CN210487599U - Rapid detection device of up-conversion luminescence immunoassay analyzer - Google Patents
Rapid detection device of up-conversion luminescence immunoassay analyzer Download PDFInfo
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- CN210487599U CN210487599U CN201921409885.5U CN201921409885U CN210487599U CN 210487599 U CN210487599 U CN 210487599U CN 201921409885 U CN201921409885 U CN 201921409885U CN 210487599 U CN210487599 U CN 210487599U
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Abstract
The utility model relates to a go up quick detection device of luminous immunoassay appearance of rotation, this quick detection device's light path system's excitation light source, the center of plastic lens and holophote sets gradually the first optical axis of constitution in same horizontal plane and from the right side left side, the holophote, even light reflex unit, the center of reagent card sets gradually the constitution second optical axis in same vertical line and from the top down, the holophote, narrowband optical filter and signal collector's center sets gradually the constitution third optical axis in same horizontal plane and from the left side right side, the holophote is 45 degrees angles respectively with first optical axis and second optical axis, even light reflex unit is 45 degrees angles respectively with second optical axis and third optical axis, the holophote is parallel with even light reflex unit. The excitation light source of the light path system is on the same side as the signal collector, so that the debugging is more convenient. The utility model discloses furthest improves and detects the flux, accords with the needs of the short-term test's of instantaneous inspection, uses the static scheme of shooing, furthest's improvement detection speed.
Description
Technical Field
The utility model relates to a medical treatment check out test set technical field especially relates to a go up quick detection device of luminous immunoassay appearance.
Background
In the prior art, the up-conversion luminescence immunoassay analyzer generally adopts motor motion to position the position of a reagent card, and belongs to the field of dynamic scanning image detection. The up-conversion luminescence immunoassay analyzer adopts a plurality of LED light sources as excitation light sources, or adopts a scheme of fixing the excitation light sources, the reagent card and the image acquisition system. The image detection is dynamically scanned, the movement time of a movement mechanism during scanning influences the detection flux, and the flux is generally calculated according to the Test quantity per hour (Test/h). The multiple LED light sources are used because the energy of a single LED light source is insufficient, but the multiple LED light sources are complex in structure and high in positioning accuracy requirement, and the detection result is influenced when one LED light source fails. The scheme of fixing an excitation light source, a reagent card and an image acquisition system is adopted, although no movement mechanism exists, the method belongs to static photographing, laser spots are not shaped, the coverage area of the spots is small, and the spots are not enough to cover the detection of a multi-band chromatographic strip (a reagent strip of a general immunochromatography method is a T-band and a C-band, and the detection of a plurality of T-bands and a C-band is carried out in the market).
Therefore, it is desirable to provide a rapid detection device for an up-conversion luminescence immunoassay analyzer, which can improve the detection speed and realize rapid detection.
SUMMERY OF THE UTILITY MODEL
In view of this, the utility model aims at providing a go up quick detection device of luminescence immunoassay appearance of revolving, save the motion, avoid the trouble that the motion probably brought, through optical path system's design, use the static scheme of shooing, improve detection speed, realize short-term test.
In order to solve the technical problem, the utility model adopts the following technical proposal:
a rapid detection device of an up-conversion luminescence immunoassay analyzer comprises a light path system, wherein the light path system comprises an excitation light source, a shaping lens, a holophote, a light-homogenizing reflecting device, a reagent card, a narrow-band optical filter and a signal collector, the centers of the excitation light source, the shaping lens and the holophote are sequentially arranged on the same horizontal plane from right to left to form a first optical axis, the centers of the holophote, the light-homogenizing reflecting device and the reagent card are sequentially arranged on the same vertical line from top to bottom to form a second optical axis, the centers of the holophote, the narrow-band optical filter and the signal collector are sequentially arranged on the same horizontal plane from left to right to form a third optical axis, and the first optical axis and the third optical axis are parallel and are all vertical to the second optical axis; the total reflection mirror is at an angle of 45 degrees with the first optical axis and the second optical axis respectively, the light uniformization reflection device is at an angle of 45 degrees with the second optical axis and the third optical axis respectively, and the total reflection mirror is parallel to the light uniformization reflection device.
