CN210145551U - Negative pressure collecting device - Google Patents
Negative pressure collecting device Download PDFInfo
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- CN210145551U CN210145551U CN201920884229.4U CN201920884229U CN210145551U CN 210145551 U CN210145551 U CN 210145551U CN 201920884229 U CN201920884229 U CN 201920884229U CN 210145551 U CN210145551 U CN 210145551U
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Abstract
The utility model provides a negative pressure collecting device, wherein a suction cavity is formed inside a box body of the negative pressure collecting device, and the box body is provided with at least one first placing hole; the placing cover is covered on the box body and is provided with at least one through second placing hole; the collecting pipe is inserted into the first placing hole, the adsorption column is inserted into the second placing hole, an air exhaust gap is formed between the discharge port of the adsorption hole and the inlet of the collecting pipe, and the suction cavity is communicated with the air exhaust gap; the negative pressure suction device is communicated with the suction cavity and is used for sucking the gas in the suction cavity. The negative pressure collecting device adopts negative pressure to suck out the macromolecules adsorbed on the adsorption column and collects the macromolecules into the collecting pipe, so that a negative pressure suction and collection experiment becomes possible, the experiment effect is good, and the use is convenient; this negative pressure collection device can handle a plurality of adsorption columns simultaneously, and can not mutual contamination between a plurality of adsorption columns, and the experimental efficiency is high.
Description
Technical Field
The utility model relates to a negative pressure collection device.
Background
Macromolecular preparations, such as protein, nucleic acid, polysaccharide, etc., require purification before use. For example, when nucleic acid is purified, the nucleic acid is washed first, and the washed nucleic acid is adsorbed on an adsorption column. At this time, the nucleic acid adsorbed on the adsorption column needs to be collected in a collection tube, and the collection tube can adopt a negative pressure suction method, but a matched experimental device with good performance is not available in the market.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a negative pressure collection device reaches and collects the purpose of adsorbing the nucleic acid on the adsorption column through the negative pressure.
In order to achieve the above object, the utility model provides a following technical scheme:
the utility model provides a negative pressure collecting device, which comprises a box body, a placing cover, at least one collecting pipe, at least one adsorption column and a negative pressure aspirator, wherein a suction cavity is formed inside the box body, and the box body is provided with at least one first placing hole; the placing cover is covered on the box body, at least one penetrating second placing hole is formed in the placing cover, and the second placing hole corresponds to the first placing hole in position; one end of the collecting pipe forms an inlet, the other end of the collecting pipe forms a seal, and the collecting pipe is inserted into the first placing hole; an adsorption hole is formed in the adsorption column, an inlet and an outlet are formed at two ends of the adsorption hole respectively, the adsorption column is inserted into the second placing hole, an air exhaust gap is formed between the outlet of the adsorption hole and the inlet of the collecting pipe, and the suction cavity is communicated with the air exhaust gap; the negative pressure suction device is communicated with the suction cavity and is used for sucking the gas in the suction cavity.
In this technical scheme, the negative pressure suction apparatus continuously produces the negative pressure, keeps the negative pressure in making the adsorption column to make and produce the negative pressure in the clearance of bleeding, follow the discharge port suction of adsorption hole with the macromolecule in the adsorption column, drip to the collecting pipe under the entry, make the macromolecule in the adsorption column collected by the collecting pipe.
Preferably, the negative pressure aspirator comprises a liquid collecting bottle, an exhaust tube and a negative pressure terminal, wherein the liquid collecting bottle is provided with a liquid inlet communicated with the suction cavity; and two ends of the exhaust tube are respectively communicated with the liquid collecting bottle and the negative pressure terminal, and the negative pressure terminal is used for extracting gas in the liquid collecting bottle.
In this technical scheme, the gas in the collecting bottle is extracted to the negative pressure terminal, makes the interior negative pressure that produces of collecting bottle to make the suction chamber produce the negative pressure. And impurity or waste liquid in the suction chamber can be stayed in the liquid collecting bottle, and the flow to the negative pressure terminal is avoided.
Preferably, the outlet of the suction cavity communicated with the liquid inlet of the liquid collecting bottle is positioned at the bottom of the suction cavity.
In this technical scheme, the export in suction chamber is located the bottom in suction chamber, is convenient for inhale the liquid trap with gas.
Preferably, the liquid inlet of the liquid collecting bottle and/or the air outlet of the liquid collecting bottle communicated with the air exhaust pipe are/is positioned at the upper part of the liquid collecting bottle.
