CN210384105U

CN210384105U - Stereotaxic instrument capable of flexibly fixing brain of large mouse and small mouse

Info

Publication number: CN210384105U
Application number: CN201920710651.8U
Authority: CN
Inventors: 代永旭
Original assignee: Thinker Tech Nanjing Biotech Ltd Co
Current assignee: Thinker Tech Nanjing Biotech Ltd Co
Priority date: 2019-05-17
Filing date: 2019-05-17
Publication date: 2020-04-24
Anticipated expiration: 2029-05-17

Abstract

The utility model provides a can fix stereotaxic appearance of big mouse brain in a flexible way, including optical plate, operation arm, fixing device, a plurality of screw holes have been seted up on the optical plate, operation arm fixed mounting is in on the optical plate, the operation arm outside is provided with the fixing device that a plurality of is used for fixed mouse brain, fixing device pass through the bolt with screw hole threaded connection. The utility model discloses can experiment many big mice simultaneously, the equipment is nimble, has improved the utilization ratio of operation arm, and experimental efficiency improves greatly, has practiced thrift the experiment cost simultaneously.

Description

Stereotaxic instrument capable of flexibly fixing brain of large mouse and small mouse

Technical Field

The utility model relates to a neurobiology laboratory glassware field particularly, relates to a can fix stereotaxic instrument of big mouse brain in a flexible way.

Background

In experiments for studying brain and behavior, stimulation, injury or injection of certain drugs to certain parts or structures in the brain of an animal is often required, and the technology is used for firstly making a detailed three-dimensional brain map of the species, and certain extracranial markers have a relatively fixed position relationship with intracranial structures, such as: bregma: at the junction of the coronal and sagittal sutures; herringbone suture tip (lambda): is positioned at the intersection point of the back fontanel suture and the sagittal suture. The location to be studied or operated on is determined in a defined reference coordinate system and the stereotaxic instrument is then used to insert the instrument or microplate or catheter into the desired site according to the parameters provided by the brain atlas.

Big mouse is the study object that neurobiology experiment was commonly used, brain stereotaxic apparatus is the basic instrument that basic platform of experiment was set up and is used in neurobiology research, there are all kinds of independent big mouse brain stereotaxic apparatuses in the existing market, but two mouse experiments can not be realized to independent a brain stereotaxic apparatus relatively expansion, for example, a standard single armed brain stereotaxic apparatus, including base, a three-dimensional cross arm and big mouse adapter, general experiment just can only experiment a mouse, digital operation arm utilization ratio is not high, if need experiment two mouse, need increase one set of brain stereotaxic apparatus, cost greatly increased, and current stereotaxic apparatus fixed mode is single, can not assemble according to the demand is nimble.

SUMMERY OF THE UTILITY MODEL

The defect to prior art exists, the utility model provides a can fix the stereotaxic appearance of big mouse brain in a flexible way can experiment many big mice simultaneously when the experiment, and the equipment is nimble, has improved the utilization ratio of operation arm, and experimental efficiency improves greatly, has practiced thrift the experiment cost simultaneously.

In order to solve the technical problem, the utility model discloses a technical scheme is: the utility model provides a can fix stereotaxic instrument of big mouse brain in a flexible way, includes optical plate, operation arm, fixing device, a plurality of screw holes have been seted up on the optical plate, operation arm fixed mounting is in on the optical plate, the operation arm outside is provided with the fixing device that a plurality of is used for fixed mouse brain, fixing device pass through the bolt with screw hole threaded connection.

According to the utility model discloses a stereotaxic instrument that embodiment provided, fixing device is the centre gripping subassembly, the centre gripping subassembly includes nose clip base, nose clip, ear pole base and ear pole, the ear pole base is two, and its relative setting on the optical plate, the fixed setting of nose clip base is on the optical plate that is located two ear pole base axis, nose clip and ear pole difference fixed mounting be in on nose clip base and the ear pole base.

According to the utility model discloses an embodiment provides a stereotaxic instrument, fixing device is the adapter, the adapter with optical plate threaded connection.

According to the utility model discloses an embodiment provides a stereotaxic instrument, the screw hole diameter is 6mm, and adjacent two centre-to-centre spacing between the screw hole is 25 mm.

