CN210079560U

CN210079560U - Variable-pitch multi-channel adjusting device and liquid transfer device comprising same

Info

Publication number: CN210079560U
Application number: CN201920468359.XU
Authority: CN
Inventors: 黄超能; 刘建安; 陈超原
Original assignee: Foshan Super Hydrogen Intelligent Equipment Co Ltd
Current assignee: Foshan Super Hydrogen Intelligent Equipment Co Ltd
Priority date: 2019-04-08
Filing date: 2019-04-08
Publication date: 2020-02-18
Anticipated expiration: 2029-04-08

Abstract

The utility model discloses a variable-pitch multichannel adjusting device, which comprises a base and a plurality of pipetting components, wherein a first linear slide rail is arranged in the base, the pipetting components are sequentially and slidably connected to the first linear slide rail, a first linear driving device is arranged on the base, and the first linear driving device drives the pipetting component positioned at the outermost side of the first linear slide rail to slide along the first linear slide rail; all be equipped with the journey spacer pin between two adjacent move liquid subassemblies, the first end both ends of journey spacer pin all are equipped with the locating part, all move liquid the subassembly in all be equipped with the spacing hole that the locating part matches the use, two adjacent move liquid subassemblies pass through the journey spacer pin carries out spacing connection. The utility model has the advantages of simple structure and compactness, can adapt to the orifice plate of two kinds of different hole intervals simultaneously under the condition of keeping multichannel structure, have good market prospect.

Description

Variable-pitch multi-channel adjusting device and liquid transfer device comprising same

Technical Field

The utility model relates to a reagent transmission technical field, in particular to but variable distance multichannel adjusting device reaches pipettor including it.

Background

The pipettor is an essential experimental instrument for all biochemical laboratories to perform immunization, cell culture, clinical diagnosis and food analysis, and the pipettor can transfer biochemical reagents into a specific experimental vessel, such as a 24-well plate, a 48-well plate, a 96-well plate or a 384-well plate. The appearance of multichannel pipettor has improved the work efficiency that moves the liquid greatly, but has different kinds of orifice plates on the market, for example ELIAS plate or cell culture board etc. to different kinds of orifice plates, its hole interval is invariable, because fixed interval's multichannel pipettor is only applicable to the orifice plate of a hole interval, consequently the laboratory often need be equipped with many multichannel pipettors, but this has increased not few expenses burden undoubtedly. Although the single-channel pipettor can be suitable for any kind of pore plate, the pipetting efficiency is too low, and a large amount of human resources are wasted.

SUMMERY OF THE UTILITY MODEL

The to-be-solved technical problem of the utility model is: the variable-pitch multi-channel adjusting device is simple and compact in structure and can meet the hole pitch requirements of different hole plates.

The utility model also provides a pipettor including variable apart from multichannel adjusting device.

The utility model provides a solution of its technical problem is:

the variable-pitch multi-channel adjusting device comprises a base and a plurality of pipetting components, wherein a first linear slide rail is arranged in the base, the pipetting components are sequentially connected onto the first linear slide rail in a sliding manner, a first linear driving device is arranged on the base, and the first linear driving device drives the pipetting components positioned at the outermost side of the first linear slide rail to slide along the first linear slide rail; all be equipped with the journey spacer pin between two adjacent move liquid subassemblies, the first end both ends of journey spacer pin all are equipped with the locating part, all move liquid the subassembly in all be equipped with the spacing hole that the locating part matches the use, two adjacent move liquid subassemblies pass through the journey spacer pin carries out spacing connection.

When two adjacent move liquid the subassembly and be in during the certain distance of mutual interval under the limiting displacement of fixed distance spacer pin, do this moment the utility model discloses an initial condition when two adjacent move liquid the mutual butt of subassembly, do this moment the utility model discloses a displacement state. All move liquid the subassembly can realize initial condition and the switching each other of displacement state under first linear drive device's the drive, the utility model has the advantages of simple structure and compactness can adapt to the orifice plate of two kinds of different hole intervals simultaneously under the condition that keeps the multichannel structure, have good market prospect.

Further, the liquid-transfering component comprises a straw part and a telescopic part, wherein the telescopic part is connected to the straw part in a sliding mode, and the telescopic part is located right above the straw part.