In the technical scheme, the liquid inlet of the liquid collecting bottle is positioned at the upper part of the liquid collecting bottle, so that the waste liquid can conveniently flow into the liquid collecting bottle; the gas outlet of the liquid collecting bottle is positioned at the upper part of the liquid collecting bottle, so that the air can be conveniently pumped.
Preferably, the number of the first placing holes is multiple, the number of the second placing holes is multiple, and the first placing holes and the second placing holes are the same in number and are arranged correspondingly; the collecting pipes and the adsorption columns are equal in number and are arranged correspondingly, and the number of the adsorption columns is equal to or less than that of the second placing holes; the negative pressure collecting device also comprises a plurality of plugs, each second placing hole is inserted into one of the adsorption column and the plugs, and the plugs are in sealing fit with the inserted second placing holes.
In this technical scheme, if the quantity of the adsorption columns that need to aspirate is less than the quantity that the hole was placed to the second, and place the stopper in the hole is placed to vacant second, make vacant second place the hole and can not leak gas, influence the suction work of vacuum suction apparatus to the adsorption columns.
Preferably, the box body comprises a shell and a collecting plate frame, the shell forms a containing cavity with an opening, the collecting plate frame is positioned in the containing cavity, a first surface of the collecting plate frame, which is far away from the opening, and an inner surface of the containing cavity enclose the suction cavity, a second surface of the collecting plate frame, which is close to the opening, and an inner surface of the containing cavity enclose a transition cavity, and the air suction gap is communicated with the transition cavity; the first hole of placing set up in collect on the grillage, it runs through still to be equipped with on the grillage to collect the suction passageway of grillage, the suction passageway will suction chamber, transition chamber are linked together.
In this technical scheme, through the setting of shell and collection grillage, make the inside formation of box body hold the chamber and with hold suction channel, the transition chamber that the chamber is linked together, make the clearance of bleeding form the negative pressure, make the macromolecule in the adsorption column can be sucked out.
Preferably, the shell includes upper housing and lower casing, the internal surface of upper housing with the internal surface of lower casing encloses into hold the chamber, the internal surface of casing is equipped with the spacing platform around circumference setting down, spacing platform has along the place the platform that sets up of radial plane and around the spacing wall that circumference set up, the first surface of collection grillage is shelved on the place the platform, the outer peripheral face of collection grillage with spacing wall contact.
In this technical scheme, divide into casing, lower casing with the shell, the installation and the dismantlement of the box body of being convenient for wash, will collect the grillage location simultaneously in the lower casing, make the box body can the rapid Assembly, the equipment mistake can not appear.
Preferably, a first positioning ring protruding towards the lower shell is arranged on a contact surface of the upper shell and the lower shell, a second positioning ring protruding towards the upper shell is arranged on a contact surface of the lower shell and the upper shell, and the outer peripheral surface of the second positioning ring is matched with the inner peripheral surface of the first positioning ring.
In this technical scheme, through the cooperation of first holding ring, second holding ring, guaranteed the accuracy of the relative position between last casing, the lower casing, guaranteed the installation and placed the lid on last casing and install the accuracy of the relative position between the collection grillage on the casing down to guaranteed that first place the hole, the second is placed the hole and can be corresponded the setting.
Preferably, the housing further comprises a sealing ring, and the sealing ring is arranged on a contact surface where the upper shell and the lower shell are contacted.
In this technical scheme, the contact surface of going up casing, casing contact down is equipped with the sealing washer, guarantees the leakproofness between casing, the casing down.
Preferably, the suction channel comprises a recess recessed inwardly from the first surface of the collection plate holder and at least one vertical through hole extending from the recess to the second surface of the collection plate holder.
In the technical scheme, the structure of the suction channel of the collecting plate frame is arranged, so that the suction airflow is kept stable, and stable negative pressure can be formed in the air exhaust gap; the collecting plate frame can be made of plastic, and the structural design is convenient for injection molding.
Preferably, the suction channel further comprises at least one circumferential through hole extending from the recess to the outer circumferential surface of the collecting ledge.
In the technical scheme, the peripheral surface of the collecting plate frame is provided with the circumferential through hole, so that the suction airflow is kept stable, and stable negative pressure can be formed in the air exhaust gap; the collecting plate frame can be made of plastic, and the structural design is convenient for injection molding.
Preferably, the negative pressure collecting device further comprises a sealing ring, the sealing ring is arranged between the placing cover and the box body, and the sealing ring is arranged around the first placing hole.
