CN210695691U

CN210695691U - CAR-T cell low temperature storage device

Info

Publication number: CN210695691U
Application number: CN201921163204.1U
Authority: CN
Inventors: 刘福泷; 王雨; 梅志超; 吴靖; 罗新高
Original assignee: Shenzhen Qianhai Precision Bio Tech Co ltd
Current assignee: Shenzhen Kekang Clinical Medicine Research Co.,Ltd.
Priority date: 2019-07-23
Filing date: 2019-07-23
Publication date: 2020-06-09
Anticipated expiration: 2029-07-23

Abstract

The utility model discloses a CAR-T cell low temperature storage device, which belongs to the technical field of cell storage, and comprises a device main body, wherein water pumps are respectively arranged at two sides of the device main body, a liquid inlet of the water pumps is connected with a liquid suction pipe, an output end of the water pumps is connected with a liquid discharge pipe, the CAR-T cell low temperature storage device is provided with a liquid guide pipe, a liquid distribution pipe and spray holes, after a cell test tube is stored, a worker can draw liquid nitrogen through the liquid suction pipe, then the liquid nitrogen is discharged into the liquid guide pipe through the liquid discharge pipe and then enters the liquid distribution pipe, because a plurality of spray holes arranged at one side of the liquid distribution pipe are sprayed out, the interior of the device is cooled, and because the plurality of spray holes are divided into two groups, the two groups of spray holes are symmetrically arranged by taking a screw rod as a center, the liquid nitrogen, therefore, the ambient temperature in the device is more uniform, and the condition of unbalanced temperature in the device is avoided.

Description

CAR-T cell low temperature storage device

Technical Field

The utility model relates to a cell storage technical field specifically is a CAR-T cell low temperature storage device.

Background

The cell storage is to store APSC multipotential cells in the cells for a certain period of time by a certain method, so as to ensure that the functions and the activities of the cells are not obviously influenced, the CAR-T cells are to utilize the 'positioning navigation device' CAR to specially identify in-vivo tumor cells, and release a large amount of various effect factors through the immune action, and the CAR-T cells can efficiently kill the tumor cells, thereby achieving the purpose of treating malignant tumors.

Current cell low temperature storage device, cell placement frame usually can not change the operation for fixed form, and application scope receives very big restriction for it is convenient inadequately when making the staff take out the cell test tube, and because the cooling mode of device generally gets into from a direction and begins the cooling, makes the inside temperature of device not enough even, leads to can causing harm to the health of cell, thereby causes the influence to the storage deadline of cell.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a CAR-T cell low temperature storage device to provide in solving above-mentioned background art when taking the cell convenient and the device internal temperature unbalance's problem inadequately.

In order to achieve the above object, the utility model provides a following technical scheme: the utility model provides a CAR-T cell low temperature storage device, includes the device main part, the water pump is all installed to the both sides of device main part, the inlet of water pump is connected with the liquid suction pipe, the output of water pump is connected with the fluid-discharge tube, the fluid-discharge tube has the branch liquid pipe that is located device main part lateral wall inside through liquid pipe connection, divide one side of liquid pipe to install a plurality of orifices, sealed lid is installed at the top of device main part, install the motor in the middle of the bottom of device main part, the output of motor is connected with the lead screw, the top of lead screw is fixed with the stopper, the thread bush has been cup jointed to the surface of lead screw, the outside of thread bush is fixed with the test tube tray through the connecting rod, the standing groove has been seted up to the surface of test tube tray.

Preferably, the plurality of spray holes are divided into two groups, and the two groups of spray holes are symmetrically arranged by taking the screw rod as a center.

Preferably, the threaded sleeve is in threaded connection with the screw rod.

Preferably, the test tube tray is located below the sealing cover.

Preferably, the test tube tray is slidably connected with the sliding groove through a sliding block.

Preferably, the outer surface of the device main body is provided with an operation table, and the operation table is respectively electrically connected with the water pump and the motor.

