CN210012839U - Constant-temperature oscillation incubation device suitable for liquid transfer workstation - Google Patents
Constant-temperature oscillation incubation device suitable for liquid transfer workstation Download PDFInfo
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- CN210012839U CN210012839U CN201822074137.8U CN201822074137U CN210012839U CN 210012839 U CN210012839 U CN 210012839U CN 201822074137 U CN201822074137 U CN 201822074137U CN 210012839 U CN210012839 U CN 210012839U
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Abstract
The utility model discloses a constant temperature oscillation incubation device suitable for a liquid transfer workstation, which comprises a constant temperature oscillation mechanism and an auxiliary mechanism; the constant-temperature oscillating mechanism comprises an oscillating module and a constant-temperature module, wherein the oscillating module comprises a fixed base, a linear motor, a motor shaft, a first fixed table, a second fixed table, a middle sliding table, an upper sliding table, an eccentric bearing, an upper sliding rod, a lower sliding rod, a self-lubricating sleeve and an oscillating table; the constant temperature module is arranged above the oscillation module and can be used for placing a microporous plate, the auxiliary mechanism comprises a box body, and a microporous plate support is placed on the box body. The device drives the eccentric bearing to rotate through the linear motor, and the eccentric bearing drives the sliding table to reciprocate along the sliding rod, so that the oscillating table is driven to realize an oscillating function. The device can cooperate mechanical tongs and the multichannel pipettor that move the liquid workstation, realizes that the micropore board is at the constant temperature oscillation and incubate the automatic transfer between device and the liquid workstation, realizes full-automatic high flux biological sample constant temperature incubation operation simultaneously.
Description
Technical Field
The utility model relates to a device is hatched in constant temperature oscillation, concretely relates to device is hatched in constant temperature oscillation suitable for move liquid workstation.
Background
Constant temperature shaking incubation is a common operation in biochemical experiments, and is commonly used in experiments such as probe modification, nucleic acid hybridization and the like. Common constant temperature oscillation device is the great incubator type of specification mostly, and its structural function is single, can not integrate in full-automatic move liquid workstation, and the access of consumptive material all relies on manual operation simultaneously, can not cooperate mechanical tongs and the multichannel pipettor that move liquid workstation, realizes the automatic transfer of micropore board between constant temperature oscillation incubation device and move liquid workstation, is unfavorable for realizing the laboratory automation.
SUMMERY OF THE UTILITY MODEL
Utility model purpose: the utility model aims at providing a device is hatched in constant temperature oscillation, the device adaptation in all kinds of full-automatic liquid-transfering work stations, can cooperate mechanical tongs and the multichannel pipettor that move the liquid work station, realize the operation is hatched in full-automatic constant temperature oscillation.
The technical scheme is as follows: a constant temperature oscillation incubation device suitable for a liquid transfer workstation comprises a constant temperature oscillation mechanism and an auxiliary mechanism; the constant-temperature oscillating mechanism comprises an oscillating module and a constant-temperature module, the oscillating module comprises a fixed base with a groove-shaped middle part, a linear motor is fixedly connected with the fixed base, a motor shaft is connected with the linear motor, an eccentric bearing is fixed on the motor shaft, a first fixed table and a second fixed table are fixed on the fixed base, a lower sliding rod which penetrates through the middle sliding table is fixed on the first fixed table and the second fixed table, an upper sliding rod which penetrates through the upper sliding table is fixed on the side wall of the fixed base, the upper sliding rod and the lower sliding rod are mutually vertical, the middle sliding table and the upper sliding table are in a shape of Chinese character 'ji', the middle sliding table is hollowed out, the eccentric bearing penetrates through the hollowed part of the upper sliding table and is flush with the top of the upper sliding table, a bulge which is arranged at the upper end of; a microporous plate can be placed on the constant temperature module; the auxiliary mechanism comprises a box body, the interior of the box body is of a hollow structure, a microporous plate support is placed at the top of the box body, and the box body is connected with the constant-temperature oscillation mechanism.
