston rod, a step cavity body inner fixed frame arranged at the bottom of the material cavity of the extruder is provided with a filter assembly, and the filter assembly is positioned right above the discharge hole; the invention provides a manual liposome extruder with strong operability and high accuracy.
Description
Technical Field
The invention relates to emulsification equipment, in particular to a manual liposome extruder.
Background
The liposome extrusion devices used in the market at present can be divided into manual operation and pneumatic operation, wherein the manual operation does not need an external energy source, and the operation is simpler, but the defects are that the manual operation is more labor-consuming and the treatment capacity is smaller.
The components of the manual liposome extruder in the current market are a glass syringe and a core module with a filter membrane which are pushed left and right, and the manual liposome extruder has the following defects:
1. the glass needle cylinder is easy to damage;
2. pushing each other back and forth is laborious;
3. some liposomes need to be heated and extruded quickly, and the equipment is not easy to heat.
In view of the above-mentioned drawbacks, the present designer has made active research and innovation to create a manual liposome extrusion device, which has industrial application value.
Disclosure of Invention
In order to solve the above technical problems, the present invention aims to provide a manual liposome extrusion device with high precision and strong operability.
The manual liposome extruder comprises a fixed frame and an extruder erected on the fixed frame, wherein a discharge hole communicated with a material cavity of the extruder is formed in the bottom of the extruder, a temperature control jacket is sleeved outside the extruder, a water inlet and a water outlet communicated with a heat preservation cavity are formed in the temperature control jacket, a feed inlet communicated with the material cavity is formed in the outer wall of the extruder, an extrusion piston capable of ascending and descending along the inner wall of the extruder is arranged in the material cavity of the extruder, the extrusion piston is fixedly connected with a handle positioned outside the extruder through a piston rod, a filter assembly is arranged in a step cavity formed in the bottom of the material cavity of the extruder, and the filter assembly is positioned right above the discharge hole.
Further, the fixed frame comprises a base and supporting legs for supporting and fixing the base, the extruder is erected on the base, and the discharge hole is connected with a discharge pipe which extends downwards and penetrates through the base.
Further, the feed inlet is connected with a feed pipe penetrating through the temperature control jacket.
Furthermore, a sealing groove is formed outside the extrusion piston, and a piston sealing ring is fixed in the sealing groove.
Further, the step cavity is a cylindrical step cavity, and the inner diameter of the step cavity is larger than that of the material cavity.
Further, the filter assembly comprises a filter plate and a support plate which are clamped in the step cavity, the support plate is located between the filter plate and the discharge hole, and a membrane sealing ring is arranged between the filter plate and the inner wall of the step cavity.
Furthermore, the membrane sealing ring is clamped between the filter plate and the inner wall of the step cavity.
Furthermore, a threaded hole is formed in the top of the extruder, and an external thread matched with the threaded hole is arranged outside the piston rod.
By the scheme, the invention at least has the following advantages:
1. stainless steel materials can be adopted, so that damage can be avoided;
2. the extrusion is from top to bottom, so that the force is more convenient to apply;
3. the extrusion temperature can be accurately controlled by the temperature control jacket.
The foregoing description is only an overview of the technical solutions of the present invention, and in order to make the technical solutions of the present invention more clearly understood and to implement them in accordance with the contents of the description, the following detailed description is given with reference to the preferred embodiments of the present invention and the accompanying drawings.
Drawings
Figure 1 is a front view of a manual liposome extruder;
fig. 2 is a cross-sectional view of the manual liposome extrusion apparatus a-a' of fig. 1.
The meanings of the reference symbols in the drawings are as follows.
1 base and 2 legs
3 extruder 4 discharge port
5 temp. control jacket 6 thermal insulation cavity
7 water inlet and 8 water outlet
9 feed inlet 10 material cavity
11 extrusion piston 12 piston rod
13 handle 14 step cavity
15 discharge pipe and 16 feed pipe
17 piston seal ring 18 filter plate
19 supporting plate 20 film sealing ring
Detailed Description
The following detailed description of embodiments of the present invention is provided in connection with the accompanying drawings and examples. The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
The manual liposome extruder shown in fig. 1 and 2 comprises a fixing frame and an extruder 3 erected on the fixing frame, wherein a discharge hole 4 communicated with a material cavity 10 of the extruder 3 is formed in the bottom of the extruder 3, a temperature control jacket 5 is sleeved outside the extruder 3, a water inlet 7 and a water outlet 8 communicated with a heat preservation cavity 6 are formed in the temperature control jacket 5, a feed inlet 9 communicated with the material cavity 10 is formed in the outer wall of the extruder 3, an extrusion piston 11 capable of ascending and descending along the inner wall of the extruder 3 is arranged in the material cavity 10 of the extruder 3, the extrusion piston 11 is fixedly connected with a handle 13 located outside the extruder 3 through a piston rod 12, a filter assembly is arranged in a fixing frame in a step cavity 14 formed in the bottom of the material cavity 10 of the extruder 3, and the filter assembly is located right above the discharge hole 4.
