CN210332288U - Box type tangential flow filtering device - Google Patents

Abstract

The utility model discloses a box-type tangential flow filtration device, it is main including box body, stack a plurality of filter unit in the box body and fix the apron on the box body with filter unit, runner macropore and runner aperture have all been opened at filter unit's both ends, it has the complete unanimity and communicating hole with runner macropore and runner aperture to open on the apron. The device adopts the tangential flow filtration mode, and every unit volume contains a large amount of filter layers, and open runner design, the diaphragm is difficult for polluting, long service life, and disposable handling capacity is big, greatly reduction in production cost.

Description

Box type tangential flow filtering device

Technical Field

The utility model relates to a box-type tangential flow filtration device that is used for biological products fields such as protein, monoclonal antibody, bacterin, blood products, filtering medium can concentrate, separate and purify target product through this box-type device.

Background

The tangential flow filtration is a filtration mode that the liquid flow direction is vertical to the filtration direction, the liquid flow generates shearing force on the surface of a filter medium, the accumulation of a cake layer or a gel layer on the membrane surface is reduced, and the filtration mode is a relatively mild separation process; the application of biological products mainly comprising proteins, blood products, vaccines, antigens and monoclonal antibodies is concentration, clarification and desalination; removing colloid particles by buffer exchange and chromatographic clarification; in addition, cell capture, washing or clarification of cell cultures, lysates, colloidal suspensions, and viral cultures, etc.;

at present, membrane products are mostly used in a roll type, plate frame type, column type or membrane mode, although most of filtration applications can be met, in some special application fields, as the components are large, the filtration mode is not mild, the residual volume is large, large waste is easily caused to samples, harsh use conditions are difficult to meet in the field of biological products, and the application of the membrane products is greatly limited; in order to obtain membrane modules of various levels for realizing laboratory research and development to industrial large-scale production, more reasonable module design is necessary, a box-type membrane module is organically superposed by utilizing multiple layers of membranes, a runner screen is added, and the box-type membrane module is sealed by utilizing hot melt adhesive, liquid polyurethane, epoxy resin, organic silica gel and the like to form a tangential flow box-type membrane module, namely, a very small membrane module has a very large filtration membrane area, small residual volume and extremely low sample loss rate, and can resist gamma rays, ethylene oxide, high-temperature steam sterilization and the like;

the filtering device is small in appearance size, large in filtering area and small in residual volume, is particularly important for biological product separation and purification, the outermost layer of a box type membrane stack sold in the market at present is of a filter screen structure, the requirement is quite high in the transportation and installation process, the outermost layer of the box type membrane stack is slightly improper, the outermost layer of the box type membrane stack can be damaged, and meanwhile due to elastic deformation of plastic, when the box type membrane stack is installed, a plurality of holes of the box type membrane stack are not completely on the same plane, liquid leakage is caused, and irreparable economic loss is caused.

SUMMERY OF THE UTILITY MODEL

To the above-mentioned not enough, the utility model provides a box-type tangential flow filter equipment.

The utility model discloses the technical scheme who adopts as follows: the utility model provides a box-like tangential flow filter device, mainly includes the box body, superposes and piles up a plurality of filter unit in the box body and fix the apron on the box body with filter unit, runner macropore and runner aperture have all been opened at filter unit's both ends, it has completely unanimous and communicating hole with runner macropore and runner aperture to open on the apron.

Preferably, the filtering units comprise two layers of filtering membranes and one layer of flow channel screen, the two layers of filtering membranes are superposed on the upper surface and the lower surface of the flow channel screen, the superposed filtering membranes are sealed to form an effective box-type filtering device, and the flow channel small holes of the filtering units are in sealing connection.

Preferably, both ends of the box body are provided with positioning clamp holes.

Preferably, the length and width dimensions of the cover plate are the same as those of the filter unit.

Preferably, the cover plate has a length and a width which are both larger than those of the filter unit and not larger than those of the outermost edge of the box body.