Has the advantages that: (1) the utility model discloses the function is complete, and whole device can directly be integrated in full-automatic move liquid workstation, and its functional mechanism both can do and place all kinds of consumptive materials, also can possess heating and vibration mixing effect. (2) The utility model discloses can realize experimental required oscillation function completely under the small and exquisite condition of simple structure, oscillation module and constant temperature module both can do not interfere with each other by the autonomous working, also can carry out work simultaneously. (3) The utility model discloses can cooperate mechanical tongs and the multichannel pipettor that move the liquid workstation, realize that the micropore board is at the constant temperature oscillation incubation device and move the automatic transfer between the liquid workstation. (4) The utility model discloses have independent the control unit, both can regard as independent miniaturized equipment to use, also can conveniently integrate to devices such as large-scale biochemical analysis instrument, satisfy user's various actual demands.
Drawings
Fig. 1 is a schematic structural diagram of the present invention;
fig. 2 is a top sectional view of the constant temperature oscillating mechanism of the present invention;
fig. 3 is a front sectional view of the constant temperature oscillating mechanism of the present invention;
FIG. 4 is an overall view of the present invention;
fig. 5 is a schematic structural diagram of the thermostatic module of the present invention;
fig. 6 is an overall outline view of the present invention incorporating a microplate.
Detailed Description
As shown in fig. 1 and 4, the constant temperature oscillation incubation device of the present invention comprises a constant temperature oscillation mechanism and an auxiliary mechanism, as shown in fig. 2-3, the constant temperature oscillation mechanism comprises an oscillation module 101 and a constant temperature module 102. The oscillating module 101 comprises a fixing base 201 with a groove-shaped middle, a linear motor 202 is fixedly connected with the fixing base 201, a motor shaft 203 is connected with the linear motor 202, an eccentric bearing 208 is fixed on the motor shaft, a first fixing table 204 and a second fixing table 205 are fixed on the fixing base, a middle sliding table 206 and an upper sliding table 207 are both in a shape like a Chinese character 'ji' and are hollow in the middle, 2 upper sliding rods 209 penetrate through the upper sliding table 207, 2 self-lubricating sleeves 213 can be arranged in four side walls of the middle sliding table 206, 2 upper sliding rods 209 penetrate through the self-lubricating sleeves, 2 lower sliding rods 210 penetrate through the self-lubricating sleeves 213 and are respectively fixedly connected with the first fixing table 204 and the second fixing table 205, and 2 lower sliding rods 210 and 2 upper sliding rods 209 are perpendicular to each other and are arranged in a shape like. The eccentric bearing 208 penetrates through the hollowed-out part of the upper sliding table 207 and is flush with the top of the upper sliding table 207, the eccentric bearing is fixedly connected with the oscillating table, specifically, two cylindrical protrusions at the upper end of the eccentric bearing 208 are matched with two cylindrical grooves in the middle of the oscillating table 214, and the oscillating table 214 is fixedly connected with the upper sliding table 207 through 4 screws. The oscillation module still includes shock attenuation post 211, and 6 total shock attenuation posts 211 are the rubber material, and its bottom is fixed on unable adjustment base 201 with the screw, and first fixed station 204, second fixed station 205 are connected with 3 top with screw fixation of shock attenuation post 211 respectively, and the effect of shock attenuation post 211 is the vibrations that the work of buffering comes from upper mechanism and produces to the stability of base and whole device has been ensured. The oscillating module further includes a configuration support block 209, and a weight support block 209 is located below the eccentric bearing 208 and fixed on the motor shaft, and the weight support block 209 rotates together with the eccentric bearing 208 and always on the other side of the eccentric bearing 208, ensuring stability of the entire apparatus when the linear motor 202 rotates at a high speed.