In addition, the pipette part comprises a pipette and a first slide block, and the pipette is fixedly connected to the first slide block; the telescopic part includes telescopic link and second slider, telescopic link fixed connection be in on the second slider, the one end of telescopic link extends the inside of liquid-transfering pipette, the telescopic link with the inside of liquid-transfering pipette keeps sealed. When the telescopic rod moves downwards, the space inside the pipette is reduced to form pressurization, so that the liquid in the pipette is discharged out of the pipette; when the telescopic rod moves upwards, the space inside the pipetting tube is increased to form negative pressure, so that the pipetting tube can suck liquid.

In addition, two second linear driving devices are further arranged on the base, a second linear sliding rail parallel to the first linear sliding rail is arranged between the two second linear driving devices, and the two second linear driving devices drive the second linear sliding rail to ascend and descend together.

In addition, the first sliding block is connected to the first linear sliding rail in a sliding mode, and the second sliding block is connected to the second linear sliding rail in a sliding mode. The second linear driving devices can simultaneously drive all the telescopic rods to ascend and descend by the arrangement, so that liquid discharge or liquid suction of all the liquid-transfer straws can be controlled at one time.

In addition, the first linear driving device and the second linear driving device are any one of an air cylinder, a hydraulic cylinder, a screw rod motor or an electric push rod. The first linear driving devices are horizontally arranged, and the two second linear driving devices are vertically and vertically arranged.

Further, the pipetting assembly located on the innermost side of the first linear slide rail is fixedly connected in the base. The setting can conveniently find the positioning original point accurately, and the original point drift is avoided.

Furthermore, two adjacent fixed-distance limiting pins are arranged in a staggered mode. Because the size of the liquid-transfering component is small, in order to avoid the interference of two adjacent fixed-distance limiting pins in a variable-distance state, the two adjacent fixed-distance limiting pins need to be arranged in a staggered mode.

Furthermore, the utility model also provides a pipettor, including triaxial work platform and foretell variable-pitch multichannel adjusting device, the pedestal connection be in on the triaxial work platform. Due to the working requirement, when the base is connected to the three-axis working platform, the setting direction of the base must ensure that the pipetting tube points vertically downwards; the three-axis working platform can drive the base to move along the X-axis direction, the Y-axis direction and the Z-axis direction.

Furthermore, a placing platform for placing the pore plate is arranged on the three-axis working platform, and a waste material box with a suction pipe clamping and stripping plate is arranged at the corner of the placing platform. When the pipette tips need to be replaced, the pipette tips are only required to be moved to the position below the clamping and releasing seam of the pipette clamping and releasing plate, the three-axis working platform is utilized to lift the height of the base, so that the pipette tips and the pipette tips can be separated, and the waste pipette tips can be collected in the waste box.

Drawings

In order to more clearly illustrate the technical solution in the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly described below. It is clear that the described figures represent only some embodiments of the invention, not all embodiments, and that a person skilled in the art can also derive other designs and figures from these figures without inventive effort.

FIG. 1 is a schematic perspective view of a variable-pitch multi-channel adjustment apparatus;

FIG. 2 is a front view of the variable pitch multi-channel adjustment mechanism;

FIG. 3 is a cross-sectional view taken along line A-A of FIG. 2;

FIG. 4 is a cross-sectional view taken along line B-B of FIG. 2;

fig. 5 is a schematic perspective view of a pipette;

fig. 6 is a partial view of the variable-pitch multi-channel adjustment device when connected to a three-axis work platform.

Detailed Description

The conception, the specific structure, and the technical effects produced by the present invention will be clearly and completely described below in conjunction with the embodiments and the accompanying drawings to fully understand the objects, the features, and the effects of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and other embodiments obtained by those skilled in the art without inventive labor based on the embodiments of the present invention all belong to the protection scope of the present invention. In addition, all the connection relations mentioned herein do not mean that the components are directly connected, but mean that a better connection structure can be formed by adding or reducing connection accessories according to the specific implementation situation. The utility model provides an each technical feature can the interactive combination under the prerequisite of conflict each other. Finally, it should be noted that the terms "center, upper, lower, left, right, vertical, horizontal, inner, outer" and the like are used herein to indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only used for convenience of description and simplification of description, but do not indicate or imply that the device or element being referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms first, second and third as used herein are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

