CN210811732U

CN210811732U - Injector for establishing animal intracranial hemorrhage model

Info

Publication number: CN210811732U
Application number: CN201821010444.3U
Authority: CN
Inventors: 杨琳; 王航; 文治洪; 代静; 董秀珍; 付峰; 代萌
Original assignee: Fourth Military Medical University FMMU
Current assignee: Fourth Military Medical University FMMU
Priority date: 2018-06-28
Filing date: 2018-06-28
Publication date: 2020-06-23
Anticipated expiration: 2028-06-28

Abstract

The utility model discloses an injector for establishing animal intracranial hemorrhage model, which belongs to the field of experimental equipment. The piston push core is connected with the push core fixing block through thread fit, and the piston push core penetrates through the push core fixing block to be connected with the upper end of the piston; the piston is positioned in the outer cylinder of the injector and is in close contact with the inner wall of the outer cylinder of the injector; the outer barrel of the syringe comprises an upper threaded section, a middle tube body section and a lower threaded section, the push core fixing block is connected with the upper threaded section in a threaded fit manner, and the needle head height adjusting bottom barrel is connected with the lower threaded section in a threaded fit manner; the lower end bulge of the needle head height adjusting bottom cylinder is connected with the injection needle. The injector has reasonable structural design, and achieves the purposes of slowly injecting blood into the cranium at different rates according to the experimental requirements and accurately positioning the position of a bleeding point in the experiment for establishing an intracranial bleeding animal model.

Description

Injector for establishing animal intracranial hemorrhage model

Technical Field

The utility model belongs to animal experiment equipment field, concretely relates to an injector for establishing animal intracranial hemorrhage model.

Background

The human diseases are of various types and the occurrence and development processes are usually very complex, so medical experiments are required to be developed to explore the pathogenesis and curative effect judgment of various diseases so as to control the diseases, prolong the life of human beings and promote the progress of medical research. However, the direct application of various medical experiments to the human body may bring risks to people, and the development of medical research is greatly limited because some diseases are not easy to be seen or the latent period is long. Animal experiments are important components in the field of medical research, and a large number of medical researches show that animal model experiments simulating human diseases can effectively overcome a plurality of defects of directly applying medical experiments to human bodies, and are helpful for understanding the occurrence of human diseases more conveniently and efficiently and exploring the development rules of the diseases.

Animal models are the prerequisite for animal experiments, accurate animal model experiments can effectively characterize human diseases, and animal experimental devices generally play an important role in the process of establishing animal models. Since the anatomical structures of human and experimental animals are very complex, the animal experimental device is required to have very good accuracy in order to accurately simulate specific diseases of human. In addition, the experimental animals are of various types, and the experimental animal device is required to have good flexibility.

Cerebrovascular diseases are the third of human lethal diseases and become the first leading death diseases of China, so the research on cerebrovascular diseases is an important direction of current medical research, and intracranial hemorrhage is an important branch and common type of cerebrovascular diseases. At present, a great number of intracranial hemorrhage animal model experiments are carried out, wherein the intracranial hemorrhage model is manufactured in an autologous blood injection mode, which is the most common model manufacturing method, and in the model manufacturing process, a micro-syringe or a common liquid syringe is selected to inject blood into the cranium. However, the micro-injector or the ordinary liquid injector is difficult to ensure that blood is slowly injected into the cranium, the real cerebral hemorrhage process cannot be simulated, the model building failure is easy to cause, and the consistency and the repeatability of the animal model building are difficult to ensure because the position of a bleeding point is difficult to accurately control by using the micro-injector or the ordinary liquid injector. Therefore, in the development of animal model experiments of intracranial hemorrhage, a syringe device for simply and effectively establishing an animal intracranial hemorrhage model is needed.

SUMMERY OF THE UTILITY MODEL

To the defect that above-mentioned prior art exists, the utility model aims to provide an injector device for establishing the intracranial hemorrhage model of animal, this injector device structural design is reasonable, can guarantee to inject with different speed slowly according to the experiment demand, can accurate control simultaneously and bleed the point position.