Preferably, the light homogenizing reflecting device comprises a composite light homogenizing plate and a dichroic mirror. Preferably, the dichroic mirror is fully transmissive for light having a wavelength of 980nm and fully reflective for light having a wavelength of 540 nm.
Preferably, the material of the light homogenizing plate is an engineering plastic film, an organic glass plate or a quartz glass plate, and the outer surface of the light homogenizing plate is provided with an atomizing layer. The principle of the light homogenizing plate is diffuse reflection, and the function of the light homogenizing plate is to homogenize light passing through the light homogenizing plate.
Preferably, the excitation light source is a semiconductor laser diode or a high-power light emitting diode, and the wavelength of the emergent light of the excitation light source is 980 nm. The semiconductor laser diode has the characteristics of good monochromaticity and small divergence angle compared with the light-emitting diode. The use of leds is generally high power with sufficient margin that can be allocated to the light homogenizing plate to achieve spot homogenization. The shaping lens is used for amplifying and shaping the banded facula of the emergent light of the excitation light source.
Preferably, the signal collector is a cmos or CCD sensor. The photoelectric diode has the advantages of high sensitivity and higher practicability compared with a photomultiplier by replacing the traditional photodiode and a traditional photocell. The narrow-band filter is used for eliminating stray light with other wavelengths.
Preferably, the reagent card is provided with up-conversion luminescent particles capable of exciting light with the wavelength of 540 nm. Using the principle of up-conversion luminescence, 980nm light having a longer wavelength is used to excite 540nm light having a shorter wavelength.
The utility model discloses a go up quick detection device's of luminous immunoassay appearance of rotation light path principle: an excitation light source is used for providing emergent light with the wavelength of 980nm, the emergent light is shaped on a first optical axis through a shaping lens to amplify and shape a banded light spot of the emergent light, then the emergent light is reflected by a total reflector to enter a second optical axis, 980nm light is homogenized by a light homogenizing plate, then vertically downwards irradiated on a reagent card after being fully transmitted by a dichroic mirror and excited to emit 540nm visible light, the 540nm visible light is vertically upwards irradiated on the dichroic mirror and then reflected by the dichroic mirror to enter a third optical axis, and the 540nm visible light is received by a signal collector after being filtered by a narrow-band filter.
The utility model has the advantages as follows:
the utility model discloses owing to adopted above technical scheme, light path system's excitation light source can be leveled, and is parallel with signal collector, and excitation light source and signal collector are in same one side, and are more convenient during the debugging. The utility model discloses a but the high-speed checking device furthest improves and detects the flux, accords with the needs of the high-speed check of real-time supervision, has saved motion, has avoided the trouble that motion probably brought, uses the static scheme of shooing, furthest's improvement detection speed.
The foregoing description is only an overview of the technical solutions of the present invention, and in order to make the technical means of the present invention more clearly understood and to make the technical means more comprehensible, and to make the above and other objects, technical features, and advantages of the present invention easier to understand, one or more preferred embodiments are listed below, and the following detailed description is given with reference to the accompanying drawings.
Drawings
One or more embodiments are illustrated by way of example in the accompanying drawings, which correspond to the figures in which like reference numerals refer to similar elements and which are not to scale unless otherwise specified.
Fig. 1 shows a schematic diagram of an optical path system of a rapid detection device of an up-conversion luminescence immunoassay analyzer according to the present invention.
Description of the main reference numerals:
1-excitation light source, 2-shaping lens, 3-total reflection mirror, 4-dichroic mirror, 5-light homogenizing plate, 6-reagent card, 7-narrow band filter and 8-signal collector.
Detailed Description
The following detailed description of the present invention is provided in conjunction with the accompanying drawings, but it should be understood that the scope of the present invention is not limited by the following detailed description.
Throughout the specification and claims, unless explicitly stated otherwise, the word "comprise", or variations such as "comprises" or "comprising", will be understood to imply the inclusion of a stated element or component but not the exclusion of any other element or component.
