CN210304350U - Nano-grade liquid drop distribution device based on wettability partition structure - Google Patents
Nano-grade liquid drop distribution device based on wettability partition structure Download PDFInfo
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- CN210304350U CN210304350U CN201920833444.1U CN201920833444U CN210304350U CN 210304350 U CN210304350 U CN 210304350U CN 201920833444 U CN201920833444 U CN 201920833444U CN 210304350 U CN210304350 U CN 210304350U
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- 239000007788 liquid Substances 0.000 title claims abstract description 29
- 238000009826 distribution Methods 0.000 title claims abstract description 24
- 238000005192 partition Methods 0.000 title claims description 13
- 238000006073 displacement reaction Methods 0.000 claims abstract description 104
- 230000035939 shock Effects 0.000 claims abstract description 7
- 239000011550 stock solution Substances 0.000 claims abstract description 5
- 238000013016 damping Methods 0.000 claims description 21
- 238000000203 droplet dispensing Methods 0.000 claims description 8
- 238000009736 wetting Methods 0.000 claims description 8
- 238000007789 sealing Methods 0.000 claims description 3
- 238000002347 injection Methods 0.000 abstract description 9
- 239000007924 injection Substances 0.000 abstract description 9
- 238000009776 industrial production Methods 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 230000003075 superhydrophobic effect Effects 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
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Abstract
The utility model discloses a receive upgrading liquid drop distributor based on wettability subregion structure, including the shock attenuation platform, be fixed with the second connecting plate on the shock attenuation platform, be fixed with the electronic displacement platform of X axle on the second connecting plate, the electronic displacement platform of X axle is fixed with first connecting plate, be fixed with the electronic displacement platform of Y axle on the first connecting plate, the electronic displacement platform of Y axle is fixed with the third connecting plate, be fixed with the electronic displacement platform of Z axle on the third connecting plate, the electronic displacement platform of Z axle is fixed with the objective table, be fixed with the manual displacement platform of Y axle on the shock attenuation platform, the manual displacement platform of X axle and the manual displacement platform of Z axle, the manual displacement platform of Z axle is fixed with the fourth connecting plate, be fixed with the syringe needle holder on the fourth connecting plate, be provided with the distribution syringe needle on the syringe needle holder, still be provided with high-precision injection pump and stock solution bottle on the shock attenuation platform. The device can realize high-efficiency automatic distribution of nano-grade liquid drops; in addition, the structure is simple, the operation is convenient, and the industrial production can be realized.
Description
Technical Field
The utility model belongs to the technical field of liquid automatic processing equipment, concretely relates to receive upgrading liquid drop distributor based on wetting partition structure.
Background
Nanoliter volume droplet dispensing is becoming increasingly important in biomedical, chemical, material synthesis, and microfluidic applications. At present, the most common droplet dispensing techniques mainly include contact dispensing techniques and non-contact dispensing techniques. For the distribution of nano-grade liquid drops, the contact type dispensing technology is high in speed, but low in precision; the non-contact type dispensing technology can meet the requirements of high precision and high efficiency at the same time, but is expensive. Therefore, there is a need to develop a nanoliter-scale droplet dispensing technique that is cost effective while meeting the requirements in terms of both accuracy and efficiency.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a receive upgrading liquid drop distributor based on wetting partition structure can realize receiving upgrading liquid drop high accuracy, efficient automatic distribution.
The utility model adopts the technical proposal that a nano-grade liquid drop distribution device based on a wettability partition structure comprises a damping table, a second connecting plate is fixed on the damping table, an X-axis electric displacement table is fixed on the second connecting plate, a first connecting plate is fixed on a carrying block of the X-axis electric displacement table, a Y-axis electric displacement table is fixed on the first connecting plate through an inner hexagon bolt, a third connecting plate is fixed on the carrying block of the Y-axis electric displacement table through an inner hexagon bolt, a Z-axis electric displacement table is fixed on the third connecting plate through an inner hexagon bolt, an L-shaped carrying block is fixed on the carrying block of the Z-axis electric displacement table through a bolt, a Y-axis manual displacement table is fixed on the damping table through an inner hexagon bolt, an X-axis manual displacement table is fixed on the carrying block of the Y-axis manual displacement table through an inner hexagon bolt, an L-shaped connecting plate is fixed on the X-axis manual displacement table through an inner hexagon bolt, l type connecting plate is fixed with Z axle manual displacement platform through hexagon socket head cap screw, there is the fourth connecting plate through hexagon socket head cap screw vertical fixation on the year thing piece of Z axle manual displacement platform, be fixed with the syringe needle holder on the fourth connecting plate, be provided with the distribution syringe needle on the syringe needle holder, still be provided with high-accuracy syringe pump and stock solution bottle on the shock attenuation bench, high-accuracy syringe pump respectively with the distribution syringe needle, the stock solution bottle passes through plastic hose sealing connection, X axle electric displacement platform, Y axle electric displacement platform and Z axle electric displacement platform all have the controller through cable junction, the controller passes through the direct string mouthful line of RS232 and is connected with computer COM mouth.