In this technical scheme, through above-mentioned seal structure, make place the lid and install on the box body to after collecting pipe, adsorption column are good, gas can only flow from the circulation direction along adsorbing the hole, the clearance of bleeding, suction chamber, and can not leak gas from other contact surfaces, guaranteed that the adsorption column can produce sufficient negative pressure in, make the macromolecule in the adsorption column can instil into in the collecting pipe.
Preferably, a sealing groove surrounding the first placing hole is formed in the surface, facing the placing cover, of the box body, and the sealing ring is placed in the sealing groove.
In the technical scheme, the sealing groove is used for positioning and placing the sealing ring, so that the sealing ring is convenient to install quickly, and the sealing effect is ensured.
Preferably, the discharge port of the adsorption column is inserted into the inlet of the collection pipe, and the suction gap is formed between the outer circumferential surface of the adsorption column and the inner circumferential surface of the collection pipe.
In this technical scheme, be separated completely between the adjacent adsorption column, avoided the mutual pollution between the adjacent adsorption column to can place more adsorption columns in limited space, make negative pressure collection device's volume accomplish littleer, more conveniently carry and operate.
Preferably, the placing cover comprises a mounting plate and at least one mounting sleeve, and the mounting plate is provided with at least one through mounting hole; the two ends of the mounting sleeve are provided with openings, the mounting sleeve is inserted into the mounting hole, and the second placing hole is formed in the inner circumferential surface of the mounting sleeve.
In this technical scheme, the installation cover is used for fixed adsorption column.
Preferably, the mounting sleeve is made of an elastic material.
In this technical scheme, the installation cover that uses elastic material to make, the change of the specification of adaptable adsorption column makes the installation cover remain the state of laminating with the adsorption column all the time.
Preferably, one end of the first placing hole facing the placing cover is provided with a groove extending around the circumferential direction, and the outer circumferential surface of the collecting pipe is provided with a flange extending around the circumferential direction; when the collecting pipe is inserted into the first placing hole, the flange of the collecting pipe is matched with the groove of the first placing hole.
In the technical scheme, the position of the collecting pipe in the first placing hole is fixed by matching the groove and the flange, so that the position error of the collecting pipe in the installation process is avoided, and the collecting effect is ensured.
On the basis of the common knowledge in the field, the above preferred conditions can be combined at will to obtain the preferred embodiments of the present invention.
The utility model discloses an actively advance the effect and lie in:
the negative pressure collecting device adopts negative pressure to suck out the macromolecules adsorbed on the adsorption column and collects the macromolecules into the collecting pipe, so that a negative pressure suction and collection experiment becomes possible, the experiment effect is good, and the use is convenient; this negative pressure collection device can handle a plurality of adsorption columns simultaneously, and can not mutual contamination between a plurality of adsorption columns, and the experimental efficiency is high.
Drawings
Fig. 1 is a schematic structural view of the negative pressure collecting device of the present invention.
Fig. 2 is a schematic structural view of the negative pressure collecting device shown in fig. 1, except for the negative pressure aspirator.
Fig. 3 is an exploded view of the negative pressure collecting device shown in fig. 2.
Fig. 4 is a front view of the negative pressure collecting device shown in fig. 2.
Fig. 5 is a schematic view of the negative pressure collecting device shown in fig. 4 in the direction of a-a.
Fig. 6 is a partially enlarged view of the negative pressure collecting device shown in fig. 5.
Fig. 7 is a schematic structural view of a collecting plate frame of the negative pressure collecting device shown in fig. 5.
Fig. 8 is a schematic cross-sectional view of the collection plate holder shown in fig. 7.
Fig. 9 is a schematic view showing the structure of a collecting pipe of the negative pressure collecting device shown in fig. 5.
Description of the reference numerals
A box body 1; suction chamber 11, outlet 111; the first placing hole 12, the groove 121; the positioning device comprises a shell 13, an opening 131, a containing cavity 132, an upper shell 133, a lower shell 134, a limiting table 135, a placing platform 136, a limiting wall 137, a sealing ring 138, a first positioning ring 139 and a second positioning ring 1310; the collecting plate frame 14, the first surface 141, the second surface 142, the suction channel 143, the notch 144, the vertical through hole 145, the circumferential through hole 146, the strip-shaped groove 147; a transition chamber 15; a seal groove 16;
placing the cover 2; the second placing hole 21; mounting plate 22, mounting hole 221; a mounting sleeve 23;
a collection pipe 3; inlet 31, flange 32;
an adsorption column 4; an adsorption hole 41, an inlet port 42, an outlet port 43;
a negative pressure aspirator 5; the liquid collecting bottle 51, the liquid inlet 511 and the gas outlet 512; an extraction pipe 52; a negative pressure terminal 53; a communicating pipe 54;
an air extraction gap 6; and a seal ring 7.
