CN210538061U

CN210538061U - Premature ejaculation animal model screening system

Info

Publication number: CN210538061U
Application number: CN201921054134.6U
Authority: CN
Inventors: 高明; 杨永清; 侯广东; 刘鹏; 孙建华; 季兴哲; 刘项; 张磊; 郭军; 张洲; 袁建林
Original assignee: Northwest Women And Children Hospital
Current assignee: Northwest Women And Children Hospital
Priority date: 2019-07-08
Filing date: 2019-07-08
Publication date: 2020-05-19
Anticipated expiration: 2029-07-08

Abstract

The utility model provides an animal model screening system of prospermia, include the model box and install the removable cover on the model box, evenly arranged four transparent male mouse casees in the model box, install the industry camera through step motor on the male mouse case, the female mouse import has been seted up between male mouse case and the model box, the female mouse import is provided with infrared ray and infrared ray sensor for one-way import and female mouse import, the other end intercommunication model box of the relative female mouse import of male mouse case just has seted up male mouse import, infrared ray sensor, step motor and industry camera all are connected with outside computer system. The utility model has the advantages of simple structure and scientific and reasonable design, by female mouse initiative selection mating male mouse, simulated because of the ejaculation that mental factors such as tension, anxiety arouse, reduced the intervention of human factor to animal mating process.

Description

Premature ejaculation animal model screening system

Technical Field

The utility model belongs to the technical field of medical instrument, concretely relates to premature ejaculation animal model screening system.

Background

Premature ejaculation is one of the most common sexual dysfunctions of men and seriously affects the quality of life of patients. The increased living standard and the overloaded work and increasing working pressure lead to the continuously increased incidence of premature ejaculation. People begin to pursue better life, but face the bad emotions of distress, worry, contusion and the like caused by premature ejaculation, so that the family relationship is nervous and the body and mind are suffering from suffering. The complex pathogenesis of premature ejaculation and large individual difference lead to poor treatment effect, which is a serious challenge for clinicians and also a major problem to be solved urgently. The elucidation of the mechanism has important value for improving the curative effect, and the animal model is an important tool for elucidating the premature ejaculation generating mechanism and making a treatment scheme. At present, a plurality of premature ejaculation animal models have different characteristics, and part of models are only suitable for experiments in animals. The reproducibility, effectiveness of animal models of premature ejaculation, and whether they can adequately mimic human clinical features, are important factors in determining the choice of their application.

Common animal model establishing methods such as a drug-induced ejaculation simulation premature ejaculation model, and various compounds, nerve conduction substances, neuropeptides and the like can promote the sexual behavior of rats, so that the rats show some characteristics similar to human premature ejaculation, and the conditions of the natural state of people are difficult to simulate; the simulation of premature ejaculation by electrical stimulation induced ejaculation, but the model is complicated to manufacture except the above mentioned need to be carried out on an anesthetized rat, is easily affected by various factors in the experimental process, and has relatively poor repeatability and representativeness; the premature ejaculation model is screened in the mating experiment, although the model is generally accepted by the theory of continuum, at least 400 male rats and matched female rats need to be purchased, 40 premature ejaculation rats are screened out for the experiment, more than 360 rest rats die, unnecessary waste is caused, and more than 400 rats need to be observed in sexual behaviors at least 2 times when screening premature ejaculation, 30min is carried out each time, and a large amount of personnel and energy are needed.

SUMMERY OF THE UTILITY MODEL

The utility model aims to solve the technical problem that lie in to above-mentioned prior art not enough, provide a premature ejaculation animal model screening system, this screening system simple structure, design scientific and reasonable is chosen the male mouse of mating by female mouse initiative, has simulated the ejaculation that arouses because of mental factors such as nervous, anxiety, has reduced the intervention of human factor to animal mating process.

In order to solve the technical problem, the utility model discloses a technical scheme is: the premature ejaculation animal model screening system is characterized by comprising a model box body and a movable cover plate arranged on the model box body, wherein four transparent male mouse boxes fixedly connected with the side wall of the model box body are uniformly arranged in the model box body, a stepping motor is arranged on the male mouse box through a motor mounting seat, an industrial camera is fixedly arranged on the stepping motor, a female mouse inlet right facing the central position of the model box body is arranged on the male mouse box, the four female mouse inlets are pairwise opposite and have equal distance with the central position of the bottom surface of the model box body, the female mouse inlet is a one-way inlet only allowing a female mouse to enter the male mouse box, an infrared emitter and an infrared sensor are arranged on the female mouse inlet, the other end of the male mouse box, which is opposite to the female mouse inlet, is provided with a male mouse inlet simultaneously communicated with the model box body, and a male mouse box cover is movably arranged, the infrared sensor, the stepping motor and the industrial camera are all connected with an external computer system, and can receive signals transmitted by the infrared sensor and transmitted by a female mouse to enter the male mouse box through the computer system, so that the stepping motor and the industrial camera are opened, and the stepping motor is controlled to adjust the industrial camera to different positions and angles according to needs, thereby shooting different photo materials.

