CN210443088U - Simulation embolism device - Google Patents
Simulation embolism device Download PDFInfo
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- CN210443088U CN210443088U CN201921388925.2U CN201921388925U CN210443088U CN 210443088 U CN210443088 U CN 210443088U CN 201921388925 U CN201921388925 U CN 201921388925U CN 210443088 U CN210443088 U CN 210443088U
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Abstract
The utility model discloses a simulated embolism device, which comprises a bottom plate, a first conduit and a second conduit, wherein the first conduit is arranged on the bottom plate and is transparent, and the first conduit is provided with an inlet, an outlet and a channel, so that physiological saline enters the channel from the inlet and flows out from the outlet; the second conduit is movably arranged in the first conduit in a penetrating manner and used for pushing the temperature-sensitive gel to the target position so that the temperature-sensitive gel forms embolism at the target position. In the utility model, the physiological saline is arranged in the first conduit and can be used for simulating the blood flowing in the blood vessel; the temperature-sensitive gel is pushed to the target position at a preset speed by virtue of the second catheter, so that the temperature-sensitive gel can form embolism at the target position, and the aim of simulating the formation of embolism in a blood vessel is fulfilled; the specification and the size of the first catheter and the second catheter can be adjusted to be suitable for simulating different embolism environments in different organs; the transparent arrangement of the first conduit is convenient for operators to visually observe the embolism condition.
Description
Technical Field
The utility model relates to a medical test instrument's technical field, concretely relates to simulation embolism device.
Background
At present, no unified simulation embolism device exists, and the simulation embolism device is generally designed and manufactured by each researcher according to the needs. The micro-fluidic chip designed by the company before is generally used for the performance test of a sample after the prescription is determined, and is beneficial to obtaining a more accurate test result; however, for the sample performance test in the formulation screening, the microfluidic chip has the following components: the chip is expensive, difficult to manufacture and not suitable for large-scale use; the chip is not easy to split, which is not beneficial to observing the shape of the gel after embolism.
Because the embolization needs to be simulated according to the gelation transition time of the temperature-sensitive gel and the anti-scouring capability during the primary screening of the formula so as to obtain a large amount of data support, the embolization simulation device is urgently needed to be simple, easy to obtain, easy to replace and easy to observe.
SUMMERY OF THE UTILITY MODEL
The utility model aims to provide a simulation embolism device aims at solving the problem that the device of traditional simulation embolism is expensive, difficult to make and inconvenient observation embolism condition.
To achieve the above object, the present invention provides a simulated embolism device, which includes:
a base plate;
the first conduit is arranged on the bottom plate, is transparent and is provided with an inlet, an outlet and a channel communicated with the inlet and the outlet, so that the physiological saline enters from the inlet, passes through the channel and flows out from the outlet; and the number of the first and second groups,
and the second conduit is movably arranged in the channel in a penetrating manner and used for pushing the temperature-sensitive gel to the target position so that the temperature-sensitive gel forms embolism at the target position.
Optionally, the simulated embolism device further comprises a temperature adjusting device, the temperature adjusting device is arranged on the bottom plate, and the temperature adjusting device is used for acting on the first conduit to adjust the temperature of the physiological saline to 35.5-41.0 ℃.
Optionally, the simulated embolism apparatus further comprises a measuring device, the measuring device is disposed on the bottom plate, and the measuring device is configured to measure a pressure change in the second conduit in a process that the temperature-sensitive gel forms the embolism.
Optionally, the simulated embolism device further comprises a pump body arranged on the bottom plate, and the pump body is used for continuously injecting the physiological saline into the channel at a constant speed.
Optionally, the first catheter has a test region, the first catheter being provided with a marker at the test region, the marker being indicative of the target location.
Optionally, the pushing speed of the temperature-sensitive gel in the second conduit is 0.2-1.0 ml/min.
Optionally, the first conduit and the second conduit are both made of a flexible plastic material.
Optionally, the pipe diameter of the second conduit is 1.0F to 4.0F.
