CN210108951U - Protein sensor based on Fano resonance - Google Patents
Protein sensor based on Fano resonance Download PDFInfo
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- CN210108951U CN210108951U CN201920772553.7U CN201920772553U CN210108951U CN 210108951 U CN210108951 U CN 210108951U CN 201920772553 U CN201920772553 U CN 201920772553U CN 210108951 U CN210108951 U CN 210108951U
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- fano resonance
- sensor
- film
- protein
- protein sensor
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- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 21
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 21
- 229910052751 metal Inorganic materials 0.000 claims description 13
- 239000002184 metal Substances 0.000 claims description 13
- 239000012528 membrane Substances 0.000 claims description 5
- 230000035945 sensitivity Effects 0.000 abstract description 9
- 238000001514 detection method Methods 0.000 description 4
- 238000002310 reflectometry Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 3
- 238000001579 optical reflectometry Methods 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000001902 propagating effect Effects 0.000 description 1
- 238000012031 short term test Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
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- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The utility model discloses a protein sensor based on Fano resonance, sensor structure from the bottom up include prism, metallic film, YF3Films and AlN films. The utility model discloses the sensor is based on Fano resonance mode, and sensitivity is high, and is fast, simple structure simultaneously, convenient operation. The utility model discloses the sensor has very high sensitivity, and sensitivity can reach 30/RIU.
Description
Technical Field
The utility model belongs to the optics field, concretely relates to sensor that carries out protein molecule detection based on Fano resonance.
Background
Surface plasmon resonance is an optical physical phenomenon in which, when an electromagnetic wave is incident on a metal dielectric interface from a prism at a certain angle, electrons on the metal surface vibrate to form a surface plasmon wave propagating along the metal dielectric interface. When the frequency of the surface plasma wave is the same as that of the incident electromagnetic wave, the two waves are strongly coupled to form surface plasma resonance. The surface plasmon resonance is very sensitive to the thickness and refractive index of the electrolyte near the metal, and can be used as a surface plasmon resonance sensor for detecting the change of relevant parameters. However, in the fields of biology and medicine, the sensitivity of surface plasmon sensors is limited and cannot meet the detection requirements for ultra-low concentrations of protein molecules.
Coupling of the surface plasmon wave and the planar waveguide may create Fano resonance. The Fano resonance has the characteristics of narrow resonance peak and severely changed asymmetric spectral line, is extremely sensitive to the change of the surrounding environment, and has wide application prospect. The protein sensor based on Fano resonance has higher sensitivity than the traditional surface plasma sensor as a novel sensor, can be used for detecting protein molecules with ultralow concentration, and realizes high-precision rapid detection.
Disclosure of Invention
The utility model aims at solving the defect that prior art exists, provide a high sensitivity protein sensor based on Fano resonance.
The utility model provides a protein sensor based on Fano resonance, this sensor structure from the bottom up include prism, metallic film, YF3Films and AlN films.
Furthermore, the AlN membrane is positioned on the uppermost layer of the sensor and is directly contacted with the medium sample to be detected.
Further, the AlN film has a thickness of 50-200 nm.
Further, the YF3The film thickness is 100-1000 nm.
Compared with the prior art, the utility model has the advantages of it is following:
the utility model adopts a special structure, which can be arranged on the metal film and YF3The interface of the film generates surface plasma wave and utilizes YF3The film, the AlN film and the medium to be detected generate a planar waveguide mode, and the surface plasma wave and the planar waveguide are coupled to form Fano resonance, so that the detection limit of the sensor can be further improved. The AlN film has good protein compatibility, can be directly combined with protein molecules of a medium to be detected and fixed on the surface, does not need other chemical reagents, and is simple and convenient. The utility model discloses a sensor simple structure, convenient to use, sensitivity is high, can realize high accuracy short-term test. The utility modelThe novel sensor has high sensitivity which can reach 30 degrees/RIU.
