CN210506161U - Generating device of 3-morpholine propanesulfonic acid - Google Patents
Generating device of 3-morpholine propanesulfonic acid Download PDFInfo
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- CN210506161U CN210506161U CN201921457286.0U CN201921457286U CN210506161U CN 210506161 U CN210506161 U CN 210506161U CN 201921457286 U CN201921457286 U CN 201921457286U CN 210506161 U CN210506161 U CN 210506161U
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Abstract
A generating device of 3-morpholine propanesulfonic acid belongs to the technical field of propanesulfonic acid. The method is characterized in that: the device comprises a reaction kettle (1), a first centrifugal machine (5), a refining kettle (7), a filter press (9), a crystallization kettle (10) and a dryer, wherein the output end of the reaction kettle (1) is connected with the first centrifugal machine (5) through a pipeline, and the output end of the first centrifugal machine (5) is sequentially connected with the refining kettle (7), the filter press (9), the crystallization kettle (10) and the dryer through pipelines; and a second centrifugal machine (11) is arranged between the outlet of the crystallization kettle (10) and the inlet of the dryer. The utility model adopts a twice centrifugation mode, and utilizes the centrifugation-refining-centrifugation process, thereby avoiding the problems of difficult effective control of purity and large energy consumption in the traditional method; meanwhile, the whole reaction process does not need high temperature and high pressure, so that the energy consumption is further reduced, the waste yield is reduced, the product utilization rate is improved, and a green and safe production mode is achieved.
Description
Technical Field
A generating device of 3-morpholine propanesulfonic acid belongs to the technical field of propanesulfonic acid.
Background
3- (N-morpholinyl) propanesulfonic acid (MOPS), 3-morpholinyl propanesulfonic acid for short is a high-quality PH value regulator, and is characterized in that: high water solubility, compatible acid-base dissociation equilibrium, low cell membrane penetration rate, low metal chelating capacity, high chemical stability and low absorption performance in an ultraviolet visible region. In biological experiments, it is an important PH stabilizing reagent, which is commonly used in biological buffers, in biochemical diagnostic kits, DNA/RNA extraction kits and PCR diagnostic kits, and can also be used to produce clavulanic acid.
However, in the existing preparation process by using 3-morpholine propanesulfonic acid, the product purity is difficult to control, high-purity products are difficult to obtain through multiple distillation-rectification treatment, the energy consumption is extremely high, and the production mode does not meet the requirements of environmental protection.
Disclosure of Invention
The utility model discloses the technical problem that will solve is: overcomes the defects of the prior art, and provides a device for generating 3-morpholine propanesulfonic acid, which has simple process, high product purity and reduced energy consumption.
The utility model provides a technical scheme that its technical problem adopted is: a device for generating 3-morpholine propanesulfonic acid is characterized in that: the device comprises a reaction kettle, a first centrifugal machine, a refining kettle, a filter press, a crystallization kettle and a dryer, wherein the output end of the reaction kettle is connected with the first centrifugal machine through a pipeline; and a second centrifugal machine is arranged between the outlet of the crystallization kettle and the inlet of the dryer.
The utility model changes the traditional production process, adopts a twice centrifugation mode, adopts a centrifugation-refining-centrifugation mode and utilizes the centrifugation-refining-centrifugation process in the production process, thereby avoiding the problems of difficult effective control of purity and large energy consumption in the traditional method; meanwhile, the whole reaction process does not need high temperature and high pressure, so that the energy consumption is further reduced, the waste yield is reduced, the product utilization rate is improved, and a green and safe production mode is achieved. Moreover, the production mode ensures that the temperature does not exceed 100 ℃ in the whole production process, greatly reduces energy consumption, and is a feasible production device with low energy consumption and low emission.
And a raw material inlet of the reaction kettle is respectively connected with a PS metering tank, an ethanol metering tank and a morpholine metering tank through pipelines.
One side of the first centrifugal machine and one side of the second centrifugal machine are respectively provided with a first centrifugate collecting tank and a second centrifugate collecting tank, the first centrifugal machine is connected with the reaction kettle through the first centrifugate collecting tank, and the second centrifugal machine is connected with the refining kettle through the second centrifugate collecting tank.
The two-step centrifugate is treated by centralized collection and loop treatment, so that the product utilization rate is improved, the waste discharge is reduced, and the product utilization rate is improved.
And control valves are arranged on pipelines of the first centrifugate collecting tank and the second centrifugate collecting tank which are connected with the reaction kettle and the refining kettle respectively.
One side of the refining kettle is provided with a water metering tank.
The dryer is an oven.
The reaction kettle, the refining kettle and the crystallization kettle are all provided with a thermometer and a pressure gauge.
