CN210668273U - Sample feeding device for capillary electrospray quantification - Google Patents
Sample feeding device for capillary electrospray quantification Download PDFInfo
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- CN210668273U CN210668273U CN201922256598.1U CN201922256598U CN210668273U CN 210668273 U CN210668273 U CN 210668273U CN 201922256598 U CN201922256598 U CN 201922256598U CN 210668273 U CN210668273 U CN 210668273U
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- quantification
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- 238000011002 quantification Methods 0.000 title claims abstract description 11
- 238000005507 spraying Methods 0.000 claims abstract description 17
- 238000001819 mass spectrum Methods 0.000 claims abstract description 11
- 238000005070 sampling Methods 0.000 claims abstract description 5
- 239000007788 liquid Substances 0.000 claims description 22
- 239000007921 spray Substances 0.000 claims description 9
- 239000004020 conductor Substances 0.000 claims description 3
- 239000000725 suspension Substances 0.000 claims description 3
- 239000012780 transparent material Substances 0.000 claims description 3
- 238000001514 detection method Methods 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 4
- 230000005611 electricity Effects 0.000 abstract description 3
- 238000002347 injection Methods 0.000 description 9
- 239000007924 injection Substances 0.000 description 9
- 239000000243 solution Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
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Abstract
The utility model discloses a sample introduction device for capillary electrospray quantification, which comprises a capillary, a sleeve, a fixed clamp, a movable clamp, a hard straight rod, a sample bottle, a direct-current high-voltage power supply and a mass spectrum sample introduction port; the fixing clamp fixedly clamps the capillary tube; moving the clamp to clamp the sleeve; the fixed clamp is fixedly arranged on the hard straight rod, and the movable clamp is movably arranged on the hard straight rod; the movable clamp drives the sleeve to move up and down in the axial direction of the capillary tube; the direct-current high-voltage power supply clamps the capillary tube through a clamp; the capillary tube is communicated with the sample bottle through the sleeve. The shape of the capillary can be selected differently according to different sampling angles, and the spraying end of the capillary can be treated to a certain extent so as to improve the effect of generating charged spraying. The utility model discloses a device can realize fast that the ration of capillary electricity spraying advances kind, and the sample consumption is low, need not complicated processing, and constructional device is simple, is applicable to the detection of trace sample.
Description
Technical Field
The utility model relates to a mass spectrometry field specifically is a sampling device for capillary electricity spraying ration.
Background
When the analyzer detects a liquid sample, the analyzer needs to push the liquid or pre-extract a quantitative sample at a sample injection position in advance to generate gas phase ions for detection. Generally, the liquid is driven by a pump or by suction under negative pressure. However, for trace liquid samples and quantitative sample injection, the traditional injection pump has large sample demand and large dead volume of a pipeline, and the sample residue is large, so that a detection signal of the trace sample cannot be rapidly obtained.
SUMMERY OF THE UTILITY MODEL
In order to overcome the defects of the prior art, the utility model provides a sample feeding device for capillary electrospray quantification.
The utility model provides a technical scheme that its technical problem adopted is:
a sample introduction device for capillary electrospray quantification comprises a capillary, a sleeve, a fixed clamp, a movable clamp, a hard straight rod, a sample bottle, a direct-current high-voltage power supply and a mass spectrum sample introduction port; the fixing clamp is used for fixedly clamping the capillary tube; the movable clamp clamps the sleeve; the fixed clamp is fixedly arranged on the hard straight rod, and the movable clamp is movably arranged on the hard straight rod; the movable clamp drives the sleeve to move up and down in the axial direction of the capillary tube; the direct-current high-voltage power supply clamps the capillary tube through a clamp; the capillary tube is communicated with the sample bottle through the sleeve.
As a preferred technical scheme of the utility model, the capillary is conductive material, and its internal diameter is 5 mu m to 500 mu m.
As an optimal technical scheme of the utility model, the one end that the capillary is close to the mass spectrum introduction port and produces the ionization spraying is provided with capillary spraying end, the inner chamber of capillary spraying end is the reducing inner chamber or the constant diameter inner chamber that the aperture shrinks gradually.
As a preferred technical solution of the present invention, the sample bottle is provided with a liquid sample to be analyzed, and the liquid sample is a clarified liquid or a suspension.
As an optimized technical scheme of the utility model, the sleeve is made by transparent material, telescopic internal diameter scope is at 300 mu m to 2mm, the sleeve outside is provided with the scale that is used for judging the capillary and gets into telescopic degree of depth.
As an optimal technical scheme of the utility model, sleeve internal diameter than the external diameter of capillary is big, the sleeve is through removing anchor clamps centre gripping sleeve at capillary axial displacement, so that the capillary inserts in the solution sample in the sleeve, the solution sample rises to the capillary top through the capillary, produces the ionization spraying through the high pressure.
