CN210092027U - Quantitative liquid extraction device - Google Patents
Quantitative liquid extraction device Download PDFInfo
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- CN210092027U CN210092027U CN201920959646.0U CN201920959646U CN210092027U CN 210092027 U CN210092027 U CN 210092027U CN 201920959646 U CN201920959646 U CN 201920959646U CN 210092027 U CN210092027 U CN 210092027U
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- 239000007788 liquid Substances 0.000 title claims abstract description 36
- 238000000605 extraction Methods 0.000 title claims abstract description 13
- 238000001514 detection method Methods 0.000 claims abstract description 10
- 239000010453 quartz Substances 0.000 claims description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 7
- AMGQUBHHOARCQH-UHFFFAOYSA-N indium;oxotin Chemical compound [In].[Sn]=O AMGQUBHHOARCQH-UHFFFAOYSA-N 0.000 claims description 3
- 238000011002 quantification Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 16
- 239000007921 spray Substances 0.000 description 10
- 239000012488 sample solution Substances 0.000 description 8
- 238000005070 sampling Methods 0.000 description 3
- 239000003990 capacitor Substances 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000004949 mass spectrometry Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008358 core component Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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Abstract
The utility model provides a quantitative extraction element of liquid, quantitative extraction element of liquid includes: the container is of a hollow structure, and two ends of the container are open; the ITO working layer is arranged in the container; a signal generator that generates a high frequency signal; the input end and the output end of the signal generator are respectively connected with the ITO working layer through the first conducting wire; the second conducting wire is connected with the ITO working layer and the current detection unit; and the input end and the output end of the current detection unit are respectively connected with the ITO working layer through second wires. The utility model has the advantages of accurate quantification, no pollution to the extracted liquid, etc.
Description
Technical Field
The utility model relates to a liquid sample, in particular to quantitative extraction element of liquid.
Background
The nanospray ion source has important research value in the aspect of small-dose proteomics mass spectrometry. The core component of the nano-spray ion source is a nano-liter electric spray nozzle, which bears the stable electric spray provided by the traditional spray nozzle and can complete sampling of small-volume samples.
The nanoliter electrospray nozzle was immersed in the sample solution and a small amount of the solution was drawn into the nanoliter electrospray nozzle using the surface tension of the solution. The aim of controlling the solution extraction amount can be achieved by controlling the depth and the duration of inserting the nano-liter electrospray nozzle into the solution, but the following two problems exist:
1. there is no clear relationship between the depth and duration of insertion of the nanoliter electrospray nozzle into the solution and the amount of solution extracted. The desired dose is typically extracted by trial and error;
2. the dose of the extracted solution cannot be rapidly known in real time, the size information of the extracted solution is repeatedly observed by naked eyes through a microscope, and the dose of the extracted solution is calculated through the geometrical relationship of the spray head.
SUMMERY OF THE UTILITY MODEL
In order to solve the defects in the prior art, the utility model provides a quantitative extraction device for liquid with high quantitative precision and no pollution to the liquid.
The utility model aims at realizing through the following technical scheme:
a device for the quantitative extraction of a liquid, comprising:
the container is of a hollow structure, and two ends of the container are open;
the ITO working layer is arranged in the container;
a signal generator that generates a high frequency signal;
the input end and the output end of the signal generator are respectively connected with the ITO working layer through the first conducting wire;
the second conducting wire is connected with the ITO working layer and the current detection unit;
and the input end and the output end of the current detection unit are respectively connected with the ITO working layer through second wires.
Compared with the prior art, the utility model discloses the beneficial effect who has does:
1. because the indium tin oxide is transparent, the appearance shape and transparency of a container such as a nano-liter electric spray nozzle are not changed, and the nano-liter electric spray nozzle is suitable for fine operation in a small space;
2, the ITO working layer is arranged in the tube wall of a container such as a nano-liter electric spray nozzle, does not contact with a sample solution and does not pollute the sample solution;
3. when the sample solution is extracted, the sampling dosage can be displayed in real time, and accurate quantitative extraction is realized.
Drawings
The disclosure of the present invention will become more readily understood with reference to the accompanying drawings. As is readily understood by those skilled in the art: these drawings are only intended to illustrate the technical solution of the present invention and are not intended to limit the scope of the present invention. In the figure:
fig. 1 is a schematic structural diagram of a device for quantitatively extracting a liquid according to an embodiment of the present invention.
Detailed Description
Fig. 1 and the following description depict alternative embodiments of the invention to teach those skilled in the art how to make and reproduce the invention. For the purpose of teaching the present invention, some conventional aspects have been simplified or omitted. Those skilled in the art will appreciate variations or substitutions from these embodiments that will be within the scope of the invention. Those skilled in the art will appreciate that the features described below can be combined in various ways to form multiple variations of the invention. Accordingly, the present invention is not limited to the following alternative embodiments, but is only limited by the claims and their equivalents.