Detailed Description
The present invention will be further described with reference to the following embodiments and drawings, and more details will be set forth in the following description in order to provide a thorough understanding of the present invention, but it is obvious that the present invention can be implemented in various other ways different from those described herein, and those skilled in the art can make similar generalizations and deductions according to the actual application without departing from the spirit of the present invention, and therefore, the scope of the present invention should not be limited by the contents of the embodiments.
Fig. 1 to 9 show an embodiment of the negative pressure collecting device of the present invention. The negative pressure collecting device comprises a box body 1, a placing cover 2, a plurality of collecting pipes 3, a plurality of adsorption columns 4 and a negative pressure aspirator 5, wherein a suction cavity 11 is formed inside the box body 1, and a plurality of first placing holes 12 are formed in the box body 1; the placing cover 2 is covered on the box body 1, a plurality of penetrating second placing holes 21 are formed in the placing cover 2, and the positions of the second placing holes 21 correspond to the positions of the first placing holes 12; one end of the collecting pipe 3 forms an inlet 31, the other end of the collecting pipe 3 forms a seal, and the collecting pipe 3 is inserted into the first placing hole 12; an adsorption hole 41 is formed inside the adsorption column 4, an inlet 42 and an outlet 43 are respectively formed at two ends of the adsorption hole 41, the adsorption column 4 is inserted into the second placing hole 21, an air exhaust gap 6 is formed between the outlet 43 of the adsorption hole 41 and the inlet 31 of the collecting pipe 3, and the suction cavity 11 is communicated with the air exhaust gap 6; the negative pressure aspirator 5 is communicated with the suction cavity 11, and the negative pressure aspirator 5 is used for sucking the gas in the suction cavity 11.
When macromolecules (such as nucleic acid) adsorbed on the adsorption columns 4 need to be collected in the collecting pipe 3, the collecting pipe 3 is inserted into the first placing hole 12, the adsorption columns 4 adsorbing the macromolecules are inserted into the second placing hole 21, the adsorption columns 4 correspond to the collecting pipes 3 one by one, and the collecting pipe 3 is arranged below each adsorption column 4. The negative pressure aspirator 5 sucks the gas in the suction chamber 11 to generate negative pressure in the air suction gap 6, so that macromolecules in the adsorption column 4 are sucked out from the discharge port 43 of the adsorption hole 41 and dripped into the collecting pipe 3 from the inlet 31, and the macromolecules in the adsorption column 4 are collected by the collecting pipe 3.
The number of the first placement holes 12 may be one or more, the number of the second placement holes 21 may be one or more, and the first placement holes 12 and the second placement holes 21 are the same in number and are provided correspondingly. The number of the first placing holes 12 and the second placing holes 21 may be designed according to the maximum number of preparations to be simultaneously processed as necessary.
The collecting pipes 3 and the adsorption columns 4 are the same in number and are arranged in one-to-one correspondence. The number of columns 4 to be used depends on the number of macromolecular preparations to be washed. When the number of the adsorption columns 4 to be used is the same as the number of the second placing holes 21, one adsorption column 4 is inserted into each second placing hole 21. When the number of the adsorption columns 4 to be used is smaller than the number of the second placing holes 21, a plug is placed in the empty second placing hole 21, and the plug is sealingly engaged with the inserted second placing hole 21. Thus, the empty second placing hole 21 does not leak air, and the suction operation of the vacuum extractor 5 on the adsorption column 4 is not affected.
For example, when the number of the first placing holes 12 and the second placing holes 21 is 48, the number of the adsorption columns 4 and the collection tubes 3 may be 1 to 48. When the number of the adsorption columns 4 and the collection tubes 3 is less than 48, the second placing hole 21 which is empty is provided with a plug. For another example, when the number of the first placing holes 12 and the second placing holes 21 is 96, the number of the adsorption columns 4 and the collection tubes 3 may be 1 to 96. When the number of the adsorption columns 4 and the collection tubes 3 is less than 96, the second placing hole 21 which is empty is plugged.
