CN210330538U - External double-light-source colposcope imaging system - Google Patents
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- CN210330538U CN210330538U CN201920388277.4U CN201920388277U CN210330538U CN 210330538 U CN210330538 U CN 210330538U CN 201920388277 U CN201920388277 U CN 201920388277U CN 210330538 U CN210330538 U CN 210330538U
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Abstract
The utility model discloses an external double-light-source colposcope imaging system, which comprises an imaging system and a light source system, wherein the imaging system comprises an external colposcope body for acquiring images and an image acquisition unit for light splitting; the light source system comprises a near-infrared light source and an LED white light source, and the center of a light beam emitted by the light source system is superposed with the imaging center of the colposcope body after the light beam is shaped, so that the colposcope body can simultaneously acquire a visible light image, a near-infrared fluorescence image and a fusion image. The beneficial effects of the utility model are mainly embodied in that: the magnification ratio and the resolution ratio are high, the visible light-near infrared fluorescence dual-mode imaging of cervical and vaginal tissues is realized, and pathological change tissues at each stage can be preliminarily marked and identified; the shaped light beam can simultaneously display a near-infrared fluorescence image and a white light image with high resolution, so that real-time video output is realized; the external structure is adopted, so that the operation and the use are convenient, and the practical application is convenient.
Description
Technical Field
The invention relates to the technical field of medical imaging, in particular to an external colposcope imaging system.
Background
Cervical cancer is one of the common gynecological genital tract malignancies. In female malignancies, the incidence is second. Worldwide, there are approximately 50 million new cases per year, 80% of which occur in developing countries. Cervical tissue is located at a deep position of the human body and needs to be observed by a special imaging device. A colposcope is a device for observing cervix uteri and is an indispensable instrument for diagnosing cervical cancer.
The existing colposcope has two types of built-in type and built-out type, for example, the built-in type colposcope with multiple imaging modes disclosed in patent 201710348007.6 has the problems of inconvenience in disinfection, discomfort of patients and the like, although the technology in the patent can realize multiple imaging modes, the technology adopts a time-sharing lighting illumination mode, so that the obtained visible light image and the fluorescence image have a certain time difference and a multi-light source fusion image cannot be generated. The external colposcope has the advantages of long working distance, high magnification, high image resolution, convenient operation and convenient disinfection. However, the existing external colposcope such as olympus VIZ-YD and leson 3ML only has a white light or green light observation function, the initial diagnosis of cervical lesions is only on subjective visual observation, the initial diagnosis result greatly depends on the clinical experience of doctors, and the visual diagnosis index is lacked.
In recent years, near-infrared fluorescence imaging technology has been widely used in clinical medical fields such as lesion tissue identification, surgical guidance, and angiography. Indocyanine green is a near-infrared fluorescent contrast agent safe to human bodies, and after a cervix is coated with indocyanine green solution, due to the high permeability and retention effect (EPR effect) of lesion tissues, the indocyanine green can be enriched in the lesion tissues. This phenomenon provides the possibility to identify early diseased tissue. The penetration depth of the near infrared fluorescence is deeper, and because the biological tissue has almost no autofluorescence in the near infrared band, the imaging target is more prominent. The high-resolution near-infrared fluorescence imaging is carried out on the cervix by combining with a colposcope, and the early focus can be effectively identified.
The existing external colposcope, such as the invention patent 'a laser induced fluorescence spectroscopy colposcope' of Chinese patent application No. 201620528626.4, uses lasers with different wave bands to scan and induce fluorescence point by point, and the imaging method has slower speed and more complex device; the invention patent 'a multimode electronic colposcope system' of Chinese patent application No. 201510979397.8 does not have the function of near fluorescence imaging.