Spatially relative terms, such as "below," "lower," "upper," "above," "upper," and the like, may be used herein for ease of description to describe one element or feature's relationship to another element or feature in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the object in use or operation in addition to the orientation depicted in the figures. For example, if the items in the figures are turned over, elements described as "below" or "beneath" other elements or features would then be oriented "above" the elements or features. Thus, the exemplary term "below" can encompass both an orientation of below and above. The article may be otherwise oriented (rotated 90 degrees or at other orientations) and the spatially relative terms used herein should be interpreted accordingly.
As shown in fig. 1, the rapid detection device of the up-conversion luminescence immunoassay analyzer comprises a light path system, wherein the light path system comprises an excitation light source 1, a shaping lens 2, a total reflector 3, a light homogenizing reflecting device, a reagent card 6, a narrowband optical filter 7 and a signal collector 8, and the centers of the excitation light source 1, the shaping lens 2 and the total reflector 3 are arranged on the same horizontal plane in sequence from right to left to form a first optical axis.
The excitation light source 1 is a semiconductor laser diode or a high-power light emitting diode, and the wavelength of emergent light of the excitation light source 1 is 980 nm. The semiconductor laser diode has the characteristics of good monochromaticity and small divergence angle compared with the light-emitting diode. The use of leds is generally powerful and has sufficient margin to allow for distribution to the homogenizing plate 5 to achieve spot homogenization. The shaping lens 2 is used for enlarging and shaping the band-shaped light spot of the outgoing light of the excitation light source 1.
The centers of the total reflector 3, the light homogenizing reflecting device and the reagent card 6 are arranged on the same vertical line in sequence from top to bottom to form a second optical axis.
The dodging reflective device comprises a composite dodging plate 5 and dichroic mirror 4. The material of the light homogenizing plate 5 is an engineering plastic film, an organic glass plate or a quartz glass plate, and the outer surface of the light homogenizing plate 5 is provided with an atomizing layer. The principle of the light homogenizing plate 5 is diffuse reflection, and the function is to homogenize the light passing through the light homogenizing plate 5. The dichroic mirror 4 transmits light having a wavelength of 980nm and totally reflects light having a wavelength of 540 nm. The reagent card 6 is provided with up-conversion luminescent particles capable of exciting light with the wavelength of 540 nm. Using the principle of up-conversion luminescence, 980nm light having a longer wavelength is used to excite 540nm light having a shorter wavelength.
The centers of the total reflection mirror 3, the narrow-band filter 7 and the signal collector 8 are arranged on the same horizontal plane in sequence from left to right to form a third optical axis.
The signal collector 8 is a COMS or CCD sensor. The photoelectric diode has the advantages of high sensitivity and higher practicability compared with a photomultiplier by replacing the traditional photodiode and a traditional photocell. The narrow-band filter 7 functions to eliminate stray light of other wavelengths.
The first optical axis and the third optical axis are parallel and are both vertical to the second optical axis; the total reflector 3 is at an angle of 45 degrees with the first optical axis and the second optical axis respectively, the light homogenizing reflecting device is at an angle of 45 degrees with the second optical axis and the third optical axis respectively, and the total reflector 3 is parallel to the light homogenizing reflecting device.
The utility model discloses a go up quick detection device's of luminous immunoassay appearance of rotation light path principle: an excitation light source 1 is used for providing emergent light with the wavelength of 980nm, the emergent light is shaped on a first optical axis through a shaping lens 2 to amplify and shape a banded light spot of the emergent light, then the emergent light is reflected by a total reflection mirror 3 to enter a second optical axis, 980nm light is homogenized through a light homogenizing plate 5, then the homogenized light is vertically irradiated on a reagent card 6 downwards after being fully transmitted by a dichroic mirror 4 and excites 540nm visible light, the 540nm visible light is vertically irradiated on the dichroic mirror 4 upwards and then reflected by the dichroic mirror 4 to enter a third optical axis, and the 540nm visible light is filtered by a narrow-band filter 7 and then received by a signal collector 8.
The utility model discloses a fast detection device of up-conversion luminescence immunoassay appearance can furthest's improvement detection speed, gets rid of the reaction time of outer reagent, and the plug-in card after possible reacting is surveyed promptly.