Optionally, the floor is dark colored compared to the first conduit.
Optionally, the pipe diameter of the first conduit is 0.2-1.0 cm; and/or the presence of a gas in the gas,
the length of the first conduit is greater than or equal to 100 cm.
According to the technical scheme of the utility model, the physiological saline is arranged in the first conduit, so that the device can be used for simulating blood circulation in blood vessels, and then the temperature-sensitive gel is pushed to a target position at a preset speed by means of the second conduit, so that the temperature-sensitive gel can form embolism at the target position, and the purpose of simulating the formation of embolism in blood vessels is achieved; in addition, the specification and the size of the first catheter and the second catheter can be adjusted according to actual needs so as to be suitable for simulating different embolism environments in different organs; in addition, the transparent arrangement of the first conduit is convenient for operators to visually observe the embolism condition, and has the advantages of simple structure, low price and easy observation.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the structures shown in the drawings without creative efforts.
Fig. 1 is a schematic top view of a simulated embolism apparatus according to an embodiment of the present invention.
The reference numbers illustrate:
| reference numerals | Name (R) | Reference numerals | Name (R) |
| 100 | Simulated |
24 | Test area |
| 1 | Base plate | 3 | A second conduit |
| 2 | A first conduit | 4 | |
| 21 | An |
200 | |
| 22 | An |
300 | Temperature- |
| 23 | Channel |
The objects, features and advantages of the present invention will be further described with reference to the accompanying drawings.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.
It should be noted that, if directional indications (such as upper, lower, left, right, front and rear … …) are involved in the embodiment of the present invention, the directional indications are only used to explain the relative position relationship between the components, the motion situation, etc. in a specific posture (as shown in the drawings), and if the specific posture is changed, the directional indications are changed accordingly.
In addition, if there is a description relating to "first", "second", etc. in the embodiments of the present invention, the description of "first", "second", etc. is for descriptive purposes only and is not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, the meaning of "and/or" appearing throughout includes three juxtapositions, exemplified by "A and/or B" including either A or B or both A and B. In addition, the technical solutions in the embodiments may be combined with each other, but it must be based on the realization of those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the combination of the technical solutions should not be considered to exist, and is not within the protection scope of the present invention.
At present, a common device for simulating embolism, such as a microfluidic chip, is generally used for sample performance test after a prescription is determined, and is beneficial to obtaining a more accurate test result; however, for the sample performance test in the formulation screening, the microfluidic chip has the following components: the chip is expensive, difficult to manufacture and not suitable for large-scale use; the chip is not easy to split, which is not beneficial to observing the shape of the gel after embolism.
Because the embolization needs to be simulated according to the gelation transition time of the temperature-sensitive gel and the anti-scouring capability during the primary screening of the formula so as to obtain a large amount of data support, the embolization simulation device is urgently needed to be simple, easy to obtain, easy to replace and easy to observe.
In view of this, the present invention provides a simulated embolism device, and fig. 1 shows an embodiment of the simulated embolism device provided by the present invention.
Referring to fig. 1, the present invention provides a simulated embolism device 100, wherein the simulated embolism device 100 includes a bottom plate 1, a first conduit 2 and a second conduit 3, wherein the first conduit 2 is disposed on the bottom plate 1, the first conduit 2 is transparent, the first conduit 2 has an inlet 21, an outlet 22 and a channel 23 communicating the inlet 21 and the outlet 22, so that a physiological saline 200 enters from the inlet 21, passes through the channel 23, and flows out from the outlet 22; the second conduit 3 is movably arranged in the channel 23 in a penetrating manner and used for pushing the temperature-sensitive gel 300 to a target position, so that the temperature-sensitive gel 300 forms an embolism at the target position.