As shown in fig. 5, the constant temperature module 102 specifically includes a heat-conducting plate 301, a heat-insulating plate 302, and a heating plate 303, wherein the bottom of the heat-insulating plate 302 is fixedly connected with the oscillating table 214, the heating plate 303 is fixedly connected with the heat-insulating plate 302 and the heat-conducting plate 301, a circle of outer heat-insulating frame is arranged on the periphery of the heat-conducting plate 301, and each of four sides of the outer heat-insulating frame has two protrusions for fixing the micro-. The heating plate 303 is an aluminum-based resistance heating plate, 132 chip resistors are welded on the surface of the heating plate, the heating power of the heating plate can be changed arbitrarily by changing the resistance of the resistors, and the heating power can be calculated accurately. The surface of the aluminum-based resistance heating plate is also integrated with a PT100 thermistor which is used for monitoring the temperature of the aluminum-based resistance heating plate in real time and used as a feedback signal for temperature control, so that the heating module is accurately controlled by temperature. The aluminum-based resistance heating plate is coated with heat-conducting silicone grease between the aluminum-based resistance heating plate and the heat conducting plate, and the aluminum-based resistance heating plate is tightly attached to the heat conducting plate through screws so as to improve the heat conducting speed.
As shown in fig. 6, the auxiliary mechanism comprises three boxes 103, the interior of each box is of a hollow structure, a microporous plate support is placed at the top of each box, a microporous plate can be placed on the microporous plate support according to actual needs, a motor driver and a control circuit board are arranged in a cavity of each box, and the boxes are connected with the constant-temperature oscillation mechanism.
The utility model discloses mechanical tongs and multichannel pipettor of cooperation liquid-transfering work station realize that the micropore board is hatched the device at constant temperature oscillation and is moved the automatic concrete step that shifts between the liquid-transfering work station as follows:
(1) preparing a test sample, preparing magnetic beads modified by probes, and extracting and amplifying NDA products to be hybridized.
(2) And adding probe modified magnetic beads, hybridization solution, NDA products and pure water into the microplate by using an eight-channel pipettor of a full-automatic pipetting workstation.
(3) Use full-automatic liquid moving workstation's mechanical tongs to shift to the micropore board that is equipped with the sample the utility model discloses an on the constant temperature oscillation mechanism, carry out the constant temperature oscillation and hatch the operation, operation process as follows:
a) the temperature is 95 ℃; time-5 minutes; the linear motor 202 rotates at 30 rpm;
b) the temperature is 55 ℃; time-60 minutes; the linear motor 202 rotates at 15 rpm.
(4) After the reaction is finished, a washing solution is added to carry out two times of washing operations, each time of washing is carried out, oscillation and uniform mixing is carried out for 3 minutes, and the rotating speed of the linear motor 202 is 60 rpm. And after the uniform mixing is finished, the mechanical gripper transfers the micro-porous plate to a full-automatic pipetting workstation for magnetic separation and supernatant removal operation.
(5) After the cleaning operation is finished, the microporous plate is transferred to a constant-temperature oscillation mechanism again, the confining liquid is added, the microporous plate is oscillated and uniformly mixed for half an hour at room temperature, the rotating speed of the linear motor 202 is 30rpm, and then the microporous plate is transferred to a magnetic separation mechanism to carry out magnetic separation and supernatant removal operation.
(6) And (4) completing the hybridization process, and collecting the sample for subsequent detection operation.
Claims (10)
1. The utility model provides a device is hatched in constant temperature oscillation suitable for move liquid workstation which characterized in that: comprises a constant temperature oscillation mechanism and an auxiliary mechanism; the constant-temperature oscillating mechanism comprises an oscillating module (101) and a constant-temperature module (102), the oscillating module (101) comprises a fixed base (201) with a groove-shaped middle part, a linear motor (202) is fixedly connected with the fixed base (201), a motor shaft (203) is connected with the linear motor (202), an eccentric bearing (208) is fixed on the motor shaft (203), a first fixed table (204) and a second fixed table (205) are fixed on the fixed base (201), a lower sliding rod (210) penetrating through a middle sliding table (206) is fixed on the first fixed table (204) and the second fixed table (205), an upper sliding rod (209) penetrating through the upper sliding table (207) is fixed on the side wall of the fixed base (201), the upper sliding rod (209) is vertical to the lower sliding rod (210), the middle sliding table (206) and the upper sliding table (207) are in a shape like a Chinese character 'ji' and have a hollowed middle part, and the eccentric bearing (208) penetrates through the hollowed part of the upper sliding table (207), the eccentric bearing (208) is flush with the top of the upper sliding table (207), and is fixedly connected with the oscillating table (214), and the oscillating table (214) is fixedly connected with the upper sliding table (207); the constant temperature module arranged above the oscillation module can be used for placing a microporous plate; the auxiliary mechanism comprises a box body (103), the inside of the box body (103) is of a hollow structure, a microporous plate support (104) is placed at the top of the box body, and the box body (103) is connected with the constant-temperature oscillation mechanism.