Compared with the prior art, the beneficial effects of the utility model are that: the CAR-T cell low-temperature storage device is provided with a lead screw, a threaded sleeve, a test tube tray, a sliding block and a sliding groove, when a cell test tube needs to be taken out, a worker can firstly open a motor to enable the lead screw to rotate, the threaded sleeve is in threaded connection with the lead screw, so that the threaded sleeve can move along with threads on the outer surface of the lead screw in the rotating process of the lead screw, the threaded sleeve can move upwards, the test tube tray is in sliding connection with the sliding groove through the sliding block, the test tube tray can slide on the sliding groove through the sliding block in the rising process, the test tube tray can stably rise along the sliding groove, the test tube tray is located below the sealing cover, the test tube tray can approach the sealing cover after rising, the worker pulls the sealing cover open, and then the cell test tube can be taken out through the test tube tray close to the sealing cover, the mode of taking is swift convenient, the condition convenient inadequately when taking the cell has been avoided, and this kind of CAR-T cell low temperature storage device is provided with the catheter, divide liquid pipe and orifice, after depositing the cell test tube, the staff can extract the liquid nitrogen through the liquid suction pipe, then arrange the catheter into through the fluid-discharge tube, then get into and divide in the liquid pipe, a plurality of orifices blowout by branch liquid pipe one side installation, cool down the device inside, and because a plurality of orifices divide into two sets ofly, two sets of orifices use the lead screw to set up as central symmetry, make orifice spun liquid nitrogen can form the offset, make dispersion each place in the device that can be faster, thereby make the ambient temperature in the device more even, and then avoided the inside temperature imbalance's of device the condition.

Drawings

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is a schematic cross-sectional view of the main body of the device of the present invention;

FIG. 3 is a schematic view of the structure of the sidewall of the main body of the device of the present invention;

fig. 4 is a schematic diagram of a partially enlarged structure of the present invention a.

In the figure: 1. a device main body; 2. an operation table; 3. a sealing cover; 4. a water pump; 5. a liquid pumping pipe; 6. a liquid discharge pipe; 7. a catheter; 8. a motor; 9. a screw rod; 10. a limiting block; 11. a threaded sleeve; 12. a connecting rod; 13. a test tube tray; 14. a placement groove; 15. spraying a hole; 16. a chute; 17. a slider; 18. a liquid separating pipe.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

In the present invention, unless otherwise expressly stated or limited, the terms "disposed," "mounted," "connected," "fixed," "sleeved," and the like are to be construed broadly, e.g., as either a fixed connection, a removable connection, or an integral part; can be mechanically or electrically connected; the two elements may be connected directly or indirectly through an intermediate medium, and the two elements may be connected internally or in an interaction relationship, and a person skilled in the art can understand the specific meaning of the above terms in the present invention according to specific situations.

Referring to fig. 1-4, the present invention provides a technical solution: a CAR-T cell low-temperature storage device comprises a device body 1, an operation table 2, a sealing cover 3, a water pump 4, a liquid suction pipe 5, a liquid discharge pipe 6, a liquid guide pipe 7, a motor 8, a screw rod 9, a limiting block 10, a thread sleeve 11, a connecting rod 12, a test tube tray 13, a placing groove 14, spray holes 15, a sliding groove 16, a sliding block 17 and a liquid distribution pipe 18, wherein the water pump 4 is installed on two sides of the device body 1, the liquid inlet of the water pump 4 is connected with the liquid suction pipe 5, the output end of the water pump 4 is connected with the liquid discharge pipe 6, the liquid discharge pipe 6 is connected with the liquid distribution pipe 18 positioned inside the side wall of the device body 1 through the liquid guide pipe 7, a plurality of spray holes 15 are installed on one side of the liquid distribution pipe 18, the sealing cover 3 is installed on the top of the device body 1, the, stopper 10 can restrict the position of thread bush 11, and thread bush 11 has been cup jointed to the surface of lead screw 9, and connecting rod 12 is fixed with test tube tray 13 in the outside of thread bush 11, and standing groove 14 has been seted up to test tube tray 13's surface, and test tube tray 13 keeps away from the one end of connecting rod 12 and is connected with spout 16 through slider 17.

Referring to fig. 1-4, the plurality of spray holes 15 are divided into two groups, and the two groups of spray holes 15 are symmetrically arranged around the screw rod 9, so that the liquid nitrogen sprayed from the spray holes 15 can form a hedging, so that the liquid nitrogen can be more rapidly dispersed in various places in the device, and the threaded sleeve 11 is in threaded connection with the screw rod 9, so that the threaded sleeve 11 can move along the threads on the screw rod 9.