Preferably, the central portion of the cover plate is hollow or porous.

Compared with the prior art, the beneficial effects of the utility model are as follows: the utility model discloses a box-type tangential flow filter equipment utilizes a plurality of filter unit, and the design mechanism is compact, and the terminal surface adopts the closing plate that has intensity sealed, forms a whole with the frame, and the installation is very simple and convenient, and the device adopts the tangential flow filtration mode, and every unit volume contains a large amount of filter layers, open runner design, and the diaphragm is difficult for receiving the pollution, long service life, and disposable processing capacity is big, greatly reduction in production cost.

Drawings

The accompanying drawings are provided to more clearly illustrate the specific embodiments and should not be construed as limiting the scope of the claims

FIG. 1 is a perspective view of a small format cassette filter assembly;

FIG. 2 is a side view of FIG. 1;

FIG. 3 is a perspective view of a large cassette filter arrangement;

FIG. 4 is a side view of FIG. 3;

FIG. 5 is a schematic view of a cover plate of a small cassette filter device, wherein the cover plate is sized to correspond to the size of the central filter unit;

FIG. 6 is a schematic view of a cover plate of a small cassette filter device, wherein the cover plate is sized to conform to the external dimensions of the cassette filter;

FIG. 7 is a schematic view of a cover plate of a small cassette filter device, wherein the cover plate is sized to correspond to the size of a central filter unit, and wherein the center of the cover plate is hollow;

FIG. 8 is a schematic view of a cover plate of a large cassette filter device, wherein the cover plate is sized to correspond to the size of the central filter unit;

FIG. 9 is a schematic view of a cover plate of a small cassette filter device, wherein the cover plate is sized to conform to the external dimensions of the cassette filter;

FIG. 10 is a schematic view of a cover plate of a small cassette filter device, wherein the cover plate is sized to correspond to the size of a central filter unit, and wherein the center is hollow.

Detailed Description

Reference will now be made in detail to the exemplary embodiments, examples of which are illustrated in the accompanying drawings. In the following description and in the drawings, the same numbers in different drawings identify the same or similar elements unless otherwise indicated. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with the present invention. Rather, they are merely examples of apparatus consistent with certain aspects of the invention, as detailed in the appended claims. Various embodiments of the present description are described in an incremental manner.

It should be noted that all the directional indicators (such as upper, lower, left, right, front and rear … …) in the embodiment of the present invention are only used to explain the relative position relationship between the components, the motion situation, etc. in a specific posture (as shown in the drawings), and if the specific posture is changed, the directional indicator is changed accordingly.

In addition, the technical solutions in the embodiments may be combined with each other, but it must be based on the realization of those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the combination of the technical solutions should not be considered to exist, and is not within the protection scope of the present invention.

Example 1:

as shown in fig. 1 and fig. 2, the box-type tangential flow filtration device provided by this embodiment mainly includes a box body 1, a plurality of filtration units 2 stacked in the box body, and a cover plate 3 for fixing the filtration units 2 to the box body, wherein the two ends of the filtration units 2 are both provided with large flow passage holes 4 and small flow passage holes 5, and the cover plate 3 is provided with holes completely consistent and communicated with the large flow passage holes and the small flow passage holes.

The filter unit includes two-layer filtration membrane and one deck runner screen cloth, two-layer filtration membrane stack is on the upper and lower surface of runner screen cloth, adopt the gluing agent to carry out the frame banding after the stack, 5 sealing connection of each filter unit's runner aperture, runner macropore 4 need not to be sealed, stoste passes through the runner macropore 4 of one end under the effect of external pressure, get into filter unit, flow back to the head tank in from other end runner macropore 4, flow in the runner aperture 5 at both ends in the permeate liquid, thereby carry out effective separation and concentration to the feed liquid.