Drawings
Fig. 1 is a schematic structural diagram of an embodiment of the present invention.
Fig. 2 is a graph illustrating the variation of reflectivity with incident angle according to the embodiment of the present invention.
Fig. 3 is a graph illustrating the variation of reflectivity with refractive index according to an embodiment of the present invention.
In the figure, 1-prism, 2-metal film, 3-YF3Membrane, 4-AlN membrane.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the drawings in the embodiments of the present invention are combined below to clearly and completely describe the technical solutions in the embodiments of the present invention.
As shown in FIG. 1, the embodiment of the present invention provides a protein sensor based on Fano resonance, which comprises a prism 1, a metal film 2, and YF3Film 3, AlN film 4. Prism 1 is located the bottom, and metal film 2 is located prism 1 top, YF3The film 3 is located above the metal film 2, and the AlN film 4 is located on the YF3And a protein molecule recognition layer which is arranged above the membrane 3 and is contacted with a medium to be detected. The prism 1 and the metal film 2 are used for exciting surface plasma wave, and the YF3The film, the AlN film and the medium to be measured are used for exciting a planar waveguide mode, and the surface plasma wave and the planar waveguide are coupled to form Fano resonance. When incident light is incident on the prism 1 at a certain angle, a part of the light is refracted at the metal films 2, YF above the prism 13Fano resonance is excited in the film 3, the AlN film 4 and the medium to be measured, the other part of light is reflected and emitted out from the prism 1, the reflected light contains Fano resonance spectrum information, and the position of the minimum value of the reflectivity of the reflected light changes along with the refractive index of the medium to be measured. By measuring the change of the position of the minimum value of the reflectivity of the reflected light along with the refractive index of the medium to be detected when Fano resonance occurs, the type and the concentration of protein molecules in the medium to be detected can be detected in an angle modulation mode.
Further, the prism 1 is an SF11 edgeThe metal film 2 is a silver film with the thickness of 50 nm; YF3The thickness of the film 3 is 800nm, the thickness of the AlN film 4 is 115nm, the refractive index of the medium to be measured is 1.3330, and the curve diagram of the change of the reflection light reflectivity along with the incident angle is shown in FIG. 2. After the protein molecules are added into the medium to be measured, the refractive index of the medium to be measured changes with the difference of the types and concentrations of the added protein molecules, and a curve diagram of the measured reflection light reflectivity changing with the refractive index is shown in fig. 3. As can be seen from the figure, when the refractive index change Δ n of the medium to be measured is 0.0001RIU, the reflected light reflectance curve position changes by 0.003 °, and thus it can be concluded that the sensitivity of the sensor is 30 °/RIU.
Claims (4)
1. A protein sensor based on Fano resonance is characterized in that the protein sensor structure based on Fano resonance comprises a prism, a metal film and YF from bottom to top3Films and AlN films.
2. The protein sensor based on Fano resonance as claimed in claim 1, wherein the AlN membrane is located on the uppermost layer of the sensor and directly contacts with the medium sample to be measured.
3. A Fano resonance-based protein sensor according to claim 1, wherein the AlN film thickness is 50-200 nm.
4. The Fano resonance-based protein sensor of claim 1, wherein the YF is3The film thickness is 100-1000 nm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920772553.7U CN210108951U (en) | 2019-05-27 | 2019-05-27 | Protein sensor based on Fano resonance |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920772553.7U CN210108951U (en) | 2019-05-27 | 2019-05-27 | Protein sensor based on Fano resonance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210108951U true CN210108951U (en) | 2020-02-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201920772553.7U Expired - Fee Related CN210108951U (en) | 2019-05-27 | 2019-05-27 | Protein sensor based on Fano resonance |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN210108951U (en) |
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2019
- 2019-05-27 CN CN201920772553.7U patent/CN210108951U/en not_active Expired - Fee Related
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20200221 Termination date: 20210527 |
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| CF01 | Termination of patent right due to non-payment of annual fee |