Compared with the prior art, the utility model discloses the beneficial effect who has is:
the utility model changes the traditional production process, adopts a twice centrifugation mode, adopts a centrifugation-refining-centrifugation mode and utilizes the centrifugation-refining-centrifugation process in the production process, thereby avoiding the problems of difficult effective control of purity and large energy consumption in the traditional method; meanwhile, the whole reaction process does not need high temperature and high pressure, so that the energy consumption is further reduced, the waste yield is reduced, the product utilization rate is improved, and a green and safe production mode is achieved. Moreover, the production mode ensures that the temperature does not exceed 100 ℃ in the whole production process, greatly reduces energy consumption, and is a feasible production device with low energy consumption and low emission.
Drawings
FIG. 1 is a schematic diagram showing the connection relationship of a device for producing 3-morpholinopropanesulfonic acid.
The device comprises a reaction kettle 1, a PS metering tank 3, an ethanol metering tank 4, a morpholine metering tank 5, a first centrifuge 6, a first centrifugate collecting tank 7, a refining kettle 8, a water metering tank 9, a filter press 10, a crystallization kettle 11, a second centrifuge 12, a second centrifugate collecting tank 13 and an oven.
Detailed Description
Fig. 1 is a preferred embodiment of the present invention, and the present invention will be further explained with reference to fig. 1.
Referring to figure 1: a generation device of 3-morpholine propanesulfonic acid comprises a reaction kettle 1, a first centrifugal machine 5, a refining kettle 7, a filter press 9, a crystallization kettle 10 and a dryer, wherein the output end of the reaction kettle 1 is connected with the first centrifugal machine 5 through a pipeline, and the output end of the first centrifugal machine 5 is sequentially connected with the refining kettle 7, the filter press 9, the crystallization kettle 10 and the dryer through pipelines; and a second centrifugal machine 11 is arranged between the outlet of the crystallization kettle 10 and the inlet of the dryer.
The raw material inlet of the reaction kettle 1 is respectively connected with a PS metering tank 2, an ethanol metering tank 3 and a morpholine metering tank 4 through pipelines. One side of the refining kettle 7 is provided with a water metering tank 8. The dryer is an oven 13. The reaction kettle 1, the refining kettle 7 and the crystallization kettle 10 are all provided with a thermometer and a pressure gauge.
One side of the first centrifugal machine 5 and one side of the second centrifugal machine 11 are respectively provided with a first centrifugate collecting tank 6 and a second centrifugate collecting tank 12, the first centrifugal machine 5 is connected with the reaction kettle 1 through the first centrifugate collecting tank 6, and the second centrifugal machine 11 is connected with the refining kettle 7 through the second centrifugate collecting tank 12. Control valves are arranged on pipelines of the first centrifugate collecting tank 6 connected with the reaction kettle 1 and the second centrifugate collecting tank 12 connected with the refining kettle 7.
The working principle and the working process are as follows: adding raw materials of ethanol and morpholine into a reaction kettle 1 in proportion, stirring for 30min until the morpholine is dissolved, adding PS into a PS metering tank 2 in proportion after heating and melting, adding PS into the reaction kettle 1 in proportion, reacting for 1-8h at 50-90 ℃, generating a substitution reaction to generate a 3-morpholine propanesulfonic acid crude product, cooling the reaction kettle 1 to 0-10 ℃, transferring a reaction product from the reaction kettle 1 to a first centrifuge 5 through a pipeline for preliminary centrifugation, collecting the centrifugate through a first centrifugate collecting tank 6, sleeving the centrifugate back to the reaction kettle 1 for reuse, transferring the centrifugate cake to a second centrifuge 11, adding water to a refining kettle 7 for dissolution and refining, after finishing refining for 3h, pumping the filtrate filtered out by a filter press 9 into a crystallization kettle 10, cooling to 10 ℃ in the crystallization kettle 10, crystallizing for 2h, then transferring to the second centrifuge for re-centrifugation, collecting the centrifugate through a second centrifugate collecting tank 12, sleeving the centrifugate back to the refining kettle 7 for, and putting the filter cake into an oven 13 for drying to obtain a product.