The utility model discloses a realize through following technical scheme:

the utility model discloses a syringe for establishing animal intracranial hemorrhage model, which comprises a syringe outer cylinder consisting of an upper thread section, a middle tube body section and a lower thread section, wherein a piston which is clung to the inner wall of the syringe outer cylinder and can linearly move is arranged in the syringe outer cylinder, and the upper end of the piston is connected with a piston push core;

a core pushing fixing block is arranged at the upper threaded section of the outer cylinder of the injector, a through hole for a piston pushing core to pass through is formed in the core pushing fixing block, internal threads are formed in the inner wall of the through hole, external threads are formed on a core rod of the piston pushing core, and the piston pushing core is in threaded connection with the core pushing fixing block; scales are arranged on the outer wall of the middle tube body section of the outer barrel of the injector; the lower part of the syringe outer cylinder is provided with a needle head height adjusting bottom cylinder, the needle head height adjusting bottom cylinder is connected with the lower part thread section in a thread matching way, and the lower part of the needle head height adjusting bottom cylinder is provided with a convex part connected with an injection needle.

Preferably, the upper thread section adopts internal threads, and external threads matched with the internal threads are arranged on the outer side of the push core fixing block.

Preferably, the upper thread section adopts internal threads, an annular groove is formed in the push core fixing block, and external threads matched with the internal threads are arranged on the inner wall of the annular groove.

Preferably, the upper thread section adopts external threads, an annular groove is formed in the push core fixing block, and internal threads matched with the external threads are arranged on the outer wall of the annular groove.

Preferably, the lower thread section adopts internal threads, and the outer wall of the needle height adjusting bottom barrel is provided with external threads matched with the internal threads.

Preferably, the lower thread section adopts an external thread, and the inner wall of the needle height adjusting bottom barrel is provided with an internal thread matched with the external thread.

Preferably, an adjusting knob is further arranged on the needle height adjusting bottom barrel.

Preferably, the piston comprises a piston main body and a piston jacket wrapped outside the piston main body, and the piston jacket is tightly attached to the inner wall of the outer cylinder of the syringe.

Further preferably, the piston housing is made of rubber; the piston push core, the push core fixing block, the piston main body, the syringe outer cylinder, the needle head height adjusting bottom cylinder, the bulge and the syringe fixing frame are all made of organic glass.

Preferably, the test device further comprises an injector fixing frame, wherein a clamping groove for fixing the injector is formed in the injector fixing frame, and a fixing hole connected with the experimental equipment is further formed in the injector fixing frame.

Compared with the prior art, the utility model discloses following profitable technological effect has:

the utility model provides a syringe for establishing animal intracranial hemorrhage model, which connects the main structural components by adopting a thread structure, on one hand, the connection mode of each component in the syringe can be simplified, and the complexity of the actual operation is reduced; on the other hand, the design of helicitic texture can reach the purpose of adjusting injection rate and height according to the experiment needs, the utility model discloses a tertiary screw thread regulation has realized the accurate control to injection rate and bleeding point position, and the concrete manifestation is in: in the first stage, the pushing core and the pushing core fixing block of the piston are adjusted through thread fit, and the pushing speed of the piston is adjusted; in the second stage, the matching distance between the push core fixing block and the upper thread section is adjusted through thread matching, so that the aim of slowly injecting blood into the cranium at different rates according to experimental requirements is fulfilled; and thirdly, as the middle tube body section of the outer tube of the injector is provided with scales, the matching distance between the bottom tube and the lower thread section is adjusted by adjusting the height of the needle head in a thread matching way, so that the specific distance of the descending of the bulge can be known, the depth of the injection needle connected with the bulge entering the intracranial space can be determined, the accurate bleeding point position and the position of the quantitative piston can be obtained, and the volume of the injection can be accurately read. The injector of the utility model has reasonable structure, simple operation and convenient use, and provides reliable guarantee for smoothly establishing the animal intracranial hemorrhage model; the split design is adopted, so that the cleaning of each part is convenient, the repeatability and the accuracy of model establishment are ensured, the method is particularly suitable for the construction of an intracranial hemorrhage animal model in animal experimental research, and the operation and the accurate modeling are convenient.

