CN210205582U - Oral cavity device of dosing - Google Patents
Oral cavity device of dosing Download PDFInfo
- Publication number
- CN210205582U CN210205582U CN201920372588.1U CN201920372588U CN210205582U CN 210205582 U CN210205582 U CN 210205582U CN 201920372588 U CN201920372588 U CN 201920372588U CN 210205582 U CN210205582 U CN 210205582U
- Authority
- CN
- China
- Prior art keywords
- oral
- mold
- movable mechanism
- drug
- delivery device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Medicinal Preparation (AREA)
Abstract
The utility model provides an oral cavity drug delivery device, which comprises a fixed mechanism and a movable mechanism, wherein the fixed mechanism and the movable mechanism are combined with each other through a magnetic force or a buckle structure; the fixing mechanism is fixed on the false tooth, the tooth socket device or the oral implant; a medicine layer is arranged in the movable mechanism. The oral cavity administration device of the utility model has simple structure, and when the administration is needed, the movable mechanism can be firmly arranged on the fixed mechanism at any time, so that active substances such as medicines and the like can be released, the treatment and/or health care functions are realized, and the detention time of the preparation on the surface of the mucous membrane is prolonged; the movable mechanism can be detached from the fixed mechanism through external force to stop administration, and the medicine taking device is convenient to use, low in cost and wide in application prospect.
Description
Technical Field
The utility model relates to a device of dosing, specifically speaking relate to a device of dosing in oral cavity.
Background
The oral mucosa drug delivery system is a novel drug delivery system developed in recent years, and refers to a preparation which is used for the drug to generate an adhesion effect with the oral mucosa by means of an adhesive high molecular polymer, so that the drug is released and absorbed by the oral mucosa to directly enter the systemic circulation, the enzyme metabolism and acid degradation of the gastrointestinal tract and the first pass effect of the liver are avoided, and the bioavailability of the drug is improved to perform local or systemic treatment and prevention. The oral mucosa drug delivery system has the characteristics of biological adhesion, convenient use, long acting period, quick response and the like, can be used for treating oral diseases, and can also be applied to the treatment and diagnosis of systemic diseases, such as cardiovascular diseases, diabetes, pain relief, sedation, anesthesia, antiemetic and the like.
The oral mucosa adhesive preparation is mainly absorbed through oral mucosa, the oral mucosa has good permeability and rich blood flow, when the adhesive preparation acts on the oral mucosa, the mucosa layer can be contacted with a swelling polymer material, the molecular chain segment of the adhesive material is embedded into the intercellular space or mutually penetrates with the adhesive chain segment in the mucus, and the polymer and the mucosa are tightly combined together through the comprehensive actions of mechanical embedding, covalent bond, electrostatic attraction, van der waals force, hydrogen bond, hydrophobic bond and the like. The material can be adhered to the surface of oral epithelial cells or the surface of mucin, the residence time of the medicine in the oral cavity is prolonged by increasing the contact time of the medicine and the oral mucosa, the osmosis of the medicine in the oral cavity is improved, the absorption efficiency of the medicine is promoted, the release of the medicine is prolonged, and meanwhile, the oral mucosa has strong stimulation tolerance capability and large capacity, and when the oral mucosa meets unfavorable conditions, an oral administration system is easy to remove to stop administration.
Currently, the usual oromucosal delivery systems exist mainly in the form of: the preparation is characterized by comprising oral cavity adhesive sheets, adhesive ointments, oral cavity adhesive films, gels and the like, wherein pores are formed by mechanical punching or laser punching to control the release of the medicine, the process is complex, the requirement on equipment is high, the adhesion effect generated by high polymer pharmaceutic adjuvants on oral mucosa is not very firm due to insufficient adhesion force of the high polymer pharmaceutic adjuvants on the oral mucosa, the patches are easy to fall off during oral cavity movement, the retention time is short, and the sustained therapeutic effect cannot be achieved. Therefore, how to increase the adhesion of the preparation to the mucosa and prolong the residence time of the preparation on the mucosal surface is an important problem to be solved in the dosage forms.
SUMMERY OF THE UTILITY MODEL
One of the purposes of the invention is to provide an oral cavity drug delivery device, which solves the problems of poor adhesion, easy falling off and short retention time of the existing oral cavity drug delivery device.