The utility model is also characterized in that,
a supporting table is further fixed on the damping table, an industrial camera is fixed on the supporting table through a camera support, and the industrial camera is connected with the microscope lens through threads.
The damping table and the supporting table are fixed through bolts.
The industrial camera is connected with the USB port of the computer through a cable.
The high-precision injection pump is connected with a COM port of a computer through an RS-232 direct serial port line.
The second connecting plate is fixed on the vibration reduction table through four inner hexagon bolts, and the X-axis electric displacement table is fixed on the second connecting plate through the inner hexagon bolts.
The utility model has the advantages that,
the device simple structure, with low costs, convenient operation can realize industrial production, can combine together wetting subregion structure and robot technology, realizes the high accuracy of nano-liter level liquid drop, high efficiency automatic distribution, still can realize more efficient liquid drop distribution through the mode that increases distribution syringe needle quantity.
Drawings
Fig. 1 is a schematic structural diagram of a nano-grade droplet dispensing device based on a wetting partition structure according to the present invention.
In the figure, 1, a high-precision injection pump, 2, a liquid storage bottle, 3, a plastic hose, 4, a fourth connecting plate, 5, a needle holder, 6, a distribution needle, 7, a microscope lens, 8, a camera bracket, 9, an industrial camera, 10, a supporting table, 11, a sample, 12, an objective table, 13, a Z-axis electric displacement table, 14, a third connecting plate, 15, a Y-axis electric displacement table, 16, a first connecting plate, 17, a damping table, 18, an X-axis electric displacement table, 19, a second connecting plate, 20, a Z-axis manual displacement table, 21, an L-shaped connecting plate, 22, an X-axis manual displacement table and 23, a Y-axis manual displacement table are arranged.
Detailed Description
The present invention will be described in detail with reference to the accompanying drawings and specific embodiments.
The utility model relates to a nanometer upgrade liquid drop distributor based on wettability partition structure, as shown in figure 1, comprising a damping table 17, a second connecting plate 19 is fixed on the damping table 17, the second connecting plate 19 is fixed on the damping table 17 through four hexagon socket head cap screws, an X-axis electric displacement table 18 is fixed on the second connecting plate 19, a threaded hole is opened on the second connecting plate 19, the X-axis electric displacement table 18 is fixed on the second connecting plate 19 through hexagon socket head cap screws, the axial direction of the X-axis electric displacement table 18 is parallel to the length direction of the damping table 17, a first connecting plate 16 is fixed on a carrying block of the X-axis electric displacement table 18, a Y-axis electric displacement table 15 is fixed on the first connecting plate 16 through hexagon socket head cap screws, the axial direction of the Y-axis electric displacement table 15 is perpendicular to the axial direction of the X-axis electric displacement table 18, a third connecting plate 14 is fixed on the carrying block of the Y-axis electric displacement table 15 through hexagon socket head cap screws, a Z-axis electric displacement table 13 is fixed on the third connecting plate 14 through an inner hexagon bolt, the axial direction of the Z-axis electric displacement table 13 is vertical to the damping table 17, and an L-shaped objective table 12 is fixed on an objective block of the Z-axis electric displacement table 13 through a bolt;
the carrier block of the X-axis electric displacement table 18 can move in the X-axis direction, the carrier block of the Y-axis electric displacement table 15 can move in the Y-axis direction, and the carrier block of the Z-axis electric displacement table 15 can move in the Z-axis direction; the X-axis electric displacement table 18, the Y-axis electric displacement table 15 and the Z-axis electric displacement table 13 are combined into a three-dimensional electric displacement platform;
a Y-axis manual displacement table 23 is fixed on the damping table 17 through inner hexagonal bolts, an X-axis manual displacement table 22 is fixed on a carrying block of the Y-axis manual displacement table 23 through inner hexagonal bolts, the axial direction of the X-axis manual displacement table 22 is vertical to the axial direction of the Y-axis manual displacement table 23, an L-shaped connecting plate 21 is fixed on the X-axis manual displacement table 22 through inner hexagonal bolts, a Z-axis manual displacement table 20 is fixed on the L-shaped connecting plate 21 through inner hexagonal bolts, a fourth connecting plate 4 is vertically fixed on the carrying block of the Z-axis manual displacement table 20 through inner hexagonal bolts, a needle head holder 5 is horizontally fixed on the fourth connecting plate 4, and a distribution needle head 6 is arranged on the needle head holder 5; the dispensing needle 6 can be provided in plurality;
the X-axis manual displacement table 22, the Y-axis manual displacement table 23 and the Z-axis manual displacement table 20 are combined into a three-dimensional manual displacement platform which can move along the directions of an X axis, a Y axis and a Z axis;