Furthermore, the upper part thread section of the outer cylinder of the injector is connected with the push core fixing block through threads, the upper part thread section is matched with the threads on the push core fixing block, and the push core fixing block can be screwed in or out relative to the outer cylinder of the injector through three combination modes, so that the piston is driven to push the core to move.

Furthermore, the lower thread section is connected with the needle head height adjusting bottom barrel through threads, the height of the needle head height adjusting bottom barrel is adjusted through the threads, and the depth of the injection needle connected with the bulge part into the skull is further adjusted.

Furthermore, the piston comprises a piston main body and a piston outer sleeve wrapped outside the piston main body, the piston main body is connected with the piston push core, and the piston outer sleeve is in close contact with the outer cylinder of the injector, so that the connection between the piston and the piston push core is met, and the piston can be ensured to move well in the outer cylinder of the injector.

Furthermore, the injector fixing frame is fixed on the experimental equipment through the fixing hole, and the injector is fixed on the injector fixing frame through the clamping groove, so that the stability of the injector in the blood injection process can be ensured.

Furthermore, an adjusting knob can be arranged on the outer wall of the needle head height adjusting bottom barrel, and the needle head height adjusting knob can be easily screwed by rotating the adjusting knob to adjust the depth of the needle head in the skull.

Drawings

Fig. 1 is a schematic structural view of the syringe of the present invention;

FIG. 2 is a schematic structural view of the outer side wall of the core pushing fixing block adopting external threads;

FIG. 3 is a schematic structural view of a core pushing fixing block adopting an annular groove external thread;

FIG. 4 is a schematic structural view of a core pushing fixing block adopting an annular groove internal thread;

FIG. 5 is a schematic view of the piston structure;

FIG. 6 is a first structural view of the outer barrel of the syringe;

FIG. 7 is a second structural view of the outer barrel of the syringe;

FIG. 8 is a third structural view of the outer barrel of the syringe;

FIG. 9 is a fourth structural view of the syringe barrel;

FIG. 10 is a schematic view of the structure of the needle height adjusting outer cylinder with internal threads;

FIG. 11 is a schematic structural view of the needle height adjusting outer cylinder with external threads;

FIG. 12 is a front view of the syringe mount;

fig. 13 is an elevational view of the syringe holder.

In the figure: 1 is a piston push core; 2, a core pushing fixing block; 21 is a through hole; 22 is an annular groove; 3 is a piston; 31 is a piston main body; 32 is a piston jacket; 4 is the outer cylinder of the syringe; 41 is an upper thread segment; 41a is an upper internal thread; 41b is an upper external thread; 42 is a middle tube section; 43 is a lower threaded segment; 43a is a lower internal thread; 43b is a lower external thread; 5 is a needle height adjusting bottom cylinder; 51a is a bottom barrel internal thread; 51b is a bottom cylinder external thread; 52 is a needle head connecting clamping groove; 53 is an adjusting knob; 6 is a convex part; 7 is a syringe fixing frame; 71 is a fixing hole; and 72 is a card slot.

Detailed Description

The present invention will now be described in further detail with reference to specific examples, which are intended to be illustrative, but not limiting, of the invention.

As shown in figure 1, the utility model discloses a syringe for establishing animal intracranial hemorrhage model, including piston push core 1, push core fixed block 2, piston 3, syringe urceolus 4, syringe needle altitude mixture control end section of thick bamboo 5 and bellying 6. The piston push core 1 penetrates through the push core fixing block 2 to be connected with the upper end of the piston 3, and the piston push core 1 is connected with the push core fixing block 2 through threads; a through hole 21 is formed in the center of the push core fixing block 2, internal threads are formed in the inner wall of the through hole 21, external threads matched with the internal threads in the through hole 21 are formed in the outer wall of the piston push core 1, and the piston push core 1 can be screwed in or out of the push core fixing block 2 through thread matching.

The syringe outer cylinder 4 comprises an upper threaded section 41, a middle tube section 42 and a lower threaded section 43, the upper threaded section 41 is connected with the push core fixing block 2, the middle tube section 42 is in close contact with the piston 3, and the lower threaded section 43 is connected with the needle height adjusting bottom cylinder 5.