In addition, the technical solutions disclosed in chinese patent application nos. 201611058128.9, 201510008183.6, 201210196099.8, 201810376241.4, and 201510008184.0 are not suitable for observing cervical tissue, although they can perform visible light and near infrared fluorescence imaging on biological tissue. Because cervical tissue is deep in the human body, pathological tissues are generally very small, a specific strong light source is required for illumination, and an imaging lens group is required to have an amplifying function, the technical schemes do not exist.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provides an external double-light-source colposcope imaging system.
The purpose of the invention is realized by the following technical scheme:
the external double-light-source colposcope imaging system comprises an imaging system, a light source system and a data processing system, wherein the imaging system comprises an external colposcope body for acquiring images and an image acquisition unit; the image acquisition unit is connected with the data processing system which can synthesize the visible light color image and the near infrared fluorescence image into a visible light-fluorescence fusion image; the light source system comprises a near infrared light source and an LED white light source, a near infrared light lens group and a visible light lens group are respectively arranged on light paths of the near infrared light source and the LED white light source, and after light beams emitted by the near infrared light source and the LED white light source are shaped by the lens groups, the centers of the light beams coincide with the imaging center of the colposcope body, so that the colposcope body can simultaneously acquire visible light images and near infrared fluorescence images.
Preferably, a first optical filter is fixedly arranged on the front side of the lens of the colposcope body, and the first optical filter is a notch filter; a coupling lens group is arranged between the colposcope body and the image acquisition unit, the coupling lens group is an achromatic lens group, and the surface of the coupling lens group is plated with a visible light-near infrared antireflection film.
Preferably, the image acquisition unit, the colposcope body and the coupling lens group share an imaging optical path.
Preferably, the image acquisition unit includes a beam splitter disposed at a front side of the color image sensor and the near-infrared image sensor, the beam splitter splitting received light into visible light and near-infrared fluorescence and being received by the color image sensor and the near-infrared image sensor, respectively.
Preferably, the near-infrared light source and the LED white light source are fixedly arranged above the colposcope body and form an included angle with the colposcope body, so that the centers of light beams emitted by the near-infrared light source and the LED white light source are coincided.
Preferably, the visible light lens group is sequentially provided with a first lens, a second lens and a second filter along an emission light path of the LED white light source, so that visible light spots generated by visible light beams on a working surface just cover an imaging field of view, and the second filter is a low-pass filter.
Preferably, the near infrared light battery of lens is followed near infrared light source's transmission light path has set gradually third lens and fourth lens, the focus of third lens is 25.4mm, the focus of fourth lens is 50mm, the interval of third lens and fourth lens is 76mm, the back focal plane department of third lens is provided with the diaphragm that is used for filtering miscellaneous light, interval 25.4mm between third lens and the diaphragm, diaphragm opening diameter is 6mm to the near infrared light facula that makes near infrared light beam produce on the working face covers the formation of image visual field.
Preferably, the near-infrared light source is connected with a driving circuit for adjusting the output power of the near-infrared light source.
Preferably, a bracket is fixedly arranged at the bottom of the colposcope body.
The invention discloses an external double-light-source colposcope imaging system which comprises an imaging system, a light source system and a data processing system, wherein the imaging system comprises an external colposcope body for acquiring images and an image acquisition unit; the light source system comprises a near-infrared light source and an LED white light source, a near-infrared light lens group and a visible light lens group are respectively arranged on light paths of the near-infrared light source and the LED white light source, and after light beams emitted by the near-infrared light source and the LED white light source are shaped by the respective lens groups, the centers of the light beams coincide with the imaging center of the colposcope body, so that the colposcope body can simultaneously acquire a visible light image and a near-infrared fluorescence image; the image acquisition unit comprises a light splitter, a color image sensor and a near-infrared image sensor, wherein the light splitter divides received light into visible light and near-infrared fluorescence which are respectively received by the color image sensor and the near-infrared image sensor; the image acquisition unit is connected with the data processing system, and the data processing system comprises a first display unit for displaying a color image formed by visible light received by the color image sensor, a second display unit for displaying a near-infrared fluorescence image formed by near-infrared fluorescence received by the near-infrared image sensor, an image synthesizer for synthesizing the visible light color image and the near-infrared fluorescence image into a visible light-fluorescence fused image, and a third display unit for displaying the visible light-fluorescence fused image.