The two ends of the box body are provided with positioning clamp holes 6, so that the whole box-type tangential flow filtration device can be conveniently positioned and fixed.

Example 2:

as shown in fig. 3 and 4, the present embodiment differs from embodiment 1 in that: the size of the cassette tangential flow filtration device was larger than that of example 1. Therefore, a plurality of large flow passage holes and a plurality of small flow passage holes are formed at two ends of the filtering unit, and holes which are completely consistent with and communicated with the large flow passage holes and the small flow passage holes are formed in the cover plate.

Example 3:

as shown in fig. 5, the cover plate of the present embodiment is the cover plate of embodiment 1, and the length and width dimensions of the cover plate are the same as those of the filter unit.

Example 4:

as shown in fig. 6, the cover plate of this embodiment is the cover plate of embodiment 1, and the length and width of the cover plate are the same as those of the outermost edge of the box body.

Example 5:

as shown in fig. 7, the cover plate of the present embodiment is the cover plate of embodiment 1, and the middle portion of the cover plate is hollow.

Example 6:

as shown in fig. 8, the cover plate of the present embodiment is the cover plate of embodiment 2, and the length and width dimensions of the cover plate are the same as those of the filter unit.

Example 7:

as shown in fig. 9, the cover plate of this embodiment is the cover plate of embodiment 2, and the length and width of the cover plate are the same as those of the outermost edge of the box body.

Example 8:

as shown in fig. 10, the cover plate of the present embodiment is the cover plate of embodiment 2, and the middle portion of the cover plate is hollow.

It should be noted that, in the above embodiments 3 to 8, the cover plate effectively increases the filtering area, and simultaneously ensures the flatness of the outermost layer of the cassette type filtering device, which is convenient for installation.

The cover plate can be plastic, metal-free plate or inorganic material, the surface of which is flat, preferably thermoplastic. The cover plate may be transparent, translucent or opaque.

The flow channel hole site of the cover plate and the flow channel hole site of the filter unit are connected into a whole, and the flow channel hole site can be locked by a gasket or can be firmly adhered by a sealing agent.

Additionally, the utility model discloses a box-type tangential flow filter device can one or more establish ties and use, and when a plurality of series connection used, increase sealed pad transitional coupling between two arbitrary box-type tangential flow filter devices, this sealed pad is totally as big as box-type filter device size, and the runner hole is corresponding, can fix the box-type tangential flow filter device of a plurality of series connections through supplementary dedicated anchor clamps simultaneously.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the scope of the invention encompassed by the appended claims, and it is also to be understood that various features of the apparatus described may be combined in various ways to produce alternative and additional embodiments.

Claims (6)

1. The utility model provides a box-like tangential flow filter equipment which characterized in that mainly includes the box body, superposes and piles up a plurality of filter unit in the box body and fix the apron on the box body with filter unit, the both ends of filter unit all open runner macropore and runner aperture, it has the hole that is identical and communicating completely with runner macropore and runner aperture to open on the apron.

2. The cartridge type tangential flow filtration device of claim 1, wherein said filtration unit comprises two filtration membranes and a flow channel screen, wherein the two filtration membranes are stacked on the upper and lower surfaces of the flow channel screen, and the stacked edge seals constitute an effective cartridge type filtration device, and the flow channel pores of each filtration unit are hermetically connected.

3. The cartridge tangential flow filtration device of claim 1 wherein the cartridge body is provided with locator holes at both ends.

4. A cartridge-type tangential flow filtration device according to claim 1, wherein the length and width dimensions of said cover plate are the same as the length and width dimensions of the filtration unit.

5. A cartridge tangential flow filtration device according to claim 1, wherein the lid sheets each have a length and width dimension greater than the length and width dimensions of the filtration unit but not greater than the length and width dimensions of the outermost edges of the cartridge body.

6. A cartridge tangential flow filtration device according to any one of claims 1 to 5, wherein the central portion of the cover plate is hollow or porous.

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