CN210261774U - Bioreactor's exhaust apparatus - Google Patents
Bioreactor's exhaust apparatus Download PDFInfo
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- CN210261774U CN210261774U CN201920930529.1U CN201920930529U CN210261774U CN 210261774 U CN210261774 U CN 210261774U CN 201920930529 U CN201920930529 U CN 201920930529U CN 210261774 U CN210261774 U CN 210261774U
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- respirator
- bioreactor
- defoaming
- defoaming tank
- tank
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Abstract
The utility model discloses an exhaust apparatus of a bioreactor, which belongs to the technical field of bioreactors. The utility model discloses exhaust apparatus mainly comprises pipeline, defoaming filling tank, respirator, and defoaming jar gas outlet passes through the pipe connection with the respirator air inlet, be provided with on the pipeline and press from both sides the cover, it has the comdenstion water import to press from both sides the cover lower extreme, and there is the comdenstion water export upper end. Gas or foam discharged in the culture process of the reactor firstly enters the defoaming tank, the foam is crushed and defoamed in the tank to form liquid, and the gas is discharged from the respirator through a pipeline. The utility model discloses can effectively solve bioreactor at the cell culture in-process because discharge gas's water content is too high or the problem of foam jam respirator to can the maximize utilize the reactor cultivate the volume, save manufacturing cost and improve production efficiency.
Description
Technical Field
The utility model belongs to the technical field of bioreactor, concretely relates to bioreactor's exhaust apparatus.
Background
At present, the device for solving the problem of the exhaust system of the reactor mainly comprises an electric heating sleeve heating respirator or a condensing device arranged on an exhaust pipeline. The heating device mainly ensures that water vapor generated during air exhaust is not easy to condense when passing through the respirator, and the condensing device mainly ensures that gas is condensed into liquid as soon as possible before passing through the respirator and does not pass through the respirator. The two devices have certain effect on solving the problem of filter element blockage in the culture production, but have no obvious effect on a reaction system with large gas demand in the culture process, particularly on the condition of generating a large amount of foam without using a defoaming agent. Great inconvenience is caused to production, and even potential safety hazards exist.
SUMMERY OF THE UTILITY MODEL
The utility model aims at effectively solving the problem that the breather is blocked due to the generation of a large amount of water vapor and foam in the process of reactor culture. Use the utility model discloses reactor exhaust apparatus can effectually prevent steam and foam jam respirator problem, practices thrift manufacturing cost, improves work efficiency.
The utility model provides an exhaust device matched with a reactor, which comprises a defoaming tank, a respirator and a pipeline; wherein the upper end of the defoaming tank is provided with a defoaming tank air inlet, a defoaming tank air outlet and an auxiliary agent feed inlet; a liquid outlet is arranged at the bottom of the defoaming tank; the respirator is an electric heating respirator, the bottom of the respirator is provided with a respirator air inlet and a respirator condensed water outlet, and the lower end of the respirator is provided with a respirator air outlet; the air outlet of the defoaming tank is connected with the air inlet of the respirator through a pipeline, the pipeline is provided with a jacket, the lower end of the jacket is provided with a condensed water inlet, and the upper end of the jacket is provided with a condensed water outlet.
The water vapor or foam generated by the exhaust of the reactor firstly enters the defoaming tank through the stainless steel pipeline, the foam is crushed into liquid in the tank, and the gas is fully heated and then discharged from the respirator.
The utility model discloses an in an embodiment, the upper end of defoaming jar still is provided with the auxiliary agent feed inlet. And additional auxiliaries such as a defoaming agent and the like can be added into the defoaming tank without influencing the reaction in the reactor.
The utility model discloses connect aseptic stock solution bucket at the liquid outlet. Prevent the defoaming from filling liquid level too high and discharging the defoaming filling liquid.
The utility model discloses be provided with sight glass and rupture disk on the defoaming jar. Wherein the sight glass is convenient for observe the inside foam condition of defoaming jar. The rupture disk prevents that defoaming jar pressure is greater than jar design pressure safety device.
The utility model discloses be provided with the cleaning ball at defoaming tank deck portion. The cleaning ball is convenient for cleaning the tank wall in the tank.
In an embodiment of the present invention, the viewing mirror is fixed on the cover through stainless steel by pressure-resistant glass and connected with the defoaming tank.
In an embodiment of the present invention, the liquid discharge port of the defoaming tank can be connected to a sterile liquid storage barrel. Avoid the liquid level in the defoaming jar too high.