As an optimized technical scheme of the utility model, the liquid volume of capillary bottom to sleeve top is the volume of the sample that the capillary ration was gathered.
Compared with the prior art, the beneficial effects of the utility model are that:
the shape of the capillary can be selected differently according to different sample introduction angles, and for example, when the sample introduction is required to be performed right at a mass spectrum sample introduction port, the capillary bent to a certain degree can be selected for sample introduction; in addition, when the spraying end of the capillary is subjected to certain treatment, the specific treatment method depends on the material; when the inner diameter of the spraying end of the capillary tube is reduced to about 50 mu m, the effect of generating charged spray can be improved. The utility model discloses a device can realize fast that the ration of capillary electricity spraying advances kind, and the sample consumption is low, need not complicated processing, and constructional device is simple, is applicable to the detection of trace sample.
Drawings
Fig. 1 is a schematic diagram of the overall structure of the basic embodiment of the present invention.
Fig. 2 is a schematic structural diagram of the remaining embodiment.
The drawing is marked with a capillary 1, a sleeve 2, a fixed clamp 3, a movable clamp 4, a hard straight rod 5, a sample bottle 6, a direct-current high-voltage power supply 7 and a mass spectrum sample inlet 8.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
A device for electrospray quantitative sample injection of a capillary 1 is shown in figures 1 and 2 and comprises the capillary 1, a sleeve 2, a fixed clamp 3, a movable clamp 4, a hard straight rod 5, a sample bottle 6, a direct-current high-voltage power supply 7 and a mass spectrum sample injection port 8; the capillary 1 is fixed in the direction vertical to the horizontal plane through the fixing clamp 3; the fixing clamp 3 is parallel to a horizontal plane and used for fixing the capillary 1; the fixed clamp 3 is fixedly arranged on the hard straight rod, the movable clamp is movably arranged on the hard straight rod, the sleeve is clamped by the movable clamp 4, and the movable clamp 4 controls the sleeve 2 to move up and down in the axial direction of the capillary 1; the direct-current high-voltage power supply 7 clamps the capillary tube 1 through a clamp and is used for generating electrospray; the mass spectrum sample inlet 8 is used for receiving sample ions generated by electrospray; the capillary tube 1 is communicated with the sample bottle 6 through the sleeve 2; the capillary 1 is made of a conductive material, the inner diameter of the capillary is 5-500 mu m, one end, close to the mass spectrum sample inlet 8, of the capillary 1 is a capillary spraying end, and an inner cavity of the capillary spraying end is a reducing inner cavity or an equal-diameter inner cavity with gradually contracted aperture. The sample bottle 6 is used for containing a liquid sample to be analyzed, such as a clear liquid or a certain amount of suspension; the sleeve 2 is made of transparent materials, the inner diameter range is 300 mu m to 2mm, and scales are arranged on the outer side of the sleeve 2 and used for judging the depth of the capillary 1 entering the sleeve 2; the inner diameter of the sleeve 2 is larger than the outer diameter of the capillary 1, the sleeve 2 is clamped by a movable clamp 4 to move in the axial direction of the capillary 1, so that the capillary 1 is inserted into a solution sample in the sleeve 2, the solution sample rises to the top end of the capillary 1 through the capillary 1, and the sleeve 2 is clamped by the movable clamp 4 to move in the axial direction of the capillary 1; the liquid volume from the bottom of the capillary 1 to the top of the sleeve 2 is the volume of the quantitative collection sample of the capillary 1; the capillary 1 and the sample bottle 6 are kept still, and the sleeve 2 is driven by a movable clamp 4 connected with the sleeve to move up and down, so that the collection and transmission of a solution sample and the sample introduction process of the capillary 1 are completed; the liquid volume from the bottom of the capillary 1 to the top of the sleeve 2 is the volume of the sample collected by the capillary 1.
After sleeve 2 got into sample bottle 6, the sample was full of through capillary action sleeve 2, afterwards remove anchor clamps 4 and upwards shift out sleeve 2 slowly sample bottle 6, this moment capillary 1 will follow sleeve 2 upper end entering, and the sample gets into from sleeve 2 under through capillary action capillary 1 to reach 1 top of capillary, the utility model discloses can directly give capillary 1 applys high voltage, makes intraductal liquid produce the electric spray at the mouth of pipe, and simultaneously at the spraying in-process, the liquid in capillary 1 can be under capillary action's drive toward the spout removal to accomplish the sampling of remaining sample in the sleeve 2, accomplish up to all sample collection in the sleeve, then quantitative sampling electric spray analysis is accomplished.