The invention has the following beneficial effects:
1. the visible light image and the near infrared fluorescence image can be obtained simultaneously, the magnification ratio is high, the resolution ratio is high, so that medical staff can better observe the pathological change tissue by means of the near infrared fluorescence imaging technology, and the treatment is more accurate and simple;
2. the shared imaging light path eliminates the time difference between the acquired images, can obtain a visible light-near infrared fluorescence fusion image, is convenient for a doctor to judge, the lesion area can be displayed by fluorescence, and the fluorescence image is fused to the visible light image, so that the judgment is more visual;
3. the external colposcope body is safer and more sanitary than the built-in colposcope, the discomfort of a patient is reduced to the greatest extent, and the external colposcope is more suitable for practical use;
4. the light splitter enables the visible light image and the near-infrared fluorescence image to be generated simultaneously, the imaging speed is high, and the working efficiency is improved;
5. compared with other imaging systems for biological tissues, the shaped light beam structure matched with the external colposcope body has stronger specificity and is more suitable for observing cervical tissues.
Drawings
The technical scheme of the invention is further explained by combining the accompanying drawings as follows:
FIG. 1: the structure of the embodiment of the invention is shown schematically;
FIG. 2: the light-emitting light path schematic diagram of the near-infrared light source in the embodiment of the invention;
FIG. 3: the light-emitting light path schematic diagram of the visible light source in the embodiment of the invention;
FIG. 4: the image processing schematic diagram of the image data processing system in the embodiment of the invention;
FIG. 5: when the power density of the exciting light is about 30mW/cm2And then, under the magnification of 15 times, acquiring a white light illumination image, a near infrared fluorescence image and a white light-fluorescence fusion image of the chicken breast coated with the indocyanine green solution at 6 frames/second.
Detailed Description
The present invention will be described in detail below with reference to specific embodiments shown in the drawings. These embodiments are not intended to limit the present invention, and structural, methodical, or functional changes that may be made by one of ordinary skill in the art in light of these embodiments are intended to be within the scope of the present invention.
In the description of the schemes, it should be noted that the terms "center", "upper", "lower", "left", "right", "front", "rear", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance. In the description of the embodiment, the operator is used as a reference, and the direction close to the operator is a proximal end, and the direction away from the operator is a distal end.
As shown in fig. 1 to 5, the present invention discloses an external dual-light source colposcope imaging system, which comprises an imaging system 100 and a light source system 200. The imaging system 100 comprises an external colposcope body 101 for acquiring images and an image acquisition unit 110 for splitting light and acquiring images; the bottom of the colposcope body 101 is fixedly provided with a telescopic support 107 for supporting the colposcope body 101. The light source system 200 includes a near-infrared light source 201 and an LED white light source 202. The light source system 200 emits a light beam to irradiate a focal region, and the reflected light beam enters the colposcope body 101 and is collected by the image collection unit 110.
Specifically, the near-infrared light source 201 in the present invention is an excitation light source. The near-infrared light source 201 and the LED white light source 202 are fixedly arranged above the colposcope body 101 and form a certain included angle with the colposcope body 101, so that the centers of light beams emitted by the near-infrared light source 201 and the LED white light source 202 coincide with each other on a working surface, and the centers of light spots of the light beams emitted by the near-infrared light source 201 and the LED white light source 202 coincide with the imaging center of the colposcope body 101, so that a visible light image and a near-infrared fluorescence image formed in the colposcope body 101 can be completely coincided.
The external colposcope body 101 is a special structure, and has a specific working distance, a small aperture, a small field of view, a relatively fixed series of parameters such as magnification and mechanical size, so that a strong light source is required for illumination, and a special design is also required for a light beam shaping structure of the light source.