Preferably, a plurality of vent holes are formed in the movable cover plate, and the vent holes provide breathing air for the experimental mouse in the model box body.

Preferably, the female mouse is placed at the center of the bottom surface of the model box body, so that the female mouse can independently and fairly select four male mice.

Preferably, the computer system uses LABVIEW software to perform operation control and data acquisition of the screening system, the LABVIEW is used for field data acquisition, motor control, image acquisition, image processing, image comparison, time recording and real-time monitoring camera shooting and storage, and remote mobile equipment such as a mobile phone is used for remote dynamic monitoring and control, and the required files and pictures are sent to the designated mailbox position after big data analysis.

Preferably, a control program can be installed on the mobile device, and the collected data information can be viewed by the mobile device in real time.

Preferably, the male mouse box is fixedly connected with the model box body through a bolt, the industrial camera is fixedly installed on the stepping motor through a screw, and the infrared emitter and the infrared sensor are adhered to the male mouse box through environment-friendly glue.

Preferably, the male rat box cover is in interference fit with the male rat inlet, and the male rat box cover is made of elastic rubber, so that the male rat cannot escape from the male rat box.

Preferably, the movable cover plate is covered after the female mouse is placed in the model box body, and the movable cover plate has a certain weight or is away from the bottom surface of the model box body by a certain height, so that the female mouse can not escape from the model box body by self.

Compared with the prior art, the utility model has the following advantage:

1. the utility model discloses simple structure, design scientific and reasonable is selected the male mouse of mating by female mouse initiative, has simulated the ejaculation arousing because of mental factors such as nervous, anxiety, has reduced the intervention of human factor to animal mating process, and the practicality is strong, and the reality is pressed close to the simulation effect, and easy operation can use widely.

2. The utility model discloses a male mouse case is provided with the one-way passageway that switches on that only allows female mouse to enter male mouse case, and male mouse case is transparent box simultaneously to female mouse can carry out the mating according to the male mouse of a favorite of self hobby random selection, avoids human intervention, and is more fair random, scientific and reasonable.

3. The utility model discloses a female and male mouse mating situation of each male mouse incasement of industrial camera real-time supervision, important information such as the accurate record female and male mouse sexual life time of science selects the male mouse of premature ejaculation through the multiple sexual life of female mouse, and the screening model cardinal number that has significantly reduced has reduced the screening time.

4. The utility model discloses a high-grade software LABVIEW of the NI company of America is used for on-the-spot data acquisition, motor control, image acquisition, image processing, image comparison, time record and real time monitoring to make a video recording and save, still uses remote mobile devices such as cell-phones to carry out long-range dynamic monitoring and control, sends required file and picture to appointed postbox position after analyzing through big data.

The present invention will be described in further detail with reference to the accompanying drawings and examples.

Drawings

Fig. 1 is a schematic structural diagram of the present invention.

Fig. 2 is a schematic structural view of the mouse box of the present invention.

Description of reference numerals:

1-a model box body; 2, a movable cover plate; 3-male mouse box;

4-step motor; 5-industrial camera; 6-male mouse box cover;

7-female mouse; 8, a motor mounting seat; 9-male mouse;

10-an infrared emitter; 11-infrared sensor; 12-import of female mouse.

Detailed Description

As shown in fig. 1 and 2, the utility model comprises a model box body 1 and a movable cover plate 2 installed on the model box body 1, four transparent male mouse boxes 3 fixedly connected with the side wall of the model box body 1 are evenly arranged in the model box body 1, a male mouse 9 is placed in the male mouse box 3, a stepping motor 4 is installed on the male mouse box 3 through a motor installation seat 8, an industrial camera 5 is fixedly installed on the stepping motor 4, a female mouse inlet 12 facing the central position of the model box body 1 is arranged on the male mouse box 3, the four female mouse inlets 12 are opposite in pairs and have equal distance from the central position of the bottom surface of the model box body 1, the female mouse inlet 12 is a one-way inlet only allowing a female mouse 7 to enter the male mouse box 3, an infrared emitter 10 and an infrared sensor 11 are arranged on the female mouse inlet 12, a male mouse inlet simultaneously communicated with the model box body 1 is arranged at the other end of the male mouse box 3 facing the female mouse inlet 12, the male mouse is characterized in that a male mouse box cover 6 is movably arranged on the male mouse inlet, the infrared sensor 11, the stepping motor 4 and the industrial camera 5 are connected with an external computer system, a signal that a female mouse 7 transmitted by the infrared sensor 11 enters the male mouse box 3 can be received by the computer system, the stepping motor 4 and the industrial camera 5 are further opened, the stepping motor 4 is controlled to adjust the industrial camera 5 to different positions and angles according to needs, and therefore different photo materials are shot.