As shown in fig. 1, the negative pressure aspirator 5 comprises a liquid collecting bottle 51, an air suction pipe 52 and a negative pressure terminal 53, wherein the liquid collecting bottle 51 is provided with a liquid inlet 511, and the liquid inlet 511 is communicated with the suction cavity 11; the two ends of the air exhaust pipe 52 are respectively communicated with the liquid collecting bottle 51 and the negative pressure terminal 53, and the negative pressure terminal 53 is used for exhausting the gas in the liquid collecting bottle 51. The negative pressure terminal 53 draws gas from the liquid trap bottle 51, and generates a negative pressure in the liquid trap bottle 51, thereby generating a negative pressure in the suction chamber 11. However, the foreign substances or waste liquid in the suction chamber 11 may remain in the liquid trap bottle 51 from flowing to the negative pressure terminal 53.
As shown in fig. 1, the vacuum extractor 5 further includes a communication pipe 54, and the communication pipe 54 communicates the liquid inlet 511 of the liquid collection bottle 51 with the outlet 111 of the suction chamber 11. To facilitate the suction, the outlet 111 of the suction chamber 11 is located at the bottom of the suction chamber 11. In addition, for the convenience of air extraction, an air outlet 512, which communicates the liquid collecting bottle 51 with the air extraction pipe 52, is located at the upper part of the liquid collecting bottle 51. The liquid inlet 511 of the liquid collecting bottle 51 is also positioned above the liquid collecting bottle 51, so that the waste liquid can flow into the liquid collecting bottle 51.
As shown in fig. 3, 5 and 6, the cartridge 1 comprises a housing 13 and a collection plate frame 14, the housing 13 forms a containing cavity 132 with an opening 131, the collection plate frame 14 is located in the containing cavity 132, a first surface 141 of the collection plate frame 14 far away from the opening 131 and an inner surface of the containing cavity 132 define a suction cavity 11, a second surface 142 of the collection plate frame 14 near the opening 131 and an inner surface of the containing cavity 132 define a transition cavity 15, and the air-extracting gap 6 is communicated with the transition cavity 15; the first placing hole 12 is arranged on the collecting plate frame 14, the collecting plate frame 14 is further provided with a suction channel 143 penetrating through the collecting plate frame 14, and the suction channel 143 communicates the suction cavity 11 with the transition cavity 15.
The suction chamber 11, the suction channel 143, the transition chamber 15 and the suction gap 6 are communicated by providing the suction channel 143 penetrating the collecting plate frame 14, thereby forming a communicated chamber. When the vacuum extractor 5 sucks the gas in the suction cavity 11, the suction gap 6 can form a negative pressure to suck the macromolecules in the adsorption column 4 out of the discharge port 43 of the adsorption hole 41.
As shown in fig. 7 to 8, the suction passage 143 of the collecting ledge 14 includes a recess 144 and a plurality of vertical through-holes 145, the recess 144 being recessed inwardly from the first surface 141 of the collecting ledge 14, the vertical through-holes 145 extending from the recess 144 to the second surface 142 of the collecting ledge 14. Suction channel 143 further includes a plurality of circumferential through-holes 146, circumferential through-holes 146 extending from recess 144 to the outer circumferential surface of collection ledge 14. The suction passage 143 of the collecting plate frame 14 is structured so as to maintain a stable suction flow and to form a stable negative pressure in the suction gap 6. The collection plate holder 14 can be made of plastic, and the above-described structural design facilitates injection molding.
The outer circumferential surface of the collecting plate frame 14 is further provided with two strip-shaped grooves 147, and the two strip-shaped grooves 147 are respectively arranged on two opposite sides of the outer circumferential surface of the collecting plate frame 14. The arrangement of the strip-shaped groove 147 is convenient for a person to grasp the collecting plate frame 14, and the collecting plate frame 14 is prevented from sliding off in the taking process.
As shown in fig. 7 and 8, one end of the first placing hole 12 facing the placing cover 2 is provided with a groove 121 extending around the circumferential direction. As shown in fig. 9, the collecting pipe 3 is provided on its outer peripheral surface with a flange 32 extending circumferentially. When the collector tube 3 is inserted into the first placing hole 12, the flange 32 of the collector tube 3 fits in the groove 121 of the first placing hole 12. Through the cooperation of recess 121, flange 32, make collecting pipe 3 fixed in the position of first placing hole 12, avoided collecting pipe 3 position error to appear in the installation, guaranteed the collection effect.