According to the utility model discloses a stereotaxic instrument that embodiment provided, the size of optical plate is 300mm 300 ~ 600mm, and thickness is 13 ~ 50 mm.

According to the utility model discloses an embodiment provides a stereotaxic instrument, install displacement sensor on the operation arm, displacement sensor electric connection has the digital display ware for show displacement information.

The beneficial effects of the utility model include: the optical plate is provided with a plurality of threaded holes, so that the operating arm and the fixing device are detachably connected with the optical plate, and the optical plate is flexible to assemble; the outer side of the operating arm is provided with a plurality of fixing devices, and after the brains of the rats are fixed on the fixing devices, the rats can share one operating arm. The experiment device has the advantages that a plurality of big mice can be simultaneously tested during experiments, the assembly is flexible, the utilization rate of the operation arm is improved, the experiment efficiency is greatly improved, and the experiment cost is saved.

Drawings

The disclosure of the present invention is explained with reference to the drawings. It is to be understood that the drawings are designed solely for the purposes of illustration and not as a definition of the limits of the invention. In the drawings, like reference numerals are used to refer to like parts. Wherein:

fig. 1 schematically shows a schematic structural diagram of a stereotaxic apparatus according to an embodiment of the present invention;

FIG. 2 is a schematic view of the clamping assembly of FIG. 1;

fig. 3 schematically shows a schematic structural diagram of a stereotaxic apparatus according to another embodiment of the present invention;

fig. 4 is a schematic structural diagram of the adapter in fig. 3.

Reference numbers in the figures: 1-optical plate, 2-manipulator arm, 3-fixing device, 31-clamping component, 3101-nose clip base, 3102-nose clip, 3103-ear bar base, 3104-ear bar, 32-adapter, 4-digital display, 5-threaded hole.

Detailed Description

It is easily understood that, according to the technical solution of the present invention, a plurality of alternative structural modes and implementation modes can be proposed by those skilled in the art without changing the spirit of the present invention. Therefore, the following detailed description and the accompanying drawings are merely illustrative of the technical solutions of the present invention, and should not be considered as limiting or restricting the technical solutions of the present invention in their entirety or in any other way.

An embodiment according to the present invention is shown in conjunction with fig. 1. The utility model provides a can fix stereotaxic instrument of big mouse brain in a flexible way, includes optical plate 1, operation arm 2, fixing device 3, has seted up a plurality of screw holes 5 on the optical plate 1, and operation arm 2 passes through bolt fixed mounting on optical plate 1, and operation arm 2 can 360 rotations, and the luffing motion range is 180, and the 2 outsides of operation arm are provided with a plurality of fixing device 3 that is used for fixed mouse brain, and fixing device 3 passes through bolt and 5 threaded connection of screw hole. When the experiment, fix the mouse brain on fixing device 3, operation arm 2 can carry out experimental operation to the mouse brain, after having operated one side mouse brain, rotates operation arm 2, carries out experimental operation to the opposite side mouse brain, utilizes single operation arm 2 can experiment many big mice simultaneously, has improved operation arm 2's utilization ratio, and experimental efficiency improves greatly, has practiced thrift the experiment cost simultaneously.

In this embodiment, the size of the optical plate 1 is 300mm × 300-600 mm, the thickness is 13-50 mm, the threaded holes 5 are uniformly distributed on the optical plate 1, the diameter of each threaded hole 5 is 6mm, and the center distance between two adjacent threaded holes 5 is 25 mm.

As shown in fig. 2, in the present embodiment, the fixing device 3 is a clamping assembly 31, the clamping assembly 31 includes a nose clip base 3101, a nose clip 3102, two ear post bases 3103 and two ear posts 3104, the nose clip 3102 is used for clamping the nose of a mouse, the ear posts 3104 are used for supporting the ear of the mouse, the ear post bases 3103 are oppositely disposed on the optical plate 1, the nose clip base 3101 is fixedly disposed on the optical plate 1 located at the central axis of the two ear post bases 3103, and the nose clip 3102 and the ear posts 3104 are respectively fixedly mounted on the nose clip base 3101 and the ear post bases 3103.