The core pushing fixing block 2 is connected with an upper threaded section 41 of the outer barrel 4 of the syringe through threads, and comprises the following three matching modes:

the first method comprises the following steps: the upper thread section 41 adopts an upper internal thread 41a, and the outer side of the push core fixing block 2 is provided with an external thread matched with the upper internal thread;

and the second method comprises the following steps: the upper thread section 41 adopts an upper internal thread 41a, an annular groove 22 is formed on the push core fixing block 2, and an external thread matched with the annular groove 22 is arranged on the inner side wall of the annular groove 22;

and the third is that: the upper thread section 41 adopts an upper external thread 41b, an annular groove 22 is arranged on the push core fixing block 2, and an internal thread adapted to the annular groove 22 is arranged on the outer side wall of the annular groove 22.

The above three matching forms can satisfy the relative rotation movement of the core pushing fixing block 2 and the syringe outer cylinder 4, and the first matching form is preferably adopted because of the simple structure.

The piston 3 is positioned in the syringe outer cylinder 4, the piston 3 is tightly attached to the inner wall of the syringe outer cylinder 4, when the piston 3 is pushed by external force, the piston can do linear motion along the inner wall of the syringe outer cylinder 4, and when the height of the piston push core 1 is adjusted, the lower end of the piston push core 1 is connected with the upper end of the piston 3, so that the moving height of the piston 3 is adjusted.

The needle height adjusting bottom barrel 5 is connected with the lower threaded section 43 of the syringe outer barrel 4 through threads, and the connection comprises the following two matching modes:

the first method comprises the following steps: when the lower thread section 43 adopts a lower internal thread 43a, the outer wall of the needle height adjusting bottom barrel 5 is provided with a bottom barrel external thread 51b matched with the lower internal thread;

and the second method comprises the following steps: when the lower thread section 43 adopts the lower external thread 43b, the inner wall of the needle height adjusting bottom barrel 5 is provided with a bottom barrel internal thread 51a matched with the lower external thread.

Preferably, when the needle height adjusting bottom barrel 5 adopts an internal thread, the adjusting knob 53 can be further arranged on the outer wall of the needle height adjusting bottom barrel 5, the needle height adjusting bottom barrel 5 can be easily screwed by rotating the adjusting knob 53, so that the needle height adjusting bottom barrel 5 can rotate relative to the syringe outer barrel 4 more easily, and the depth of the needle 6 in the cranium can be conveniently adjusted through the thread.

The boss 6 is provided with a needle head connecting groove 52 for connecting various types of injection needles.

As shown in fig. 12-13, stability and convenience when considering the use, the utility model discloses still set up syringe mount 7, be equipped with draw-in groove 72 on syringe mount 7, will the syringe fix in draw-in groove 72, still be equipped with fixed orifices 71 on syringe mount 7, be fixed in experimental facilities such as animal experiment platform or stereotaxic apparatus with syringe mount 7 through fixed orifices 71 on, can guarantee the stability of syringe at injection blood in-process.

Preferably, the piston push core 1, the push core fixing block 2, the injector outer cylinder 4, the needle head height adjusting bottom cylinder 5, the bulge 6 and the injector fixing frame 7 are all made of polymethyl methacrylate, commonly called organic glass; as shown in fig. 5, the piston 3 includes two parts, a piston main body 21 and a piston outer cover 32, the piston main body 31 is made of plexiglas, and the piston outer cover 32 is made of rubber.

The utility model discloses an injector for establishing animal intracranial hemorrhage model, when using:

firstly, fixing the injector in a clamping groove 72 of an injector fixing frame 7, secondly, fixing the injector fixing frame 7 on experimental equipment through a fixing hole 71, then injecting animal autoblood into a middle tube body section 42 of an injector outer tube 4, after the animal skull drilling is finished, enabling an injection needle connected with a convex part 6 to enter the cranium along a skull hole, adjusting the depth of the injection needle connected with the convex part 6 to enter the cranium through a needle head height adjusting bottom tube 5, and finally, slowly injecting the blood into the cranium at a certain speed through adjusting a piston push core 1.