Preferably, a plurality of vent holes are formed in the movable cover plate 2 to provide breathing air for the laboratory mouse in the model box body 1.

Preferably, the female mouse 7 is placed at the center of the bottom surface of the model box 1, so that the female mouse 7 can independently and fairly select four male mice 9.

Preferably, the computer system uses LABVIEW software for operational control and data collection of the screening system.

Preferably, the male mouse box 3 is fixedly connected with the model box body 1 through bolts, the industrial camera 5 is fixedly installed on the stepping motor 4 through screws, and the infrared emitter 10, the infrared sensor 11 and the motor installation seat 8 are adhered to the male mouse box 3 through environment-friendly glue.

Preferably, the male rat box cover 6 is in interference fit with the male rat inlet, and the male rat box cover 6 is made of elastic rubber, so that the male rat 9 cannot escape from the male rat box 3.

Preferably, the movable cover plate 2 is covered after the female mouse 7 is placed in the model box body, and the movable cover plate 2 has a certain weight or is separated from the bottom surface of the model box body 1 by a certain height, so that the female mouse 7 can not automatically escape from the model box body 1.

The utility model discloses during the use, first put four male mice 9 who have taken the medicine into four male mouse casees 3 respectively through male mouse import and cover male mouse case lid 6, put female mouse 7 in the central point of model box 1 bottom plate and cover removable cover 2 after that, female mouse 7 can select a chinese mind male mouse 9 at random this moment, and go into corresponding male mouse case 3, female mouse 7 can be sensed by infrared sensor 11 of dress 12 department at female mouse import when getting into, infrared sensor 11 passes this information to computer system, after receiving the signal through LABVIEW software, control step motor 4 and open industrial camera 5 video recording in the required scope of shooing, collection picture that does not stop and required picture are compared, required picture refers to shoot and preserve the picture flow of drawing through the camera before the experiment, from it choose the picture that can represent typical action, after the first female male mouse mating information, the LABVIEW step motor 4 stops moving, a camera of the industrial camera 5 is positioned to the current position, a timer is started, the camera monitors and judges whether the mating process is finished or not in the process, the timing is stopped after the mating process is finished, the data and pictures are sent to a designated mailbox, and the computer continues to monitor and wait for the start of the next mating event. The next female mouse 7 can possibly run into other male mouse boxes 3 to find other male mice 9 for mating, and finally the premature ejaculation male mouse 9 is selected according to the sexual life time recorded by the video and photo stream. After the experiment is started, a mobile phone can log in a server to remotely check a camera and monitor a computer system keyboard.

The above description is only for the preferred embodiment of the present invention, and is not intended to limit the present invention in any way. Any simple modifications, changes and equivalent changes made to the above embodiments according to the technical spirit of the present invention all fall within the protection scope of the technical solution of the present invention.

Claims

1. The premature ejaculation animal model screening system is characterized by comprising a model box body (1) and a movable cover plate (2) arranged at the upper end of the model box body (1), wherein four transparent male mouse boxes (3) which are fixedly connected with the side wall of the model box body (1) and used for placing male mice (9) are uniformly arranged in the model box body (1), a stepping motor (4) is arranged on each male mouse box (3) through a motor mounting seat (8), an industrial camera (5) is fixedly mounted on each stepping motor (4), a female mouse inlet (12) which is just opposite to the central position of the model box body (1) is formed in each male mouse box (3), the four female mouse inlets (12) are opposite in pairs and equal in distance from the central position of the bottom surface of the model box body (1), and the female mouse inlet (12) is a one-way inlet which only allows female mice (7) to enter the male mouse boxes (3), install infrared emitter (10) and infrared sensor (11) on female mouse import (12), the male mouse import that communicates model box (1) lateral wall simultaneously is seted up to the other end that is relative female mouse import (12) on male mouse case (3), the activity is provided with male mouse case lid (6) in the male mouse import, infrared sensor (11), step motor (4) and industrial camera (5) all are connected with computer system.

2. The premature ejaculation animal model screening system of claim 1, wherein the movable cover plate (2) is provided with a plurality of vent holes.

3. The premature ejaculation animal model screening system according to claim 1, wherein the female mouse (7) is placed at the center of the bottom surface of the model case (1).

4. The system of claim 1, wherein the computer system uses LABVIEW software to control the operation of the screening system and collect data.

5. The premature ejaculation animal model screening system of claim 1, wherein the male mouse box (3) is fixedly connected with the model box body (1) through bolts, the industrial camera (5) is fixedly installed on the stepping motor (4) through screws, and the infrared emitter (10), the infrared sensor (11) and the motor mounting seat (8) are connected to the male mouse box (3) through environment-friendly glue.

6. The premature ejaculation animal model screening system of claim 1, wherein the male mouse box cover (6) is in interference fit with the male mouse inlet, and the male mouse box cover (6) is made of elastic rubber.