The foregoing descriptions of specific exemplary embodiments of the present invention have been presented for purposes of illustration and description. It is not intended to limit the invention to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teaching. The exemplary embodiments were chosen and described in order to explain certain principles of the invention and its practical application to enable one skilled in the art to make and use various exemplary embodiments of the invention and various alternatives and modifications as are suited to the particular use contemplated. Any simple modifications, equivalent changes and modifications made to the above exemplary embodiments shall fall within the scope of the present invention.
Claims (7)
1. A rapid detection device of an up-conversion luminescence immunoassay analyzer is characterized by comprising an optical path system, the light path system comprises an excitation light source (1), a shaping lens (2), a total reflector (3), a uniform light reflection device, a reagent card (6), a narrow-band optical filter (7) and a signal collector (8), the centers of the excitation light source (1), the shaping lens (2) and the total reflector (3) are arranged on the same horizontal plane in sequence from right to left to form a first optical axis, the centers of the total reflector (3), the light homogenizing reflecting device and the reagent card (6) are arranged on the same vertical line in sequence from top to bottom to form a second optical axis, the centers of the total reflector (3), the narrow-band filter (7) and the signal collector (8) are positioned on the same horizontal plane and are sequentially arranged from left to right to form a third optical axis, and the first optical axis and the third optical axis are parallel and are all vertical to the second optical axis;
the light-homogenizing reflecting device is characterized in that the total reflecting mirror (3) is at an angle of 45 degrees with the first optical axis and the second optical axis respectively, the light-homogenizing reflecting device is at an angle of 45 degrees with the second optical axis and the third optical axis respectively, and the total reflecting mirror (3) is parallel to the light-homogenizing reflecting device.
2. The rapid detection device of the up-conversion luminescence immunoassay analyzer according to claim 1, wherein the light homogenizing reflection device comprises a composite light homogenizing plate (5) and a dichroic mirror (4).
3. The rapid detection device of the up-conversion luminescence immunoassay analyzer according to claim 2, wherein the dichroic mirror (4) is totally transmissive for 980nm wavelength light and totally reflective for 540nm wavelength light.
4. The rapid detection device of the up-conversion luminescence immunoassay analyzer according to claim 2, wherein the light homogenizing plate (5) is made of an engineering plastic film, an organic glass plate or a quartz glass plate, and the outer surface of the light homogenizing plate (5) is provided with an atomizing layer.
5. The rapid detection device of the up-conversion luminescence immunoassay analyzer according to claim 1, wherein the excitation light source (1) is a semiconductor laser diode or a high-power light emitting diode, and the wavelength of the emergent light of the excitation light source (1) is 980 nm.
6. The rapid detection device of the up-conversion luminescence immunoassay analyzer of claim 1, wherein the signal collector (8) is a COMS or CCD sensor.
7. The rapid detection device of the up-conversion luminescence immunoassay analyzer according to claim 1, wherein the reagent card (6) is provided with up-conversion luminescence particles capable of exciting light with a wavelength of 540 nm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921409885.5U CN210487599U (en) | 2019-08-28 | 2019-08-28 | Rapid detection device of up-conversion luminescence immunoassay analyzer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921409885.5U CN210487599U (en) | 2019-08-28 | 2019-08-28 | Rapid detection device of up-conversion luminescence immunoassay analyzer |
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| Publication Number | Publication Date |
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| CN210487599U true CN210487599U (en) | 2020-05-08 |
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| CN201921409885.5U Active CN210487599U (en) | 2019-08-28 | 2019-08-28 | Rapid detection device of up-conversion luminescence immunoassay analyzer |
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Address after: 065000 No. 70, Guandong Road, Langfang Development Zone, Langfang City, Hebei Province Patentee after: HOTGEN (LANGFANG) BIOTECH Co.,Ltd. Address before: 065000 6th floor, No. 6 plant of Wantong Industrial Co., Ltd., West Chuangye Road, Langfang Development Zone, Langfang City, Hebei Province Patentee before: HOTGEN (LANGFANG) BIOTECH Co.,Ltd. |