In the technical scheme of the utility model, the physiological saline 200 is arranged in the first conduit 2 and can be used for simulating the blood circulation in the blood vessel, and then the temperature-sensitive gel 300 is pushed to the target position at a preset speed by means of the second conduit 3, so that the temperature-sensitive gel 300 can form embolism at the target position, and the purpose of simulating the formation of embolism in the blood vessel is achieved; in addition, the size of the first catheter 2 and the second catheter 3 can be adjusted according to actual needs, so as to be suitable for simulating different embolism environments in different organs; in addition, the transparent arrangement of the first conduit 2 is convenient for operators to visually observe the embolism condition, and has the advantages of simple structure, low price and easy observation.
It should be noted that the bottom plate 1 in the present design may be embodied as a flat plate, a table of a test table, or other suitable platform; the first conduit 2 may be directly placed on the base plate 1, or may be mounted on the base plate 1 through a mounting member, such as a bracket, an elastic buckle, a clamping member, or a suction member, and the specific structure can refer to the prior art. In addition, since the present design does not limit the placement position of the bottom plate 1, and in turn, does not limit the placement position of the first conduit 2, for example, when the bottom plate 1 is disposed to extend in the up-down direction, the first conduit 2 is also disposed to extend in the up-down direction; when the bottom plate 1 is horizontally extended, the first conduit 2 is also horizontally extended.
In addition, in order to realize that the second conduit 3 can be movably arranged in the first conduit 2, the movement of the second conduit 3 can be directly completed by manual control of an operator, which is beneficial to simplifying the whole structure of the simulated embolism device 100 and reducing the economic cost; of course, an electric control driving assembly may be specially configured to drive the second conduit 3, for example, a telescopic cylinder may be provided, and a driving rod of the telescopic cylinder is connected to the second conduit 3 in a driving manner, so that the second conduit 3 may be inserted into the channel 23 in an extending direction, which is helpful to improve the position accuracy of the second conduit 3 during insertion.
Further, in order to simulate the circulation environment of blood in a human blood vessel more truly, for example, the temperature of the saline 200 is maintained at 37 ℃, in an embodiment, the saline 200 may be heated in advance, so that the saline 200 is heated to 37 ℃ and then is injected into the channel 23, but in this scheme, the constant temperature is maintained for a limited time, and the temperature gradually decreases as the saline 200 continues to circulate. In this embodiment, the simulated embolism device 100 further includes a temperature adjustment device (not shown in the drawings), the temperature adjustment device is disposed on the bottom plate 1, the temperature adjustment device is configured to act on the first conduit 2 to adjust the temperature of the physiological saline 200 to 35.5-41.0 ℃, the temperature of 35.5-41.0 ℃ better conforms to the body temperature environment of the human body in the normal state, the temperature adjustment device can continuously act on the first conduit 2, and then the physiological saline 200 in the first conduit 2 is always maintained at, for example, 37 ℃ to establish a constant temperature environment better conforming to the normal state of the human body. Of course, the present design does not limit the specific form of the temperature adjusting device, and the temperature adjusting device may be a heating plate with controllable temperature, the heating plate is disposed on the bottom plate 1 and is adjacent to the first conduit 2 for continuously heating the first conduit 2; or, the temperature adjusting device may be a water bath tank, the water bath tank is arranged on the bottom plate 1, constant temperature water is contained in the water bath tank, and the first conduit 2 is placed in the constant temperature water.
In addition, in this embodiment, the simulated embolism apparatus 100 further comprises a measuring device (not shown in the drawings), which is disposed on the bottom plate 1 and is used for measuring the pressure change in the second conduit 3 during the process of forming the embolism by the temperature-sensitive gel 300. When the pushing process of the temperature-sensitive gel 300 in the second conduit 3 is realized by an electrically controlled driving source, such as a telescopic cylinder or a variable speed pump, the speed and the time from the temperature-sensitive gel 300 to the target position can be obtained by directly measuring the power output end of the electrically controlled driving source; in addition, the measuring device may further include a pressure detector, which is an existing product, and the pressure detector monitors the pressure change in the temperature-sensitive gel 300 in the second conduit 3 in real time during the movement, and generally, when the pressure change is abnormal, for example, the pressure value is obviously increased, it can indicate that the temperature-sensitive gel 300 has substantially formed an embolism. The measuring device is convenient for operators to obtain more and more accurate data, and is beneficial to subsequent analysis.