In one embodiment of the present invention, the respirators are multiple groups of parallel respirators.
In one embodiment of the present invention, the heating jacket in the respirator is an electrical heating blanket.
In an embodiment of the present invention, the pipeline is a stainless steel pipeline.
In one embodiment of the present invention, the conduit is sealed with the breather and the defoaming tank by O-rings.
The utility model discloses at least, have following one kind effect:
compared with the prior art, the utility model, the bubble of reactor can take place effectual broken defoaming through the defoaming jar, then gaseous rethread pipeline advances the respirator and discharges, and wherein the respirator has electrical heating, has to encrypt on the pipeline and closes the cover that presss from both sides, and it has the comdenstion water inlet to press from both sides the cover below, and there is the comdenstion water delivery port upper end, plays the effect of condensation. Therefore, the air bubbles in the reaction system with large demand are broken more thoroughly, the exhaust of the reactor is smoother, and the respirator is not damaged.
The utility model discloses can make the reactor exhaust more unobstructed, the difficult jam of exhaust filter core, effectually prevent that the reactor from producing the foam and causing the problem of exhausting smoothly or blockking up the respirator when exhausting in the cultivation process.
This device can realize and sterilize with the reactor autoclaving together or sterilize alone, and the defoaming jar also can sterilize alone with the multiunit group calling aspirator, has realized that emergency does not also influence production in production. Can carry out the CIP washing alone, realize the cleanness of pipeline and liquid storage pot and do not have the residue.
Additionally, the utility model discloses can add extra auxiliaries such as defoaming agent and carry out the processing of reaction bubble, not influence the reaction in the reactor.
Drawings
FIG. 1 is a schematic view of the internal structure of a bioreactor exhaust apparatus of the present invention; wherein, 1 defoaming and filling; 2, an air outlet of the defoaming tank; 3, an air inlet of a defoaming tank; 4, a breather air outlet; 5, a condensed water outlet; 6, a feeding hole; 7 a condensed water inlet; 8 liquid outlet; 9 a respirator condensed water outlet; 10 respirator air inlet; 11 a pipeline; 12 a respirator; 13 jacket.
FIG. 2 is a schematic diagram of the defoaming tank in the exhaust apparatus of the bioreactor of the present invention; wherein, 14 the cleaning ball; 15 view mirrors; 16 rupture discs.
FIG. 3 is a schematic view of a respirator in a bioreactor exhaust apparatus of the present invention; wherein, 17 respirator vent; 18 an electrically heated jacket; 19 a filter element.
Detailed Description
To achieve the above objects, features and advantages and in accordance with the purpose of the invention, as embodied and broadly described herein, the present invention will be described in detail with reference to the accompanying drawings.
The invention is further described below with reference to the accompanying drawings:
fig. 1 is a schematic view of the internal structure of the present invention; wherein, 1 defoaming and filling; 2, an air outlet of the defoaming tank; 3, an air inlet of a defoaming tank; 4, a breather air outlet; 5, a condensed water outlet; 6, an auxiliary agent feeding hole; 7 a condensed water inlet; 8 liquid outlet; 9 a respirator condensed water outlet; 10 respirator air inlet.
To achieve the above objects, features and advantages and in accordance with the purpose of the invention, as embodied and broadly described herein, the present invention will be described in detail with reference to the accompanying drawings.
The invention is further described below with reference to the accompanying drawings:
as shown in fig. 1, the utility model comprises a defoaming tank 1, a respirator 12 and a pipeline 11; wherein the upper end of the defoaming tank 1 is provided with a defoaming tank air inlet 3, a defoaming tank air outlet 2 and an auxiliary agent feed inlet 6; a liquid outlet 8 is arranged at the bottom of the defoaming tank; the respirator 12 is an electric heating respirator, the bottom of the respirator 12 is provided with a respirator air inlet 10 and a respirator condensed water outlet 9, and the upper end of the respirator 12 is provided with a respirator air outlet 4; an air outlet 2 of the defoaming tank is connected with an air inlet 10 of the respirator through a pipeline, a jacket 13 is arranged on the pipeline 11, a condensed water inlet 7 is arranged at the lower end of the jacket, and a condensed water outlet 5 is arranged at the upper end of the jacket.
The utility model discloses still can irritate continuous nonrust steel pipeline at respirator and defoaming and add airtight clamp cover, it has the water inlet to press from both sides the cover below, and there is the delivery port upper end, plays the effect of condensation.