The utility model discloses an embodiment:
the shape of the capillary 1 can be selected differently according to different sample introduction angles. As shown in fig. 2, when the sample injection needs to be performed right at the mass spectrum sample injection port 8, the capillary 1 bent to a certain degree can be selected for sample injection. When the sleeve 2 enters the liquid during analysis, the liquid is required to be filled in the sleeve 2; the sleeve 2 moves upwards along with the clamp, and liquid in the sleeve 2 cannot slide down due to capillary action and can be used for subsequent sample injection of the capillary 1; in the process that the capillary tube 1 enters the sleeve 2, the sample feeding amount of a sample is controlled by controlling the depth of the sample entering the sleeve 2, and the sample can rise to the top end of the capillary tube 1 due to the capillary action; the high-voltage direct-current power supply can directly power up the conductive capillary tube 1, so that the electro-spray effect of the capillary tube 1 is achieved, the design of a power-up device is reduced, and the complexity of the structure is reduced; the spray generated by the powered metal capillary 1 can be directed to the sample inlet of an analytical instrument for analysis.
When the spray end of the capillary 1 is subjected to a predetermined treatment, the specific treatment method depends on the material. When the inner diameter of the capillary spray port is reduced to about 50 μm, the effect of generating charged spray can be improved.
It is obvious to a person skilled in the art that the invention is not restricted to details of the above-described exemplary embodiments, but that it can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Claims (7)
1. The utility model provides a sampling device for capillary electrospray is quantitative which characterized in that: the device comprises a capillary tube, a sleeve, a fixed clamp, a movable clamp, a rigid straight rod, a clamp, a sample bottle, a direct-current high-voltage power supply and a mass spectrum sample inlet; the fixing clamp is used for fixedly clamping the capillary tube; the movable clamp clamps the sleeve; the fixed clamp is fixedly arranged on the hard straight rod, and the movable clamp is movably arranged on the hard straight rod; the movable clamp drives the sleeve to move up and down in the axial direction of the capillary tube; the direct-current high-voltage power supply clamps the capillary tube through a clamp; the capillary tube is communicated with the sample bottle through the sleeve.
2. The sample introduction device for capillary electrospray quantification as claimed in claim 1, wherein: the capillary is made of conductive material, and the inner diameter of the capillary is 5-500 mu m.
3. The sample introduction device for capillary electrospray quantification as claimed in claim 2, wherein: the capillary is close to the one end that the mass spectrum introduction port produced the ionization spraying and is provided with the capillary spraying end, the inner chamber of capillary spraying end is the reducing inner chamber or the constant diameter inner chamber that the aperture shrinks gradually.
4. The sample introduction device for capillary electrospray quantification as claimed in claim 1, wherein: the sample bottle is internally provided with a liquid sample to be analyzed, and the liquid sample is clear liquid or suspension liquid.
5. The sample introduction device for capillary electrospray quantification as claimed in claim 1, characterized by: the sleeve is made of transparent materials, the inner diameter range of the sleeve is 300 mu m to 2mm, and scales for judging the depth of the capillary tube entering the sleeve are arranged on the outer side of the sleeve.
6. The sample introduction device for capillary electrospray quantification as claimed in claim 1, wherein: the inner diameter of the sleeve is larger than the outer diameter of the capillary, the sleeve is clamped by a movable clamp to move in the axial direction of the capillary, so that the capillary is inserted into a solution sample in the sleeve, the solution sample rises to the top end of the capillary through the capillary, and ionized spray is generated through high pressure.
7. The sample introduction device for capillary electrospray quantification as claimed in claim 1, wherein: the liquid volume from the bottom of the capillary to the top of the sleeve is the volume of the sample quantitatively collected by the capillary.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922256598.1U CN210668273U (en) | 2019-12-16 | 2019-12-16 | Sample feeding device for capillary electrospray quantification |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922256598.1U CN210668273U (en) | 2019-12-16 | 2019-12-16 | Sample feeding device for capillary electrospray quantification |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210668273U true CN210668273U (en) | 2020-06-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201922256598.1U Active CN210668273U (en) | 2019-12-16 | 2019-12-16 | Sample feeding device for capillary electrospray quantification |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN210668273U (en) |
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2019
- 2019-12-16 CN CN201922256598.1U patent/CN210668273U/en active Active
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: 230000, 1st to 5th floors, Building B13 West, Hefei Innovation and Technology Park, Sugang Road, Feixi County Economic Development Zone, Hefei City, Anhui Province Patentee after: Zhiqin Instrument (Hefei) Co.,Ltd. Country or region after: China Address before: Room 901, unit a, G4, TCL International e city, 1001 Zhongshan Garden Road, Xili street, Nanshan District, Shenzhen, Guangdong 518000 Patentee before: CHIN INSTRUMENT Co.,Ltd. Country or region before: China |
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| CP03 | Change of name, title or address |