a supporting table 10 is further fixed on the damping table 17, an industrial camera 9 is fixed on the supporting table 10 through a camera support 8, and the industrial camera 9 is connected with the microscope lens 7 through threads; the damping table 17 and the support table 10 are fixed through bolts;
the shock absorption table 17 is also provided with a high-precision injection pump 1 and a liquid storage bottle 2, and the high-precision injection pump 1 is respectively connected with the distribution needle 6 and the liquid storage bottle 2 in a sealing way through plastic hoses 3;
the X-axis electric displacement table 18, the Y-axis electric displacement table 15 and the Z-axis electric displacement table 13 are all connected with a controller through cables;
the high-precision injection pump 1 is connected with a COM port of a computer through an RS-232 direct serial port line;
the controller is a four-channel servo controller carried by an electric displacement platform manufacturer, the controller is connected with a COM port of a computer through an RS232 direct serial port line, and the industrial camera 9 is connected with the computer through a self-carried cable (a USB port).
The X-axis electric displacement table 18, the Y-axis electric displacement table 15 and the Z-axis electric displacement table 13 all drive the carrying block to realize reciprocating linear motion through the ball screw driven by the direct current motor, and the main parameters are as follows: the stroke is 25mm, the maximum speed is 20mm/s, and the minimum displacement is 0.2 mu m;
the manufacturers of the X-axis electric displacement table 18, the Y-axis electric displacement table 15 and the Z-axis electric displacement table 13 are both Germany Physik Instrument GmbH & Co.KG with the model of M-122.2 DD;
the manufacturer of the controller is German Physik Instrument GmbH & Co.KG, and the model is C-884.4 DB;
the production producers of the X-axis manual displacement table 22, the Y-axis manual displacement table 23 and the Z-axis manual displacement table 20 are all Beijing Zhuoli Han worker instruments Co., Ltd, and the model is PSM25-65 SR;
the production manufacturer of the high-precision injection pump 1 is a Tecan Group of Switzerland, and the model is XCalibur;
the production manufacturer of the industrial camera 9 is Point Grey GmbH & Co.KG, Canada, and the model is GS3-U3-23S 6M;
the producer of the microscope lens 7 is the American Edmund Optics GmbH & Co. KG, with the model number of VZM1000 i;
the utility model relates to a receive upgrading liquid drop distributor based on wetting partition structure, its concrete theory of operation is:
manufacturing a sample with a wettability partition structure according to a preparation process, and dividing the surface of the sample into a hydrophilic area and a super-hydrophobic area; mounting prepared sample 11 on stage 12; after the driving programs of the X-axis electric displacement table 18, the Y-axis electric displacement table 15, the Z-axis electric displacement table 13 and the high-precision injection pump 1 are installed on a computer, the corresponding hardware can be controlled independently by operating under respective control software panels, the controller controls the electric displacement tables to control the X-axis electric displacement table 18, the Y-axis electric displacement table 15 and the Z-axis electric displacement table 13, so that the object stage 12 moves in X, Y and Z dimensions, and the high-precision injection pump 1 conveys liquid in a liquid storage bottle to a distribution needle and forms mother liquid drops. The three manual displacement tables are manually controlled, the overall position of the three-dimensional manual displacement platform can be adjusted by changing the placing position of the Y-axis manual displacement table 23 on the damping table 17, then the positions of all the axes are manually adjusted to fix the distribution needle 6, and the distribution needle 6 is ensured to be kept still in the liquid drop distribution process, so that the three-dimensional electric displacement platform can do relative motion to complete liquid drop distribution, the object stage 12 can be driven to do relative motion by controlling the movement of all the axes of the three-dimensional electric displacement platform, and when mother liquid drops pass through a hydrophilic area on the surface, a sub liquid drop with a determined volume can be distributed in the hydrophilic area; for the other regions, no droplets are dispensed due to their superhydrophobic character; the movement of the object stage 12 is controlled to enable the mother liquid drops to sequentially and rapidly pass through all hydrophilic positions on the sample, so that sub liquid drops with determined volumes can be respectively distributed on all hydrophilic areas, and the high-precision and high-efficiency automatic distribution of nano-liter liquid drops is completed. The industrial camera 9 and the microscope lens 7 are mainly responsible for real-time monitoring and observing the dispensing result (taking a picture of the dispensed droplets, then calculating the volume of the droplets in matlab, and verifying the dispensing result).