Next, in this embodiment, the simulated embolism apparatus 100 further includes a pump body 4, the pump body 4 is disposed on the bottom plate 1, and the pump body 4 is used for continuously injecting the physiological saline 200 into the channel 23 at a constant rate. Under the action of the pump body 4, the physiological saline 200 has more balanced and more stable kinetic potential energy, so that the physiological saline 200 can be ensured to continuously move in the channel 23, and the real circulation condition of blood in the blood vessel of the human body can be better met. Of course, the speed of the pump body 4 can be set to suit different blood flow conditions at different organs.
In view of the above, in the present embodiment, the first catheter 2 has a testing region 24, and the first catheter 2 is provided with a mark (not shown in the drawing) at the testing region 24, and the mark is used for indicating the target point position. The arrangement of the test area 24 and the mark is not limited in this embodiment, and may be adjusted according to the needs of practical application. The indication may be, for example, a numbered scale or otherwise. Of course, the testing area 24 and the mark may also be disposed on the bottom plate 1, which is not described herein.
In the embodiment, the pushing speed of the temperature-sensitive gel 300 in the second conduit 3 is 0.2-1.0 ml/min. If the pushing speed is too high, the temperature-sensitive gel 300 is pushed to the target position too fast, so that the temperature-sensitive gel 300 is easy to escape, and embolism cannot be formed smoothly, so that the accuracy of a test result is influenced; on the contrary, if the pushing speed is too low, the retention time of the temperature-sensitive gel 300 in the second conduit 3 is prolonged, so that the temperature-sensitive gel 300 does not reach the target position, namely, an embolism is formed, and the accuracy of the test result is also influenced.
Next, in the present embodiment, the first conduit 2 and the second conduit 3 are both made of flexible plastic material. For example, the first catheter 2 and the second catheter 3 may be directly used as conventional medical catheters. On the one hand, the first conduit 2 and the second conduit 3 made of flexible plastic material have sufficient flexibility to be easily bent, so that the first conduit 2 can be installed to fit the specification of the base plate 1, and the second conduit 3 can be inserted to fit the shape of the first conduit 2. For example, when the bottom plate 1 is small, the first conduit 2 can be operated to bend on the bottom plate 1 for a plurality of times to save space occupation, of course, the bend can not block the communication of the channel 23; then the second conduit 3 is operated to smoothly pass through the first conduit 2. On the other hand, the first catheter 2 made of flexible plastic material is easy to cut, for example, to a desired length according to the test environment before testing, and to cut open after the temperature-sensitive gel 300 forms an embolism, thereby facilitating the observation of the embolism.
The design does not limit the pipe diameters of the first conduit 2 and the second conduit 3, and the inner diameter of the first conduit 2 is ensured to be larger than the outer diameter of the second conduit 3. However, for the convenience of testing, in the present embodiment, the pipe diameter of the second conduit 3 is 1.0F to 4.0F, and in this case, the pipe length of the second conduit 3 is preferably 100cm to 130cm, for example, the specification of the second conduit 3 may be 2.7F/130 cm. When the simulated embolism device 100 is used for simulating the vascular embolism condition of the human brain, the pipe diameter of the second catheter 3 is preferably less than 1.8F; when the simulated embolism device 100 is used for simulating the vascular embolism condition of the liver of a human body, the pipe diameter of the second conduit 3 is preferably within the range of 2.7F-4.0F; when the simulated embolism device 100 is used for simulating the human general vascular embolism situation, the pipe diameter of the second catheter 3 is preferably 2.7F.
Further, in the present embodiment, the color of the bottom plate 1 is set to be dark compared to the first conduit 2. For example, a coating of a dark color, such as the usual black, dark grey or dark blue, etc., may be applied to the base plate 1. The first conduit 2 is transparent, the color of the first conduit is colorless or light color, and obvious color difference is formed between the first conduit and the bottom plate 1 with dark color, so that the embolism condition of the temperature-sensitive gel 300 in the first conduit 2 can be easily and visually checked, and the temperature-sensitive gel has the advantages of convenience in operation and easiness in observation.