The principle of the manual liposome extruder provided by the invention is as follows:
the liposome extruder 3 mainly has the function that liposome passes through a membrane with a specific size so as to achieve the effects of reducing the particle size and enabling the particle size to be uniform, the main function is to provide a filter membrane in a filter assembly, the specifications of the filter membranes on the market are specific, and the membrane used by the manual extruder 3 is generally 19mm, so the manual liposome extruder 3 is different from the traditional extruder 3 which extrudes back and forth, the manual liposome extruder provided by the application can be extruded from top to bottom, labor can be saved, other materials except for a sealing element are stainless steel, the service life is longer, the extruder 3 is not easily damaged by people, a temperature control jacket 5 which is arranged outside the extruder 3 can be heated in a water bath and can control the temperature more accurately, the feed port 9 can be designed into a standard injector feed port 9, the liposome can be sucked by the standard injector and then fed through the feed port 9, and the feed cavity 10 is filled with the liposome during extrusion and can pass through the filter membrane in the filter assembly only by pressing the liposome downwards, after extrusion, the extrusion piston 11 is required to return to the initial state to continue feeding, and the function of the extrusion piston is to provide the stroke.
In view of the preferred embodiment of the present invention, in order to collect the material from the discharge port 4, the fixing frame includes a base 1 and legs 2 supporting and fixing the base 1, the extruder 3 is mounted on the base 1, and the discharge port 4 is connected to a discharge pipe 15 extending downward and penetrating through the base 1.
In view of the preferred embodiment of the present invention, the inlet 9 is connected to a feed tube 16 which passes through the temperature-controlled jacket 5 in order to communicate with a standard syringe which has aspirated liposomes and to feed the liposomes through the inlet 9.
In view of the preferred embodiment of the present invention, in order to prevent the material from overflowing from the top, a sealing groove is formed outside the extrusion piston 11, and a piston sealing ring 17 is fixed in the sealing groove.
In view of the preferred embodiment of the present invention, in order to clamp the filter assembly in the stepped cavity 14, the stepped cavity 14 is a cylindrical stepped cavity 14, and the inner diameter of the stepped cavity 14 is larger than the inner diameter of the material cavity 10.
In view of the preferred embodiment of the present invention, in order to support the filter plate 18 and prevent the material from extruding out of the filter membrane on the filter plate 18 by the support plate 19, the filter assembly includes the filter plate 18 and the support plate 19 clamped in the stepped cavity 14, the support plate 19 is located between the filter plate 18 and the discharge port 4, and the membrane sealing ring 20 is located between the filter plate 18 and the inner wall of the stepped cavity 14.
In view of the preferred embodiment of the present invention, the membrane seal ring 20 is clamped between the filter plate 18 and the inner wall of the stepped cavity 14 for better sealing performance.
In view of the preferred embodiment of the present invention, in order to rotate the handle 13 conveniently, a threaded hole is formed at the top of the extruder 3, and an external thread matched with the threaded hole is formed outside the piston rod 12.
The invention has the following advantages by the aid of the character expression and the accompanying drawings:
1. the extrusion is from top to bottom, so that the force is more convenient to apply;
2. the extrusion temperature can be accurately controlled by the temperature control jacket;
3. compared with the traditional manual extruder, the extruder has no wearing parts and has a good market in the aspects of economy and practicality.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, it should be noted that, for those skilled in the art, many modifications and variations can be made without departing from the technical principle of the present invention, and these modifications and variations should also be regarded as the protection scope of the present invention.