The depth of the core pushing fixing block 2 entering the outer cylinder 4 of the injector is adjusted by screwing in or screwing out the core pushing fixing block 2, namely the depth of the piston pushing core 1 entering the outer cylinder 4 of the injector is adjusted, the depth of the piston pushing core 1 entering the core pushing fixing block 2 can also be adjusted, the depth of the piston pushing core 1 entering the injector is further adjusted, and different pushing speeds of the piston 3 are realized by adjusting the piston pushing core 1 and the core pushing fixing block 2.

Each part is independently designed, and after the model building device is used, each part can be disassembled and cleaned, so that each part can be conveniently cleaned, and the repeatability and the accuracy of model building are ensured.

To sum up, the utility model provides an injector for establishing animal intracranial hemorrhage model has realized can slowly injecting blood to encephalic with different rates according to the experiment demand in establishing intracranial hemorrhage animal model experiment, and accurate positioning bleeding point position simultaneously can carry out accurate control to the preparation of intracranial hemorrhage animal model, and the building of intracranial hemorrhage animal model in the specially adapted animal experimental study is convenient for operate and accurate modeling.

Claims

1. A syringe for establishing an animal intracranial hemorrhage model is characterized by comprising a syringe outer cylinder (4) consisting of an upper thread section (41), a middle tube body section (42) and a lower thread section (43), wherein a piston (3) which is clung to the inner wall of the syringe outer cylinder (4) and can linearly move is arranged in the syringe outer cylinder (4), and the upper end of the piston (3) is connected with a piston push core (1);

a push core fixing block (2) is arranged at the upper threaded section (41) of the outer cylinder (4) of the injector, a through hole (21) for a piston push core (1) to pass through is formed in the push core fixing block (2), internal threads are formed on the inner wall of the through hole (21), external threads are formed on a core rod of the piston push core (1), and the piston push core (1) is in threaded connection with the push core fixing block (2); scales are arranged on the outer wall of the middle tube body section (42) of the outer barrel (4) of the injector; a needle head height adjusting bottom barrel (5) is arranged at a lower threaded section (43) of the syringe outer barrel (4), the needle head height adjusting bottom barrel (5) is connected with the lower threaded section (43) in a threaded fit mode, and a protruding portion (6) connected with an injection needle is arranged on the lower portion of the needle head height adjusting bottom barrel (5).

2. The injector for establishing the animal intracranial hemorrhage model according to claim 1, wherein the upper thread section (41) adopts internal threads, and the outer side of the push core fixing block (2) is provided with external threads matched with the internal threads.

3. The injector for establishing the animal intracranial hemorrhage model according to claim 1, wherein the upper thread section (41) adopts internal threads, the push core fixing block (2) is provided with an annular groove (22), and the inner wall of the annular groove (22) is provided with external threads matched with the internal threads.

4. The injector for establishing the animal intracranial hemorrhage model according to claim 1, wherein the upper thread section (41) adopts external threads, the push core fixing block (2) is provided with an annular groove (22), and the outer wall of the annular groove (22) is provided with internal threads matched with the external threads.

5. The injector for establishing the animal intracranial hemorrhage model according to claim 1, wherein the lower threaded section (43) adopts an internal thread, and the outer wall of the needle height adjusting base cylinder (5) is provided with an external thread matched with the internal thread.

6. The injector for establishing the animal intracranial hemorrhage model according to claim 1, wherein the lower threaded section (43) adopts an external thread, and the inner wall of the needle height adjusting bottom barrel (5) is provided with an internal thread matched with the external thread.

7. Syringe for establishing an intracranial hemorrhage model in an animal as claimed in claim 6, in which the needle height-adjusting base (5) is also provided with an adjusting knob (53).

8. The injector for establishing the animal intracranial hemorrhage model as defined in any one of claims 1-7, wherein the piston (3) comprises a piston main body (31) and a piston jacket (32) wrapped outside the piston main body (31), and the piston jacket (32) is tightly attached to the inner wall of the injector outer cylinder (4).

9. The injector for establishing the animal intracranial hemorrhage model according to any one of claims 1 to 7, further comprising an injector fixing frame (7), wherein the injector fixing frame (7) is provided with a clamping groove (72) for fixing the injector, and the injector fixing frame (7) is further provided with a fixing hole (71) connected with experimental equipment.