Further, in the present embodiment, the diameter and length of the first guide duct 2 are not limited in the present design, but preferably, the diameter of the first guide duct 2 may be set to 0.2 to 1.0 cm; and/or the length of the first conduit 2 is greater than or equal to 100 cm. Due to the arrangement, different embolism conditions of different organs of a human body can be adapted more easily, so that the embolism simulation device is more universal.
The above only be the preferred embodiment of the utility model discloses a not consequently restriction the utility model discloses a patent range, all are in the utility model discloses a conceive, utilize the equivalent structure transform of what the content was done in the description and the attached drawing, or direct/indirect application all is included in other relevant technical field the utility model discloses a patent protection within range.
Claims (10)
1. A simulated embolic device, comprising:
a base plate;
the first conduit is arranged on the bottom plate, is transparent and is provided with an inlet, an outlet and a channel communicated with the inlet and the outlet, so that the physiological saline enters from the inlet, passes through the channel and flows out from the outlet; and the number of the first and second groups,
and the second conduit is movably arranged in the channel in a penetrating manner and used for pushing the temperature-sensitive gel to the target position so that the temperature-sensitive gel forms embolism at the target position.
2. The simulated embolization device of claim 1, further comprising a temperature adjustment device disposed on the base plate, the temperature adjustment device being configured to act on the first conduit to adjust the temperature of the saline solution to 35.5 ℃ to 41.0 ℃.
3. A simulated embolization device according to claim 1, further comprising a measuring means provided in the base plate for measuring the pressure change in the second conduit during formation of the plug from the temperature sensitive gel.
4. The simulated embolic device of claim 1, further comprising a pump body disposed in the base plate, the pump body configured to continuously inject the saline into the channel at a constant rate.
5. The simulated embolization device of claim 1, wherein the first catheter has a test region, the first catheter being provided with a marker at the test region, the marker indicating the target location.
6. The simulated embolization device of claim 1, wherein the push speed of the temperature-sensitive gel in the second conduit is 0.2-1.0 ml/min.
7. A simulated embolic device as in claim 1, wherein the first conduit and the second conduit are each made of a flexible plastic material.
8. A simulated embolization device according to claim 1, wherein the second catheter has a tube diameter of from 1.0F to 4.0F.
9. The simulated embolic device of claim 1, wherein said floor is a dark color compared to said first conduit.
10. The simulated embolization device according to claim 1, wherein the first conduit has a tube diameter of 0.2 to 1.0 cm; and/or the presence of a gas in the gas,
the length of the first conduit is greater than or equal to 100 cm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921388925.2U CN210443088U (en) | 2019-08-23 | 2019-08-23 | Simulation embolism device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921388925.2U CN210443088U (en) | 2019-08-23 | 2019-08-23 | Simulation embolism device |
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| CN210443088U true CN210443088U (en) | 2020-05-01 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113284388A (en) * | 2021-05-26 | 2021-08-20 | 广东广纳安疗科技有限公司 | In-vitro vascular embolism simulation system and method |
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2019
- 2019-08-23 CN CN201921388925.2U patent/CN210443088U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113284388A (en) * | 2021-05-26 | 2021-08-20 | 广东广纳安疗科技有限公司 | In-vitro vascular embolism simulation system and method |
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| TR01 | Transfer of patent right |
Effective date of registration: 20230808 Address after: 510700 room 1003, building D, No. 136, Kaiyuan Avenue, Huangpu District, Guangzhou City, Guangdong Province Patentee after: Guangdong Guangna Anyu Technology Co.,Ltd. Address before: Room 1-5 / F, building B4, Wuhan National Biological Industry (Jiufeng innovation) base, 666 Gaoxin Avenue, Donghu New Technology Development Zone, Wuhan City, Hubei Province, 430000 Patentee before: ANEW-MED LIFE SCIENCE (WUHAN) Co.,Ltd. |
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