Referring to fig. 1 to 4, the test tube tray 13 is located below the sealing cover 3, so that a worker can take out a cell test tube in the test tube tray 13 by opening the sealing cover 3, and the test tube tray 13 is slidably connected to the sliding groove 16 through the slider 17, so that the test tube tray 13 can slide on the sliding groove 16 through the slider 17.

Referring to fig. 1-2, an operation panel 2 is disposed on an outer surface of the device body 1, and the operation panel 2 is electrically connected to the water pump 4 and the motor 8, respectively, so that a worker can operate the water pump 4 and the motor 8 by using the operation panel 2.

The working principle is as follows: firstly, the worker installs the device, connects the liquid pumping pipe 5 with the liquid nitrogen tank, after the cell test tube is stored, then switches on the power, the worker turns on the water pump 4, the liquid nitrogen is pumped through the liquid pumping pipe 5, then the liquid nitrogen is discharged into the liquid guide pipe 7 through the liquid discharge pipe 6, then the liquid nitrogen enters the liquid distribution pipe 18, the liquid nitrogen is sprayed out from the plurality of spray holes 15 arranged on one side of the liquid distribution pipe 18, the interior of the device is cooled, and because the plurality of spray holes 15 are divided into two groups, the two groups of spray holes 15 are symmetrically arranged by taking the screw rod 9 as the center, the liquid nitrogen sprayed out from the spray holes 15 can form the opposite impact, the liquid nitrogen can be rapidly dispersed in each place in the device, thereby the environmental temperature in the device is more uniform, when the cell test tube needs to be taken out, the worker can firstly turn on the motor 8, the motor 8 enables the screw rod, make and rotate the in-process at lead screw 9, thread bush 11 can be along with the thread movement of lead screw 9 surface, thereby let thread bush 11 upwards move, and because test tube tray 13 passes through slider 17 and spout 16 sliding connection, make thread bush 11 at the ascending in-process, test tube tray 13 can slide on spout 16 through slider 17, thereby make test tube tray 13 can follow the stable rise of spout 16, and because test tube tray 13 is located the below of sealed lid 3, make and to be close to sealed lid 3 after test tube tray 13 rises, the staff pulls open sealed lid 3 afterwards, then can take out the cell test tube through the test tube tray 13 that is close to sealed lid 3, it is swift convenient to take the mode.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A CAR-T cell cryogenic storage device comprising a device body (1), characterized in that: the device is characterized in that water pumps (4) are installed on two sides of the device body (1), a liquid inlet of each water pump (4) is connected with a liquid pumping pipe (5), an output end of each water pump (4) is connected with a liquid discharging pipe (6), each liquid discharging pipe (6) is connected with a liquid separating pipe (18) located inside the side wall of the device body (1) through a liquid guiding pipe (7), a plurality of spray holes (15) are installed on one side of each liquid separating pipe (18), a sealing cover (3) is installed on the top of the device body (1), a motor (8) is installed in the middle of the bottom of the device body (1), an output end of the motor (8) is connected with a lead screw (9), a limiting block (10) is fixed on the top of the lead screw (9), a threaded sleeve (11) is sleeved on the outer surface of the lead screw (9), and a test tube tray (, a placing groove (14) is formed in the outer surface of the test tube tray (13), and one end, far away from the connecting rod (12), of the test tube tray (13) is connected with a sliding groove (16) through a sliding block (17).

2. A CAR-T cell cryopreservation device as claimed in claim 1 wherein: the plurality of spray holes (15) are divided into two groups, and the two groups of spray holes (15) are symmetrically arranged by taking the screw rod (9) as a center.

3. A CAR-T cell cryopreservation device as claimed in claim 1 wherein: the threaded sleeve (11) is in threaded connection with the screw rod (9).

4. A CAR-T cell cryopreservation device as claimed in claim 1 wherein: the test tube tray (13) is positioned below the sealing cover (3).

5. A CAR-T cell cryopreservation device as claimed in claim 1 wherein: test tube tray (13) pass through slider (17) and spout (16) sliding connection.

6. A CAR-T cell cryopreservation device as claimed in claim 1 wherein: the outer surface of the device main body (1) is provided with an operation table (2), and the operation table (2) is respectively electrically connected with the water pump (4) and the motor (8).