As shown in fig. 6, in order to prevent the adjacent adsorption columns 4 from being contaminated with each other, the discharge ports 43 of the adsorption columns 4 are inserted into the inlet 31 of the collection pipe 3, and the evacuation gap 6 is formed between the outer peripheral surface of the adsorption column 4 and the inner peripheral surface of the collection pipe 3. In order to ensure that the adsorption column 4 can be inserted into the collection tube 3, the discharge port 43 of the adsorption column 4 is made into a tapered shape, so that the diameter of the discharge port 43 of the adsorption column 4 is smaller than the diameter of the inlet 31 of the collection tube 3, and an air extraction gap 6 is formed between the outer circumferential surface of the adsorption column 4 and the inner circumferential surface of the collection tube 3. Through above-mentioned structure, being separated completely between the adjacent adsorption column 4, having avoided the mutual contamination between the adjacent adsorption column 4 to can place more adsorption columns 4 in limited space, make negative pressure collection device's volume accomplish littleer, more conveniently carry and operate.
As shown in fig. 5 to 6, in order to facilitate mounting and dismounting and cleaning, the housing 13 includes an upper case 133 and a lower case 134, an inner surface of the upper case 133 and an inner surface of the lower case 134 enclose a housing chamber 132, an inner surface of the lower case 134 is provided with a stopper table 135 disposed around a circumferential direction, the stopper table 135 has a placing platform 136 disposed along a radial plane and a stopper wall 137 disposed around the circumferential direction, a first surface 141 of the collecting ledge 14 rests on the placing platform 136, and an outer circumferential surface of the collecting ledge 14 is in contact with the stopper wall 137.
During installation, the collecting plate frame 14 is placed in the lower shell 134, the first surface 141 of the collecting plate frame 14 is placed on the placing platform 136, and the outer peripheral surface of the collecting plate frame 14 is in contact with the limiting wall 137, so that the position of the collecting plate frame 14 in the lower shell 134 is fixed; the upper case 133 is mounted on the lower case 134.
In order to ensure the accuracy of the relative position between the upper and lower cases 133 and 134, the contact surface of the upper and lower cases 133 and 134 has a first positioning ring 139 protruding toward the lower case 134, and the contact surface of the lower case 134 and the upper case 133 has a second positioning ring 1310 protruding toward the upper case 133.
When the upper housing 133 is mounted on the lower housing 134, the second positioning ring 1310 is within the first positioning ring 139, and the outer peripheral surface of the second positioning ring 1310 mates with the inner peripheral surface of the first positioning ring 139. Through the cooperation of first holding ring 139, second holding ring 1310, guaranteed the accuracy of the relative position between upper housing 133, lower casing 134 to guaranteed the installation place on upper housing 133 cover 2 and the installation collect the relative position's between the grillage 14 on casing 134 down the accuracy, guaranteed that first place hole 12 and second place hole 21 and can correspond the setting, thereby guaranteed that adsorption column 4, collecting pipe 3 can correspond the setting each other.
In order to ensure the sealing property between the upper casing 133 and the lower casing 134, a gasket 138 is provided on the contact surface between the upper casing 133 and the lower casing 134.
The structure of the box body 1 is arranged, so that the box body 1 is integrally easy to disassemble, and is convenient to clean after an experiment. Meanwhile, when the device is installed, the device can be quickly combined, and assembly errors can not occur.
In order to guarantee the tightness of the contact surface between the placing cover 2 and the box body 1, the negative pressure collecting device further comprises a sealing ring 7, the sealing ring 7 is arranged between the placing cover 2 and the box body 1, and the sealing ring 7 is arranged around the first placing hole 12. For placing the sealing ring 7, the surface of the box 1 facing the placing cover 2 is provided with a sealing groove 16 arranged around the first placing hole 12, in which sealing groove 16 the sealing ring 7 is placed.
Through above-mentioned seal structure, the messenger places lid 2 and installs on box body 1 to after collecting pipe 3, adsorption column 4 are good, gas can only follow along adsorbing hole 41, air exhaust clearance 6, the circulation direction flow in suction chamber 11, and can not leak gas from other contact surfaces, guaranteed that 4 internal energy of adsorption column produce sufficient negative pressure, make the macromolecule in the adsorption column 4 can drip into in the collecting pipe 3.
As shown in fig. 5 to 6, the placing cover 2 includes a mounting plate 22 and a plurality of mounting sleeves 23, and a plurality of mounting holes 221 are formed through the mounting plate 22; both ends of the mounting sleeve 23 are opened, the mounting sleeve 23 is inserted into the mounting hole 221, and the inner peripheral surface of the mounting sleeve 23 forms the second placing hole 21. The mounting sleeve 23 is used for fixing the adsorption column 4. The mounting sleeve 23 is preferably made of an elastomeric material, such as silicone or the like. The mounting sleeve 23 made of elastic material can adapt to the change of the shape of the adsorption column 4, so that the mounting sleeve 23 is always attached to the adsorption column 4.