Another object of the present invention is to provide a method for preparing an oral administration device, which is capable of being slowly released into the oral cavity, rapidly absorbed, reduced in the influence of gastric emptying, and improved in the bioavailability of the drug.
It is a further object of the present invention to provide a method of using an oral delivery device.
One of the objects of the invention is achieved by:
an oral cavity drug delivery device comprises a fixed mechanism and a movable mechanism, wherein the fixed mechanism and the movable mechanism are combined with each other through a magnetic force or a buckle structure; the fixing mechanism is fixed on the false tooth, the tooth socket device or the oral implant; a medicine layer is arranged in the movable mechanism.
When the fixing mechanism and the moving mechanism are combined with each other through a snap structure, the snap structure may be a structure known to those skilled in the art.
When the fixed mechanism and the movable mechanism are combined with each other by a magnetic force, a magnetic material member, i.e., a magnetic element such as a magnet, is provided in the fixed mechanism, and a combination member (e.g., an iron piece) combined with the magnetic material member is provided in the movable mechanism.
Preferably, the fixing mechanism is a magnet, and the coupling member coupled to the magnetic material member in the moving mechanism is made of iron, cobalt, nickel, an alloy of at least two materials at an arbitrary ratio, or the like.
Preferably, the movable mechanism comprises a mold in which the drug layer is disposed and the coupling member, the mold being fixedly attached to the coupling member, such as by adhesive bonding, as is known to those skilled in the art.
When the fixed mechanism and the movable mechanism are combined with each other through magnetic force, a magnetic material part is arranged in the movable mechanism, and a combination part combined with the magnetic material part is arranged in the fixed mechanism.
The movable mechanism comprises a mold and the magnetic material component, i.e. the magnetic element such as a magnet, wherein the drug layer is arranged in the mold, and the mold is fixedly connected with the magnetic material component by a fixed connection manner known to those skilled in the art such as bonding.
Preferably, a drug layer and a photo-curing resin controlled release layer are arranged in the mold, and the photo-curing resin controlled release layer is arranged on the outer side of the drug layer; the medicine layer comprises an active medicine or a mixture layer of the active medicine and auxiliary materials; the photo-curing resin controlled release layer comprises a mixture of photo-curing resin and a pore-forming agent, and the mass ratio of the photo-curing resin to the pore-forming agent is 0.5: 1-100: 1.
More preferably, the mass ratio of the light-cured resin layer to the pore-foaming agent is 20: 1-10: 3.
Optionally, the mass ratio of the drug layer to the light-cured resin layer is 1: 1-1: 200.
Preferably, the mould is cylindrical, square channel or other shape and has an upper surface with a surface area of 5mm2~100 mm2The depth is 0.5-8 mm. The mold may be made of Polyethylene (PE), polyvinyl chloride (PVC), polypropylene (PP), Polystyrene (PS), Polytetrafluoroethylene (PTFE), and the like. Preferably, the mold is a cylindrical mold, the outer diameter of the cylindrical mold is 3-12 mm, and the height of the cylindrical mold is 2-8 mm.
The medicine layer comprises an active medicine or a mixture layer of the active medicine and auxiliary materials. Suitable drugs can be selected according to specific conditions, therapeutic effects and/or health care effects, etc., thereby playing a role in treating diseases or regulating body functions. The adjuvant can be pharmaceutically common adjuvants such as starch, lactose, microcrystalline cellulose, sucrose, etc.
When the medicine layer is a mixture layer of the active medicine and the auxiliary materials, the mass of the auxiliary materials contained in the mixture layer is preferably 2-200 mg.
Optionally, the drug layer is prepared by the following method: after the active drug is pulverized, the drug powder of the appropriate particle size is added directly to the mold.
Optionally, the drug layer is prepared by the following method: preparing the active drug and a volatile solvent into a solution of 0.005-50 mg/ml to obtain a drug solution, transferring the drug solution into the mold, and volatilizing the solvent.
Optionally, the drug layer is prepared by the following method: preparing the active medicine and a volatile solvent into a solution of 0.005-50 mg/ml, adding auxiliary materials, uniformly mixing, drying, and transferring into the mold.
Optionally, the drug layer is prepared by the following method: and uniformly mixing the active medicine powder and the auxiliary material powder, and transferring the mixture into the mold.
The volatile solvent can be one or a mixture of at least two of water, ethanol, methanol, ethyl acetate, dichloromethane, chloroform, etc. which can dissolve the medicine.