Preferably, raw materials of ethanol and morpholine are added into a reaction kettle 1 in proportion and stirred for 30min until morpholine is dissolved, PS is added into the reaction kettle 1 in proportion after being heated and melted through a PS metering tank 2, substitution reaction is carried out after 2h reaction at 60 ℃ to generate a 3-morpholine propanesulfonic acid crude product, the reaction kettle 1 is cooled to 10 ℃, the reaction kettle 1 is transferred to a first centrifuge 5 for centrifugation, a centrifugate is collected through a first centrifugate collecting tank 6 and then is sleeved back to the reaction kettle 1 for reuse, a centrifugal filter cake is transferred to a refining kettle 7 for dissolution and refining by adding water, the centrifugate is pressed into a filter press 9 after 3h and is cooled to 10 ℃ in a crystallization kettle 10 for crystallization for 2h, then the centrifugate is transferred to a second centrifuge 11 for centrifugation, the centrifugate is collected through a second centrifugate collecting tank 12 and then is sleeved back to the refining kettle 7 for reuse, and the.
The utility model changes the traditional production process, adopts a twice centrifugation mode, adopts a centrifugation-refining-centrifugation mode and utilizes the centrifugation-refining-centrifugation process in the production process, thereby avoiding the problems of difficult effective control of purity and large energy consumption in the traditional method; meanwhile, the whole reaction process does not need high temperature and high pressure, so that the energy consumption is further reduced, the waste yield is reduced, the product utilization rate is improved, and a green and safe production mode is achieved. Moreover, the production mode ensures that the temperature does not exceed 100 ℃ in the whole production process, greatly reduces energy consumption, and is a feasible production device with low energy consumption and low emission.
While the invention has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention. However, any simple modification, equivalent change and modification made to the above embodiments according to the technical substance of the present invention still belong to the protection scope of the technical solution of the present invention.
Claims (7)
1. A device for generating 3-morpholine propanesulfonic acid is characterized in that: the device comprises a reaction kettle (1), a first centrifugal machine (5), a refining kettle (7), a filter press (9), a crystallization kettle (10) and a dryer, wherein the output end of the reaction kettle (1) is connected with the first centrifugal machine (5) through a pipeline, and the output end of the first centrifugal machine (5) is sequentially connected with the refining kettle (7), the filter press (9), the crystallization kettle (10) and the dryer through pipelines; and a second centrifugal machine (11) is arranged between the outlet of the crystallization kettle (10) and the inlet of the dryer.
2. The apparatus for producing 3-morpholine propane sulfonic acid as claimed in claim 1, wherein: and a raw material inlet of the reaction kettle (1) is respectively connected with the PS metering tank (2), the ethanol metering tank (3) and the morpholine metering tank (4) through pipelines.
3. The apparatus for producing 3-morpholine propane sulfonic acid as claimed in claim 1, wherein: one side of the first centrifugal machine (5) and one side of the second centrifugal machine (11) are respectively provided with a first centrifugal liquid collecting tank (6) and a second centrifugal liquid collecting tank (12), the first centrifugal machine (5) is connected with the reaction kettle (1) through the first centrifugal liquid collecting tank (6), and the second centrifugal machine (11) is connected with the refining kettle (7) through the second centrifugal liquid collecting tank (12).
4. The apparatus according to claim 3, wherein: and the pipelines of the first centrifugate collecting tank (6) connected with the reaction kettle (1) and the second centrifugate collecting tank (12) connected with the refining kettle (7) are respectively provided with a control valve.
5. The apparatus for producing 3-morpholine propane sulfonic acid as claimed in claim 1, wherein: one side of the refining kettle (7) is provided with a water metering tank (8).
6. The apparatus for producing 3-morpholine propane sulfonic acid as claimed in claim 1, wherein: the dryer is an oven (13).
7. The apparatus for producing 3-morpholine propane sulfonic acid as claimed in claim 1, wherein: the reaction kettle (1), the refining kettle (7) and the crystallization kettle (10) are all provided with a thermometer and a pressure gauge.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921457286.0U CN210506161U (en) | 2019-09-04 | 2019-09-04 | Generating device of 3-morpholine propanesulfonic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921457286.0U CN210506161U (en) | 2019-09-04 | 2019-09-04 | Generating device of 3-morpholine propanesulfonic acid |
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| Publication Number | Publication Date |
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| CN210506161U true CN210506161U (en) | 2020-05-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201921457286.0U Active CN210506161U (en) | 2019-09-04 | 2019-09-04 | Generating device of 3-morpholine propanesulfonic acid |
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| CN (1) | CN210506161U (en) |
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2019
- 2019-09-04 CN CN201921457286.0U patent/CN210506161U/en active Active
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Effective date of registration: 20220606 Address after: No. 35, Fengguan Road, Qilu Chemical Industry Zone, Linzi District, Zibo City, Shandong Province 255410 Patentee after: SHANDONG YONGHAO NEW MATERIAL TECHNOLOGY CO.,LTD. Address before: No. 58, ethylene Beishan Road, Linzi District, Zibo City, Shandong Province 255400 Patentee before: SHANDONG YINGHUAN CHEMICAL Co.,Ltd. |
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