The negative pressure collecting device comprises the following assembling steps before negative pressure collection:
1) the pre-cleaning work of the upper shell 133, the lower shell 134, the collecting plate frame 14, the mounting plate 22, the mounting sleeve 23 and other parts is completed;
2) placing the collecting plate holder 14 in the lower case 134 with the first surface 141 of the collecting plate holder 14 resting on the placing platform 136 and the outer circumferential surface of the collecting plate holder 14 in contact with the stopper wall 137;
3) the upper shell 133 is arranged on the lower shell 134, the second positioning ring 1310 is arranged in the first positioning ring 139, the outer peripheral surface of the second positioning ring 1310 is matched with the inner peripheral surface of the first positioning ring 139, and the upper shell 133, the lower shell 134 and the collecting plate frame 14 form a box body 1;
4) the mounting sleeve 23 is mounted in the mounting hole 221 of the mounting plate 22 to constitute the set cover 2.
The negative pressure collecting method of the negative pressure collecting device comprises the following steps:
① mounting the header tube 3 in the first placement hole 12 of the header plate holder 14, the flange 32 of the header tube 3 fitting into the groove 121 of the first placement hole 12;
② placing the sealing ring 7 in the sealing groove 16 of the box body 1, and then placing the placing cover 2 on the sealing ring 7;
③ the adsorption column 4 with adsorbed macromolecules is inserted into the second placing hole 21 (i.e. the mounting sleeve 23), a plug is placed in the empty second placing hole 21, the plug is hermetically matched with the inserted second placing hole 21, the discharge port 43 of the adsorption hole 41 is arranged corresponding to the inlet 31 of the collecting tube 3, and an air-extracting gap 6 is formed between the discharge port 43 of the adsorption hole 41 and the inlet 31 of the corresponding collecting tube 3;
④ the negative pressure terminal 53 is opened to make the suction chamber 11, the air-extracting gap 6 and the adsorption hole 41 form negative pressure, so that the macromolecules adsorbed in the adsorption hole 41 flow into the corresponding collection tube 3 from the discharge port 43 of the adsorption hole 41.
According to the negative pressure collecting device, the macromolecules adsorbed on the adsorption column are sucked out by adopting negative pressure and collected into the collecting pipe, so that a negative pressure suction and collection experiment becomes possible, the experiment effect is good, and the use is convenient; this negative pressure collection device can handle a plurality of adsorption columns simultaneously, and can not mutual contamination between a plurality of adsorption columns, and the experimental efficiency is high.
Although the present invention has been described with reference to the preferred embodiments, it is not intended to limit the present invention, and those skilled in the art can make various changes and modifications without departing from the spirit and scope of the present invention. Any modification, equivalent changes and modifications of the above embodiments according to the technical spirit of the present invention, which do not depart from the technical scope of the present invention, fall within the protection scope defined by the claims of the present invention.
Claims (17)
1. A negative pressure collecting device, comprising:
the suction box comprises a box body, a suction cavity is formed inside the box body, and the box body is provided with at least one first placing hole;
the placing cover is covered on the box body, at least one penetrating second placing hole is formed in the placing cover, and the second placing hole corresponds to the first placing hole in position;
at least one collecting pipe, wherein one end of the collecting pipe forms an inlet, the other end of the collecting pipe forms a seal, and the collecting pipe is inserted into the first placing hole;
at least one adsorption column, wherein an adsorption hole is formed inside the adsorption column, an inlet and an outlet are respectively formed at two ends of the adsorption hole, the adsorption column is inserted into the second placing hole, an air exhaust gap is formed between the outlet of the adsorption hole and the inlet of the collecting pipe, and the suction cavity is communicated with the air exhaust gap;
the negative pressure suction device is communicated with the suction cavity and is used for sucking the gas in the suction cavity.
2. The negative pressure collection device of claim 1, wherein the negative pressure aspirator comprises:
the liquid collecting bottle is provided with a liquid inlet which is communicated with the suction cavity;
the two ends of the exhaust pipe are respectively communicated with the liquid collecting bottle and the negative pressure terminal, and the negative pressure terminal is used for extracting gas in the liquid collecting bottle.
3. The negative pressure collecting device according to claim 2, wherein: the outlet of the suction cavity communicated with the liquid inlet of the liquid collecting bottle is positioned at the bottom of the suction cavity.
4. The negative pressure collecting device according to claim 2, wherein: the liquid inlet of the liquid collecting bottle and/or the air outlet of the liquid collecting bottle communicated with the air exhaust pipe are/is positioned at the upper part of the liquid collecting bottle.