The photocuring resin controlled release layer can control the drug layer to release the drug in the forms of quick release, slow release, controlled release and the like by adjusting the thickness of the controlled release layer and the using amount of components such as a pore-forming agent and the like.
The pore-foaming agent has certain water solubility, and can be one pore-foaming agent or a mixture of at least two pore-foaming agents; preferably, the pore-forming agent is one or a mixture of at least two of polyethylene glycol (PEG 400), polyvinylpyrrolidone (PVP), tween 80, Poloxamer 188 (Poloxamer 188), sodium lauryl sulfate, lactose, sucrose, mannitol, fructose, glucose and the like mixed in any proportion.
The photo-curing resin controlled release layer is prepared by adopting the following method: dissolving the photocuring resin and a pore-foaming agent in a solvent according to a mass ratio of 0.5: 1-100: 1, uniformly mixing to obtain a mixture, injecting the mixture into the mold to volatilize the solvent, and curing to obtain the photocuring resin.
Preferably, the curing is performed under irradiation of a photo-curing machine.
The second purpose of the invention is realized by the following steps:
a method of making an oral delivery device comprising the steps of:
(a) arranging the fixing mechanism on a false tooth, a tooth socket device or an oral implant;
(b) preparing the movable mechanism:
(b-1) fixedly connecting the mold with the coupling part;
(b-2) weighing the active drug, adding the active drug into the mold, and preparing the drug layer; or weighing the active drug layer and the auxiliary materials, uniformly mixing to obtain a first mixture, and adding the first mixture into the mold to obtain the drug layer;
(b-3) weighing the photocuring resin, the pore-forming agent and the solvent, and uniformly mixing to obtain a second mixture;
(b-4) adding the second mixture above the drug layer in the mould, volatilizing the solvent, and curing and forming.
The die is cylindrical, square groove-shaped or other shapes, and the surface area of the upper surface of the die is 5mm2~100 mm2The depth is 0.5-8 mm. The mold may be made of Polyethylene (PE), polyvinyl chloride (PVC), polypropylene (PP), Polystyrene (PS), Polytetrafluoroethylene (PTFE), and the like. Preferably, the mold is a cylindrical mold, the outer diameter of the cylindrical mold is 3-12 mm, and the height of the cylindrical mold is 2-8 mm.
The medicine layer can be an active medicine layer or a mixture layer of the active medicine and auxiliary materials. The adjuvant can be pharmaceutically common adjuvants such as starch, lactose, microcrystalline cellulose, sucrose, etc.
Optionally, the mass ratio of the drug layer to the light-cured resin layer is 1: 1-1: 200.
When the medicine layer is a mixture layer of the active medicine and the auxiliary materials, the mass of the auxiliary materials contained in the mixture layer is preferably 2-200 mg. The active drug may be selected as appropriate depending on the particular condition, therapeutic effect and/or health effect, etc.
Optionally, the drug layer is prepared by the following method: the active agent is pulverized to a suitable particle size and the active agent powder is added directly to the mold.
Optionally, the drug layer is prepared by the following method: preparing the active drug and the volatile solvent into a solution of 0.005-50 mg/ml to obtain an active drug solution, and transferring the active drug solution into the mold to volatilize the volatile solvent.
Optionally, the drug layer is prepared by the following method: preparing the active drug and a volatile solvent into 0.005-50 mg/ml active drug solution, adding auxiliary materials into the active drug solution, uniformly mixing, drying, and transferring the active drug solution into the mold.
Optionally, the drug layer is prepared by the following method: and uniformly mixing the active medicament and the auxiliary materials, and transferring the mixture into the mold.
The volatile solvent can be one or a mixture of at least two of water, ethanol, methanol, ethyl acetate, dichloromethane, chloroform, etc. which can dissolve the medicine.
In the step (b-3), the solvent may be one or a mixture of at least two of water, ethanol, methanol, ethyl acetate, dichloromethane, chloroform, etc. which can dissolve the drug, in any ratio.
The pore-foaming agent has certain water solubility, and can be one pore-foaming agent or a mixture of at least two pore-foaming agents; preferably, the pore-forming agent is one or a mixture of at least two of polyethylene glycol (PEG 400), polyvinylpyrrolidone (PVP), tween 80, poloxamer 188, sodium lauryl sulfate, lactose, sucrose, mannitol, fructose, glucose and the like mixed in any proportion.