Example 1:
fig. 1 schematically shows a schematic structural diagram of a device for quantitatively extracting a liquid according to embodiment 1 of the present invention, and as shown in fig. 1, the device for quantitatively extracting a liquid includes:
a container 11, such as a quartz tube, wherein the container 11 has a hollow structure and is open at two ends, so that when the lower end of the container 11 is immersed in a liquid, the solution can enter the container 11;
the ITO working layer 21 is an ITO layer, and the ITO working layer 21 is arranged in the container 11, such as embedded between the inner wall and the outer wall of the container 11, so that the ITO working layer 21 is prevented from polluting liquid entering the container 11 and affecting the detection of the liquid;
a signal generator 31, the signal generator 31 generating a high frequency signal;
the input end and the output end of the signal generator are respectively connected with the ITO working layer through the first conducting wire;
the second conducting wire is connected with the ITO working layer and the current detection unit;
and the input end and the output end of the current detection unit 41 are respectively connected with the ITO working layer 21 through second wires.
The working process of the quantitative liquid extraction device is as follows:
the bottom end of the container is immersed in the liquid, so that the liquid enters the container;
the signal generator generates a high-frequency signal and transmits the high-frequency signal to the ITO working layer, and a coupling capacitor is generated between quartz, solution and quartz through the ITO working layer and is equivalent to a resistor, so that a tiny current change can be generated through the solution;
the current detection unit obtains the change value of the current, the current change quantity is related to the liquid level of the sample solution in the container, the liquid level height of the sample solution in the container can be calculated by calculating the current change quantity, and the volume of the sample solution in the container can be calculated by combining the geometric shape of the container.
Example 2:
according to the utility model discloses the application example of the quantitative extraction element of liquid in mass spectrometry.
In this application example, as shown in fig. 1, the container 11 is a nano-liter electrospray nozzle made of quartz; the container 11 comprises a first portion 12 and a second portion 13, the first portion 12 being cylindrical inside; the inner diameter of the second portion 13 is gradually reduced along the direction away from the first portion 12, that is, the inner part of the second portion 13 is in a circular truncated cone shape; the ITO working layers 21 are made of indium tin oxide and are of strip structures, and the two working layers 21 are oppositely arranged between the inner wall and the outer wall of the container 11 and extend along the length direction of the container 11; the two working layers 21 are symmetrical about the central axis of the container 11, that is, the central axes of the two working layers 21 and the central axis of the container 11 are coplanar, so as to avoid contact with the sample liquid entering the container 11; the signal generator 31 has a switch.
The working process of the quantitative liquid extraction device is as follows:
the bottom end of the container is immersed in the liquid, so that the liquid enters the container;
the signal generator generates a high-frequency signal and transmits the high-frequency signal to the ITO working layer, and a coupling capacitor is generated between quartz, solution and quartz through the ITO working layer and is equivalent to a resistor, so that a tiny current change can be generated through the solution; the volume of the sample solution entering the spray head can be obtained in real time by detecting the current change;
when the sampling volume is reached, the spray head is separated from the surface of the solution;
when the high-voltage electrode is inserted, the first lead is disconnected by the switch, so that the discharge interference of the high-voltage electrode is prevented.
Claims (9)
1. A quantitative liquid extraction device is characterized in that: the device for quantitatively extracting liquid comprises:
the container is of a hollow structure, and two ends of the container are open;
the ITO working layer is arranged in the container;
a signal generator that generates a high frequency signal;
the input end and the output end of the signal generator are respectively connected with the ITO working layer through the first conducting wire;
the second conducting wire is connected with the ITO working layer and the current detection unit;
and the input end and the output end of the current detection unit are respectively connected with the ITO working layer through second wires.
2. The device for quantitatively extracting a liquid according to claim 1, wherein: the container includes:
a first portion having a cylindrical interior;
a second portion having an inner diameter that tapers in a direction away from the first portion.
3. The device for quantitatively extracting a liquid according to claim 2, wherein: the interior of the second part is in a shape of a circular truncated cone.
4. The device for quantitatively extracting a liquid according to claim 1, wherein: the ITO working layer is arranged between the inner wall and the outer wall of the container.
5. The device for quantitatively extracting a liquid according to claim 4, wherein: the two ITO working layers are oppositely arranged in the container, and the central axes of the two ITO working layers and the central axis of the container are coplanar.
6. The device for quantitatively extracting a liquid according to claim 1, wherein: the container is a nanoliter electrospray nozzle.
7. The device for quantitatively extracting a liquid according to claim 1, wherein: the signal generator has a switch.
8. The device for quantitatively extracting a liquid according to claim 1, wherein: the ITO working layer adopts indium tin oxide.
9. The device for quantitatively extracting a liquid according to claim 1, wherein: the container is made of quartz.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920959646.0U CN210092027U (en) | 2019-06-24 | 2019-06-24 | Quantitative liquid extraction device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920959646.0U CN210092027U (en) | 2019-06-24 | 2019-06-24 | Quantitative liquid extraction device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210092027U true CN210092027U (en) | 2020-02-18 |
Family
ID=69484062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920959646.0U Active CN210092027U (en) | 2019-06-24 | 2019-06-24 | Quantitative liquid extraction device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN210092027U (en) |
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2019
- 2019-06-24 CN CN201920959646.0U patent/CN210092027U/en active Active
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Address after: West side of 1st floor, 1st floor, Building A, No. 288 Jingu Middle Road (East), Yinzhou District, Ningbo City, Zhejiang Province, 315000 Patentee after: CHINA INNOVATION INSTRUMENT Co.,Ltd. Country or region after: China Address before: Room 304, D Building, Kexin Building, 655 Xueshi Road, Yinzhou District, Ningbo City, Zhejiang Province, 315000 Patentee before: CHINA INNOVATION INSTRUMENT Co.,Ltd. Country or region before: China |
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