Fig. 1 to 4 show a preferred embodiment of a variable-pitch multi-channel adjusting device according to the invention. As shown in the figure, the variable-pitch multi-channel adjusting device comprises a base 100 and a plurality of pipetting assemblies 200, wherein a first linear sliding rail 110 is arranged in the base, a containing cavity 120 is arranged in the base, and the first linear sliding rail and the pipetting assemblies are both positioned in the containing cavity. Since the common format of the well plate is 3X8, 6X8, 12X8 or 48X8, the number of wells in each column of the well plate is eight, and thus the number of pipetting modules is four or eight, preferably eight. As shown in fig. 4, the pipetting assembly comprises a pipette part 210 and a telescopic part 220, the pipette part comprises a pipette tube 211 and a first slide block 212, the upper part of the pipette tube is fixedly connected inside the first slide block, and the lower part of the pipette tube extends out of the base; the telescopic part comprises a telescopic rod 221 and a second sliding block 222, and the upper end of the telescopic rod is fixedly connected inside the second sliding block; the second slider is located right above the first slider, two third linear slide rails 213 are arranged on the first slider, a third linear bearing 225 matched with the third linear slide rails is arranged in the second slider, and the second slider is connected to the third linear slide rails in a sliding manner. The lower extreme of telescopic link extends to the inside of pipetting straw, the telescopic link with the inside of pipetting straw keeps sealed, makes when the telescopic link moves down, the inside space reduction of pipetting straw forms the pressure boost for liquid in the pipetting straw is discharged outside the pipetting straw, and when the telescopic link moved up, the inside space increase of pipetting straw formed the negative pressure, makes the pipetting straw can inhale liquid. In order to keep the telescopic rod sealed from the interior of the pipetting tube, a plurality of sealing rings 223 are provided around the telescopic rod, all of which are located at the inlet of the pipetting tube.

As shown in fig. 1 and fig. 2, all the first sliding blocks are provided with first linear bearings 214 matching with the first linear sliding rails, and the plurality of first sliding blocks are sequentially connected to the first linear sliding rails in a sliding manner; in order to improve the stability of first slider when sliding, the quantity of first linear slide rail is more than two, the utility model discloses preferably four, four first linear slide rail rectangle distributes in the base. Because the volume of the first sliding block is small, in order to avoid the interference of two adjacent linear bearings, the two adjacent linear bearings need to be arranged in a staggered manner; be equipped with four first through-holes 215 on the first slider, four the position of first through-hole is with four the position of first linear slide rail is corresponding, wherein is equipped with on the first through-hole in upper left corner and lower right corner first linear bearing correspondingly, is equipped with on the first through-hole in the lower left corner of first slider and the upper right corner adjacent with it first linear bearing for when two adjacent first slider butts, first linear bearing can keep away the sky in the first through-hole.

As shown in fig. 1 and 2, a first linear driving device 300 is disposed on the base, and the first linear driving device drives the first slider located at the outermost side of the first linear sliding rail to slide along the first linear sliding rail, and referring to fig. 2, the first slider located at the outermost side refers to a first slider closest to the first linear driving device, specifically, located at the leftmost end of the first linear sliding rail, and the first slider located at the innermost side refers to a first slider farthest from the first linear driving device, specifically, located at the rightmost end of the first linear sliding rail; the base is further provided with two second linear driving devices 400, a second linear sliding rail 410 parallel to the first linear sliding rail is arranged between the two second linear driving devices, and the two second linear driving devices drive the second linear sliding rail to ascend and descend together. First linear drive with second linear drive is any one of cylinder, pneumatic cylinder, lead screw motor or electric putter, because the stroke precision of lead screw motor is higher, consequently the utility model provides a first linear drive and the equal preferred lead screw motor of second linear drive, the horizontal level setting of first linear drive, two the equal vertical setting of second linear drive. As shown in fig. 3, a second through hole 216 is provided in the first slider located at the outermost side of the first linear guideway, a first lead screw nut 310 is provided in the second through hole, and a lead screw 320 on the first linear driving device is matched with the first lead screw nut for use, so that the first linear driving device can drive the first slider to slide along the first linear guideway; meanwhile, part of the first sliding blocks also need to be provided with the second through holes, and the second through holes in the part of the first sliding blocks mainly play a role in avoiding the space for the screw rods on the first linear driving device.