2. The constant temperature shaking incubation device suitable for pipetting stations of claim 1, wherein: four side walls of the middle sliding table (206) are provided with self-lubricating sleeves (213), the upper sliding rod (209) penetrates through the self-lubricating sleeves (213), and the lower sliding rod (210) penetrates through the self-lubricating sleeves (213) to be fixedly connected with the first fixing table (204) and the second fixing table (205) respectively.
3. The constant temperature shaking incubation device suitable for pipetting stations of claim 1, wherein: the constant temperature module (102) comprises a heat insulation plate (302), a heating plate (303) and a heat conduction plate (301), the bottom of the heat insulation plate (302) is fixedly connected with the oscillating table (214), and the heating plate (303) is fixedly connected with the heat insulation plate (302) and the heat conduction plate (301) respectively; and a motor driver and a control circuit board are arranged in the cavity of the box body (103).
4. The constant temperature shaking incubation device suitable for pipetting stations of claim 1, wherein: the oscillation module further comprises a damping column (211), the bottom end of the damping column (211) is fixed on the fixing base (201) through screws, and the top end of the damping column (211) is fixedly connected with the first fixing table (204) and the second fixing table (205) through screws respectively.
5. The constant temperature shaking incubation device suitable for pipetting stations of claim 1, wherein: the eccentric bearing (208) has a protrusion at its upper end that mates with a recess in the middle of the oscillating table (214).
6. The constant temperature shaking incubation device suitable for pipetting stations of claim 1, wherein: the upper sliding rod (209) and the lower sliding rod (210) are both provided with 2 sliding rods which are arranged in a # -shaped manner.
7. The constant temperature shaking incubation device suitable for pipetting stations of claim 1, wherein: the oscillating module further comprises a configuration supporting block (209), and the counterweight supporting block (209) is positioned below the eccentric bearing (208) and fixed on the motor shaft (203).
8. The constant temperature shaking incubation device suitable for pipetting stations of claim 1, wherein: the periphery of the heat conducting plate (301) is also provided with an outer heat insulation frame (304).
9. The isothermal oscillating incubation device suitable for pipetting stations according to claim 8, characterized in that: the four sides of the outer insulating frame (304) have two protrusions (305) on each side.
10. The isothermal oscillating incubation device suitable for pipetting stations according to claim 3, characterized in that: heating plate (303) are aluminium base resistance heating plate, and there are chip resistor and temperature sensor on aluminium base resistance heating plate surface, scribble heat conduction silicone grease between aluminium base resistance heating plate and heat-conducting plate (301).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822074137.8U CN210012839U (en) | 2018-12-11 | 2018-12-11 | Constant-temperature oscillation incubation device suitable for liquid transfer workstation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201822074137.8U CN210012839U (en) | 2018-12-11 | 2018-12-11 | Constant-temperature oscillation incubation device suitable for liquid transfer workstation |
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| CN210012839U true CN210012839U (en) | 2020-02-04 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109504600A (en) * | 2018-12-11 | 2019-03-22 | 东南大学 | A kind of constant temperature oscillation incubating device suitable for liquor removing workstation |
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2018
- 2018-12-11 CN CN201822074137.8U patent/CN210012839U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109504600A (en) * | 2018-12-11 | 2019-03-22 | 东南大学 | A kind of constant temperature oscillation incubating device suitable for liquor removing workstation |
| CN109504600B (en) * | 2018-12-11 | 2024-08-13 | 东南大学 | Constant-temperature oscillation incubation device suitable for pipetting workstation |
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