In order to further normalize the light spots formed on the working surface by the near-infrared light source 201 and the LED white light source 202, a near-infrared light lens group and a visible light lens group are respectively arranged on the light paths of the near-infrared light source 201 and the LED white light source 202. As shown in fig. 2, the near-infrared light lens group is sequentially provided with a third lens 207 and a fourth lens 208 along an emission light path of the near-infrared light source 201, a focal length of the third lens 207 is 25.4mm, a focal length of the fourth lens 208 is 50mm, a diaphragm 209 for filtering out stray light is arranged at a rear focal plane of the third lens 207, a distance between the third lens 207 and the fourth lens 208 is 76mm, a distance between the third lens 207 and the diaphragm 209 is 25.4mm, and an opening diameter of the diaphragm 209 is 6mm, so that light beams emitted by the near-infrared light source 201 form light spots with regular shapes on a working surface. As shown in fig. 3, the visible light lens group is sequentially provided with a first lens 205 and a second lens 206 along the emission light path of the LED white light source 202, so that a visible light spot generated by a visible light beam on a working surface just covers an imaging field of view.
In order to further improve the image quality, a second filter 203 is fixedly arranged on the front side of the LED white light source 202, and the second filter 203 is a low-pass filter allowing only light with a wavelength of 650nm or less to pass through. The near-infrared light source 201 is connected to a driving circuit 204 for adjusting the output power of the near-infrared light source 201, so that the near-infrared light source 201 generates a stable output. The front side of the lens of the colposcope body 101 is fixedly provided with a first optical filter 102, and the first optical filter 102 is a notch filter so as to ensure that white light and fluorescence are passed through without affecting the imaging quality. The first filter 102 and the second filter 203 are both detachable, so that they can be replaced according to different imaging requirements.
The image acquisition unit 110 includes a beam splitter 113, a color image sensor 114, and a near-infrared image sensor 115. The optical splitter 113 is a beam splitter prism and/or a dichroic mirror, and is configured to separate the received white light and the received near-infrared fluorescence, and receive the white light and the received near-infrared fluorescence by the color image sensor and the near-infrared image sensor, respectively, and the optical splitter 113 is built in the dual CCD camera (not shown in the figure); the color image sensor 114 is a color charge coupled device or a color CMOS image sensor; the near-infrared image sensor 115 is a near-infrared charge coupled device or a near-infrared CMOS image sensor.
Specifically, the beam splitter 113 has a transmission portion and a reflection portion to split the received imaging optical path into visible light imaging and near infrared fluorescence imaging, the color image sensor 114 is disposed on the rear side of the transmission portion, and the near infrared image sensor 115 is disposed on the reflection surface of the reflection portion. The transmissive portion receives and transmits visible light images and does not transmit near infrared fluorescence images, the transmitted visible light images being received by the color image sensor 114. The reflective portion reflects the near-infrared fluorescence image, which is received by the near-infrared image sensor 115 after reflection. In the preferred embodiment of the invention, the imaging is transmitted visible light imaging and reflected near infrared fluorescence imaging, and in other embodiments, the imaging can be transmitted near infrared fluorescence imaging and reflected visible light imaging.
A coupling lens group 106 is arranged between the colposcope body 101 and the image acquisition unit 110, and in order to realize simultaneous acquisition of visible light images and near-infrared fluorescence images, the image acquisition unit 110, the colposcope body 101 and the coupling lens group 106 share an imaging light path. Specifically, the coupling lens group 106 is disposed between the beam splitter 113 and the colposcope body 101, and the coupling lens group 106 is an achromatic lens group and is configured to adjust the size of the image formed by the colposcope body 101, so that the size of the image formed by the colposcope body 101 matches the size of the color image sensor 114 and the size of the near-infrared image sensor 115, and in other embodiments, other suitable coupling lens groups may be selected to obtain a maximum imaging field of view.