Claims (6)
1. The nano-upgrading liquid drop distribution device based on the wettability partition structure is characterized by comprising a damping table (17), wherein a second connecting plate (19) is fixed on the damping table (17), an X-axis electric displacement table (18) is fixed on the second connecting plate (19), a first connecting plate (16) is fixed on a carrying block of the X-axis electric displacement table (18), a Y-axis electric displacement table (15) is fixed on the first connecting plate (16) through inner hexagonal bolts, a third connecting plate (14) is fixed on a carrying block of the Y-axis electric displacement table (15) through inner hexagonal bolts, a Z-axis electric displacement table (13) is fixed on the third connecting plate (14) through inner hexagonal bolts, an L-shaped carrying block (12) is fixed on the carrying block of the Z-axis electric displacement table (13) through bolts, and a Y-axis manual displacement table (23) is fixed on the damping table (17) through inner hexagonal bolts, there are manual displacement platform of X axle (22) through hexagon socket head cap screw on the thing piece of carrying of the manual displacement platform of Y axle (23), there are L type connecting plate (21) through hexagon socket head cap screw on the manual displacement platform of X axle (22), L type connecting plate (21) are fixed with manual displacement platform of Z axle (20) through hexagon socket head cap screw, it has fourth connecting plate (4) to vertically be fixed with through hexagon socket head cap screw on the thing piece of carrying of the manual displacement platform of Z axle (20), be fixed with syringe needle holder (5) on fourth connecting plate (4), be provided with distribution syringe needle (6) on syringe needle holder (5), still be provided with high-precision syringe pump (1) and stock solution bottle (2) on shock attenuation platform (17), high-precision syringe pump (1) pass through plastic hose (3) sealing connection with distribution syringe needle (6), stock solution bottle (2) respectively, X axle electric displacement platform (18), The Y-axis electric displacement table (15) and the Z-axis electric displacement table (13) are both connected with a controller through cables, and the controller is connected with a COM port of a computer through an RS232 direct serial port line.
2. The device for dispensing nano-liter-grade liquid drops based on the wettability partition structure is characterized in that a supporting table (10) is further fixed on the damping table (17), an industrial camera (9) is fixed on the supporting table (10) through a camera bracket (8), and the industrial camera (9) is connected with the microscope lens (7) through threads.
3. The nano-liter-scale droplet dispensing apparatus based on a wetting partition structure of claim 2, wherein the damping table (17) and the support table (10) are fixed by bolts.
4. A nano-liter droplet dispensing apparatus based on a wettability zone structure according to claim 2, wherein said industrial camera (9) is connected to a computer USB port by a cable.
5. A nano-liter droplet dispensing apparatus based on a wetting zone structure according to claim 1, characterized in that the high precision syringe pump (1) is connected to a computer COM port by RS-232 direct serial line.
6. The nanoliter droplet dispensing apparatus based on a wetting partition structure, according to claim 1, wherein the second connecting plate (19) is fixed on the vibration damping table (17) by four hexagon socket head cap screws, and the X-axis electric displacement table (18) is fixed on the second connecting plate (19) by hexagon socket head cap screws.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920833444.1U CN210304350U (en) | 2019-06-04 | 2019-06-04 | Nano-grade liquid drop distribution device based on wettability partition structure |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920833444.1U CN210304350U (en) | 2019-06-04 | 2019-06-04 | Nano-grade liquid drop distribution device based on wettability partition structure |
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| Publication Number | Publication Date |
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| CN210304350U true CN210304350U (en) | 2020-04-14 |
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| CN201920833444.1U Expired - Fee Related CN210304350U (en) | 2019-06-04 | 2019-06-04 | Nano-grade liquid drop distribution device based on wettability partition structure |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110252592A (en) * | 2019-06-04 | 2019-09-20 | 陕西科技大学 | A kind of nanoliter level liquid droplet distribution device and method based on wetability partitioned organization |
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2019
- 2019-06-04 CN CN201920833444.1U patent/CN210304350U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110252592A (en) * | 2019-06-04 | 2019-09-20 | 陕西科技大学 | A kind of nanoliter level liquid droplet distribution device and method based on wetability partitioned organization |
| CN110252592B (en) * | 2019-06-04 | 2021-03-16 | 陕西科技大学 | Nano-liter-level liquid drop distribution device and method based on wettability partition structure |
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Granted publication date: 20200414 |