The utility model discloses can connect aseptic defoaming agent at auxiliary agent feed inlet 6, can irritate for the defoaming and add additional auxiliary agents such as defoaming agent, do not influence the reaction in the reactor.
The utility model discloses still can connect aseptic stock solution bucket at the discharge gate, prevent that the defoaming from irritating the liquid level too high, liquid is irritated in the discharge defoaming.
The utility model discloses still can be provided with sight glass 15 and rupture disk 16 on the defoaming jar, wherein the inside foam condition of defoaming jar is convenient for observe by the sight glass. The rupture disk prevents that defoaming jar pressure is greater than jar design pressure safety device.
The utility model discloses still can also be provided with cleaning ball 14 at defoaming tank deck portion, the inside tank wall of washing jar is convenient for to the cleaning ball.
The utility model discloses a 12 except that respirator air inlet 10 of respirator, respirator gas outlet 4 still include 18 electrical heating cover, 19 filter cores and 17 respirator gas vents. Wherein the respirator vent 17 is available for venting during autoclaving.
Compared with the prior art, the utility model, the bubble in the reactor can take place broken defoaming irritating through the defoaming, then discharge from the respirator again, and the respirator has the electric heating blanket, and the below still can add nonrust steel pipeline with airtight clamp cover, and it has the water inlet to press from both sides the cover below, and there is the delivery port upper end. The condensation function is realized. The more thorough breakage of the bubbles enables the reactor to exhaust more smoothly.
The protection scope of the present invention is not limited to the above embodiments, and any modifications, equivalent replacements, and improvements that can be made by a person skilled in the art within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. An exhaust device of a bioreactor is characterized by comprising a defoaming tank, a respirator and a pipeline; wherein the upper end of the defoaming tank is provided with a defoaming tank air inlet, a defoaming tank air outlet and an auxiliary agent feed inlet; a liquid outlet is arranged at the bottom of the defoaming tank; the respirator is an electric heating respirator, the bottom of the respirator is provided with a respirator air inlet and a respirator condensed water outlet, and the upper end of the respirator is provided with a respirator air outlet; the defoaming tank gas outlet and the respirator gas inlet are connected through a pipeline, a jacket is arranged on the pipeline, a condensed water inlet is arranged at the lower end of the jacket, and a condensed water outlet is arranged at the upper end of the jacket.
2. The exhaust device of the bioreactor according to claim 1, wherein the defoaming tank is further provided with an additive feeding hole at the upper end.
3. The exhaust apparatus of bioreactor according to claim 1 or 2, wherein the defoaming tank is further provided with a sight glass at the upper end thereof.
4. The exhaust apparatus of bioreactor according to claim 1, wherein the defoaming tank is further provided with a rupture disk at the upper end.
5. The exhaust apparatus of a bioreactor according to claim 1, wherein the liquid outlet of the defoaming tank is connected to a sterile liquid storage barrel.
6. The bioreactor exhaust system according to claim 1, wherein the plurality of parallel connected respirators.
7. The bioreactor exhaust apparatus according to claim 1, wherein the upper end of the respirator is provided with an exhaust port.
8. The bioreactor exhaust system according to claim 1, wherein the conduit is a stainless steel conduit.
9. The bioreactor exhaust apparatus according to claim 1, wherein the defoaming tank is provided at an upper end thereof with a cleaning ball.
10. The bioreactor exhaust system according to claim 1, wherein the tubing is sealed to the breather and antifoam tank by O-rings.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920930529.1U CN210261774U (en) | 2019-06-19 | 2019-06-19 | Bioreactor's exhaust apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920930529.1U CN210261774U (en) | 2019-06-19 | 2019-06-19 | Bioreactor's exhaust apparatus |
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| Publication Number | Publication Date |
|---|---|
| CN210261774U true CN210261774U (en) | 2020-04-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201920930529.1U Active CN210261774U (en) | 2019-06-19 | 2019-06-19 | Bioreactor's exhaust apparatus |
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| CN (1) | CN210261774U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115634642A (en) * | 2021-07-19 | 2023-01-24 | 河北大景大搪化工设备有限公司 | Chlorinated fatty acid methyl ester reaction tower and preparation device formed by same |
-
2019
- 2019-06-19 CN CN201920930529.1U patent/CN210261774U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115634642A (en) * | 2021-07-19 | 2023-01-24 | 河北大景大搪化工设备有限公司 | Chlorinated fatty acid methyl ester reaction tower and preparation device formed by same |
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