The image acquisition unit 110 is further connected with a data processing system 300 for synthesizing the visible light color image and/or video and the near infrared fluorescence image and/or video into a white light-fluorescence fused image and/or video. Specifically, the data processing system 300 performs image enhancement on the acquired near-infrared fluorescence image and/or video, and then superimposes the image onto a green channel of the visible light color image and/or video to synthesize a white light-fluorescence fused image and/or video.
The working principle is shown in figure 4:
first, the color image sensor 114 collects white light illumination images
The near-infrared image sensor 115 collects a near-infrared fluorescence image I. Then, contrast enhancement and pseudo color conversion are carried out on the near-infrared fluorescence image, and the near-infrared fluorescence image is displayed in green to obtain a pseudo color near-infrared fluorescence image
Thereafter, the white light is illuminated to image IwAnd a pseudo-color near-infrared fluorescence image InCarrying out fusion to obtain a white light-fluorescence fusion image IfThe fusion algorithm is as follows:
wherein, R, G and B respectively represent red, green and blue channel information in the white light illumination image. R ', G ', B ' respectively represent red, green and blue channel information in the fused image. And m and n represent image fusion proportion. Finally, the white light is illuminated to image IwNear infrared fluorescence image InWhite light-fluorescence fused image IfAnd respectively displayed.
The present invention will be further described with reference to the following examples.
The experimental subject is chicken breast. The experimental procedure was as follows:
1. turning on the LED white light source 202, and adjusting the distance between the experimental subject and the imaging system 100, so that the color image sensor 114 acquires a clear white light image of the chicken breast;
2. turning on the near infrared light source 201;
3. applying an indocyanine green solution with the concentration of 1mg/mL to partial areas of chicken breast meat, and collecting a near-infrared fluorescence image through the near-infrared image sensor 115;
4. adjusting the output power of the near-infrared light source 201 through the driving circuit 204 to make the fluorescence image appropriate in brightness;
5. data processing is performed using the data processing system 300.
The obtained white light illumination image, near infrared fluorescence image, and white light-fluorescence fusion image are shown in fig. 5. It can be seen that the area coated with the indocyanine green solution is clearly shown.
It should be understood that although the present description refers to embodiments, not every embodiment contains only a single technical solution, and such description is for clarity only, and those skilled in the art should make the description as a whole, and the technical solutions in the embodiments can also be combined appropriately to form other embodiments understood by those skilled in the art.
The above-listed detailed description is only a specific description of a possible embodiment of the present invention, and they are not intended to limit the scope of the present invention, and equivalent embodiments or modifications made without departing from the technical spirit of the present invention should be included in the scope of the present invention.
Claims (10)
1. External two light source colposcope imaging system which characterized in that: the external colposcope system comprises an imaging system (100), a light source system (200) and a data processing system (300), wherein the imaging system (100) comprises an external colposcope body (101) used for acquiring images and an image acquisition unit (110); the data processing system (300) capable of synthesizing the visible light color image and the near infrared fluorescence image into a visible light-fluorescence fused image is connected with the image acquisition unit (110); the light source system (200) comprises a near-infrared light source (201) and an LED white light source (202), a near-infrared light lens group and a visible light lens group are respectively arranged on light paths of the near-infrared light source (201) and the LED white light source (202), and after being shaped by the lens groups, light beams emitted by the near-infrared light source (201) and the LED white light source (202) are respectively superposed with the imaging center of the colposcope body (101) at the centers, so that the colposcope body (101) can simultaneously acquire visible light images and near-infrared fluorescence images.
2. The external dual-light-source colposcopic imaging system of claim 1, wherein: a first optical filter (102) is fixedly arranged on the front side of a lens of the colposcope body (101), and the first optical filter (102) is a notch filter; a coupling lens group (106) is arranged between the colposcope body (101) and the image acquisition unit (110), the coupling lens group (106) is an achromatic lens group, and the surface of the coupling lens group is plated with a visible light-near infrared antireflection film.