Claims (8)
1. A manual liposome extruder, comprising: including the mount and erect extruder on the mount, the bottom of extruder set up with the discharge gate that the material chamber of extruder is linked together, the extruder overcoat is equipped with the temperature control jacket, set up water inlet and the delivery port that is linked together with the heat preservation chamber on the temperature control jacket, set up on the outer wall of extruder with the feed inlet that the material chamber is linked together, be equipped with in the material chamber of extruder can along the extrusion piston of the inner wall oscilaltion of extruder, extrude the piston pass through the piston rod with be located handle fixed connection outside the extruder, the mount is equipped with filter assembly in the step cavity that the material chamber bottom of extruder was equipped with, filter assembly is located directly over the discharge gate.
2. The manual liposome extruder of claim 1, wherein: the fixed frame comprises a base and supporting legs for supporting and fixing the base, the extruder is erected on the base, and the discharge port is connected with a discharge pipe which extends downwards and penetrates through the base.
3. The manual liposome extruder of claim 1, wherein: the feed inlet is connected with a feed pipe penetrating through the temperature control jacket.
4. The manual liposome extruder of claim 1, wherein: and a sealing groove is formed outside the extrusion piston, and a piston sealing ring is fixed in the sealing groove.
5. The manual liposome extruder of claim 1, wherein: the step cavity is a cylindrical step cavity, and the inner diameter of the step cavity is larger than that of the material cavity.
6. The manual liposome extruder of claim 1, wherein: the filter assembly comprises a filter plate and a support plate which are clamped in the step cavity, the support plate is positioned between the filter plate and the discharge hole, and a membrane sealing ring is arranged between the filter plate and the inner wall of the step cavity.
7. The manual liposome extruder of claim 6, wherein: the membrane sealing ring is clamped between the filter plate and the inner wall of the step cavity.
8. The manual liposome extruder of claim 1, wherein: the top of the extruder is provided with a threaded hole, and the outside of the piston rod is provided with an external thread matched with the threaded hole.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011192390.9A CN112169400A (en) | 2020-10-30 | 2020-10-30 | Manual liposome extruder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011192390.9A CN112169400A (en) | 2020-10-30 | 2020-10-30 | Manual liposome extruder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112169400A true CN112169400A (en) | 2021-01-05 |
Family
ID=73916165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011192390.9A Pending CN112169400A (en) | 2020-10-30 | 2020-10-30 | Manual liposome extruder |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112169400A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020050660A1 (en) * | 1990-10-05 | 2002-05-02 | Coe Royden M. | Liposome extrusion process |
| CN202236354U (en) * | 2011-09-28 | 2012-05-30 | 苏州瑞纳生化技术有限公司 | Extruder |
| CN208389527U (en) * | 2018-05-25 | 2019-01-18 | 安拓思纳米技术（苏州）有限公司 | Liposome squeezes out dedicated tank body extruder |
| CN209699649U (en) * | 2018-12-21 | 2019-11-29 | 益阳橡胶塑料机械集团有限公司 | It is a kind of to facilitate the refining glue device for carrying out temperature adjusting |
| CN210815110U (en) * | 2019-08-24 | 2020-06-23 | 江苏竞诺择生物医药科技有限公司 | Micro liposome extruder |
| CN213912562U (en) * | 2020-10-30 | 2021-08-10 | 安拓思纳米技术（苏州）有限公司 | Manual liposome extruder |
-
2020
- 2020-10-30 CN CN202011192390.9A patent/CN112169400A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020050660A1 (en) * | 1990-10-05 | 2002-05-02 | Coe Royden M. | Liposome extrusion process |
| CN202236354U (en) * | 2011-09-28 | 2012-05-30 | 苏州瑞纳生化技术有限公司 | Extruder |
| CN208389527U (en) * | 2018-05-25 | 2019-01-18 | 安拓思纳米技术（苏州）有限公司 | Liposome squeezes out dedicated tank body extruder |
| CN209699649U (en) * | 2018-12-21 | 2019-11-29 | 益阳橡胶塑料机械集团有限公司 | It is a kind of to facilitate the refining glue device for carrying out temperature adjusting |
| CN210815110U (en) * | 2019-08-24 | 2020-06-23 | 江苏竞诺择生物医药科技有限公司 | Micro liposome extruder |
| CN213912562U (en) * | 2020-10-30 | 2021-08-10 | 安拓思纳米技术（苏州）有限公司 | Manual liposome extruder |
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