Mouse nose clip or rat nose clip can be chooseed for use to the nose clip 3102 to carry out big mouse experiment simultaneously, the special gaseous anaesthetic mask of change can be installed additional to big mouse nose clip, can realize the requirement of gas anesthesia such as isoflurane, gas flurane.

As shown in fig. 3 and 4, in another embodiment of the present invention, the difference from the above embodiment is: the fixing device 3 is an adapter 32, the model of which can be selected from a Rewold 68010 model, and the adapter 32 is used for fixing the mouse brain.

Furthermore, a displacement sensor is installed on the operating arm 2, the displacement sensor is electrically connected with a digital display 4, the type of the displacement sensor can be HLC-M, and the type of the digital display 4 can be XSA-CH1WV 0. During the experiment, the displacement distance of the operation arm 2 on the three axes X, Y, Z can be displayed on the digital display 4 in real time, and the display is visual and clear.

To sum up, the beneficial effects of the utility model include: the optical plate 1 is provided with a plurality of threaded holes 5, so that the operating arm 2 and the fixing device 3 are detachably connected with the optical plate 1, the assembly is flexible, the levelness and the verticality of the nasal clamp base and the ear bar base which are arranged on the optical plate are calibrated according to the international standard, the relative distance between the nasal clamp and the ear bar is consistent with the size of a universal locator on the market, and the habit of an operator and the expansion of universal accessories are facilitated; a plurality of fixing devices 3 are arranged on the outer side of the operating arm 2, and after the brains of the rats are fixed on the fixing devices 3, one operating arm 2 can be shared; the device has the advantages that a plurality of large mice can be tested simultaneously during the test, the assembly is flexible, the utilization rate of the operating arm 2 is improved, the operating arm 2 is a digital display three-dimensional cross operating arm, the displacement distance of the operating arm 2 on the X, Y, Z three-axis is displayed on the digital display 4, the precision is 0.01mm, the reading does not need to look at a scale on the operating arm 2, and therefore the reading operation is not influenced when the operating arm 2 rotates at any angle; a plurality of operating arms 2 and fixing devices 3 can be installed on the optical plate 1, a plurality of groups of experiments can be conducted simultaneously, the assembling is flexible, the experiment efficiency is greatly improved, and the experiment cost is saved.

The technical scope of the present invention is not limited to the content in the above description, and those skilled in the art can make various modifications and alterations to the above embodiments without departing from the technical spirit of the present invention, and these modifications and alterations should fall within the protection scope of the present invention.

Claims

1. The utility model provides a can fix stereotaxic instrument of big mouse brain in a flexible way, its characterized in that, includes optical plate (1), operation arm (2), fixing device (3), a plurality of screw holes (5) have been seted up on optical plate (1), operation arm (2) fixed mounting be in on optical plate (1), operation arm (2) outside is provided with fixing device (3) that a plurality of is used for fixed mouse brain, fixing device (3) pass through the bolt with screw hole (5) threaded connection.

2. Stereotaxic instrument according to claim 1, wherein the fixing device (3) is a clamping assembly (31), the clamping assembly (31) comprises a nose clip base (3101), a nose clip (3102), an ear post base (3103) and an ear post (3104), the ear post bases (3103) are two and are oppositely arranged on the optical plate (1), the nose clip base (3101) is fixedly arranged on the optical plate (1) which is located at the central axis of the two ear post bases (3103), and the nose clip (3102) and the ear post (3104) are respectively fixedly arranged on the nose clip base (3101) and the ear post base (3103).

3. Stereotaxic instrument according to claim 1, wherein the fixing means (3) is an adapter (32), said adapter (32) being in threaded connection with the optical plate (1).

4. Stereotaxic instrument according to claim 1, wherein the threaded holes (5) have a diameter of 6mm and the distance between two adjacent threaded holes (5) is 25 mm.

5. Stereotaxic instrument according to claim 1, wherein the optical plate (1) has dimensions of 300mm x 300-600 mm and a thickness of 13-50 mm.

6. Stereotaxic instrument according to any of claims 1 to 5, wherein a displacement sensor is mounted on the operating arm (2), and the displacement sensor is electrically connected with a digital display (4) for displaying displacement information.