5. The negative pressure collection device of claim 1, wherein: the number of the first placing holes is multiple, the number of the second placing holes is multiple, and the first placing holes and the second placing holes are the same in number and are correspondingly arranged; the collecting pipes and the adsorption columns are equal in number and are arranged correspondingly, and the number of the adsorption columns is equal to or less than that of the second placing holes;
the negative pressure collecting device also comprises a plurality of plugs, each second placing hole is inserted into one of the adsorption column and the plugs, and the plugs are in sealing fit with the inserted second placing holes.
6. The negative pressure collection device of claim 1, wherein: the box body comprises a shell and a collecting plate frame, the shell forms an accommodating cavity with an opening, the collecting plate frame is positioned in the accommodating cavity, a first surface, far away from the opening, of the collecting plate frame and the inner surface of the accommodating cavity enclose a suction cavity, a second surface, close to the opening, of the collecting plate frame and the inner surface of the accommodating cavity enclose a transition cavity, and the air exhaust gap is communicated with the transition cavity; the first hole of placing set up in collect on the grillage, it runs through still to be equipped with on the grillage to collect the suction passageway of grillage, the suction passageway will suction chamber, transition chamber are linked together.
7. The negative pressure collection device of claim 6, wherein: the shell includes casing and lower casing, go up the casing the internal surface with the internal surface of casing encloses down hold the chamber, the internal surface of casing is equipped with around the spacing platform of circumference setting down, spacing platform has along the place the platform of radial plane setting and around the spacing wall of circumference setting, the first surface of collecting the grillage is shelved on the place the platform, the outer peripheral face of collecting the grillage with spacing wall contacts.
8. The negative pressure collection device of claim 7, wherein: the contact surface of the upper shell and the lower shell is provided with a first positioning ring protruding towards the direction of the lower shell, the contact surface of the lower shell and the upper shell is provided with a second positioning ring protruding towards the direction of the upper shell, and the outer peripheral surface of the second positioning ring is matched with the inner peripheral surface of the first positioning ring.
9. The negative pressure collection device of claim 7, wherein: the shell further comprises a sealing ring, and the sealing ring is arranged on a contact surface where the upper shell and the lower shell are in contact.
10. The negative pressure collection device of claim 6, wherein: the suction channel comprises a recess recessed inwardly from the first surface of the collection plate holder and at least one vertical through hole extending from the recess to the second surface of the collection plate holder.
11. The negative pressure collection device of claim 10, wherein: the suction channel further comprises at least one circumferential through hole extending from the recess to the outer circumferential surface of the collecting ledge.
12. The negative pressure collection device of claim 1, wherein: the negative pressure collecting device further comprises a sealing ring, the sealing ring is arranged between the placing cover and the box body, and the sealing ring surrounds the first placing hole.
13. The negative pressure collection device of claim 12, wherein: the surface of the box body facing the placing cover is provided with a sealing groove surrounding the first placing hole, and the sealing ring is placed in the sealing groove.
14. The negative pressure collection device of claim 1, wherein: the discharge port of the adsorption column is inserted into the inlet of the collection pipe, and the air extraction gap is formed between the outer peripheral surface of the adsorption column and the inner peripheral surface of the collection pipe.
15. The negative pressure collecting device as claimed in claim 1, wherein the placing cover comprises:
the mounting plate is provided with at least one through mounting hole;
the two ends of the mounting sleeve are provided with openings, the mounting sleeve is inserted into the mounting hole, and the inner peripheral surface of the mounting sleeve forms the second placing hole.
16. The negative pressure collection device of claim 15, wherein: the mounting sleeve is made of an elastic material.
17. The negative pressure collection device of claim 1, wherein: a groove extending in the circumferential direction is formed in one end, facing the placing cover, of the first placing hole, and a flange extending in the circumferential direction is formed in the outer circumferential surface of the collecting pipe; when the collecting pipe is inserted into the first placing hole, the flange of the collecting pipe is matched with the groove of the first placing hole.
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| CN201920884229.4U CN210145551U (en) | 2019-06-12 | 2019-06-12 | Negative pressure collecting device |
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| CN201920884229.4U CN210145551U (en) | 2019-06-12 | 2019-06-12 | Negative pressure collecting device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110193216A (en) * | 2019-06-12 | 2019-09-03 | 江苏睿玻生物科技有限公司 | Negative pressure collecting device and negative pressure collection method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110193216A (en) * | 2019-06-12 | 2019-09-03 | 江苏睿玻生物科技有限公司 | Negative pressure collecting device and negative pressure collection method |
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