As shown in fig. 1 and fig. 2, the second linear slide rail is fixedly connected between the lead screw nut blocks 420 on the two second linear driving devices, second linear bearings 223 matched with the second linear slide rail are arranged in all the second slide blocks, and the second slide blocks are sequentially connected to the second linear slide rail in a sliding manner; in order to improve the stability of the second sliding block during sliding, the number of the second linear sliding rails is two. Because the volume of the second sliding block is small, in order to avoid the interference of two adjacent second linear bearings, the two adjacent second linear bearings need to be arranged in a staggered manner; as shown in fig. 1, two second through holes 224 are formed in the second slider, the positions of the two second through holes correspond to the positions of the two second linear sliding rails, wherein the second linear bearing is disposed on the first through hole on the left side, and correspondingly, the second linear bearing is disposed on the first through hole on the right side of the adjacent first slider, so that when the two adjacent second sliders are abutted, the second linear bearing can avoid a gap in the second through hole. The second linear driving devices can simultaneously drive all the telescopic rods to ascend and descend by the arrangement, so that liquid discharge or liquid suction of all the liquid-transfer straws can be controlled at one time.

As shown in fig. 3, a fixed-distance limit pin 500 is arranged between two adjacent first sliding blocks, a limit part 510 is arranged at each of the first end and the last end of the fixed-distance limit pin, a limit hole 217 matched with the limit part for use is arranged in each first sliding block, the limit holes are stepped holes, and the two adjacent first sliding blocks are in limit connection through the fixed-distance limit pins. In order to install the fixed-distance limiting pin in the limiting hole, the limiting part is specifically a screw, the middle part of the fixed-distance limiting pin is specifically a pin column 520 with internal threads, and the size of a nut of the screw is larger than that of the pin column. The installation method of the fixed-distance limiting pin and the limiting hole comprises the following steps: firstly, connecting one end of the pin column by using a screw to form a semi-finished product of the fixed-distance limiting pin, then penetrating the semi-finished product of the fixed-distance limiting pin through two adjacent limiting holes, and finally connecting the other end of the pin column by using a screw to form the fixed-distance limiting pin, wherein the maximum distance between two adjacent first sliding blocks is fixed by the fixed-distance limiting pin. Because the size of the first sliding block is small, in order to avoid interference between two adjacent fixed-distance limiting pins when the two adjacent first sliding blocks are mutually abutted, the two adjacent fixed-distance limiting pins need to be arranged in a staggered mode.

In order to conveniently find and align the positioning origin and avoid the origin from drifting, the first slide block which is positioned at the innermost side of the first linear slide rail is fixedly connected in the base. If the first slide block is not fixedly connected in the base, when the first linear driving device drives the first slide block positioned at the outermost side of the first linear slide rail outwards, if the first linear driving device deviates from the initial position, the positions of all the liquid transfer assemblies deviate from the original position; if the first sliding block is fixedly connected in the base, the maximum adjusting positions of all the liquid-transferring assemblies are fixed under the limiting action of the fixed-distance limiting pin, and the maximum adjusting positions are the original positions.

The working principle of the variable-pitch multi-channel adjusting device is as follows: when the distance is required to be changed, the first linear driving device drives the liquid transferring assembly positioned at the outermost side of the first linear slide rail to move towards other liquid transferring assemblies, and when all the liquid transferring assemblies are mutually abutted, the distance changing state of the utility model is realized; when needs reset, first linear drive device drives and is located the first linear slide rail moves the liquid subassembly and leaves other and move the liquid subassembly in the outside under the limiting displacement of journey spacer pin, after adjacent two move the liquid subassembly and be separated by the certain distance, the former moves the liquid subassembly and can drive the next and move liquid subassembly and together remove to analogize from this, finally adjacent two move the interval between the liquid subassembly by journey spacer pin is fixed, does this moment the utility model discloses an initial condition.

As shown in fig. 5 and 6, the utility model also provides a pipettor, the pipettor includes triaxial work platform 600 and foretell variable distance multichannel adjusting device, triaxial work platform includes X axle moving mechanism 610, Y axle moving mechanism 620 and Z axle moving mechanism 630, Y axle moving mechanism sliding connection be in X axle moving mechanism, Z axle moving mechanism sliding connection be in Y axle moving mechanism, wherein base sliding connection be in on the Z axle moving mechanism, make triaxial work platform can drive variable distance multichannel adjusting device removes along X axle direction, Y axle direction and Z axle direction. Due to the working requirement, when the base is connected on the Z-axis moving mechanism in a sliding manner, the base is arranged in the direction that the pipetting probe points downwards vertically.