The third purpose of the invention is realized by the following steps:
an application method of an oral administration device comprises the steps of firstly arranging a fixing mechanism of the oral administration device on a false tooth, a tooth socket device or an oral implant; the movable mechanism of the oral delivery device described above is then combined with the fixed mechanism.
When the administration is not needed, the administration device can be removed from the denture, the mouthpiece device, or the oral implant with forceps.
The oral cavity drug delivery device is provided with the fixing mechanism and the movable mechanism which can be matched with each other, and the fixing mechanism is arranged in the oral cavity, so that a novel device convenient for drug delivery is provided. When the oral cavity biological adhesive preparation needs to be administered, the movable mechanism is combined with the fixed mechanism, the defects that the oral cavity mucosa adhesive action of the conventional oral cavity biological adhesive preparation is not firm and is easy to fall off in the state of oral cavity activity are overcome, the detention time of the preparation on the surface of the mucosa is prolonged, active substances such as medicaments and the like can be released, the medicaments can be absorbed through the oral cavity mucosa in the oral cavity, and meanwhile, the medicaments can enter the gastrointestinal tract along with saliva to be absorbed, so that the local oral cavity treatment or cleaning action or the whole body treatment action is exerted, the treatment and/or health care function is realized, and the defects of the conventional oral cavity biological adhesive preparation.
The invention adopts inert medicinal grade and food grade raw materials as preparation materials of the oral cavity drug delivery device, and is safe and nontoxic; different active substances can be selectively added into the medicine layer in the movable mechanism according to requirements, so that different effects are achieved, and the application range is wide.
The invention has simple structure, the fixed mechanism and the movable mechanism can be firmly combined, the movable mechanism can be arranged on the fixed mechanism at any time or the movable mechanism is detached from the fixed mechanism by external force to stop the administration, the use is convenient, the cost is low, and the invention has wide application prospect.
Drawings
Fig. 1 is a schematic structural diagram of embodiment 4 of the present invention.
Fig. 2 is a schematic structural diagram of the movable mechanism of the present invention.
In the figure, 1, a mold, 2, a photo-curing resin controlled release layer, 3, a drug layer, 4, a combination part, 5, a fixing mechanism, 6 and a denture.
FIG. 3 is a graph of the in vitro mean release profile of the oral delivery devices prepared in examples 1-3.
FIG. 4 is a graph of the in vitro cumulative release profile of the oral delivery devices prepared in examples 1-3.
FIG. 5 is a graph of the in vitro mean release profile of the oral delivery devices prepared in examples 4-6.
FIG. 6 is a graph of the in vitro cumulative release profile of the oral delivery devices prepared in examples 4-6.
Detailed Description
The present invention is further illustrated by the following examples, which are given by way of illustration only and are not intended to limit the scope of the present invention in any way.
Procedures and methods not described in detail in the following examples are conventional methods well known in the art, and the reagents used in the examples are either analytically or chemically pure and are either commercially available or prepared by methods well known to those of ordinary skill in the art. The following embodiments all achieve the object of the present invention.
Example 1
The oral administration device comprises a fixed mechanism and a movable mechanism.
A fixing mechanism: implanting into oral implant, drilling hole in dental crown part of the oral implant, wherein the shape and size of the hole are based on an embeddable polypropylene cylinder mould, the outer diameter of the cylinder mould is 4.5mm, and the height is 3 mm. Magnet pieces are fitted into the drilled holes.
A movable mechanism: the bottom of the polypropylene mould is adhered with a combination part iron sheet; dissolving huperzine A in methanol to obtain 250mg/ml solution, transferring appropriate amount of mixture into polypropylene mold with 1ml injector, standing until the solvent volatilizes, avoiding bubble generation during operation process, wherein each mold contains huperzine A powder 3 mg; dispersing the light-cured resin and PEG400 into an ethanol solution according to the mass ratio of 10: 3, mixing for 10min, then dropwise adding into molds, so that each mold contains 24mg of light-cured resin and 24mg of PEG4007.2mg of light-cured resin, volatilizing a solvent, and then curing under the irradiation of a light-curing machine.
The movable mechanism is arranged in the drill hole on the oral implant, and the movable mechanism and the fixed mechanism can be tightly combined by means of magnetic force and shape.