3. The external dual-light-source colposcopic imaging system of claim 2, wherein: the image acquisition unit (110), the colposcope body (101) and the coupling lens group (106) share an imaging optical path.
4. The external dual-light-source colposcopic imaging system of claim 3, wherein: the image acquisition unit (110) comprises a light splitter (113), a color image sensor (114) and a near-infrared image sensor (115), wherein the light splitter (113) is arranged at the front side of the color image sensor (114) and the near-infrared image sensor (115), and the light splitter (113) separates received light into visible light and near-infrared fluorescence and is respectively received by the color image sensor (114) and the near-infrared image sensor (115).
5. The external dual-light-source colposcopic imaging system of claim 1, wherein: the near-infrared light source (201) and the LED white light source (202) are fixedly arranged above the colposcope body (101) and form an included angle with the colposcope body (101), so that the centers of light beams emitted by the near-infrared light source (201) and the LED white light source (202) coincide.
6. The external dual-light-source colposcopic imaging system of claim 1, wherein: the visible light lens group is sequentially provided with a first lens (205), a second lens (206) and a second filter (203) along the emission light path of the LED white light source (202) so that visible light spots generated on a working surface by visible light beams cover an imaging view field, and the second filter (203) is a low-pass filter.
7. The external dual-light-source colposcopic imaging system as claimed in any one of claims 1 to 6, wherein: the near infrared light lens group is followed the transmission light path of near infrared light source (201) has set gradually third lens (207) and fourth lens (208), the focus of third lens (207) is 25.4mm, the focus of fourth lens (208) is 50mm, the interval of third lens (207) and fourth lens (208) is 76mm, the back focal plane department of third lens (207) is provided with diaphragm (209) that are used for filtering miscellaneous light, interval 25.4mm between third lens (207) and diaphragm (209), diaphragm opening diameter is 6mm to the near infrared light facula that makes near infrared light beam produce on the working face covers the visual field of formation of image.
8. The external dual-light-source colposcopic imaging system of claim 1, wherein: the near-infrared light source (201) is connected with a driving circuit (204) for adjusting the output power of the near-infrared light source (201).
9. The external dual-light-source colposcopic imaging system of claim 1, wherein: the bottom of the colposcope body (101) is fixedly provided with a bracket (107).
10. External two light source colposcope imaging system which characterized in that: the external colposcope system comprises an imaging system (100), a light source system (200) and a data processing system (300), wherein the imaging system (100) comprises an external colposcope body (101) used for acquiring images and an image acquisition unit (110); the light source system (200) comprises a near-infrared light source (201) and an LED white light source (202), a near-infrared light lens group and a visible light lens group are respectively arranged on light paths of the near-infrared light source (201) and the LED white light source (202), and after being shaped by the lens groups, light beams emitted by the near-infrared light source (201) and the LED white light source (202) are respectively superposed with the imaging center of the colposcope body (101) at the center, so that the colposcope body (101) can simultaneously acquire visible light images and near-infrared fluorescence images; the image acquisition unit (110) comprises a light splitter (113), a color image sensor (114) and a near-infrared image sensor (115), wherein the light splitter (113) splits received light into visible light and near-infrared fluorescence and is received by the color image sensor (114) and the near-infrared image sensor (115) respectively; the data processing system (300) is connected with the image acquisition unit (110), and the data processing system (300) comprises a first display unit for displaying a color image formed by visible light received by the color image sensor (114), a second display unit for displaying a near infrared fluorescence image formed by near infrared fluorescence received by the near infrared image sensor (115), an image synthesizer for synthesizing the visible light color image and the near infrared fluorescence image into a visible light-fluorescence fused image, and a third display unit for displaying the visible light-fluorescence fused image.
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