For convenient use, be equipped with the place the platform 700 that is used for placing the orifice plate on the triaxial work platform, place the platform is located the below of liquid-transfering pipette, place the platform's upper left corner is equipped with the waste material box 710 that has pipette card take-off board 711, be equipped with card and take-off seam 712 on the pipette card take-off board, the interval of card taking-off seam is less than the size of pipette tip. The pipette tip belongs to plastic consumables and is arranged at the tail end of the liquid transfer pipette; when the pipette tips need to be replaced, the pipette tips can be separated from the pipette tips and collected into the waste box only by moving the pipette tips to the position below the clamping and separating seam and lifting the height of the pipette tips by the Z-axis movement mechanism.

While the preferred embodiments of the present invention have been described in detail, it will be understood by those skilled in the art that the foregoing and various other changes, omissions and deviations in the form and detail thereof may be made without departing from the scope of this invention.

Claims

1. Variable-pitch multi-channel adjusting device, its characterized in that: the automatic liquid transferring device comprises a base (100) and a plurality of liquid transferring assemblies (200), wherein a first linear slide rail (110) is arranged in the base (100), the liquid transferring assemblies (200) are sequentially connected onto the first linear slide rail (110) in a sliding mode, a first linear driving device (300) is arranged on the base (100), and the first linear driving device (300) drives the liquid transferring assemblies (200) located on the outermost side of the first linear slide rail (110) to slide along the first linear slide rail (110); all be equipped with journey spacing pin (500) between two adjacent liquid removing assemblies (200), the head and the end both ends of journey spacing pin (500) all are equipped with locating part (510), all move liquid all be equipped with in the subassembly (200) with spacing hole (217) that locating part (510) match the use, two adjacent liquid removing assemblies (200) pass through journey spacing pin (500) carry out spacing connection.

2. The variable pitch multi-channel adjustment device of claim 1, wherein: the liquid transfer assembly (200) comprises a straw part (210) and a telescopic part (220), wherein the telescopic part (220) is connected to the straw part (210) in a sliding mode, and the telescopic part (220) is located right above the straw part (210).

3. The variable pitch multi-channel adjustment device of claim 2, wherein: the pipette part (210) comprises a pipette tip (211) and a first slide block (212), and the pipette tip (211) is fixedly connected to the first slide block (212); the telescopic part (220) comprises a telescopic rod (221) and a second sliding block (222), the telescopic rod (221) is fixedly connected to the second sliding block (222), one end of the telescopic rod (221) extends into the pipetting tube (211), and the telescopic rod (221) and the pipetting tube (211) are sealed.

4. A variable-pitch multi-channel adjustment device according to claim 3, characterized in that: the base (100) is further provided with two second linear driving devices (400), a second linear sliding rail (410) parallel to the first linear sliding rail (110) is arranged between the two second linear driving devices (400), and the two second linear driving devices (400) drive the second linear sliding rail (410) to ascend and descend together.

5. The variable pitch multi-channel adjustment device of claim 4, wherein: the first sliding block (212) is connected to the first linear sliding rail (110) in a sliding mode, and the second sliding block (222) is connected to the second linear sliding rail (410) in a sliding mode.

6. The variable pitch multi-channel adjustment device of claim 4, wherein: the first linear driving device (300) and the second linear driving device (400) are any one of an air cylinder, a hydraulic cylinder, a screw rod motor or an electric push rod.

7. The variable pitch multi-channel adjustment device of claim 1, wherein: the pipetting assembly (200) positioned at the innermost side of the first linear slide rail (110) is fixedly connected in the base (100).

8. The variable pitch multi-channel adjustment device of claim 1, wherein: two adjacent fixed-distance limiting pins (500) are arranged in a staggered mode.

9. A pipette, characterized by: comprising a three-axis working platform (600) and a variable-pitch multi-channel adjustment device according to any one of claims 1 to 8, the base (100) being connected to the three-axis working platform (600).

10. A pipette as defined in claim 9, wherein: the three-axis working platform (600) is provided with a placing platform (700) for placing a hole plate, and a waste box (710) with a suction pipe clamp stripping plate (711) is arranged at the corner of the placing platform (700).