Example 2
A fixing mechanism: implanting into oral implant, and drilling on the upper dental crown part, wherein the shape and size of the implant are based on an embeddable polyvinyl chloride mold cylinder with outer diameter of 4.5mm and height of 3 mm. And embedding and mounting a magnet in the drilled hole.
A movable mechanism: the bottom of the polyvinyl chloride mould is adhered with a combined part iron sheet; adding 2.5g huperzine A into 10ml methanol solution (250mg/ml) to dissolve the medicine sufficiently, transferring a proper amount of mixture into a polyvinyl chloride cylindrical mould by using a 1ml syringe, standing until the solvent is volatilized, and avoiding the generation of bubbles as much as possible in the operation process, wherein each mould contains 3mg huperzine A; dispersing the light-cured resin and a pore-forming agent polyvinylpyrrolidone K30 (PVP K30) into ethanol according to the mass ratio of 10: 3 for mixing, injecting the mixture of the light-cured resin and the pore-forming agent into a mold to volatilize a solvent, and then curing under the irradiation of a light curing machine.
The movable mechanism is arranged in the drill hole on the oral implant, and the movable mechanism and the fixed mechanism can be tightly combined by means of magnetic force and shape.
Example 3
A fixing mechanism: implanting the implant into the oral cavity, and then drilling a hole on the upper dental crown part, wherein the shape and the size are based on an embeddable PVC cylindrical mould, the outer diameter of the cylindrical mould is 4.5mm, and the height of the cylindrical mould is 3 mm. And embedding and mounting a magnet in the drilled hole.
A movable mechanism: iron sheets are adhered to the bottom of the PVC mould; adding 2.5g huperzine A into 10ml methanol solution (250mg/ml) to fully dissolve the medicine, transferring a proper amount of mixture into a PVC cylindrical mould by using a 1ml syringe, standing until the solvent is volatilized, and avoiding the generation of bubbles as much as possible in the operation process, wherein each mould contains 3mg huperzine A; dispersing the light-cured resin and the pore-forming agent poloxamer 188 into a solvent according to the mass ratio of 10: 3 for mixing, injecting the mixture of the light-cured resin and the pore-forming agent into a mold for volatilizing the solvent, and then curing under the irradiation of a light curing machine.
The movable mechanism is arranged in the drill hole on the oral implant, and the movable mechanism and the fixed mechanism can be tightly combined by means of magnetic force and shape.
Oral administration feasibility studies were performed on the oral administration devices prepared in examples 1 to 3, respectively. The in vitro release assay was performed as follows: putting the prepared oral administration device into a 100ml glass bottle, adding 10ml of distilled water as a release medium, taking samples at different times respectively at the temperature of 37 ℃ and the stirring speed of 75 r/m, replacing fresh release medium, filtering the samples, measuring absorbance at 310nm by using an ultraviolet-visible spectrophotometer, and calculating the release degree.
The results obtained in examples 1 to 3 are shown in FIGS. 3 to 4. As can be seen from FIG. 3, the samples prepared in examples 1 to 3 exhibited a relatively stable release from day 2, except for a relatively high release at day 1. The prepared oral administration device can release the medicine more stably within 12 days.
Example 4
A fixing mechanism: taking a removable denture 6 for oral cavity, selecting a certain artificial tooth on the denture 6, drilling a hole on the crown part, wherein the shape and size of the hole are based on an embeddable PVC cylindrical mould 1, the outer diameter of the mould 1 is 4.5mm, and the height is 3 mm. A fixing mechanism 5, which is a magnet piece, is fitted into a hole drilled in the denture.
A movable mechanism: the bottom of the PVC mould 1 is adhered with a binding part 4 iron sheet. Weighing tamsulosin hydrochloride and sucrose, fully and uniformly mixing according to the mass ratio of 2:8, transferring a proper amount of mixture into PVC cylindrical molds 1, wherein each mold contains 10 mg of tamsulosin hydrochloride, and obtaining a drug layer 3; dispersing the photocuring resin and PEG400 into an ethanol solution according to the mass ratio of 20: 1, mixing for 10min, then dropwise adding into a cylindrical mold, injecting the mixture of the photocuring resin and a pore-forming agent into the mold to volatilize a solvent, and then curing under irradiation of a photocuring machine to obtain the photocuring resin controlled release layer 2.
The movable mechanism is arranged in a drill hole on the removable denture, and the movable mechanism and the fixed mechanism 5 can be tightly combined by means of magnetic force and shape.
Example 5
A fixing mechanism: taking a removable denture for oral cavity, selecting a certain artificial tooth on the denture, drilling a hole on the dental crown part, wherein the shape and size of the hole are based on an embeddable PVC cylindrical mould, the outer diameter of the mould is 4.5mm, and the height of the mould is 3 mm. A magnet piece is fitted into a hole drilled in the denture.
A movable mechanism: the bottom of the PVC mould is adhered with a combined part iron sheet; weighing tamsulosin hydrochloride and sucrose, fully and uniformly mixing the tamsulosin hydrochloride and the sucrose according to the mass ratio of 2:8, and transferring a proper amount of mixture into a PVC cylindrical die. Each mould contains 10 mg of tamsulosin hydrochloride; dispersing the light-cured resin and PEG400 into an ethanol solution according to the mass ratio of 40: 3, mixing for 10min, injecting the mixture of the light-cured resin and the pore-forming agent into a mold to volatilize a solvent, and then curing under the irradiation of a light curing machine.
The movable mechanism is arranged in the drill hole on the removable denture, and the movable mechanism and the fixed mechanism can be tightly combined by means of the magnetic force and the shape.
Example 6
A fixing mechanism: taking a removable denture for oral cavity, selecting a certain artificial tooth on the denture, drilling a hole on the dental crown part, wherein the shape and size of the hole are based on an embeddable PVC cylindrical mould, the outer diameter of the mould is 4.5mm, and the height of the mould is 3 mm. A magnet piece is fitted into a hole drilled in the denture.
A movable mechanism: the bottom of the PVC mould is adhered with a combined part iron sheet. Weighing tamsulosin hydrochloride and sucrose according to the mass ratio of 2:8, fully and uniformly mixing, and transferring a proper amount of mixture into a PVC cylindrical die, wherein the outer diameter of the die is 4.5mm, and the height of the die is 3 mm. Each mold contained 10 mg of tamsulosin hydrochloride. Dispersing the light-cured resin and PEG400 into an ethanol solution according to the mass ratio of 10: 1, mixing for 10min, injecting the mixture of the light-cured resin and the pore-forming agent into a mold to volatilize a solvent, and then curing under the irradiation of a light curing machine.
The movable mechanism is arranged in the drill hole on the removable denture, and the movable mechanism and the fixed mechanism can be tightly combined by means of the magnetic force and the shape.
Oral administration feasibility studies were performed on the oral administration devices prepared in examples 4 to 6, respectively. The in vitro release assay was performed as follows: putting the prepared oral administration device into a 100ml glass bottle, adding 10ml of distilled water as a release medium, taking samples at different times at the temperature of 37 ℃ and the stirring speed of 75 r/m, replacing fresh release media, filtering the samples, measuring absorbance at 225 nm by using an ultraviolet-visible spectrophotometer, and calculating the release degree. The oral administration feasibility results of the oral administration devices prepared in examples 4 to 6 are shown in fig. 5 to 6.
Claims (8)
1. An oral cavity drug delivery device is characterized by comprising a fixing mechanism and a moving mechanism, wherein the fixing mechanism and the moving mechanism are combined with each other through a magnetic force or a buckle structure; the fixing mechanism is fixed on the false tooth, the tooth socket device or the oral implant; a medicine layer is arranged in the movable mechanism.
2. The oral drug delivery device according to claim 1, wherein the fixing means and the moving means are coupled to each other by magnetic force, a magnetic material member is provided in the fixing means, and a coupling member coupled to the magnetic material member is provided in the moving means.
3. The oral delivery device of claim 2, wherein the securing mechanism is a magnet.
4. The oral delivery device of claim 2, wherein the movable mechanism comprises a mold in which the drug layer is disposed and the engagement member, the mold being fixedly coupled to the engagement member.
5. The oral drug delivery device according to claim 1, wherein the fixing means and the moving means are coupled to each other by magnetic force, a magnetic material member is provided in the moving means, and a coupling member coupled to the magnetic material member is provided in the fixing means.
6. The oral delivery device of claim 5, wherein the movable mechanism comprises a mold and the magnetic material member, the drug layer being disposed within the mold, the mold being fixedly attached to the magnetic material member.
7. The oral delivery device of claim 4 or 6, wherein the die is cylindrical or square-grooved and has an upper surface with a surface area of 5mm2~100 mm2The depth is 0.5-8 mm; the mould consists of polyethyleneMade of materials such as ethylene, polyvinyl chloride, polypropylene, polystyrene or polytetrafluoroethylene.
8. The oral delivery device of claim 4 or 6, wherein a drug layer and a photo-curable resin controlled-release layer are provided within the mold, the photo-curable resin controlled-release layer being provided outside the drug layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920372588.1U CN210205582U (en) | 2019-03-22 | 2019-03-22 | Oral cavity device of dosing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920372588.1U CN210205582U (en) | 2019-03-22 | 2019-03-22 | Oral cavity device of dosing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210205582U true CN210205582U (en) | 2020-03-31 |
Family
ID=69921777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920372588.1U Active CN210205582U (en) | 2019-03-22 | 2019-03-22 | Oral cavity device of dosing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN210205582U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109908461A (en) * | 2019-03-22 | 2019-06-21 | 河北大学 | A kind of oral administration device and the preparation method and application thereof |
| CN113499534A (en) * | 2021-08-11 | 2021-10-15 | 牡丹江医学院 | Fixed-point nursing device for dental ulcer |
-
2019
- 2019-03-22 CN CN201920372588.1U patent/CN210205582U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109908461A (en) * | 2019-03-22 | 2019-06-21 | 河北大学 | A kind of oral administration device and the preparation method and application thereof |
| CN109908461B (en) * | 2019-03-22 | 2024-04-12 | 河北大学 | Oral administration device and preparation method and application thereof |
| CN113499534A (en) * | 2021-08-11 | 2021-10-15 | 牡丹江医学院 | Fixed-point nursing device for dental ulcer |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102480958B (en) | sublingual apomorphine | |
| US6997909B2 (en) | Low profile combination device for gastrostomy or jejunostomy applications having anti-granuloma formation characteristics | |
| CN111568887A (en) | Bulleyaconitine A dissolvable microneedle patch and preparation method thereof | |
| CN210205582U (en) | Oral cavity device of dosing | |
| Zhang et al. | Polymeric microneedles integrated with metformin-loaded and PDA/LA-coated hollow mesoporous SiO2 for NIR-triggered transdermal delivery on diabetic rats | |
| JP2012500230A (en) | Gastric retention drug release system and method and use thereof | |
| CN101287423A (en) | Drug-containing implants and methods of use thereof | |
| CN104117137A (en) | Capsule type hollow medicine loading micro-needle array and producing method thereof | |
| Abrbekoh et al. | Application of microneedle patches for drug delivery; doorstep to novel therapies | |
| CN102961365B (en) | Terbutaline sulphate oral instant membrane and preparation method thereof | |
| US20110250269A1 (en) | Highly efficient and long-acting slow-release formulation of poorly soluble drugs and preparation method thereof | |
| CN102068404A (en) | Nimesulide temperature sensitive hydrogel and preparation method thereof | |
| WO2021244630A1 (en) | Heat-resistant implantable polymer microneedle and preparation method therefor and application thereof | |
| CN1857730B (en) | Degradable implated medicine release-controlling carrier with micropores and cavities and its preparing process | |
| Shi et al. | Novel 3D printed device with integrated macroscale magnetic field triggerable anti-cancer drug delivery system | |
| CN108464967A (en) | A kind of biological needle and preparation method thereof for subcutaneous medicament controlled release | |
| Mbituyimana et al. | Polymer-based microneedle composites for enhanced non-transdermal drug delivery | |
| CN110198730A (en) | H2O2Responsive nano particle and application thereof | |
| KR20130091760A (en) | Devices and methods for intravaginal delivery of drugs and other substances | |
| CN109908461B (en) | Oral administration device and preparation method and application thereof | |
| CN103785101A (en) | Electric field multi-pulse drug release device and manufacturing method and application thereof | |
| CN109875954B (en) | Medicinal and mechanical composition and preparation method thereof | |
| CN101703463A (en) | Paracetamol temperature sensitive gel and preparation method and application thereof | |
| CN101618027B (en) | Aceclofenac bi-layer osmotic pump controlled release tablets and preparation method thereof | |
| KR101513812B1 (en) | Method of preparing microstructure for hydrophobic drug delivery |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |